<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0" xmlns:itunes="http://www.itunes.com/dtds/podcast-1.0.dtd" xmlns:googleplay="http://www.google.com/schemas/play-podcasts/1.0"><channel><title><![CDATA[Dr. Mercola's Censored Library (Private Membership)]]></title><description><![CDATA[Join the private membership of Dr. Mercola's Censored Library today to begin accessing must-read information you won't find anywhere else. ]]></description><link>https://takecontrol.substack.com</link><image><url>https://substackcdn.com/image/fetch/$s_!EIeH!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa8bcadf2-4229-431c-bac8-74bb04c0d20e_400x400.png</url><title>Dr. Mercola&apos;s Censored Library (Private Membership)</title><link>https://takecontrol.substack.com</link></image><generator>Substack</generator><lastBuildDate>Fri, 29 May 2026 15:48:38 GMT</lastBuildDate><atom:link href="https://takecontrol.substack.com/feed" rel="self" type="application/rss+xml"/><copyright><![CDATA[Dr. Joseph Mercola]]></copyright><language><![CDATA[en]]></language><webMaster><![CDATA[jm@mercola.com]]></webMaster><itunes:owner><itunes:email><![CDATA[jm@mercola.com]]></itunes:email><itunes:name><![CDATA[Dr. Joseph Mercola]]></itunes:name></itunes:owner><itunes:author><![CDATA[Dr. Joseph Mercola]]></itunes:author><googleplay:owner><![CDATA[jm@mercola.com]]></googleplay:owner><googleplay:email><![CDATA[jm@mercola.com]]></googleplay:email><googleplay:author><![CDATA[Dr. Joseph Mercola]]></googleplay:author><itunes:block><![CDATA[Yes]]></itunes:block><item><title><![CDATA[★Could Your 'Healthy' Routine Be Backfiring?]]></title><description><![CDATA[Research on a rare fat-loss disorder shows that when the body loses functional fat cells, blood sugar control worsens, triglycerides rise, and harmful fatty acids increase in the bloodstream.]]></description><link>https://takecontrol.substack.com/p/may-29-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-29-2026-take-control-nl</guid><pubDate>Fri, 29 May 2026 04:01:13 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/0f52c916-f1ed-4506-8a4c-b3f6492bfaed_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260529_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp" width="220" height="55" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260529_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw" fetchpriority="high"></picture><div></div></div></a></figure></div><h2><strong>&#9733; </strong>TOP STORY</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/29/rapid-fat-loss.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260529_TC">Could Your &#8216;Healthy&#8217; Routine Be Backfiring?</a></h4><p>New research suggests that when your body changes too fast, it may release hidden stress signals that disrupt blood sugar balance, strain your liver, and quietly push your metabolism in the wrong direction.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/29/rapid-fat-loss.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260529_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/29/rapid-fat-loss.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260529_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!7xzU!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!7xzU!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 848w, 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loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128200;</strong> TRENDING NEWS</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/29/emulsifiers-in-ice-cream.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2HL&amp;utm_campaign=20260529_TC">This Ingredient in Ice Cream Keeps It from Melting but Harms Your Gut (and Overall) Health</a></h4><p>Cool and refreshing, ice cream is a favorite summertime treat, but watch out - it contains this commonly used additive that&#8217;s wreaking havoc on your gut health.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/29/emulsifiers-in-ice-cream.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260529_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[New Study Gives More Insight on How Ozempic Use Affects Muscle Health]]></title><description><![CDATA[New study reveals Ozempic reduces muscle strength by 10% and shrinks organs like liver by 50%, raising serious concerns about long-term health risks.]]></description><link>https://takecontrol.substack.com/p/how-ozempic-use-affects-muscle-health</link><guid isPermaLink="false">https://takecontrol.substack.com/p/how-ozempic-use-affects-muscle-health</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Fri, 29 May 2026 03:33:43 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/650be682-f8ec-4a2d-b901-0f809eb72316_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!mIM3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!mIM3!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!mIM3!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/c9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:33530,&quot;alt&quot;:&quot;how ozempic use affects muscle health&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/173070429?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="how ozempic use affects muscle health" title="how ozempic use affects muscle health" srcset="https://substackcdn.com/image/fetch/$s_!mIM3!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!mIM3!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc9ad1e1c-090c-4ad9-8755-44b6d24bbc68_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Ozempic, originally developed for Type 2 diabetes, is now widely used for weight loss, but new research shows serious effects on muscle and organ health</p></li><li><p>A study in Cell Metabolism found Ozempic reduces lean mass by around 10% in mice, with the liver shrinking nearly 50%, raising concerns about long-term organ function</p></li><li><p>Researchers observed a mismatch between muscle size and strength, with some muscles staying the same size but losing power, suggesting potential frailty risk and reduced physical performance in animal models &#8212; effects requiring confirmation in human clinical trials</p></li><li><p>Older adults may face a higher risk, as age&#8209;related weakness combined with potential drug&#8209;related declines in strength may undermine independence, mobility, and overall longevity</p></li><li><p>Long-term use of Ozempic and similar GLP-1 drugs is also associated with adverse side effects like dental issues, eye damage, mental health risks, and possible weight regain following discontinuation</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!BY4i!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 424w, 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class="image-caption">Advertisement</figcaption></figure></div><p>Ozempic, known generically as semaglutide, is a drug originally developed to treat Type 2 diabetes, and it works by mimicking a natural hormone called GLP-1. Its commonly advertised effects include regulating blood sugar, slowing digestion, and reducing appetite &#8212; and these are the reasons why many are now relying on it to further their weight loss goals.</p><p>But as the number of people worldwide using these drugs continues to grow, so does the list of damaging health effects that are being associated with it. One study, for example, linked Ozempic to effects on muscle strength, even though muscle size remains stable. In animal models, this was associated with increased frailty risk and reduced physical performance &#8212; findings researchers note urgently need confirmation in human clinical trials.</p><div id="youtube2-57_HONwY1tA" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;57_HONwY1tA&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/57_HONwY1tA?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Study Finds Unexpected Patterns in Muscle Health During Ozempic Use</strong></h2><p>A recent animal study published in Cell Metabolism investigated how Ozempic changes body tissues beyond just fat loss.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> Conducted by researchers from the University of Utah Health, the study found that although changes in muscle mass appear trivial, the same cannot be said for muscle strength. According to a press release from the University, this points out &#8220;an urgent need for clinical studies to pin down the full effects of the popular medications.&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a></p><ul><li><p><strong>The research used mice as the study population and produced surprising results &#8212;</strong> They found that the lean mass of the test subjects dropped by about 10% overall. However, most of that decrease came not from skeletal muscle but from organs like the liver, which shrank nearly in half.</p></li><li><p><strong>This means that your organs are also reshaping during weight changes &#8212;</strong> The researchers said that some organ shrinkage is considered normal during healthy weight loss. However, the exact effects on humans are still unclear.</p></li><li><p><strong>Skeletal muscles also shrank slightly &#8212;</strong> The researchers noted a 6% reduction in these muscles, although this wasn&#8217;t enough to explain the total lean mass loss. Some muscles even stayed the same size. The researchers explained that this could reflect a &#8220;return to baseline,&#8221; because when you gain fat, your body also tends to build more muscle just to move the extra weight around. As fat goes away, that supportive muscle drops as well.</p></li><li><p><strong>A significant finding was the mismatch between muscle size and muscle strength &#8212;</strong> When the scientists tested how much force the mice&#8217;s muscles could produce, they found some muscles got weaker even though their size looked unchanged. In others, strength remained unchanged.</p></li><li><p><strong>These effects raise particular concerns for older adults &#8212;</strong> People over 60 years old are already at a higher risk for muscle weakness and mobility issues, so if the drug-related strength declines observed in mice translate to humans, it could increase falls and reduce independence. As senior author Katsu Funai, Ph.D., emphasized, &#8220;the loss of physical function is a strong predictor of not just quality of life but longevity.&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a></p></li></ul><p>The researchers cautioned against drawing one-to-one comparisons with people, stressing the urgency of conducting human clinical trials to confirm these findings. They explained that while the mice in the study became obese from eating a high-fat diet, human weight gain comes from many causes, including poor sleep, stress, and genetics.</p><p>Still, there are similar studies highlighting these effects of Ozempic and similar GLP-1 receptor agonist medications on your musculoskeletal health, adding to the growing body of evidence suggesting that rapid weight loss has damaging consequences for your well-being.</p><h2><strong>Ozempic Alters More Than Just Your Weight</strong></h2><p>Earlier this year, I published an article on <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/06/05/ozempic-alarming-long-term-health-effects.aspx">how Ozempic leads to alarming side effects</a></strong>, affecting users not just physically but also psychologically, and even influencing their long-term health trajectory. One of the primary points I raised was that these drugs are leading to severe loss of muscle and bone.</p><ul><li><p><strong>GLP-1 drugs reduce lean mass, according to studies &#8212;</strong> To better understand, it&#8217;s important to know what &#8220;lean mass&#8221; is. Simply put, this refers to the weight of everything in your body except fat &#8212; muscle mass, bone mass, organ size, fluids, and water in fat tissues.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a></p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>According to one review, up to 40% of total weight lost on semaglutide may come from lean mass, while liraglutide, the active ingredient in Victoza, a GLP-1 drug similar to Ozempic, has been linked to a reduction of up to 60% of total weight lost.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a> A 2023 study published in Diabetes Care also compared semaglutide and tirzepatide with a placebo and found lean mass reduction accounted for 15% or less in total weight loss across all groups.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-6" href="#footnote-6" target="_self">6</a></p></li><li><p><strong>GLP-1s help you shed fat, but cause you to lose valuable tissue, too &#8212;</strong> One clinical trial involving 140 participants with a mean age of 52 looked at the effects of semaglutide and found that during a 68-week period, they were able to lose 23 pounds of fat &#8212; but at the same time, lost about 15 pounds of lean muscle mass as well. That&#8217;s nearly 40% of their total weight loss coming from tissue the body actually needs to survive and thrive.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-7" href="#footnote-7" target="_self">7</a></p></li><li><p><strong>Rapid weight loss also causes you to lose important bone tissue &#8212;</strong> A 2024 study involving 195 participants found that liraglutide led to lower bone density &#8212; particularly in the spine and hip. Published in the JAMA Network Open, the study said:</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>&#8220;Liraglutide alone led to weight and fat loss compared with placebo; however, this was associated with decreased hip and spine BMD compared with placebo and exercise alone.&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-8" href="#footnote-8" target="_self">8</a></p></li><li><p><strong>This combination of reduced muscle mass and low bone mineral density poses a mortality risk, especially to older people &#8212;</strong> Having low muscle mass and fragile bones leads to a higher risk of injury from falls, particularly in older populations who struggle with mobility. It may also compromise your immune system,<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-9" href="#footnote-9" target="_self">9</a> potentially reducing your body&#8217;s ability to handle infections, which is also a common health concern among the elderly.</p></li></ul><h2><strong>Muscle and Bone Damage Make Up Just a Fraction of Ozempic&#8217;s Overall Impact on Health</strong></h2><p>Ozempic has become a &#8220;global sensation,&#8221; with an estimated 20 million people using it annually to help them reach their weight loss goals faster.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-10" href="#footnote-10" target="_self">10</a> But as more and more people become hooked on this trend, the more its ugly side starts to surface. That&#8217;s the thing about taking shortcuts, especially when it comes to your health &#8212; there can be serious consequences.</p><p>I&#8217;ve been sounding the alarm about GLP-1 agonists for a few years now, and if you do an in-depth search on this site, you&#8217;ll see the many articles I&#8217;ve written exposing the pitfalls of these so-called &#8220;miracle drugs.&#8221; Below, I&#8217;ve highlighted some examples of side effects associated with Ozempic and other similar medications:</p><ul><li><p><strong>Noticeable physical changes &#8212;</strong> These include what&#8217;s called &#8220;Ozempic face,&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-11" href="#footnote-11" target="_self">11</a> which is when a person loses too much facial fat, leading to a hollowed-out, gaunt appearance, and &#8220;Ozempic breast&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-12" href="#footnote-12" target="_self">12</a> in women, wherein their breasts become &#8220;saggy&#8221; or &#8220;deflated&#8221; due to too much fat loss.</p></li><li><p><strong>Dental health problems &#8212;</strong> There are now increasing cases of tooth- and gum-related health issues among those who use GLP-1 medications &#8212; a phenomenon dubbed as &#8220;<strong><a href="https://articles.mercola.com/sites/articles/archive/2025/08/11/ozempic-teeth.aspx">Ozempic teeth</a></strong>.&#8221; These include symptoms like tooth decay, oral infections, bad breath, and dental collapse. Even those with no prior history of dental disease are experiencing these side effects.</p></li><li><p><strong><a href="https://articles.mercola.com/sites/articles/archive/2024/09/07/ozempic-linked-increased-risk-blindness.aspx">Blindness</a> &#8212;</strong> A 2024 study published by JAMA Ophthalmology found a link between semaglutide and non-arteritic anterior ischemic optic neuropathy (NAION) among Type 2 diabetics and overweight or obese participants.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This condition is marked by a loss of blood flow to the optic nerve, the neural pathway connecting your eyes to your brain.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>According to the study findings, semaglutide was associated with a 4.28 times higher likelihood of developing NAION among diabetic participants, and a 7.64 times higher likelihood among those who were overweight or obese.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-13" href="#footnote-13" target="_self">13</a></p></li><li><p><strong><a href="https://articles.mercola.com/sites/articles/archive/2024/10/30/ozempic-weight-loss-drugs-deaths.aspx">Suicide ideation</a> &#8212;</strong> One JAMA Network Open analysis of World Health Organization (WHO) adverse-event reports found a 45% greater rate of suicidal ideation reports among patients taking semaglutide compared to other medications.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-14" href="#footnote-14" target="_self">14</a> This may be related to how the drug&#8217;s main component targets GLP-1 receptors, which are present not just in the digestive tract but also in brain areas involved in managing emotions.</p></li><li><p><strong>Kidney damage &#8212;</strong> There are reports of semaglutide users experiencing kidney issues like acute interstitial nephritis (AIN), a serious kidney inflammation, and focal segmental glomerulosclerosis (FSGS). FSGS is associated with an increased risk of kidney failure.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-15" href="#footnote-15" target="_self">15</a></p></li><li><p><strong><a href="https://articles.mercola.com/sites/articles/archive/2024/05/08/ozempic-weight-loss-injections-health-effects.aspx">Gastrointestinal problems</a> &#8212;</strong> A 2023 study published in JAMA linked GLP-1 agonists to an increased risk of serious health conditions like pancreatitis, stomach paralysis, and bowel obstruction.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-16" href="#footnote-16" target="_self">16</a> There are also studies warning about the possible risk of these drugs causing fatal intestinal obstructions.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-17" href="#footnote-17" target="_self">17</a></p></li><li><p><strong><a href="https://articles.mercola.com/sites/articles/archive/2023/06/14/semaglutide-kidney-and-gastro-issues.aspx">Thyroid tumors and other cancers</a> &#8212;</strong> There are animal studies showing semaglutide causes thyroid C-cell tumors &#8220;at clinically relevant exposures,&#8221; a reason why this medication carries a black box warning.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-18" href="#footnote-18" target="_self">18</a> There&#8217;s also an incident in a trial wherein a patient developed metastatic pancreatic carcinoma about 65 days post-treatment.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-19" href="#footnote-19" target="_self">19</a></p></li></ul><h2><strong>There&#8217;s Also the Problem with &#8216;Ozempic Rebound&#8217;</strong></h2><p>Another issue with taking shortcuts to lose weight is that the effects are not long-term &#8212; eventually, many patients end up gaining back the weight they lost, meaning all their efforts go down the drain. This is what&#8217;s called &#8220;Ozempic rebound.&#8221;</p><p>For example, a clinical trial conducted in 2022 found that among 327 long-term semaglutide users, many of those who stopped using the drug regained about two-thirds of their lost weight within a year.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-20" href="#footnote-20" target="_self">20</a></p><ul><li><p><strong>Stopping Ozempic may bring back all your hunger cues and cravings &#8212;</strong> Basically, when you take Ozempic and then go cold turkey, the hunger cues it had suppressed come raging back. This leads you to revert to unhealthy eating, which causes the weight to return.</p></li><li><p><strong>Even the other purported &#8220;health benefits&#8221; disappear &#8212;</strong> Ozempic is said to help reduce blood pressure, but this could bounce back when you discontinue using the drug.</p></li><li><p><strong>Patients are advised to stop the drug after a period of use &#8212;</strong> During this time, they need to assess their cravings for carbohydrates. Benjamin Bikman, Ph.D., a metabolic scientist at Brigham Young University in Utah, said in a Daily Mail article, &#8220;Ideally, a person has learned how to eat better and control carb cravings and their weight loss can be sustained in the long run.&#8221;<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-21" href="#footnote-21" target="_self">21</a></p></li></ul><h2><strong>There Are Better Strategies to Help Manage Your Weight</strong></h2><p>Going back to the featured study, the researchers noted that their findings on muscle stress can provide insights to help in the production of other weight loss drugs. &#8220;There are many additional weight loss drugs that are in clinical trials and coming out in the next three to five years,&#8221; Funai says. &#8220;But with all those clinical trials, if they&#8217;re interested in measuring lean mass loss, they need to consider physical function,&#8221; Funai said.</p><p>But that is exactly what&#8217;s wrong with this picture &#8212; many have become so engrossed by these quick remedies to shed pounds and fail to realize that these are not long-term solutions.</p><p>I believe that the key to eliminating excess fat and maintaining a healthy weight lies in optimizing your cellular energy production. And while it involves a multifaceted approach that takes time and effort to implement, the payback is so much better, as it leads to safer, healthier results &#8212; something GLP-1 receptor agonists don&#8217;t offer. Here are key strategies that I recommend for healthy weight management.</p><ol><li><p><strong>Eliminate vegetable oils and ultraprocessed foods from your diet &#8212;</strong> These contain high amounts of linoleic acid (LA), which disrupt your metabolic pathways and alter how your body stores fat. Instead, cook your meals using tallow, grass fed butter, or ghee. Ideally, keep your LA intake around 5 grams per day; if you can get it down to 2 grams, that would be better.</p></li><li><p><strong>Shift your carbohydrate sources gradually &#8212;</strong> Choose fruits, whole grains, and well-cooked vegetables as your carb sources. If your gut is compromised, start by introducing easily digestible carbohydrates like whole fruit or white rice before incorporating more complex carbs. For those with severe gut issues, sipping dextrose water will provide the cells with a steady source of easy-to-digest, healthy carbohydrates for energy.</p></li><li><p><strong>Consider your protein intake &#8212;</strong> Aim for 0.8 grams of protein per pound of your ideal body weight from a mix of high-quality animal sources. This may help support muscle maintenance, tissue repair, and hormone balance. If you exercise frequently, you might need to slightly increase your intake. My suggestion is to take it slow and listen to how your body responds.</p></li><li><p><strong>Support your mitochondrial health with other healthy habits &#8212;</strong> Getting daily sun exposure is one example; however, if you&#8217;re still consuming vegetable oils, make sure to avoid intense midday sun for at least six months. Research suggests vegetable oils may accumulate in skin tissue and contribute to oxidative stress under UV exposure.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-22" href="#footnote-22" target="_self">22</a> Learn more about this by reading &#8220;<strong><a href="https://articles.mercola.com/sites/articles/archive/2026/06/08/clearing-vegetable-oils-from-your-skin.aspx">The Fast-Track Path to Clearing Vegetable Oils from Your Skin</a></strong>.&#8221;</p></li><li><p><strong>Boost your GLP-1 levels naturally with Akkermansia muciniphila &#8212;</strong> This bacterium is a keystone strain in your microbiome. Having higher levels of Akkermansia is associated with lower weight, better blood sugar control, lower inflammation, and less body fat. Meanwhile, having lower levels is linked to obesity.</p></li></ol><h2><strong>Frequently Asked Questions (FAQs) About Ozempic and Muscle Health</strong></h2><p><strong>Q: What is Ozempic and why are so many people using it?</strong></p><p><strong>A: </strong>Ozempic, or semaglutide, was originally designed to manage Type 2 diabetes by mimicking a natural hormone called GLP-1. It helps regulate blood sugar, slows digestion, and curbs appetite. Because of these effects, millions worldwide now use it as a quick solution for weight loss, making it one of the most talked-about drugs in recent years.</p><p><strong>Q: How does Ozempic affect muscle health?</strong></p><p><strong>A: </strong>Animal studies show that Ozempic use may reduce muscle strength even when muscle size remains mostly stable. This could create a hidden problem &#8212; your muscles may look the same but perform worse. This decline in strength may increase the risk of frailty, falls, injuries, and loss of independence, particularly as you age.</p><p><strong>Q: Does Ozempic impact organs and bones too?</strong></p><p><strong>A: </strong>Yes, it does. Research has shown that Ozempic may not only reduce fat but also shrink organ size, especially in the liver, which shrank nearly in half in animal studies. It may also lead to possible decreased bone density in the spine and hips, raising the risk of fractures, frailty, and health complications, especially in older adults.</p><p><strong>Q: What other side effects are linked to Ozempic?</strong></p><p><strong>A: </strong>Beyond weight loss, Ozempic has been tied to a wide range of non-favorable side effects. These include sagging skin and facial fat loss (&#8221;Ozempic face&#8221;), dental collapse known as &#8220;Ozempic teeth,&#8221; vision damage, kidney issues, gastrointestinal paralysis, pancreatic tumors, and even higher rates of suicidal thoughts.</p><p><strong>Q: Is weight loss from Ozempic permanent?</strong></p><p><strong>A: </strong>No, the results often do not last. Many users experience &#8220;Ozempic rebound,&#8221; where they regain most of the weight they have lost within a year after stopping the drug. Hunger and cravings return quickly, and even the temporary health benefits, like lower blood pressure, diminish.</p><p><em>These findings include results from animal models and clinical research. Results may not apply to all individuals.</em></p><p><em>This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making changes to your health regimen.</em></p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/7-days-meditation&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/7-days-meditation"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00331-6">Cell Metabolism, August 5, 2025, Volume 37, Issue 8, Pages 1619-1620</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://healthcare.utah.edu/newsroom/news/2025/08/new-study-raises-questions-about-how-ozempic-affects-muscle-size-and-strength">University of Utah Health, August 5, 2025</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://healthcare.utah.edu/newsroom/news/2025/08/new-study-raises-questions-about-how-ozempic-affects-muscle-size-and-strength">University of Utah Health, August 5, 2025</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://www.medicalnewstoday.com/articles/drugs-does-ozempic-make-you-lose-muscle#preventing-muscle-loss">Medical News Today, August 1, 2025</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-5" href="#footnote-anchor-5" class="footnote-number" contenteditable="false" target="_self">5</a><div class="footnote-content"><p><a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15728">Diabetes, Obesity, and Metabolism, September 2024, Volume 26, Issue S4, Pages 16-27</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-6" href="#footnote-anchor-6" class="footnote-number" contenteditable="false" target="_self">6</a><div class="footnote-content"><p><a href="https://diabetesjournals.org/care/article/46/5/998/148546/Tirzepatide-Reduces-Appetite-Energy-Intake-and-Fat">Diabetes Care 2023;46(5):998-1004</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-7" href="#footnote-anchor-7" class="footnote-number" contenteditable="false" target="_self">7</a><div class="footnote-content"><p><a 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data-component-name="FootnoteToDOM"><a id="footnote-19" href="#footnote-anchor-19" class="footnote-number" contenteditable="false" target="_self">19</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8717485/">J Investig Med. 2021 Oct 27;70(1):5&#8211;13</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-20" href="#footnote-anchor-20" class="footnote-number" contenteditable="false" target="_self">20</a><div class="footnote-content"><p><a href="https://pubmed.ncbi.nlm.nih.gov/35441470/">Diabetes Obes Metab. 2022 Aug;24(8):1553-1564</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-21" href="#footnote-anchor-21" class="footnote-number" contenteditable="false" target="_self">21</a><div class="footnote-content"><p><a href="https://www.dailymail.co.uk/health/article-14584347/doctor-predicts-three-terrifying-long-term-health-effects-ozempic.html">Daily Mail, April 1, 2025</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-22" href="#footnote-anchor-22" class="footnote-number" contenteditable="false" target="_self">22</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11719646/">Int J Mol Sci. 2024 Dec 30;26(1):246</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★The Hidden Foods That May Be Triggering Gut Inflammation]]></title><description><![CDATA[Personalized nutrition using biomarkers and AI can help manage IBD by identifying food triggers unique to your gut, offering relief beyond generic diets.]]></description><link>https://takecontrol.substack.com/p/may-28-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-28-2026-take-control-nl</guid><pubDate>Thu, 28 May 2026 04:00:54 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/975f6c9e-bd31-4bbd-833f-02b1e6484cc3_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260528_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp" width="220" height="55" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260528_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw" fetchpriority="high"></picture><div></div></div></a></figure></div><h2><strong>&#9733; </strong>TOP STORY</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/28/precision-nutrition-for-ibd.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260528_TC">The Hidden Foods That May Be Triggering Gut Inflammation</a></h4><p>Chronic digestive issues, fatigue, and unexplained weight changes often trace back to hidden imbalances in your gut microbiome - and emerging data shows these patterns may also increase the risk of more serious diseases over time.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/28/precision-nutrition-for-ibd.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260528_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source 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src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read 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href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4HL&amp;utm_campaign=20260528_TC">Breaking News: What You Need to Know</a></h4><p>Up-to-date info on the latest health-related news happening in the world.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260528_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Geranylgeraniol (GG) Reverses Pain, Gut Damage, and Mitochondrial Dysfunction in Diabetic Neuropathy]]></title><description><![CDATA[Researchers found that a naturally occurring compound called geranylgeraniol (GG) reduced diabetic nerve pain by 35% in rats even without significantly improving blood sugar control.]]></description><link>https://takecontrol.substack.com/p/dietary-geranylgeraniol-diabetic-neuropathy</link><guid isPermaLink="false">https://takecontrol.substack.com/p/dietary-geranylgeraniol-diabetic-neuropathy</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Thu, 28 May 2026 03:33:50 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/d68f9d1b-6a67-4fae-ae10-b9ad17ccd4fa_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!yc22!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!yc22!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!yc22!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!yc22!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!yc22!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!yc22!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:37191,&quot;alt&quot;:&quot;dietary geranylgeraniol diabetic neuropathy&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/196736889?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F11f16b60-f74e-4223-a5d6-88385bcd677a_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="dietary geranylgeraniol diabetic neuropathy" title="dietary geranylgeraniol diabetic neuropathy" 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class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Researchers found that a naturally occurring compound called geranylgeraniol (GG) reduced diabetic nerve pain by 35% in rats even without significantly improving blood sugar control</p></li><li><p>Diabetic neuropathy involves far more than elevated glucose levels because gut barrier breakdown, mitochondrial dysfunction, and chronic inflammation all contribute to nerve irritation and pain sensitivity</p></li><li><p>GG improved tight junction proteins in the intestines, helping reduce the leakage of bacterial toxins that fuel inflammatory stress throughout the nervous system</p></li><li><p>Beneficial gut bacteria require properly tolerated carbohydrates and fermentable fibers to produce butyrate, a short-chain fatty acid that helps maintain the gut barrier and supports healthier nerve function</p></li><li><p>Daily habits that improve mitochondrial energy production, including removing seed oils, restoring healthy carbohydrate intake, getting regular sunlight exposure and improving sleep quality, help calm the inflammatory signals that keep nerves hypersensitive</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!BY4i!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 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srcset="https://substackcdn.com/image/fetch/$s_!BY4i!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>Diabetic neuropathy affects up to 75% of adults with diabetes, yet most people understand it only as a complication of high blood sugar. Researchers from Texas Tech University Health Sciences Center argue in the International Journal of Molecular Sciences that framing neuropathy as a blood sugar problem misses most of what&#8217;s actually driving the pain.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup></p><p>The condition involves a cascade of interconnected failures &#8212; nerve damage, yes, but also gut barrier breakdown, mitochondrial dysfunction, and chronic inflammation &#8212; and treating it may require addressing all of them together. This distinction changes what solutions are even worth considering.</p><p>That&#8217;s where a naturally occurring compound called <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/03/23/geranylgeraniol-statin-muscle-pain-solution.aspx">geranylgeraniol</a></strong>, or GG, enters the picture. It&#8217;s already present in your body, it&#8217;s found in common foods like fruits, vegetables, and grains, and it appears to work on the parts of this problem that glucose control doesn&#8217;t reach.</p><p>Your body converts GG into a compound called geranylgeranyl pyrophosphate &#8212; think of it as a molecular building block your cells use to assemble energy machinery, repair membranes, and keep insulin signaling running smoothly. Without enough of it, those systems degrade quietly in the background.</p><p>Researchers tested whether supplementing with it could reduce nerve pain and restore cellular function through pathways that have nothing to do with glucose control, and what they found challenges some long-held assumptions about what diabetic neuropathy actually is.</p><div id="youtube2-_-iVbRMbrfw" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;_-iVbRMbrfw&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/_-iVbRMbrfw?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Gut Repair Changed Nerve Pain Even When Blood Sugar Stayed High</strong></h2><p>For the study, researchers investigated whether GG could reduce nerve pain, inflammation, and intestinal damage in diabetic rats.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> GG helps support the systems your cells use to create energy and maintain healthy tissue function. The study examined whether improving mitochondrial function and gut integrity with GG could reduce diabetic neuropathy symptoms even without major changes in glucose control.</p><p>Researchers fed rats a high-fat diet, induced diabetes, and then supplemented one group with GG for six weeks. Instead of measuring only pain levels, they also tracked gut bacteria, inflammatory markers, <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/05/mitochondrial-energy-production.aspx">mitochondrial repair systems</a></strong>, and anxiety-like behaviors.</p><ul><li><p><strong>The diabetic rats developed widespread metabolic dysfunction &#8212;</strong> Compared to healthy controls, the diabetic rats showed insulin resistance, impaired glucose tolerance, gut microbiome disruption, and signs of mitochondrial breakdown inside the colon. The researchers also observed anxiety-like behaviors, reduced movement confidence, and heightened sensitivity to touch, showing how deeply metabolic dysfunction affects the nervous system.</p></li><li><p><strong>Pain sensitivity dropped by 35% after GG supplementation &#8212;</strong> One of the biggest findings involved mechanosensitive pain, meaning pain triggered by touch or pressure. Researchers used the von Frey test, which measures how strongly an animal reacts to physical stimulation. Rats given GG showed a 35% reduction in pain sensitivity compared to untreated diabetic rats. In practical terms, the nerves became less reactive and less irritated.</p></li><li><p><strong>The rats also behaved less fearful and anxious &#8212;</strong> <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/01/06/diabetic-peripheral-neuropathy.aspx">Chronic nerve pain</a></strong> affects emotional regulation alongside physical sensation. Untreated diabetic rats avoided open spaces and displayed behaviors tied to fear and anxiety. After GG supplementation, the rats explored open areas more often and spent more time there. That shift suggests GG improved neurological stress responses alongside pain sensitivity.</p></li><li><p><strong>Blood sugar remained impaired despite the pain improvements &#8212;</strong> The GG supplement did not significantly improve insulin resistance, glucose tolerance, or pancreatic beta-cell damage. Beta cells are the insulin-producing cells inside your pancreas. Even though glucose metabolism stayed impaired, pain levels, inflammatory markers, and mitochondrial function improved anyway.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Most diabetic neuropathy discussions focus almost entirely on glucose levels. This study showed that restoring mitochondrial function and intestinal integrity improved pain outcomes even while metabolic dysfunction remained present.</p></li></ul><h2><strong>Gut Bacteria and Mitochondrial Repair Reshaped the Pain Response</strong></h2><p>As part of the study, researchers measured claudin-3, a tight junction protein that helps seal the intestinal lining. Tight junctions work like protective seals between intestinal cells. Once those seals weaken, bacterial toxins leak into circulation and trigger immune activation throughout the body. Diabetic rats showed lower claudin-3 levels, while GG supplementation significantly increased them.</p><ul><li><p><strong>Lower gut permeability reduced inflammatory overload &#8212;</strong> Once the <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/01/19/deep-dive-into-butyrate-guts-powerhouse-molecule.aspx">gut barrier</a></strong> weakens, the immune system stays trapped in a chronic inflammatory state that worsens mitochondrial stress and nerve irritation. By improving tight junction integrity, GG reduced one of the upstream triggers driving the inflammatory cycle. That matters because many people with metabolic disease live in a constant low-grade inflammatory state without realizing the gut often sits at the center of the problem.</p></li><li><p><strong>Several beneficial gut bacteria declined in diabetic rats &#8212;</strong> The diabetic animals showed reduced levels of Eubacterium coprostanoligenes, Lachnospiraceae, and Oscillospiraceae. These bacteria help support the intestinal mucus layer and regulate anti-inflammatory signaling. At the same time, inflammatory-associated bacteria like Clostridium sensu stricto increased.</p></li><li><p><strong>GG improved microbial diversity even without fully correcting dysbiosis &#8212;</strong> The supplement didn&#8217;t completely restore the gut microbiome, but it increased alpha diversity. Alpha diversity refers to the variety of microbes living inside the gut. Higher diversity usually reflects a more resilient and stable microbial environment. Think of it like strengthening the ecosystem inside your digestive tract so harmful organisms have a harder time dominating the environment.</p></li><li><p><strong>The strongest improvements appeared inside the mitochondria &#8212;</strong> Researchers measured markers tied to mitochondrial fusion, fission, repair, and turnover. Healthy mitochondria constantly merge, divide, and recycle damaged components to maintain stable energy production. In the diabetic rats, this repair system became severely disrupted.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The GG supplement raised levels of two markers involved in mitochondrial fusion and the production of new mitochondria. More mitochondrial repair and renewal translates into stronger cellular energy production, which directly affects nerve stability and inflammation control.</p></li><li><p><strong>Markers of mitochondrial breakdown dropped sharply &#8212;</strong> Before supplementation, the diabetic rats showed elevated levels of markers that reflect excessive mitochondrial fragmentation and stress-driven recycling of damaged mitochondria. GG lowered these markers. That shift indicates the cells moved away from a breakdown state and back toward more stable energy production.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The researchers also found lower TNF-alpha levels after GG supplementation. TNF-alpha acts like a cellular alarm signal that amplifies inflammation and pain sensitivity. Once TNF-alpha stays elevated, nerves become more reactive and irritated. Lowering that inflammatory pressure helps calm the nervous system and reduce hypersensitivity.</p></li></ul><h2><strong>Support Mitochondrial Repair and Gut Integrity to Calm Diabetic Nerve Pain</strong></h2><p>The findings from this study point toward a clear direction. GG worked not by fixing blood sugar, but by restoring the two systems that keep nerve pain locked in place &#8212; mitochondrial function and gut barrier integrity. When those systems stabilized, pain signals dropped, inflammatory overload eased, and the nervous system became less reactive. That gives you a practical framework for what to address next.</p><p>GG helps your cells maintain the machinery required to produce energy and repair damaged tissue. The steps below build on that same logic &#8212; starting with GG itself, then targeting the mitochondrial and gut conditions the research identified as central to the pain cycle.</p><ol><li><p><strong>Increase your intake of GG and use the right form &#8212;</strong> GG naturally occurs in foods like tomatoes, carrots, olives, and some grains, but supplemental forms provide far more concentrated support. Most commercial GG supplements contain 150 milligrams (mg) to 300 mg per softgel.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Look for supplements containing &#8220;GG-Gold&#8221; or similar branded forms of trans-geranylgeraniol derived from annatto seeds because these are the most studied forms. GG can be taken with or without food. GG has an excellent safety profile. That said, always consult with a health care provider familiar with your medical history before starting any new supplement.</p></li><li><p><strong>Feed your cells the raw materials required for nerve repair &#8212;</strong> Your nerves don&#8217;t heal in a low-energy environment. Every repair process inside your body depends on stable adenosine triphosphate (ATP) production, and ATP production drops sharply when your metabolism stays trapped in chronic stress mode. Carbohydrate restriction and ultraprocessed diets often worsen metabolic dysfunction because they suppress mitochondrial energy production instead of restoring it.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Most adults do best with roughly 250 grams of healthy carbohydrates daily, and active individuals often require more. The key is choosing carbohydrates your gut tolerates well while rebuilding metabolic flexibility. Start with easier-to-digest options like whole fruit and white rice. As digestion and gut function improve, gradually add more root vegetables and well-tolerated higher-fiber carbohydrates.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Protein intake also matters. Aim for about 0.8 grams per pound (or 1.76 grams per kilogram) of lean body mass, with one-third coming from <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/09/04/boost-your-collagen-intake-with-these-foods.aspx">collagen-rich sources</a></strong> like slow-cooked meats or bone broth. Collagen provides glycine and other amino acids tied to connective tissue repair, gut barrier support, and nervous system stability.</p></li><li><p><strong>Repair the gut environment that keeps inflammation switched on &#8212;</strong> Diabetic neuropathy often overlaps with bloating, unstable digestion, food sensitivities, and fluctuating energy because the gut barrier and microbiome become disrupted alongside the nervous system. Once your intestinal lining weakens, bacterial toxins leak into circulation and trigger chronic inflammatory stress that aggravates nerve irritation.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>One of the most important goals is restoring the bacteria that produce short-chain fatty acids like <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/01/05/butyrate-gut-environment-energy-production.aspx">butyrate</a></strong>. Butyrate serves as a primary fuel source for colon cells and helps maintain the oxygen-free environment beneficial gut bacteria require to survive. Once butyrate production drops, harmful oxygen-tolerant bacteria gain ground, gut permeability worsens, and inflammatory stress increases throughout the body.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>That is where carbohydrates and fiber become important. Beneficial gut bacteria rely on carbohydrates and fermentable fibers to produce butyrate. Without enough properly tolerated carbohydrates, your microbiome struggles to rebuild itself and colon cells lose an important fuel source needed to maintain the gut barrier. The problem is that many people with metabolic dysfunction and gut damage tolerate large amounts of fiber very poorly in the beginning.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The rebuilding process works best gradually. As mentioned, start with easy-to-digest carbohydrates such as fruit and white rice. After tolerance improves, slowly introduce additional root vegetables and higher-fiber foods so beneficial bacteria have more material to produce butyrate without overwhelming digestion.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Aggressive high-fiber diets too early often backfire because excessive fermentation increases endotoxin production and intestinal irritation in already damaged guts. Seed oils deserve special attention as well because excess <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/07/28/linoleic-acid-high-intake-standard-american-diet.aspx">linoleic acid</a></strong> (LA) damages mitochondrial membranes and intensifies oxidative stress throughout the gut and nervous system.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Removing soybean oil, canola oil, sunflower oil, and other vegetable oils helps improve mitochondrial function for increased cellular energy. Replace them with stable fats like tallow, ghee, or grass fed butter.</p></li><li><p><strong>Use light exposure and targeted nutrients to improve nerve resilience &#8212;</strong> Your nervous system depends on nutrients that support electrical signaling, tissue repair, and mitochondrial energy production. <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/10/29/b-vitamins-health-benefits.aspx">Vitamins B1, B6, and B12</a></strong> play direct roles in maintaining healthy nerve communication and protecting the myelin sheath surrounding nerves. Deficiencies in these nutrients strongly correlate with chronic nerve pain.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Vitamin D also influences nerve function, insulin sensitivity, and inflammatory regulation.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> Regular <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/03/30/sensible-sun-exposure-supports-overall-health.aspx">sunlight exposure</a></strong> supports healthy vitamin D levels while improving circadian rhythm signaling and mitochondrial energy production. Morning outdoor light exposure helps reset your biological clock, while gradual midday sun exposure supports deeper metabolic repair.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Avoid intense sun exposure from 10 a.m. to 4 p.m. until you&#8217;ve reduced seed oil intake for at least six months, since high LA levels increase your skin&#8217;s sensitivity to the sun.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p><strong><a href="https://articles.mercola.com/sites/articles/archive/2024/11/18/red-light-therapy-benefits.aspx">Red light therapy</a></strong>, also called photobiomodulation, works through a similar energy-supportive mechanism. Specific red and near-infrared wavelengths stimulate mitochondrial function directly inside tissues, improving circulation and lowering inflammatory stress within damaged nerves. Consistent exposure often improves pain sensitivity, recovery, and mobility because healthier mitochondria produce more cellular energy for tissue repair.</p></li><li><p><strong>Lower the daily inflammatory signals that keep nerves hypersensitive &#8212;</strong> When inflammatory signaling stays elevated long term, nerves become overly reactive and pain thresholds drop sharply. Daily habits either calm or amplify those signals. Walking after meals improves glucose handling and circulation. Strength training twice a week improves mitochondrial function and insulin sensitivity.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Sleep quality also plays a major role because poor sleep raises stress hormones and inflammatory signaling that keep your nervous system stuck in a hyperreactive state. Alcohol also deserves attention because it damages mitochondria, worsens gut permeability, and intensifies inflammatory stress throughout the nervous system.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The goal of each of these steps is the same: reduce the inflammatory load your nervous system is carrying, restore the cellular energy it needs to repair itself, and give your gut the conditions it needs to stop feeding the fire. When all three stabilize together, the pain signals that once seemed permanent often quiet down, sometimes significantly.</p></li></ol><h2><strong>FAQs About GG and Diabetic Neuropathy</strong></h2><p><strong>Q: What is GG, and why does it matter for diabetic nerve pain?</strong></p><p><strong>A: </strong>GG is a naturally occurring compound found in foods like tomatoes, carrots, olives, and certain grains. Your body uses it to produce compounds involved in mitochondrial energy production, cellular repair, and insulin signaling. In the study, GG reduced pain sensitivity, improved gut barrier integrity, and lowered inflammatory signaling in diabetic rats, even though blood sugar control stayed impaired.</p><p><strong>Q: How does gut health affect diabetic neuropathy?</strong></p><p><strong>A: </strong>The study showed that diabetic neuropathy involves more than damaged nerves. Gut barrier dysfunction and microbiome imbalance also play major roles. Once the intestinal lining weakens, bacterial toxins leak into circulation and trigger chronic inflammation that aggravates nerve irritation. Researchers found that GG improved tight junction integrity and increased microbial diversity, which helped calm inflammatory stress linked to nerve pain.</p><p><strong>Q: Why are mitochondria important in diabetic neuropathy?</strong></p><p><strong>A: </strong>Mitochondria are the energy-producing structures inside your cells. Your nerves require enormous amounts of energy to maintain healthy signaling and repair tissue damage. The researchers found that diabetic rats showed major signs of mitochondrial breakdown, while GG improved markers tied to mitochondrial repair, fusion, and biogenesis. Healthier mitochondria produce more ATP, which helps stabilize nerves and lower inflammatory stress.</p><p><strong>Q: Why does the article recommend carbohydrates if gut health is damaged?</strong></p><p><strong>A: </strong>Beneficial gut bacteria rely on carbohydrates and fermentable fibers to produce butyrate, a short-chain fatty acid that fuels colon cells and helps maintain the gut barrier. The key is introducing carbohydrates gradually and choosing easier-to-digest options first. Whole fruit and white rice often work better early on because many people with gut dysfunction tolerate high-fiber diets very poorly at first.</p><p><strong>Q: What daily habits help calm hypersensitive nerves?</strong></p><p><strong>A: </strong>Daily habits strongly influence inflammatory signaling and mitochondrial function. Walking after meals improves circulation and glucose handling. Strength training supports mitochondrial energy production and insulin sensitivity. Sleep quality also matters because poor sleep raises inflammatory stress hormones.</p><p>Sunlight exposure, red light therapy, and removing seed oils help support healthier mitochondrial function, while alcohol worsens gut permeability, mitochondrial damage, and nerve irritation.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/how-ozempic-use-affects-muscle-health&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/how-ozempic-use-affects-muscle-health"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.mdpi.com/1422-0067/26/24/12133">International Journal of Molecular Sciences 2025, 26(24), 12133</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.mdpi.com/1422-0067/26/24/12133">International Journal of Molecular Sciences 2025, 26(24), 12133</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://www.dovepress.com/the-benefits-of-add-on-therapy-of-vitamin-d-5000-iu-to-the-vitamin-d-l-peer-reviewed-fulltext-article-JPR">Dove Press December 19, 2021; 2021: 3865-3875</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★Something Isn't Adding Up with These Popular Shots]]></title><description><![CDATA[Thousands of lawsuits claim GLP-1 weight-loss drugs caused severe injuries, including digestive shutdown, organ damage, vision loss, and neurological complications tied to nutrient depletion.]]></description><link>https://takecontrol.substack.com/p/may-27-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-27-2026-take-control-nl</guid><pubDate>Wed, 27 May 2026 04:00:51 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Shop now before it ends tonight.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260527_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3647,&quot;alt&quot;:&quot;shop now&quot;,&quot;title&quot;:&quot;shop now&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260527_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/184393155?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="shop now" title="shop now" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128200;</strong> TRENDING NEWS</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/27/lower-cholesterol-naturally-and-safely.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2HL&amp;utm_campaign=20260527_TC">Lower Cholesterol, Naturally and Safely - No Statins Required</a></h4><p>Confused about cholesterol? You&#8217;re not alone - and the truth may surprise you. This deep dive uncovers why inflammation, not LDL, is the real risk factor, and how simple, proven lifestyle changes and natural therapies can safely lower cholesterol - no statins required.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/27/lower-cholesterol-naturally-and-safely.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260527_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260527_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, 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https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/category/1995/1/energy-production?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Thumb&amp;utm_campaign=20260527_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!QvCx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg 424w, 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[What Is Somatic Therapy? ]]></title><description><![CDATA[Somatic therapy works by focusing on physical sensations like tightness or shallow breathing, helping you retrain your nervous system instead of just analyzing your thoughts.]]></description><link>https://takecontrol.substack.com/p/somatic-therapy</link><guid isPermaLink="false">https://takecontrol.substack.com/p/somatic-therapy</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Wed, 27 May 2026 03:33:26 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/be2f90a2-caf6-4323-9a2a-8b1c5866ebc2_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!Q3LY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!Q3LY!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!Q3LY!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:37570,&quot;alt&quot;:&quot;somatic therapy&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/194765260?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="somatic therapy" title="somatic therapy" srcset="https://substackcdn.com/image/fetch/$s_!Q3LY!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!Q3LY!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7a8cf310-a433-4ba7-afff-cd2d446dab71_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Your body can stay stuck in a stress response long after a threat is gone, which explains why you can feel tension, anxiety, or unease even when your mind knows you&#8217;re safe</p></li><li><p>Somatic therapy works by focusing on physical sensations like tightness or shallow breathing, helping you retrain your nervous system instead of just analyzing your thoughts</p></li><li><p>Simple techniques like shaking, somatic grounding, and controlled breathing help release stored stress and allow your body to complete reactions that were never finished</p></li><li><p>Research shows body-based therapies improve trauma symptoms, mood, and sleep, especially when practiced consistently over structured sessions</p></li><li><p>Building awareness of your body signals gives you more control over emotional reactions, helping you stay calm, recover faster from stress, and feel more stable day to day</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!BY4i!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!BY4i!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg" width="1272" height="254" 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srcset="https://substackcdn.com/image/fetch/$s_!BY4i!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!BY4i!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F23a65c5a-3316-46a8-ac62-6987ee209b45_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>You can sit in a quiet room, feel completely safe, and still notice your chest tighten or your breath turn shallow. You know nothing is wrong. Your body disagrees. That disconnect, between what your mind understands and what your nervous system keeps doing, is what somatic therapy targets. It&#8217;s a body-centered approach that uses movement, breath work, and physical awareness to resolve stress and trauma that remain active in your nervous system long after the original event has passed.</p><p>Unlike conventional talk therapy, which works primarily through conversation and cognitive understanding, somatic therapy starts with what your body is doing right now &#8212; the tension, the shallow breathing, the tightness you carry without realizing it. Interest in this approach has surged in recent years, and for good reason.</p><p>Talk therapy helps you understand your experiences, but understanding alone doesn&#8217;t always quiet a nervous system that remains locked in a stress response. Your body can keep reacting long after the threat is gone, and no amount of insight changes that on its own. Here&#8217;s what that looks like biologically. When your brain detects a threat, your autonomic nervous system activates. Your muscles tense to prepare for action. Stress hormones flood your system.</p><p>If you actually run or fight, those responses complete their cycle and your body returns to baseline. But if the response gets interrupted &#8212; you freeze, you suppress the reaction, you push through &#8212; your nervous system doesn&#8217;t get the signal that the threat is over. The activation stays. Your muscles hold their brace. Your stress hormones keep cycling. That&#8217;s what practitioners mean when they say stress is &#8220;stored&#8221; in your body.</p><p>That raises a direct question: if stress lives in your body, not just your thoughts, does it make sense to address it physically rather than verbally? The research and real-world accounts below show how people are already putting that idea to the test, and what the results look like so far.</p><div id="youtube2-oEjLa5d7PkU" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;oEjLa5d7PkU&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/oEjLa5d7PkU?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Movement-Based Therapy Shows Real World Emotional Release</strong></h2><p>A New York Times article highlighted how people actively use movement inside therapy sessions to deal with stress and trauma.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> Instead of only talking through problems, individuals incorporate physical actions like shaking, breath work, and posture changes. The foundation of this method comes from psychologist Peter A. Levine, who developed somatic experiencing in the 1970s.</p><p>His core idea is that during stressful events, your body mobilizes a cascade of neurochemical and muscular responses &#8212; adrenaline surges, muscles brace, your heart rate spikes &#8212; all designed to help you fight or flee. If you can&#8217;t do either, because you&#8217;re a child with no escape or an adult frozen in a high-pressure situation, that mobilized energy doesn&#8217;t discharge.</p><p>It stays locked in your muscles and nervous system. Over time, it drives ongoing tension and emotional distress, even when the original threat is long gone.</p><p>Movement and awareness provide a way to discharge that stored energy so your system can return to a calmer state. In one example, a woman described practicing &#8220;somatic shaking,&#8221; where she moves her body for several minutes to release tension. She said it&#8217;s &#8220;like a moving meditation,&#8221; explaining that it looks unusual but delivers real emotional relief.</p><ul><li><p><strong>Real people report emotional breakthroughs that talk therapy alone didn&#8217;t provide &#8212;</strong> The article describes individuals who spent years in conventional therapy but still felt stuck, especially when dealing with deep-rooted trauma. After adding movement, they experienced something different.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>One participant noted that after five to 10 minutes of shaking, she often sits quietly and allows deeper emotions to surface, sometimes leading to crying. That emotional release signals something important. Your body holds onto unprocessed experiences, and when you give it a way to express them physically, those emotions finally come out.</p></li><li><p><strong>Simple techniques form the core of this approach &#8212;</strong> The methods described are straightforward and accessible. They include:</p><ul><li><p><strong>Shaking or movement to release tension &#8212;</strong> Short bursts of movement help discharge built-up stress energy in your body.</p></li><li><p><strong>Somatic grounding exercises to reconnect with the present &#8212;</strong> This means focusing on physical contact, like your feet on the floor, to stabilize your nervous system.</p></li><li><p><strong>Breath work and posture adjustments &#8212;</strong> Changing how you breathe or sit directly affects how your body responds to stress.</p></li></ul></li><li><p><strong>Therapists guide you to notice where emotions live in your body &#8212;</strong> A key technique involves slowing everything down. Instead of jumping straight into problem-solving, therapists ask questions like, &#8220;Where do you feel that in your body?&#8221;</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>That question shifts your attention inward. It trains you to recognize physical signals tied to emotions. For example, <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/04/21/anger-management-techniques.aspx">anger</a></strong> might show up as tight shoulders, while anxiety could feel like a knot in your stomach. Once you identify those signals, you gain a new level of awareness that makes your reactions easier to manage.</p></li><li><p><strong>Movement becomes a tool to express what was never expressed &#8212;</strong> Another powerful technique involves acting out responses your body never completed. The article explains that clients might simulate running away by jogging in place or practice saying &#8220;Stop!&#8221; with their hand extended.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>These actions help complete stress responses that were interrupted during past experiences. This matters because your body remembers unfinished reactions. When you physically act them out, you give your nervous system a sense of closure.</p></li><li><p><strong>Not everyone responds the same way, and evidence remains limited &#8212;</strong> Experts quoted in the article stress that somatic therapy shows promise but still lacks strong, large-scale research support. Some techniques, like <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/09/28/proper-breathing.aspx">breathing exercises</a></strong> and muscle relaxation, already appear in established therapies. However, when grouped together as a standalone approach, the results are still under investigation.</p></li></ul><h2><strong>Your Nervous System Drives Long-Term Stress Patterns</strong></h2><p>Personal accounts and clinical observations point in a promising direction, but they don&#8217;t tell us how reliably these outcomes occur or why they work at a physiological level. For that, structured research offers a clearer picture, and the findings so far reinforce what practitioners have been seeing in their sessions.</p><p>A report published by Meridian University pulls together several peer-reviewed findings on somatic trauma therapy, showing how the approach focuses on physical sensations as the starting point for healing.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> Instead of asking you to analyze what happened, this approach tracks what your body is doing in real time. That shift matters because many people already understand their past experiences mentally, yet still feel stuck physically.</p><p>The research highlights that this method works in the &#8220;space between what the mind has processed and what the body continues to hold,&#8221; which gives you a direct path to address symptoms that talking alone hasn&#8217;t resolved.</p><ul><li><p><strong>People with trauma often live with a body that stays on high alert &#8212;</strong> The population described includes individuals with chronic stress and trauma histories, especially those who experienced repeated or early-life stress. The findings show that the nervous system can stay activated long after the original event ends. In everyday terms, your body acts like danger is still present. That leads to constant tension, emotional strain, and difficulty calming down.</p></li><li><p><strong>Research shows measurable improvements across multiple areas &#8212;</strong> A 2023 meta-analysis cited in the source reviewed 29 studies involving body-based therapies for trauma and found moderate improvements in key symptoms.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> These included reductions in trauma-related distress, better mood, and improved sleep.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>That combination matters because these issues often occur together. When sleep improves, your energy and focus improve. When emotional distress drops, daily interactions feel easier. The results show that addressing your body changes multiple systems at once, not just how you think.</p></li><li><p><strong>Specific therapies show strong results in controlled trials &#8212;</strong> One randomized controlled trial described in the research involved 63 participants who completed 15 weekly sessions of somatic experiencing.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a> The results showed large reductions in trauma severity and depression compared to those who received no treatment. Another study involving women with childhood trauma found improvements in body awareness, anxiety levels, and the ability to self-soothe after 20 sessions.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a></p></li><li><p><strong>Attention to body signals improves emotional control &#8212;</strong> A 2024 review of 43 studies found that awareness of internal body sensations strongly links to emotional regulation.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-6" href="#footnote-6" target="_self">6</a> When you get better at noticing what&#8217;s happening inside your body, you handle stress more effectively. You recover faster after being triggered. That creates a practical skill you can build over time. Think of it like training a muscle. The more you practice noticing and responding calmly, the stronger that ability becomes.</p></li><li><p><strong>The therapy uses structured techniques to retrain your system &#8212;</strong> Sessions follow a guided process that includes several core steps. These techniques create a sense of control, step by step:</p><ul><li><p><strong>Noticing sensations as they arise &#8212;</strong> You learn to identify physical signals like tightness or warmth without reacting immediately.</p></li><li><p><strong>Alternating between comfort and discomfort &#8212;</strong> This keeps your system from becoming overwhelmed and builds tolerance gradually.</p></li><li><p><strong>Revisiting past-linked sensations in small, controlled doses &#8212;</strong> Practitioners call this titration; think of it like adjusting a dimmer switch gradually instead of flipping a floodlight on full blast. You approach the difficult sensation just enough to process a small piece, then pull back to safety before your system gets overwhelmed.</p></li></ul></li><li><p><strong>Progress depends on pacing and safety, not intensity &#8212;</strong> The research emphasizes that sessions move slowly, based on what your nervous system can handle at any moment. This pacing prevents overwhelm and builds trust in your own body. When you feel safe during the process, you stay engaged. Over time, that consistent engagement leads to stronger regulation, better emotional balance, and improved daily function.</p></li></ul><h2><strong>How to Retrain Your Body to Release Stress</strong></h2><p>Your body holds onto patterns that your mind already understands. That&#8217;s the root issue. You think you have moved on, yet your nervous system still reacts like the past is happening now. Focus on changing that pattern directly. You&#8217;re not trying to think your way out of stress. You&#8217;re teaching your body a new response through repetition, awareness, and controlled movement.</p><p>If you feel stuck, tense for no clear reason, or emotionally reactive in situations that don&#8217;t match the intensity, this approach gives you something practical to work with. You build control step by step. You train your system the same way you would train strength or endurance.</p><ol><li><p><strong>Start by tracking where stress lives in your body &#8212;</strong> Sit or lie down in a quiet space and spend two to three minutes scanning slowly from the top of your head to the soles of your feet. Don&#8217;t try to fix anything, just notice. Where do you feel tightness? Pressure? Warmth? Numbness? Do this at the same time each day, ideally in the morning before your routine starts or at night before sleep.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Within a week or two of consistent practice, you&#8217;ll start catching stress signals you previously missed entirely. You&#8217;re building awareness of internal signals, which research links to better emotional control. If you ignore these signals, your body keeps reacting automatically. When you notice them consistently, you interrupt that pattern and begin to take control.</p></li><li><p><strong>Use short bursts of movement to discharge tension &#8212;</strong> Stand with your feet shoulder-width apart, knees slightly bent, and begin shaking your hands and arms. Let the movement spread into your shoulders, torso, and legs until your whole body is involved. Keep going for five to 10 minutes. You can put on music if it helps you stay with it. Afterward, stand or sit still for at least two minutes with your eyes closed. Notice what you feel.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Some people experience warmth, tingling, a wave of emotion, or a sudden sense of calm. Whatever comes up, don&#8217;t judge it or try to analyze it. Just observe. The goal is to release built-up stress energy stored in your system, similar to the &#8220;somatic shaking&#8221; described in practice. Afterward, sit quietly and observe what comes up. If emotions surface, let them. That release is your body completing a response that stayed unfinished.</p></li><li><p><strong>Alternate between comfort and mild discomfort &#8212;</strong> Shift your focus between a neutral or pleasant sensation and a tense area. Start with something mild, like a slightly stiff neck, not your most painful spot. Hold your attention on the discomfort for three to five seconds, then return to your anchor (your breath, the feeling of your hands resting on your legs) for 10 to 15 seconds.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Repeat for two to three minutes. If at any point the discomfort intensifies sharply or you feel panicky, return to your anchor and stay there. The goal is gradual exposure, not endurance. This method keeps you from becoming overwhelmed while building tolerance and trains your system to stay regulated under stress.</p></li><li><p><strong>Practice somatic grounding to reset your nervous system &#8212;</strong> Place your feet firmly on the floor. Press your hands against a wall or chair. Focus on physical contact. Grounding helps your body recognize that you&#8217;re safe in the present moment. If your mind starts racing, bring your attention back to that physical connection.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This is a simple way to stop stress from escalating. Somatic grounding is different from &#8220;<strong><a href="https://articles.mercola.com/sites/articles/archive/2024/11/02/earthing-mats-and-sleep-quality.aspx">earthing</a></strong>,&#8221; the practice of walking barefoot outdoors to absorb the Earth&#8217;s electrons. While earthing is a biophysical practice, somatic grounding is a nervous system reset.</p></li><li><p><strong>Rehearse actions your body hasn&#8217;t completed &#8212;</strong> If you felt frozen in a past situation, act out the response now. Push your hand forward and say &#8220;Stop.&#8221; Step back as if you&#8217;re leaving. These movements help your body finish stress responses that were interrupted. Over time, this reduces the intensity of automatic reactions because your system no longer carries that unfinished energy.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>If your trauma history involves abuse, violence, or events that feel overwhelming to recall, practice this step with a trained somatic therapist rather than on your own. The technique is powerful precisely because it accesses deep nervous system patterns, and a practitioner can help you pace the process safely. For everyday stress responses, such as a confrontation you didn&#8217;t stand up to or a moment you froze during a presentation, self-practice is generally safe and effective.</p></li></ol><p>Each step builds on the last. You&#8217;re not forcing change. You&#8217;re creating it through repetition. The more you practice, the more your body shifts from constant tension to a state that feels stable, controlled, and calm.</p><h2><strong>FAQs About Somatic Therapy</strong></h2><p><strong>Q: What is somatic therapy in simple terms?</strong></p><p><strong>A: </strong>Somatic therapy is a body-focused approach that helps you process stress and trauma by working with physical sensations instead of only thoughts. It uses movement, breath work, and awareness to address tension and reactions stored in your nervous system, which often remain even after you understand your experiences mentally.</p><p><strong>Q: Why does my body still feel stressed even when I feel safe?</strong></p><p><strong>A: </strong>Your nervous system learns patterns during stressful or traumatic events and keeps repeating them. This means your body stays on alert, creating symptoms like tight muscles, shallow breathing, and emotional reactivity, even when no danger exists. These patterns persist because your body never completed its original stress response.</p><p><strong>Q: How is somatic therapy different from talk therapy?</strong></p><p><strong>A: </strong>Talk therapy focuses on understanding your experiences through conversation. Somatic therapy focuses on what your body is doing in the moment. Instead of analyzing events, you learn to notice physical sensations and change how your body responds, which helps resolve stress patterns that talking alone doesn&#8217;t fix.</p><p><strong>Q: What techniques are used in somatic therapy?</strong></p><p><strong>A: </strong>Common techniques include shaking to release tension, grounding exercises to feel stable, breath work to calm your system, and acting out physical responses that were never completed. These methods help your body discharge stored stress and retrain how it reacts to triggers.</p><p><strong>Q: Does somatic therapy actually work?</strong></p><p><strong>A: </strong>Research shows moderate improvements in trauma symptoms, mood, and sleep, with stronger results in structured programs lasting several weeks. Studies also show that increasing awareness of body sensations improves emotional control and recovery from stress. While evidence continues to develop, many people report meaningful relief when they address the physical side of stress.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/dietary-geranylgeraniol-diabetic-neuropathy&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/dietary-geranylgeraniol-diabetic-neuropathy"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.nytimes.com/2026/04/06/well/mind/somatic-therapy.html">The New York Times April 6, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://meridianuniversity.edu/content/somatic-trauma-therapy-working-with-the-bodys-memory">Meridian University March 29, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jts.22968">Journal of Traumatic Stress September 13, 2023</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://onlinelibrary.wiley.com/doi/10.1002/jts.22189">Journal of Traumatic Stress June 6, 2017</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-5" href="#footnote-anchor-5" class="footnote-number" contenteditable="false" target="_self">5</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/abs/10.1080/15299732.2020.1760173">Journal of Trauma &amp; Dissociation May 18, 2020, Volume 22, Issue 1</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-6" href="#footnote-anchor-6" class="footnote-number" contenteditable="false" target="_self">6</a><div class="footnote-content"><p><a href="https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1355442/full">Frontiers in Psychiatry May 21, 2024</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★The Hidden Food That May Wreck Your Metabolism]]></title><description><![CDATA[The fundamental philosophy of health is alignment with nature. For generations, humans thrived without pharmaceutical intervention.]]></description><link>https://takecontrol.substack.com/p/may-26-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-26-2026-take-control-nl</guid><pubDate>Tue, 26 May 2026 04:00:53 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/5d3b1242-cfa9-4c3d-90b0-fb68cdf07e3b_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260526_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260526_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, 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href="https://articles.mercola.com/sites/articles/archive/2026/04/26/nature-aligned-health.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260526_TC">The Hidden Food That May Wreck Your Metabolism</a></h4><p>Many of today&#8217;s common health issues share a similar root - a growing gap between modern habits and the conditions your body evolved to expect over thousands of years.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/26/nature-aligned-health.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260526_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/26/nature-aligned-health.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260526_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!7xzU!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!7xzU!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 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src="https://substackcdn.com/image/fetch/$s_!_HE1!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa35258e8-9123-4875-96a6-5ead0ee2fe88_580x200.jpeg" width="580" height="200" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/a35258e8-9123-4875-96a6-5ead0ee2fe88_580x200.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:200,&quot;width&quot;:580,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:85893,&quot;alt&quot;:&quot;Memorial Day Sale: 25% Off Sitewide** - 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Stock up now and step into summer with savings.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260526_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3647,&quot;alt&quot;:&quot;shop now&quot;,&quot;title&quot;:&quot;shop now&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260526_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/184393155?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="shop now" title="shop now" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128200;</strong> TRENDING NEWS</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2024/05/24/exercise-lowering-stress.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2HL&amp;utm_campaign=20260526_TC">Major Study - This Lowers &#8216;Brain Stress&#8217; and Blood Pressure</a></h4><p>A study of 50,359 participants (with hundreds completing brain imaging tests) has found a direct link between higher levels of this and lower &#8216;brain stress&#8217; linked to hardening of the arteries and increased blood pressure.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2024/05/24/exercise-lowering-stress.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260526_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2024/05/24/exercise-lowering-stress.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260526_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/26/the-hidden-key-to-boundless-energy.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3HL&amp;utm_campaign=20260526_TC">What&#8217;s Really Behind Your Sluggish Metabolism?</a></h4><p>It&#8217;s not what you think. A surprising factor is interfering with your body&#8217;s ability to produce energy efficiently.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/26/the-hidden-key-to-boundless-energy.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260526_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/26/the-hidden-key-to-boundless-energy.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260526_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" 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srcset="https://substackcdn.com/image/fetch/$s_!QvCx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg 424w, https://substackcdn.com/image/fetch/$s_!QvCx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg 848w, https://substackcdn.com/image/fetch/$s_!QvCx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!QvCx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!QvCx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg" width="580" height="170" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/0c713d15-c396-41d9-8a32-14b757a8236a_580x170.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:170,&quot;width&quot;:580,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:40583,&quot;alt&quot;:&quot;Shop Energy Production Supplements&quot;,&quot;title&quot;:&quot;Shop Energy Production 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Stronger Slow-Wave Sleep Helps Older Adults Regulate Anxiety Overnight]]></title><description><![CDATA[Older adults with weaker slow-wave sleep experienced significantly higher anxiety levels the next day, suggesting sleep quality may influence emotional stability more than total sleep duration.]]></description><link>https://takecontrol.substack.com/p/strong-slow-wave-sleep-anxiety</link><guid isPermaLink="false">https://takecontrol.substack.com/p/strong-slow-wave-sleep-anxiety</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Tue, 26 May 2026 03:33:48 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/1cbf8ffa-4866-4c1c-8a28-23178f277e29_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!XSQL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!XSQL!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!XSQL!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:39452,&quot;alt&quot;:&quot;strong slow wave sleep anxiety&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/196748974?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="strong slow wave sleep anxiety" title="strong slow wave sleep anxiety" srcset="https://substackcdn.com/image/fetch/$s_!XSQL!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!XSQL!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4a6f7d15-2e64-490b-9b33-9f26da04010b_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Older adults with weaker slow-wave sleep &#8212; the deepest stage of non-REM sleep &#8212; experienced significantly higher anxiety levels the next day, showing that sleep quality affects emotional stability more than total hours slept</p></li><li><p>Researchers found that age-related shrinkage in emotional processing regions of the brain reduced the brain&#8217;s ability to generate restorative deep sleep, linking brain aging directly to worsening overnight anxiety regulation</p></li><li><p>The study showed that anxiety and poor sleep reinforce each other in a self-perpetuating cycle, where disrupted sleep raises anxiety levels and elevated anxiety further disrupts future sleep</p></li><li><p>Follow-up testing over roughly four years revealed that participants with the largest decline in slow-wave sleep also experienced greater increases in anxiety over time, suggesting that worsening deep sleep actively drives emotional dysregulation during aging</p></li><li><p>Daily habits such as morning sunlight exposure, lower nighttime stress, consistent bedtimes, regular movement and a dark, cool sleep environment help strengthen slow-wave sleep and improve your brain&#8217;s overnight emotional recovery</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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class="sizing-normal" alt="Visit Mercola Market" title="Visit Mercola Market" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>Nearly 90% of people with dementia develop neuropsychiatric symptoms at some point during the disease, according to researchers in Communications Psychology.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> Anxiety sits near the center of that problem. In adults over 60, anxiety disorders rank among the most common mental health conditions, and each additional anxiety symptom almost doubles the risk of progression from mild cognitive impairment to Alzheimer&#8217;s disease over three years.</p><p>Anxiety isn&#8217;t simply being &#8220;stressed&#8221; or &#8220;on edge.&#8221; It&#8217;s your nervous system stuck in a state of low-grade alarm &#8212; racing thoughts, muscle tension, poor concentration, and the kind of irritability where small inconveniences feel disproportionately overwhelming. Many people blame aging itself when sleep worsens and emotional resilience disappears, but that explanation is incomplete.</p><p>Research from the University of California, Berkeley points to something far more specific: a breakdown in the deepest stage of non-rapid eye movement (non-REM) sleep, when your brain performs overnight restoration and emotional recalibration. When that stage weakens, the next day&#8217;s emotional baseline shifts in ways that are rarely connected back to the night before.</p><p>That finding shifts the conversation around sleep and aging in an important direction. The issue is not only how long you sleep. The real question becomes whether your brain still produces the deep restorative sleep needed to reset emotional stress overnight.</p><div id="youtube2-0juvsBK6k4g" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;0juvsBK6k4g&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/0juvsBK6k4g?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Deep Sleep Protects Your Brain from Overnight Anxiety</strong></h2><p>The study examined 61 cognitively healthy adults older than 65 to determine whether impaired slow-wave sleep explained rising anxiety during aging. Slow-wave sleep is the deepest stage of non-REM sleep &#8212; think of it as your brain&#8217;s overnight maintenance shift.</p><p>Brain waves slow to long, rolling pulses (about one per second), cellular cleanup ramps up, and the emotional circuits that handled yesterday&#8217;s stress get recalibrated for tomorrow. Researchers used overnight sleep lab monitoring, brain scans, and anxiety questionnaires to see how these systems interacted with each other.</p><ul><li><p><strong>Lower deep sleep predicted higher anxiety the next day &#8212;</strong> Participants with fewer slow waves during sleep woke up with significantly greater anxiety symptoms. Researchers found the strongest link during NREM2 sleep, a stage where your brain transitions into <strong><a href="https://articles.mercola.com/sites/articles/archive/2023/08/07/sleep-and-emotional-health.aspx">deeper restoration</a></strong>.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The relationship remained significant even after adjusting for age, gender, overall sleep time, and baseline anxiety levels. In plain language, this means sleep quality mattered more than simply spending more hours in bed.</p></li><li><p><strong>More sleep did not automatically equal better emotional recovery &#8212;</strong> One of the most important findings involved the difference between sleep quantity and sleep structure. Someone could technically sleep seven or eight hours yet still fail to produce enough restorative slow-wave activity. That person still woke up emotionally strained. The results also explained why anxiety and sleep problems often spiral together.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Researchers described a &#8220;negative feedback cycle&#8221; where poor sleep raises anxiety, and rising anxiety then disrupts future sleep even more. Once that cycle starts, emotional strain and nighttime sleep disruption reinforce each other repeatedly. You might recognize this pattern personally: one restless night leaves you tense the next day, then that tension makes the next night even worse.</p></li><li><p><strong>The study showed that slow-wave sleep acted like a nighttime emotional reset button &#8212;</strong> Researchers explained that strong slow-wave activity helped the brain &#8220;recalibrate&#8221; emotional circuits overnight. Think of it like clearing background noise from your nervous system before the next day begins. Without that reset process, emotional tension carried forward into the morning.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>That pattern helps explain why <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/10/08/poor-sleep-disease-risk.aspx">poor sleepers</a></strong> often feel emotionally overwhelmed by small stressors that barely affected them years earlier.</p></li><li><p><strong>Scientists also tracked participants over time to see whether the problem worsened with age &#8212;</strong> A subgroup of 24 participants returned roughly four years later for repeat testing. During that period, slow-wave sleep continued to decline. Researchers found that participants with the largest drop in slow-wave activity also showed higher anxiety levels during follow-up testing. The data strengthened the idea that worsening deep sleep actively drives worsening emotional regulation over time.</p></li><li><p><strong>The brain scans revealed why this happens &#8212;</strong> Researchers examined regions involved in emotional control, including the amygdala and insula. These areas help process fear, emotional awareness, stress reactions, and <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/07/19/sleep-apnea-cognitive-decline.aspx">emotional memory</a></strong>. Participants with greater shrinkage in these regions produced fewer slow waves during sleep. In other words, aging-related brain atrophy weakened the brain&#8217;s ability to generate the kind of deep sleep needed for emotional recovery.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>More atrophy led to weaker slow-wave sleep, and weaker slow-wave sleep led to higher next-day anxiety. When researchers ran the numbers, deep sleep wasn&#8217;t just associated with the anxiety-atrophy link &#8212; it was the actual mechanism connecting them. Brain shrinkage didn&#8217;t cause anxiety directly. It caused anxiety by stealing deep sleep.</p></li></ul><h2><strong>Protect Your Deep Sleep Before Anxiety Gains Momentum</strong></h2><p>The research showed that weaker slow-wave sleep &#8212; the deepest and most restorative stage of sleep &#8212; directly tracked with higher <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/21/what-they-dont-tell-you-about-anxiety.aspx">anxiety levels</a></strong> and worsening overnight emotional recovery. While this study focused on adults over 65, slow-wave sleep begins declining in your 30s, meaning the foundation you build now determines how well your brain ages.</p><p>If you&#8217;ve recognized yourself in this pattern &#8212; restless nights followed by tense, irritable days &#8212; the good news is that slow-wave sleep responds quickly to the right factors. The goal isn&#8217;t simply &#8220;getting more sleep.&#8221; You need to rebuild the conditions that allow your brain to produce strong, uninterrupted deep sleep again. Your daytime habits, light exposure, stress load, movement patterns, and metabolic health all shape whether that happens.</p><ol><li><p><strong>Anchor your circadian rhythm with morning and midday sunlight &#8212;</strong> Your brain relies on light signals to regulate melatonin, cortisol, and sleep architecture. If you spend most of your day indoors under artificial lighting, your nervous system loses the timing cues required for restorative deep sleep. Ideally, get outside within 30 minutes of waking and expose your eyes and skin to natural sunlight daily.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Morning light helps lock in your circadian rhythm, while midday sun supports <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/04/15/sun-exposure-cellular-health.aspx">cellular energy</a></strong> production and mitochondrial function. If your diet has been high in <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/02/16/seed-oils-and-heart-disease-connection.aspx">seed oils</a></strong>, including soybean, corn, sunflower, safflower, and canola oils, avoid peak sun exposure (10 a.m. to 4 p.m.) until you have removed them for at least six months. This is because seed oils are high in <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/07/28/linoleic-acid-high-intake-standard-american-diet.aspx">linoleic acid</a></strong> (LA), which increases your skin&#8217;s sensitivity to the sun.</p></li><li><p><strong>Lower the stress chemistry that keeps your brain alert at night &#8212;</strong> Your nervous system doesn&#8217;t have an off switch; it has a dimmer. And if you&#8217;ve spent the day in fight-or-flight mode, that dimmer takes time to come down. Chronic mental stress, emotional overload, and constant stimulation keep stress hormones elevated long after the day ends. That makes it harder for your brain to enter the deep slow-wave sleep needed for overnight emotional recovery.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Build quiet transition periods into your evening instead of pushing your brain at full speed until bedtime. If your <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/05/02/cognitive-shuffling.aspx">thoughts race at night</a></strong>, spend 10 minutes writing down unfinished tasks or worries before getting into bed. Gentle stretching, slow breathing, and calm routines help shift your nervous system out of a fight-or-flight state. Repeating the same calming habits nightly teaches your brain that it&#8217;s safe to power down.</p></li><li><p><strong>Protect the first half of your night when deep sleep is strongest &#8212;</strong> Most of your slow-wave sleep happens during the earlier part of the night. If you stay awake too late, scroll on your phone in bed, or fall asleep in front of the television before moving to bed hours later, you disrupt the period when your brain performs its deepest emotional recovery work.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Keep your bedtime consistent, even on weekends. Give yourself enough time to sleep before midnight instead of pushing your sleep window later and later. If you often wake up wired in the middle of the night, avoid heavy meals, intense exercise, and emotionally stimulating conversations too close to bedtime.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Your brain needs a calm, predictable transition into sleep if you want stronger overnight emotional recovery. In addition, <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/06/04/drinking-alcohol-dementia-risk-brain-lesions.aspx">avoid alcohol</a></strong>, as it&#8217;s one of the most potent suppressors of slow-wave sleep &#8212; even moderate evening drinking can cut deep sleep substantially.</p></li><li><p><strong>Use daily movement to stabilize your nervous system &#8212;</strong> Sedentary routines increase tension in your body and make restorative sleep harder to achieve. <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/09/22/best-exercises-for-insomnia.aspx">Regular movement</a></strong> lowers stress hormones, improves blood sugar regulation, and helps your brain transition into deeper sleep later that night.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Walking remains one of the simplest and most effective tools. If you&#8217;re older, exhausted, or under chronic stress, gentle consistency works better than punishing workouts. Short walks after meals, outdoor movement, and moderate <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/04/05/strength-training-helps-prevent-insomnia-in-seniors.aspx">strength training</a></strong> help calm your nervous system instead of overstimulating it. Your goal is to feel physically restored by the end of the day rather than depleted.</p></li><li><p><strong>Build a sleep environment that supports uninterrupted deep sleep &#8212;</strong> Your bedroom environment directly affects how much restorative slow-wave sleep your brain produces. Even small disruptions such as light leaking through curtains, a warm room, or repeated noise interruptions fragment deep sleep and leave your nervous system less emotionally stable the next day.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Keep your room dark, quiet, and cool. Blackout curtains, reducing nighttime noise, and <strong><a href="https://articles.mercola.com/sites/articles/archive/2019/06/06/how-temperature-affects-sleep.aspx">lowering room temperature</a></strong> often improve sleep depth quickly. If you wake frequently to urinate, stop large amounts of fluids close to bedtime. If you fall asleep with the television on, replace that habit with calming music, quiet stretching, or slow breathing exercises.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Dimming lights after sunset signals your brain that night has begun, a cue that&#8217;s been hardwired into human biology for hundreds of thousands of years and disrupted only in the last century. Repeated nightly, this small change can help train your brain into deeper and <strong><a href="https://articles.mercola.com/sites/articles/archive/2022/02/20/why-do-you-need-sleep.aspx">more restorative sleep</a></strong> patterns over time.</p></li></ol><h2><strong>FAQs About Slow-Wave Sleep and Anxiety</strong></h2><p><strong>Q: What is slow-wave sleep, and why does it matter for anxiety?</strong></p><p><strong>A: </strong>Slow-wave sleep is the deepest stage of non-REM sleep, when your brain performs overnight restoration and emotional recalibration. During this stage, your brain slows down dramatically, helping regulate stress responses, emotional stability, and nervous system recovery. The study found that older adults with weaker slow-wave sleep woke up with significantly higher anxiety levels the next day.</p><p><strong>Q: Why does anxiety often get worse with age?</strong></p><p><strong>A: </strong>The research showed that aging-related shrinkage in brain regions tied to emotional control reduces the brain&#8217;s ability to generate restorative slow-wave sleep. As deep sleep declines, your brain loses part of its overnight emotional reset process. That creates a cycle where poor sleep raises anxiety, and rising anxiety disrupts future sleep even more.</p><p><strong>Q: Does sleeping longer fix the problem?</strong></p><p><strong>A: </strong>Not necessarily. The study found that sleep quality mattered more than total hours slept. Someone could spend seven or eight hours in bed yet still fail to produce enough slow-wave activity for proper emotional recovery. Deep, uninterrupted sleep mattered far more than simply increasing sleep duration.</p><p><strong>Q: What habits improve slow-wave sleep naturally?</strong></p><p><strong>A: </strong>Morning sunlight, consistent bedtimes, daily movement, and lower nighttime stress all support stronger slow-wave sleep. Keeping your room cool, dark, and quiet also helps protect deep sleep from interruptions. Avoiding stimulating activities, bright screens, and emotional stress close to bedtime further improves your brain&#8217;s ability to enter restorative sleep stages.</p><p><strong>Q: Why does one bad night of sleep affect emotions so strongly the next day?</strong></p><p><strong>A: </strong>The study described slow-wave sleep as a nighttime emotional reset system. When deep sleep becomes fragmented or shortened, emotional stress from the previous day carries forward into the next morning instead of getting processed overnight. That is why poor sleep often leaves you more irritable, emotionally reactive, and overwhelmed by stressors that normally wouldn&#8217;t bother you.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/somatic-therapy&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/somatic-therapy"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12917002/">Communications Psychology 2026 Feb 4;4:34</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★After a Bad Night, This Starts to Take Over]]></title><description><![CDATA[A recent study shows how sleep quality and sleep duration influence real-world eating behavior.]]></description><link>https://takecontrol.substack.com/p/may-25-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-25-2026-take-control-nl</guid><pubDate>Mon, 25 May 2026 04:00:33 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/1c6d24fb-3c76-4782-884c-03949c353710_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp" width="220" height="55" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260525_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" 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fetchpriority="high"></picture><div></div></div></a></figure></div><h2><strong>&#9733; </strong>TOP STORY</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/25/sleepless-nights-comfort-eating-overeating.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260525_TC">After a Bad Night, This Starts to Take Over</a></h4><p>Researchers found that even one stretch of poor sleep quietly shifts your brain and appetite signals - making certain cravings stronger, meals more irregular, and decisions around food far harder to control the next day.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/25/sleepless-nights-comfort-eating-overeating.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/25/sleepless-nights-comfort-eating-overeating.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260525_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!7xzU!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 424w, 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href="https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Thumb&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!g4QL!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 424w, https://substackcdn.com/image/fetch/$s_!g4QL!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 848w, https://substackcdn.com/image/fetch/$s_!g4QL!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 1272w, 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Day&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Thumb&amp;utm_campaign=20260525_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/198522479?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="Memorial Day Sale: 25% Off Sitewide** - Last Day" title="Memorial Day Sale: 25% Off Sitewide** - Last Day" srcset="https://substackcdn.com/image/fetch/$s_!g4QL!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 424w, https://substackcdn.com/image/fetch/$s_!g4QL!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 848w, https://substackcdn.com/image/fetch/$s_!g4QL!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!g4QL!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F40636b10-0a45-49e8-bbb2-294c93bbca70_580x200.jpeg 1456w" sizes="100vw"></picture><div></div></div></a></figure></div><h6>Advertisement</h6><h4><a href="https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1HL&amp;utm_campaign=20260525_TC">Save up to 25% Sitewide This Memorial Day - Last 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It&#8217;s not even stress. This silent killer is disguised as something harmless - routine, even comforting. But beneath the surface, it&#8217;s triggering heart failure, brain decay, and slow-motion metabolic collapse.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/25/ultraprocessed-foods-cardiovascular-deaths.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/25/ultraprocessed-foods-cardiovascular-deaths.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260525_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/25/ct-scan-cancer-risk.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3HL&amp;utm_campaign=20260525_TC">Are CT Scans the Hidden Cancer Risk No One Warned You About?</a></h4><p>This hidden danger in your doctor&#8217;s office quietly increases your cancer risk with each exposure. CT scans emit radiation that damages DNA, but simple steps help protect you from unnecessary harm.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/25/ct-scan-cancer-risk.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, 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srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128293;</strong> HOT</h2><h4><a href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4HL&amp;utm_campaign=20260525_TC">Breaking News: What You Need to Know</a></h4><p>Up-to-date info on the latest health-related news happening in the world.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260525_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260525_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[C15:0 and Brain Aging — What Bottlenose Dolphins Can Teach Us About Cognitive Health]]></title><description><![CDATA[Research on dolphins reveals C15:0, a fat in dairy and grass fed meat, protects brain cells, lowers inflammation, and may help prevent Alzheimer's disease.]]></description><link>https://takecontrol.substack.com/p/pentadecanoic-acid-and-brain-health</link><guid isPermaLink="false">https://takecontrol.substack.com/p/pentadecanoic-acid-and-brain-health</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Mon, 25 May 2026 03:33:49 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/13559a2c-ca13-45e1-bf50-2a51d64f486e_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!GODM!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!GODM!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!GODM!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!GODM!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!GODM!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!GODM!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg" width="773" height="434" 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srcset="https://substackcdn.com/image/fetch/$s_!GODM!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!GODM!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!GODM!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!GODM!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F71a1f845-38c4-4688-907e-312a4f698e27_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div 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C15:0 levels with lower rates of diabetes, liver disease, and cardiovascular conditions that share metabolic pathways with brain aging</p></li><li><p>Replacing seed oils with traditional saturated fats, increasing dietary C15:0 from full-fat dairy and pasture-raised meats, and discussing C15:0 supplementation with a qualified health care provider may form part of a broader strategy for supporting brain and metabolic health as you age</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, 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class="image-caption">Advertisement</figcaption></figure></div><p>Alzheimer&#8217;s disease is a devastating condition that robs people of their memory, independence, and quality of life. Families often watch loved ones slip into confusion, lose the ability to solve simple problems, and eventually struggle to recognize even the people closest to them. With global cases projected to reach nearly 78 million by 2030, it stands as one of the greatest health challenges of our time.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup></p><p>What makes this especially urgent is that the disease doesn&#8217;t develop overnight. Long before symptoms appear, changes in your brain quietly unfold &#8212; changes that are now being studied in surprising places. By exploring how aging impacts both the human body and even certain animals, researchers are uncovering overlooked factors that drive memory loss and cognitive decline.</p><p>One discovery gaining attention is the role of specific dietary fats in either protecting or damaging the brain. While certain dietary fats are associated with elevated inflammation markers, other fats &#8212; including the odd-chain saturated fat pentadecanoic acid (C15:0) &#8212; have been studied for their relationship to cell membrane stability, metabolic markers, and brain aging.</p><p>Oddly enough, studying dolphins is helping to uncover how brain deterioration develops, and revealing that raising C15:0 intake has been investigated as a nutritional factor on age-related cognitive change. To see how this connection was made, it helps to look more closely at what the dolphin study uncovered.</p><div id="youtube2-Ya-5M76rT5I" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;Ya-5M76rT5I&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/Ya-5M76rT5I?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Dolphins Reveal Surprising Clues About Human Brain Aging</strong></h2><p>In a study published in the International Journal of Molecular Sciences, researchers studied dolphins cared for by the U.S. Navy Marine Mammal Program to better understand Alzheimer&#8217;s-like changes.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> These dolphins often live decades longer than those in the wild, making them an ideal model for studying aging.</p><p>Scientists wanted to know whether dolphins develop the same brain changes seen in people with Alzheimer&#8217;s disease, such as sticky amyloid plaques and brain inflammation, and whether C15:0 status is associated with these changes.</p><ul><li><p><strong>Older dolphins showed brain changes similar to Alzheimer&#8217;s in humans &#8212;</strong> Of the 19 dolphin brains examined, 93% had amyloid plaques, with the highest concentration found in the hippocampus, the brain&#8217;s memory center. Older dolphins had significantly more plaques compared to younger ones. In addition, markers of inflammation were widespread, and the hippocampus showed the greatest activity in immune cells that trigger inflammation when the brain is under stress.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>These changes closely matched patterns seen in humans &#8212; The hippocampus was not only the site of the most plaque buildup but also the region with the highest inflammation, echoing what doctors see in Alzheimer&#8217;s patients.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>On average, plaque densities in dolphins were measured at 3.8 per square millimeters, falling between levels seen in elderly people without dementia and those with severe memory problems. This observational comparison is again, based on 19 dolphin brains. Meanwhile, the human comparison ranges are drawn from prior literature. Note that these findings are to be interpreted as preliminary.</p></li><li><p><strong>C15:0 works on two important brain pathways at once &#8212;</strong> The cited research reported associations between C15:0 status and markers related to serotonin turnover and dopamine signaling &#8212; the brain signal tied to motivation, focus, and movement.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Continuing this line of thought, higher C15:0 status was associated with lower inflammation markers and indicators of brain cell stability. Whether dietary or supplemental C15:0 affects memory or mood in healthy adults remains an open research question.</p></li><li><p><strong>C15:0 also addressed hidden drivers of brain decline &#8212;</strong> Researchers proposed a mechanism in which low C15:0 status may contribute to red blood cell fragility and increased iron-mediated oxidative stress. Low C15:0 intake makes red blood cells fragile, which triggers a chain reaction leading to iron overload and ferroptosis &#8212; a destructive form of cell death that spills inflammation and oxidative stress across your body.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>In dolphins, this syndrome set the stage for liver, heart, and brain problems. Going back to the dolphin study, higher C15:0 status was associated with reduced markers of this oxidative cycle. And again, whether this translates to memory protection in humans requires further research.</p></li><li><p><strong>The biological story ties directly back to you &#8212;</strong> If you want to protect your brain as you age, the research points to C15:0 as a nutrient associated with cell membrane stability, lower inflammation markers, and sustained neurotransmitter signaling. Investigators have suggested it may be relevant to research on the metabolic factors linked with cognitive aging.</p></li></ul><p><em>DISCLAIMER: These findings are from laboratory or animal research and may not directly apply to human health.</em></p><h2><strong>C15:0 Gains Recognition as a Powerful Nutrient</strong></h2><p>For a review published in Biochimie, scientists analyzed decades of nutritional and clinical research to determine whether C15:0 should be considered an essential nutrient like omega-3 fats.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> Unlike essential fats that your body can&#8217;t produce in sufficient amounts, C15:0 is often missing in modern diets because of the widespread shift away from full-fat dairy and pasture-raised animal products.</p><p>The review examined both population studies and intervention trials, highlighting C15:0&#8217;s broad effects on metabolic, immune, and cellular health.</p><ul><li><p><strong>C15:0 linked to lower disease risk &#8212;</strong> People with higher blood levels of C15:0 had significantly lower rates of Type 2 diabetes, liver disease, and cardiovascular conditions. In long-term studies, these individuals were less likely to die prematurely from chronic diseases compared to those with low C15:0 status. These findings suggest a possible association between dietary C15:0 intake and lower chronic disease incidence, though causation has not been established in interventional research.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>In supplementation studies conducted in research settings, purified C15:0 was reported to improve markers of liver function, inflammation, and glucose handling. Effects in participants with metabolic dysfunction varied, and results in research settings may not be applicable to all individuals. These results suggest C15:0 status is a research-relevant factor in the metabolic conditions associated with cognitive aging.</p></li><li><p><strong>C15:0 may help stabilize fragile cell membranes &#8212;</strong> The review described C15:0 as interacting with cellular energy-sensing pathways. Researchers have linked these pathways to fuel efficiency and cellular maintenance, though further work is needed to confirm clinical relevance.</p></li><li><p><strong>Inflammation reduction was an observed effect &#8212;</strong> Chronic inflammation has been associated with many age-related conditions, from heart disease to Alzheimer&#8217;s. The review described how C15:0 reduced pro-inflammatory cytokines &#8212; chemical messengers that keep your immune system in a constant state of alarm. By lowering these signals, C15:0 helped the body return to balance, preventing the slow, hidden damage that underlies many chronic illnesses.</p></li><li><p><strong>Hormone and mitochondrial health were also supported &#8212;</strong> Researchers reported that C15:0 was associated with changes in stress-related hormone markers and indicators of mitochondrial function. Better mitochondria mean stronger energy production, less fatigue, and more resilience against cellular aging. These effects together explain why people with higher C15:0 levels show greater overall vitality as they age.</p></li><li><p><strong>C15:0 deserves to be classified as an essential fat &#8212;</strong> Just like omega-3s were once overlooked before being universally recognized as vital for heart and brain health, C15:0 is now stepping into the spotlight. For you, this means that ensuring your diet includes adequate sources of C15:0 is one practical step that some researchers have linked to long-term metabolic and cognitive health.</p></li></ul><p><em>DISCLAIMER: These findings are from research conducted in clinical settings. Results may not apply to all individuals.</em></p><h2><strong>Practical Dietary Strategies for Your Long-Term Brain and Metabolic Health</strong></h2><p>You have more control over your long-term brain health than you might think. The research shows that C15:0, found in full-fat dairy and pasture-raised meats, has been studied as a nutrient that may support cell membrane stability and inflammation balance, with implications for memory and mood research.</p><p>At the same time, you need to reduce linoleic acid (LA) from vegetable oils, which research links to mitochondrial stress and have been associated with markers of cognitive aging. It takes about two years to purge LA from your system, but increasing your intake of C15:0 may support cellular remodeling and resilience as LA levels decline. Here&#8217;s how to apply this knowledge in your daily life.</p><ol><li><p><strong>Replace vegetable oils with healthier fats &#8212;</strong> Stop cooking with seed oils like soybean, corn, safflower, and sunflower oil, which are loaded with LA and drive chronic inflammation. Swap them for grass-fed butter, ghee, or tallow. Also eliminate ultraprocessed foods &#8212; a primary source of seed oils. This single step starts the process of lowering the toxic burden of LA in your body.</p></li><li><p><strong>Increase your intake of C15:0 through food &#8212;</strong> Bring back organic, full-fat dairy like raw, grass fed milk, yogurt, and cheese if you tolerate them, or choose grass fed beef and lamb. These foods are natural sources of C15:0, which supports cellular integrity and protects your mitochondria from damage.</p></li><li><p><strong>Consider taking 250 milligrams of C15:0 &#8212;</strong> Use either a pure pentadecanoic acid powder or a verified high-C15 butter or ghee concentrate. Splitting the dose across meals keeps your plasma levels steady and ensures maximum tissue uptake.</p></li><li><p><strong>Track your status to measure progress &#8212;</strong> Every three months, use an RBC or dried-blood-spot test to confirm that your C15:0 levels are 0.4% or higher and your LA has dropped below 5% of your total fats. These numbers confirm your cells are remodeling and healing. If your numbers stall, it&#8217;s a sign to check for hidden sources of vegetable oils or inconsistent dosing.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p><em>DISCLAIMER: Talk to your health care provider about whether this testing is appropriate for you.</em></p></li><li><p><strong>Adopt daily habits that protect your brain from inflammation and sugar swings &#8212;</strong> Keep your brain sharp by moving your body every day, getting deep, restorative sleep, and using stress-relieving practices like meditation or slow breathing. Cut back on refined sugars and ultraprocessed snacks, since big blood sugar swings leave your brain feeling foggy and drained.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>These simple routines work hand in hand with C15:0, lowering inflammation and strengthening brain cells while your body clears out harmful LA and restores healthier function.</p></li></ol><h2><strong>FAQs About C15:0 and Brain Aging</strong></h2><p><strong>Q: What makes Alzheimer&#8217;s disease such an urgent health concern?</strong></p><p><strong>A: </strong>Alzheimer&#8217;s disease slowly destroys memory, problem-solving skills, and independence. By 2030, nearly 78 million people worldwide are expected to live with it. Because the disease develops years before symptoms appear, research is increasingly focused on factors that influence brain aging earlier in life.</p><p><strong>Q: Why are dolphins being studied to understand Alzheimer&#8217;s?</strong></p><p><strong>A: </strong>Bottlenose dolphins cared for by the U.S. Navy live long enough to show age-related changes in their brains. Researchers found that dolphins naturally develop amyloid plaques and brain inflammation &#8212; hallmarks of Alzheimer&#8217;s also seen in humans. This makes them a valuable model for understanding brain aging.</p><p><strong>Q: What is C15:0, and why is it important for brain health?</strong></p><p><strong>A: </strong>C15:0, also called pentadecanoic acid, is an odd-chain saturated fat found in full-fat dairy and pasture-raised meats. Research has associated C15:0 with cell membrane stability, lower inflammation markers, and sustained dopamine signaling, which may relate to memory and mood.</p><p><strong>Q: How is C15:0 different from the fats found in vegetable oils?</strong></p><p><strong>A: </strong>Vegetable oils are high in LA, which damages mitochondria, increases inflammation, and speeds up cognitive decline. It takes about two years to clear LA from your body, but C15:0 speeds up this process. C15:0 protects your cells, lowers inflammatory damage, and supports healthier energy production in your brain.</p><p><strong>Q: What practical steps can I take to lower LA and raise my C15:0 levels?</strong></p><p><strong>A: </strong>You can replace seed oils with healthier fats like grass fed butter, ghee, coconut oil, or tallow; eat more full-fat, grass fed dairy and meats; supplement with 250 milligrams of purified C15:0; test your C15:0 and LA levels every few months; and build habits like daily movement, quality sleep, stress management, and limiting ultraprocessed foods to keep your brain sharp.</p><p><em>DISCLAIMER: This article is for informational purposes only and does not constitute medical advice. Consult a qualified health care provider before making changes to your health regimen.</em></p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/strong-slow-wave-sleep-anxiety&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/strong-slow-wave-sleep-anxiety"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.mdpi.com/1422-0067/26/8/3746">International Journal of Molecular Health 2025, 26(8), 3746</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.mdpi.com/1422-0067/26/8/3746">International Journal of Molecular Health 2025, 26(8), 3746</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://www.sciencedirect.com/science/article/pii/S0300908424002347">Biochimie December 2024, Volume 227, Part B, Pages 123-129</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★Why Is This Showing Up in Cancer Tissue?]]></title><description><![CDATA[Researchers found microscopic plastic particles in 90% of prostate tumor samples, with cancerous tissue containing significantly more plastic than nearby healthy tissue.]]></description><link>https://takecontrol.substack.com/p/may-24-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-24-2026-take-control-nl</guid><pubDate>Sun, 24 May 2026 04:00:53 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/08b62ead-5cac-43ab-bd48-a637e5559a56_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, 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data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260524_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" 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fetchpriority="high"></picture><div></div></div></a></figure></div><h2><strong>&#9733; </strong>TOP STORY</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/24/microplastics-prostate-tumor.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260524_TC">Why Is This Showing Up in Cancer Tissue?</a></h4><p>Scientists weren&#8217;t searching for it - yet it appeared in the vast majority of samples, raising unsettling questions about what&#8217;s quietly entering the body and where it may be accumulating over time.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/24/microplastics-prostate-tumor.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/24/microplastics-prostate-tumor.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260524_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!7xzU!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb7e03-e5bb-43d7-b50d-5961cecb4ac6_750x25.png 424w, 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This Memorial Day weekend, enjoy the savings while you can. It&#8217;s the perfect time to stock up and save on what you love. Shop now before it&#8217;s too late - this weekend only!</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=dnlsubstack&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3647,&quot;alt&quot;:&quot;shop now&quot;,&quot;title&quot;:&quot;shop now&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=dnlsubstack&amp;utm_medium=email&amp;utm_content=dpe1Bttn&amp;utm_campaign=20260524_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/184393155?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="shop now" title="shop now" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128200;</strong> TRENDING NEWS</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/24/probiotics-fermented-dairy-osteoporosis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2HL&amp;utm_campaign=20260524_TC">This &#8216;Living&#8217; Food Might Be the Secret to Staying Strong</a></h4><p>It&#8217;s been quietly reversing age-related decline, rebuilding the body from within, and outperforming mainstream treatments - yet almost no one realizes what it&#8217;s truly capable of.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/24/probiotics-fermented-dairy-osteoporosis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/24/probiotics-fermented-dairy-osteoporosis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260524_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/24/natural-ways-to-manage-sinusitis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3HL&amp;utm_campaign=20260524_TC">Natural Sinusitis Treatments That Actually Work</a></h4><p>Your sinuses are responsible for filtering air entering your body. But when these become inflamed, you develop a condition known as sinusitis, which affects your breathing.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/24/natural-ways-to-manage-sinusitis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/24/natural-ways-to-manage-sinusitis.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260524_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4HL&amp;utm_campaign=20260524_TC">Breaking News: What You Need to Know</a></h4><p>Up-to-date info on the latest health-related news happening in the world.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260524_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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srcset="https://substackcdn.com/image/fetch/$s_!pK_w!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg 424w, https://substackcdn.com/image/fetch/$s_!pK_w!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg 848w, https://substackcdn.com/image/fetch/$s_!pK_w!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!pK_w!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg 1456w" sizes="100vw"><img 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[The Mitochondrial Roots of Fatty Liver — and the Supporting Role of Choline]]></title><description><![CDATA[Fatty liver disease has become one of the most widespread chronic liver conditions, now affecting 47.8% of US adults, yet it remains largely misunderstood and improperly treated.]]></description><link>https://takecontrol.substack.com/p/mitochondrial-roots-of-fatty-liver</link><guid isPermaLink="false">https://takecontrol.substack.com/p/mitochondrial-roots-of-fatty-liver</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Sun, 24 May 2026 03:34:04 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/9e207cc6-bc66-422f-ae98-87ffc345167b_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!bBEx!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!bBEx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!bBEx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/b6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:34106,&quot;alt&quot;:&quot;mitochondrial roots of fatty liver&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/164991361?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="mitochondrial roots of fatty liver" title="mitochondrial roots of fatty liver" srcset="https://substackcdn.com/image/fetch/$s_!bBEx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!bBEx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb6962840-1b4e-44ab-8dc4-e94cb61cc007_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Fatty liver disease has become one of the most widespread chronic liver conditions, now affecting 47.8% of U.S. adults, yet it remains largely misunderstood</p></li><li><p>Emerging research reveals that fatty liver disease is not simply about fat buildup, but may also be linked to deeper mitochondrial dysfunction associated with toxic byproducts of linoleic acid (LA) and ethanol metabolism</p></li><li><p>These toxic compounds, 4-HNE from LA and acetaldehyde from ethanol, have been shown to damage mitochondrial membranes, compromise energy production, and contribute to the inflammation associated with liver degeneration</p></li><li><p>Choline plays a central role in supporting this process by helping replenish membrane phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE), which support fat export and mitochondrial resilience</p></li><li><p>Reducing dietary sources of LA and alcohol while increasing choline intake through diet &#8212; and supplementation under the guidance of your health care provider&#8212; may help support liver health and metabolic balance</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, 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srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>Your liver works like a factory, processing everything you eat and drink, filtering toxins, producing important compounds, and supporting digestion. But when too much fat builds up inside this factory, its operations begin to break down. This is what happens with fatty liver disease, which now affects about 47.8% of U.S. adults, making it one of the most common chronic liver conditions.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup></p><p>Despite its prevalence, fatty liver disease remains poorly addressed because its underlying mechanisms have been oversimplified and misunderstood for decades. In my narrative review, &#8220;Fatty Liver Reexamined: Choline and Mitochondrial Toxin Amelioration,&#8221; published in the World Journal of Biological Chemistry, December 5, 2025, I present evidence showing fatty liver disease is not just about fat storage, but a deeper problem rooted in mitochondrial breakdown.</p><p>Two key compounds, ethanol and linoleic acid (LA), play a central role in its development. One nutrient, however, may play a supportive role &#8212; choline. This article summarizes the key points of my paper. You can view the full published paper below, or for an easier read, download the simplified paper at the end of the article.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://substackcdn.com/image/fetch/$s_!xsJX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!xsJX!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 424w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 848w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!xsJX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg" width="860" height="150" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:150,&quot;width&quot;:860,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;View the Full Study Here&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="View the Full Study Here" title="View the Full Study Here" srcset="https://substackcdn.com/image/fetch/$s_!xsJX!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 424w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 848w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!xsJX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9dbf5ae7-2f16-4df7-837d-1a520d4a9ed5_860x150.jpeg 1456w" sizes="100vw"></picture><div></div></div></a></figure></div><h2><strong>Fatty Liver as a Mitochondrial Disease</strong></h2><p>Fatty liver disease has undergone a major conceptual shift, both in how it is diagnosed and in how its root causes are understood. The term metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced older labels like nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).</p><p>My preferred way of describing this condition is simply fatty liver disease. The additional attribution to cause is just medical jargon that provides no additional information about the condition itself, and all three are synonyms for fatty liver disease.</p><ul><li><p><strong>Mitochondrial dysfunction is increasingly recognized as a central feature of fatty liver disease &#8212;</strong> The two most significant drivers in modern diets, ethanol and LA, each produce toxic aldehyde byproducts when metabolized in the liver. Ethanol is converted into acetaldehyde, while LA breaks down into 4-hydroxynonenal (4-HNE), both of which are highly reactive and damaging to mitochondria.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Research indicates these aldehydes may bind to proteins, phospholipids, and mitochondrial DNA, which can impair oxidative phosphorylation and reduce the liver&#8217;s ability to generate adenosine triphosphate (ATP). Over time, this is associated with reduced capacity to oxidize fats, which may contribute to lipid accumulation inside hepatocytes.</p></li><li><p><strong>Mitochondrial damage is linked to inflammation and disease progression &#8212;</strong> As mitochondrial membranes are damaged by these aldehydes, the inner membrane loses integrity and protein complexes responsible for energy production are disrupted. The resulting decline in ATP production coincides with increased leakage of reactive oxygen species (ROS), compounding oxidative stress.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Mitochondria begin to release signals that activate immune responses, including mitochondrial DNA and other damage-associated molecules. This is associated with hepatic inflammation and may contribute to the progression from simple fat accumulation to steatohepatitis and, eventually, fibrosis that may lead to cirrhosis.</p></li><li><p><strong>Ethanol and LA follow the same toxic pathway &#8212;</strong> Figure 1 below illustrates the shared toxicity pathway of ethanol and LA, showing how both compounds drive the same cascade of mitochondrial injury, oxidative stress, and inflammatory signaling.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Although one source is traditionally viewed as &#8220;alcoholic&#8221; and the other &#8220;nonalcoholic,&#8221; the internal damage they cause is nearly identical at the cellular level. This overlap helps explain why researchers now advocate for abandoning the alcohol-based distinction in favor of a unified diagnosis under the umbrella of MASLD.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!LihT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!LihT!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!LihT!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!LihT!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!LihT!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!LihT!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg" width="700" height="700" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:700,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;mechanism of mitochondrial toxicity induced by la and ethanol&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="mechanism of mitochondrial toxicity induced by la and ethanol" title="mechanism of mitochondrial toxicity induced by la and ethanol" srcset="https://substackcdn.com/image/fetch/$s_!LihT!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!LihT!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!LihT!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!LihT!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37314e08-46a8-472e-b08c-37c1091c6638_700x700.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Figure 1: Mechanism of Mitochondrial Toxicity Induced by LA and Ethanol</figcaption></figure></div></li><li><p><strong>LA plays a particularly insidious role in this progression &#8212;</strong> Once incorporated in cell membranes, LA becomes highly vulnerable to damage when the liver is under oxidative stress. 4-HNE sticks to important proteins inside mitochondria and interferes with how they work.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>It also disrupts the normal signals that help mitochondria adapt to stress and throws off their ability to divide or repair themselves. These changes weaken the liver&#8217;s energy system, making it harder for the liver to cope with damage or recover from injury.</p></li><li><p><strong>Fatty liver affects all body types and backgrounds &#8212;</strong> National Health and Nutrition Examination Survey (NHANES) data show that fatty liver is prevalent across a wide range of ethnicities and body types. The table below shows this demographic spread, underscoring the reality that liver fat accumulation is a systemic issue tied to modern dietary and lifestyle patterns, not a condition confined to specific groups.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!T5KJ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!T5KJ!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!T5KJ!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg" width="700" height="394" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:394,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;prevalence of fatty liver disease&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="prevalence of fatty liver disease" title="prevalence of fatty liver disease" srcset="https://substackcdn.com/image/fetch/$s_!T5KJ!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!T5KJ!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d3c8a79-c986-4a78-a84d-d487cf576dd4_700x394.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Table 1: Prevalence of Fatty Liver Disease</figcaption></figure></div></li><li><p><strong>The importance of redefining fatty liver disease &#8212;</strong> Redefining fatty liver disease in terms of mitochondrial health and metabolic overload offers a more biologically coherent understanding of what drives this global epidemic. It shows that the real issue is the liver&#8217;s declining ability to produce energy and repair itself, especially when it&#8217;s being hit by harmful compounds. Learn more about mitochondrial damage and liver dysfunction in &#8220;<strong><a href="https://articles.mercola.com/sites/articles/archive/2025/01/02/masld.aspx">Unveiling the Dual Nature of Fatty Liver Disease</a></strong>.&#8221;</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>To help support the liver and reduce the risk of disease progression, it&#8217;s important to reduce these damaging inputs and support mitochondrial health. That said, choline may play a key role in this supportive process.</p></li></ul><h2><strong>What Is Choline and How Does It Support Liver Function?</strong></h2><p>Choline is an essential nutrient that plays a pivotal role in liver function, mitochondrial performance, and membrane integrity. It was officially classified as essential by the Institute of Medicine in 1998<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> after growing evidence showed that the human body cannot synthesize enough of it to meet physiological demand.</p><p>Most people fall short of optimal intake, especially during periods of increased metabolic stress such as pregnancy, aging, or chronic illness, when the need for choline intensifies across multiple organ systems.</p><ul><li><p><strong>Choline is absorbed in the gut and routed according to the body&#8217;s needs &#8212;</strong> Specialized transporter proteins help choline cross the intestinal wall and enter the bloodstream. From there, choline enters cells and follows several metabolic routes, depending on the body&#8217;s needs.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>A large portion is directed toward the synthesis of phospholipids, especially phosphatidylcholine (PC), which is the most abundant phospholipid in mammalian cell membranes. Roughly 95% of the body&#8217;s choline is stored in this form.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> <a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a> <a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a></p></li><li><p><strong>Choline enables the export of fat from hepatocytes &#8212;</strong> To help the liver export fat, choline is turned into phosphatidylcholine (PC) through a multi-step process called the CDP-choline pathway, as shown in Figure 2. First, an enzyme called choline kinase adds a phosphate group to choline, turning it into phosphocholine. Then, another enzyme uses a molecule called CTP to activate phosphocholine, creating CDP-choline, the key building block of PC.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This middle step is the most tightly controlled part of the pathway, acting as a checkpoint for PC production. In the final step, CDP-choline is joined with a fat-based molecule called diacylglycerol (DAG), forming PC, which the liver then uses to build membranes and ship fat out of the cell.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!Nsx6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!Nsx6!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!Nsx6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg" width="700" height="700" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:700,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;choline&#8217;s conversion to phosphatidylcholine (pc)&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="choline&#8217;s conversion to phosphatidylcholine (pc)" title="choline&#8217;s conversion to phosphatidylcholine (pc)" srcset="https://substackcdn.com/image/fetch/$s_!Nsx6!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!Nsx6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0bfddf14-2bda-4a90-9905-df5c422f3f1b_700x700.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Figure 2: Choline&#8217;s Conversion to Phosphatidylcholine (PC)</figcaption></figure></div></li><li><p><strong>Choline supports healthy fat metabolism and cellular membrane integrity &#8212;</strong> Once formed, PC is inserted into cellular membranes and packaged into very-low-density lipoproteins (VLDLs), which transport triglycerides from the liver into circulation.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>As shown in Figure 3, this process begins in the endoplasmic reticulum, where PC enables the early steps of VLDL assembly. Triglycerides from lipid droplets are added, and the VLDL particle then matures in the Golgi apparatus before being exported into the bloodstream. Without sufficient PC, research suggests this pathway is compromised, fat may accumulate inside hepatocytes, and the liver&#8217;s ability to regulate lipid metabolism and maintain structural integrity may be reduced.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!uB--!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!uB--!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 424w, https://substackcdn.com/image/fetch/$s_!uB--!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 848w, https://substackcdn.com/image/fetch/$s_!uB--!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!uB--!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!uB--!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg" width="700" height="560" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:560,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;role of choline in vldl assembly and lipid export&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="role of choline in vldl assembly and lipid export" title="role of choline in vldl assembly and lipid export" srcset="https://substackcdn.com/image/fetch/$s_!uB--!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 424w, https://substackcdn.com/image/fetch/$s_!uB--!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 848w, https://substackcdn.com/image/fetch/$s_!uB--!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!uB--!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe002101c-baca-40f8-a1f2-47449df2a591_700x560.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Figure 3: Role of Choline in VLDL Assembly and Lipid Export</figcaption></figure></div></li><li><p><strong>Choline contributes to the synthesis of phosphatidylethanolamine (PE) &#8212;</strong> PE makes up 20% to 30%<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-6" href="#footnote-6" target="_self">6</a> of total membrane phospholipids and is especially enriched in mitochondrial membranes, where it plays a key role in energy metabolism. PE can also be made inside mitochondria through a different route.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This alternative pathway produces PE right where it&#8217;s needed most &#8212; at the center of energy production. In addition, the body can convert PE into PC by adding methyl groups, a process that depends on nutrients like folate, vitamin B12, and methionine. These nutrients help carry out essential chemical reactions that connect choline metabolism to gene regulation, detoxification, and cardiovascular support.</p></li><li><p><strong>Maintaining a healthy PC:PE ratio for normal membrane behavior &#8212;</strong> Since PC and PE are two major building blocks of cell membranes, their shape matters. PC has a large, wide head that helps membranes stay flat and firm, like a smooth sheet.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>PE, on the other hand, has a smaller head that lets membranes curve and bend, which is needed to form bubble-like structures called vesicles that move materials around the cell. The balance between PC and PE helps control how flexible or rigid the membrane is, which affects how cells grow, send signals, and remove damaged parts.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>When the body doesn&#8217;t make enough PE, mitochondria become stressed and less efficient at making energy. This can lead to more damage from unstable molecules called free radicals. On the flip side, increasing PE levels, such as by supplementing with ethanolamine, has been shown to help cells clean up waste, boost energy production, and even extend lifespan in some studies, suggesting it may support healthy aging and metabolism.</p></li><li><p><strong>Choline also supports methylation by being oxidized to form betaine &#8212;</strong> Betaine is a compound that helps add chemical tags called methyl groups to other molecules. This process turns homocysteine into methionine, which the body then uses to make S-adenosylmethionine (SAM), a key helper in many reactions. These methyl tags support important functions like repairing DNA, making neurotransmitters, and controlling inflammation.</p></li><li><p><strong>The liver not only stores fat during choline deficiency but also loses functional integrity &#8212;</strong> The image below illustrates the hepatic consequences of choline deficiency. The healthy hepatocyte shows a strong membrane, working mitochondria, and very little fat inside.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The steatotic hepatocyte, by contrast, is swollen with fat droplets, has damaged mitochondria, and shows signs of membrane breakdown. This highlights how low choline intake disrupts fat processing and energy production in the liver, setting the stage for fatty liver disease.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!K9oT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!K9oT!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!K9oT!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg" width="700" height="394" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:394,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;impact of choline deficiency on liver function&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="impact of choline deficiency on liver function" title="impact of choline deficiency on liver function" srcset="https://substackcdn.com/image/fetch/$s_!K9oT!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!K9oT!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F179045b1-867a-4964-a312-dc7989dae6e2_700x394.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Figure 4: Impact of Choline Deficiency on Liver Function</figcaption></figure></div></li></ul><h2><strong>Choline&#8217;s Multifaceted Roles in Your Overall Health</strong></h2><p>Choline&#8217;s roles go beyond liver function. Once absorbed into cells, choline enters a network of metabolic routes that support brain signaling, gene regulation, fat metabolism, and bile composition. When choline intake is insufficient, problems emerge in multiple tissues at once, highlighting just how biologically central this nutrient is.</p><ul><li><p><strong>Choline fuels the nervous system as the precursor to acetylcholine &#8212;</strong> Acetylcholine is a neurotransmitter required for learning, memory, and muscle coordination. It plays a major role in both the central nervous system and peripheral motor control.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Because neurons only produce acetylcholine if enough choline is available at their synaptic terminals, inadequate choline intake can impair cognitive performance and motor function. Researchers continue to study choline&#8217;s therapeutic value in neurological conditions such as Alzheimer&#8217;s disease and other neurodegenerative disorders.</p></li><li><p><strong>Choline is essential for fetal development and infant brain growth &#8212;</strong> During pregnancy, maternal choline supports the development of the fetal hippocampus and other brain regions involved in memory and learning. Observational and small clinical studies suggest that children of mothers who consumed higher levels of choline during pregnancy (with one trial using up to 930 milligrams per day<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-7" href="#footnote-7" target="_self">7</a>) may perform better on certain cognitive tasks. However, note that larger trials are needed.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Methylation processes that shape the fetal epigenome also rely on choline, alongside folate and vitamin B12. If any of these nutrients fall short, methylation capacity may decline and homocysteine levels may rise, which has been associated in research with an increased risk of neural tube defects and long-term developmental changes.</p></li><li><p><strong>Methylation pathways depend on choline-derived betaine &#8212;</strong> Through its conversion to betaine, choline sustains the body&#8217;s one-carbon metabolism, which regulates gene activity, neurotransmitter balance, and membrane synthesis. This methylation support also extends cardiovascular protection. When choline or betaine levels fall short, methylation falters, homocysteine builds up, and the risk of metabolic disturbances increases.</p></li><li><p><strong>Choline maintains gallbladder and bile function &#8212;</strong> PC makes up 10% to 15%<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-8" href="#footnote-8" target="_self">8</a> of bile lipids and helps keep cholesterol dissolved, which may reduce the likelihood of gallstone formation. Without enough choline, bile composition may become unstable, which can increase the risk of gallstone formation and fat malabsorption. In one animal model, choline deficiency was associated with a higher risk of gallstone formation and altered bile lipid profiles.<sup>&#8224;</sup></p></li><li><p><strong>Genetic and life stage factors increase choline needs &#8212;</strong> In one genetic study,<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-9" href="#footnote-9" target="_self">9</a> roughly 40&#8211;45% of premenopausal women developed signs of organ dysfunction on a very-low-choline diet &#8212; a vulnerability concentrated in carriers of a phosphatidylethanolamine N-methyltransferase (PEMT) gene variant (rs12325817) that blunts estrogen&#8217;s induction of endogenous choline synthesis and elevates their dietary choline requirement.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>At the same time, aging reduces the liver&#8217;s capacity to make choline and increases reliance on dietary intake. These factors help explain why many older adults and pregnant women are particularly vulnerable to deficiency.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p><em><sup>&#8224;</sup>Disclaimer: These findings are drawn in part from laboratory and animal research, and may not directly apply to human health.</em></p></li></ul><h2><strong>How Much Choline Do You Need?</strong></h2><p>Considering the essential roles that choline plays in your body, a deficiency in this nutrient doesn&#8217;t just impair one pathway. It undermines the structural and metabolic foundation of multiple organ systems. Surveys indicate that more than 90% of Americans do not consume the adequate intake level for choline, and the effects of insufficient intake may not be apparent in the short term.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-10" href="#footnote-10" target="_self">10</a></p><ul><li><p><strong>Current choline guidelines aim to prevent damage, not optimize health &#8212;</strong> The current adequate intake (AI) levels in the table below were set by the Institute of Medicine in 1998<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-11" href="#footnote-11" target="_self">11</a> and are meant to prevent overt liver injury, not to optimize long-term mitochondrial performance or metabolic resilience. These values vary by age, sex, and physiological demand.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!98bm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!98bm!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 424w, https://substackcdn.com/image/fetch/$s_!98bm!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 848w, https://substackcdn.com/image/fetch/$s_!98bm!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!98bm!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!98bm!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg" width="700" height="454" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:454,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;choline requirements across different populations&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="choline requirements across different populations" title="choline requirements across different populations" srcset="https://substackcdn.com/image/fetch/$s_!98bm!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 424w, https://substackcdn.com/image/fetch/$s_!98bm!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 848w, https://substackcdn.com/image/fetch/$s_!98bm!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!98bm!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b6b80d2-d4a8-447a-93e4-0e8687ab1c73_700x454.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Table 2: Choline Requirements Across Different Populations</figcaption></figure></div></li><li><p><strong>Several factors increase choline requirements beyond the baseline &#8212;</strong> As shown in the table above, women of childbearing age may have lower choline needs if estrogen is high, as estrogen stimulates endogenous choline synthesis. But in postmenopausal women or those with low estrogen, dietary choline becomes more important. Genetic variations also matter, as certain polymorphisms reduce the body&#8217;s ability to make or recycle choline, raising the risk of liver dysfunction on low-choline diets.</p></li><li><p><strong>Metabolic stress raises choline demand across the board &#8212;</strong> During pregnancy, choline needs spike due to fetal brain development, placental transport, and maternal methylation load. In individuals with fatty liver, diabetes, or obesity, choline is rapidly used for membrane repair, detoxification, and mitochondrial phospholipid replenishment, making deficiency more likely even at modest intake levels.</p></li><li><p><strong>Diet also plays a major role &#8212;</strong> Plant-based diets typically supply far less choline than omnivorous ones, since the richest sources, such as egg yolks, liver, and red meat, are often limited or excluded. Eggs are especially important, as one yolk provides about 125 milligrams of choline, and they remain the most practical dietary source for most people. But decades of anticholesterol messaging discouraged egg consumption, unintentionally contributing to widespread choline deficiency.</p></li><li><p><strong>Egg access has also become more difficult &#8212;</strong> Avian flu outbreaks, supply chain disruptions, and shifting animal welfare policies have led to higher prices and limited availability in some regions. These barriers, combined with growing public pressure to adopt plant-based diets, have made it harder for many people to meet their choline needs through food. Without eggs or liver in the diet, most people fall far below optimal intake unless they supplement.</p></li></ul><h2><strong>Strategies to Support Your Liver Health</strong></h2><p>Maintaining liver health involves more than removing triggers. It also means supporting your liver&#8217;s energy production, structural maintenance, and the cellular signals involved in fat metabolism. Here are some of the strategies that research suggests may help:</p><ul><li><p><strong>Cut back on vegetable oils and eliminate alcohol intake &#8212;</strong> A key first step is to reduce the dietary compounds that research has linked to ongoing liver stress. LA is the primary fat in processed vegetable oils like soybean, corn, sunflower, safflower, and canola oil.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>You&#8217;ll also find it in margarine, mayonnaise, salad dressings, fast food, chips, crackers, granola, and nearly every ultraprocessed snack. Ethanol, the active ingredient in alcohol, is also used in many extracts, sauces, and processed flavorings. Removing these inputs may reduce stress on the liver and support its ability to produce energy and clear fat.</p></li><li><p><strong>Increase your dietary choline consumption &#8212;</strong> Once damaging inputs are reduced, the liver needs adequate raw materials to support ongoing membrane and lipid metabolism. The table below shows the best dietary sources of this nutrient, with pastured eggs and grass fed organ meats being the highest.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>While some plant foods, like soybeans, broccoli, cauliflower, and Brussels sprouts, contain modest amounts, they usually aren&#8217;t enough on their own. If you&#8217;re on a plant-based diet, you&#8217;ll need to be especially mindful about including high-choline foods or considering supplementation to close the gap.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!rqbG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!rqbG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!rqbG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg" width="700" height="700" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:700,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;dietary source of choline&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="dietary source of choline" title="dietary source of choline" srcset="https://substackcdn.com/image/fetch/$s_!rqbG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 424w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 848w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!rqbG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F641800e7-883e-4042-a0c2-61f711efa6ff_700x700.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Table 3: Dietary Source of Choline</figcaption></figure></div></li><li><p><strong>Consider choline supplementation under your health care provider&#8217;s guidance when diet falls short &#8212;</strong> If you&#8217;re not meeting your choline needs through food, supplementation may be an option to discuss with a qualified health care provider. Different forms of choline have distinct absorption and metabolic profiles. The table below compares these forms based on their choline content, absorption, biological activity, and clinical relevance, to help inform a conversation with your provider.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Standard choline supplements like choline bitartrate are poorly absorbed and have been associated with elevated trimethylamine N-oxide (TMAO), a compound linked in research to cardiovascular risk. Higher-bioavailability forms such as citicoline (CDP-choline) or alpha-GPC have shown more favorable absorption and TMAO profiles in research and may be worth discussing with your health care provider.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!uQtq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!uQtq!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!uQtq!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg" width="700" height="394" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/f235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:394,&quot;width&quot;:700,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;comparative analysis of choline supplement forms&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="comparative analysis of choline supplement forms" title="comparative analysis of choline supplement forms" srcset="https://substackcdn.com/image/fetch/$s_!uQtq!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 424w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 848w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!uQtq!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff235df50-5f3d-4311-adc6-6af7a798d115_700x394.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Table 4: Comparative Analysis of Choline Supplement Forms</figcaption></figure></div></li></ul><p>When used together, these strategies represent a unified approach that research suggests may support the liver&#8217;s ability to export fat, help protect mitochondria from ongoing damage, and support metabolic balance at the cellular level. For more strategies to maintain liver health, check out &#8220;<strong><a href="https://articles.mercola.com/sites/articles/archive/2025/04/24/fatty-liver-disease.aspx">Developing a Fatty Liver Increases Your Risk of Mortality</a></strong>.&#8221;</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!tJeg!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!tJeg!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 424w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 848w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!tJeg!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg" width="860" height="250" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:250,&quot;width&quot;:860,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:&quot;Download PDF of the Simplified Paper&quot;,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="Download PDF of the Simplified Paper" title="Download PDF of the Simplified Paper" srcset="https://substackcdn.com/image/fetch/$s_!tJeg!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 424w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 848w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!tJeg!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcb26f3d8-7204-4d3b-b388-63b85c69d438_860x250.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p><em>Disclaimer: These findings are from research conducted in clinical settings. Results may not apply to all individuals.</em></p><h2><strong>Frequently Asked Questions (FAQs) About Fatty Liver Disease and Choline</strong></h2><p><strong>Q: What causes fatty liver disease besides alcohol?</strong></p><p><strong>A: </strong>Fatty liver disease can be caused by dietary factors beyond alcohol, particularly excess LA from vegetable oils like soybean, corn, sunflower, and canola. These fats break down into toxic aldehydes that damage mitochondria and impair the liver&#8217;s ability to burn fat. Poor choline intake also contributes by impairing fat export from the liver.</p><p><strong>Q: How is mitochondrial dysfunction linked to fatty liver disease?</strong></p><p><strong>A: </strong>Research increasingly points to mitochondrial dysfunction as a central feature of fatty liver disease. When mitochondria are damaged, especially by aldehydes from alcohol and LA, they lose the ability to produce energy efficiently. This breakdown may reduce fat oxidation and contribute to fat buildup, inflammation, and progression to steatohepatitis or fibrosis.</p><p><strong>Q: Can fatty liver be improved through lifestyle and dietary changes?</strong></p><p><strong>A: </strong>Early, small human studies suggest that fatty liver may be improved through lifestyle and nutritional changes, though larger randomized trials are still needed. Reducing intake of vegetable oils and alcohol, increasing choline, and supporting mitochondrial function may help support healthy fat metabolism and liver function. These changes target underlying contributors, rather than only symptoms, and should be undertaken in consultation with a qualified health care provider.</p><p><strong>Q: What is choline and why is it important for liver health?</strong></p><p><strong>A: </strong>Choline is an essential nutrient used to produce phosphatidylcholine, a key compound that helps the liver package and export fat. Inadequate choline intake has been associated with increased fat accumulation in liver cells, which may contribute to fatty liver disease. Choline also supports methylation, mitochondrial function, and bile formation.</p><p><strong>Q: What are the best dietary sources of choline?</strong></p><p><strong>A: </strong>Top dietary sources of choline include pastured egg yolks, organ meats, and grass fed beef. Pastured eggs alone provide about 125 to 150 mg of choline per yolk, depending on the hen&#8217;s diet and environment. While some plant foods like broccoli, cauliflower, and soy contain small amounts, they usually don&#8217;t provide enough to meet the body&#8217;s needs.</p><p><em>Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult a qualified health care provider before making changes to your health regimen.</em></p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/pentadecanoic-acid-and-brain-health&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/pentadecanoic-acid-and-brain-health"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div 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digestion, which drains vitamin B1 and triggers a rare but life-threatening brain disorder marked by confusion, balance problems, and vision loss.]]></description><link>https://takecontrol.substack.com/p/may-23-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-23-2026-take-control-nl</guid><pubDate>Sat, 23 May 2026 04:01:09 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/66cb802d-5de6-4d63-b929-c90a6e2507c6_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260523_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260523_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, 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Only&quot;,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/sitewide-memorial-day-sale?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe1Thumb&amp;utm_campaign=20260523_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/198238997?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F892bfb74-c7c9-4a0e-90d9-b003f9605b43_580x200.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="Memorial Day Sale: 20% Off Sitewide** - This Weekend Only" title="Memorial Day Sale: 20% Off Sitewide** - This Weekend Only" srcset="https://substackcdn.com/image/fetch/$s_!yqdb!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F892bfb74-c7c9-4a0e-90d9-b003f9605b43_580x200.jpeg 424w, 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But to achieve these benefits, the right kind of exercise needs to be done, such as plyometric exercises.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/23/benefit-of-plyometric-exercises-for-adults.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260523_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://articles.mercola.com/sites/articles/archive/2026/04/23/benefit-of-plyometric-exercises-for-adults.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260523_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3HL&amp;utm_campaign=20260523_TC">Breaking News: What You Need to Know</a></h4><p>Up-to-date info on the latest health-related news happening in the world.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art3Bttn&amp;utm_campaign=20260523_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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Health&quot;,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/category/1098/1/brain-memory-health?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Thumb&amp;utm_campaign=20260523_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/198238997?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="Shop Brain &amp; Memory Health" title="Shop Brain &amp; Memory Health" srcset="https://substackcdn.com/image/fetch/$s_!pK_w!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9fefd6c2-e286-4818-a256-3f3a07327bed_580x170.jpeg 424w, 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Sauna Bathing Can Help You Fight Off Infections Faster — Here's Why]]></title><description><![CDATA[A single sauna session raises your body temperature to a fever-like range, which activates your immune system and moves defensive cells into circulation where they can respond faster to infections.]]></description><link>https://takecontrol.substack.com/p/sauna-bathing</link><guid isPermaLink="false">https://takecontrol.substack.com/p/sauna-bathing</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Sat, 23 May 2026 03:33:06 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/de4a1101-b813-49b8-ac4f-ad7cd6149302_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div 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data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:29451,&quot;alt&quot;:&quot;sauna bathing&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/195338676?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="sauna bathing" title="sauna bathing" srcset="https://substackcdn.com/image/fetch/$s_!ik1C!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!ik1C!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!ik1C!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!ik1C!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F930f569c-2f35-4ee3-a784-a88d9b850f2d_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>A single sauna session raises your body temperature to a fever-like range, which activates your immune system and moves defensive cells into circulation where they can respond faster to infections</p></li><li><p>Your immune system reacts immediately during heat exposure, with key immune cells increasing right after a session and some staying elevated afterward, giving you a short-term advantage against incoming pathogens</p></li><li><p>The benefit comes from reaching a specific internal temperature, not just sitting in a hot room, which is why tracking your body temperature gives you more precise and effective results</p></li><li><p>Regular sauna use trains your immune system to respond more quickly over time, improving your baseline ability to detect and fight infections before they take hold</p></li><li><p>Heat works best when combined with strong foundational habits like proper nutrition and energy production, ensuring your immune system has both the signal and the fuel to respond efficiently</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, 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srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>When you step into a sauna, your body does something remarkable; it mimics one of its oldest and most effective defense strategies: a fever. That deliberate rise in temperature is more than relaxation or a good sweat. It&#8217;s a signal. And your immune system is listening.</p><p>Research published in the journal Temperature shows that even a single sauna session sets off a rapid, measurable shift in how your immune system behaves.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> Within minutes, defensive cells move out of storage and into circulation, ready to identify and neutralize threats. Communication between immune cells changes too, becoming more coordinated and responsive. It happens in real time, while you&#8217;re still in the heat.</p><p>What makes this finding so striking is how reliably it occurs. The response didn&#8217;t depend on being young, lean, or in peak health. It happened across a wide range of adults, including those carrying the kind of everyday health burdens many people deal with. That suggests the mechanism is built into human biology and available to nearly anyone willing to sit in the heat long enough to trigger it.</p><p>This matters because infections move quickly. If your immune system is already activated and circulating when a pathogen arrives, you gain a head start that can shape whether you get sick at all, or how hard the illness hits. It also helps explain why regular sauna users tend to experience fewer respiratory infections and lower rates of several chronic diseases.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> To understand why heat has this effect, and how to use it without overdoing it, it helps to look at exactly what happens inside your body during and after a session.</p><div id="youtube2-R18cZI_DrUE" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;R18cZI_DrUE&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/R18cZI_DrUE?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>A Single Sauna Session Rapidly Mobilizes Your Immune Defense</strong></h2><p>To see exactly how this plays out, a team of researchers put the sauna-immune connection under the microscope, tracking what happens in real time as people participate in a standard Finnish <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/02/13/sauna-health-benefits.aspx">sauna session</a></strong>.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a></p><p>The researchers focused on immune cells and signaling molecules, asking a simple but powerful question: does <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/08/30/how-infrared-heat-can-supercharge-your-workout.aspx">heat exposure</a></strong> activate your immune system in a meaningful way? To find out, they measured blood markers before, immediately after, and 30 minutes after a 30-minute sauna session at about 73 degrees C (163 degrees F).<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a></p><p>The researchers studied 51 middle-aged adults, including both men and women around age 50, many with common health risks like <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/01/08/hypertension-and-brain-health.aspx">high blood pressure</a></strong> or obesity. That matters because it mirrors real-world conditions. These were not perfectly healthy individuals. Despite that, the immune response was clear and immediate. White blood cell counts rose right after the sauna session, and some remained elevated even after recovery.</p><ul><li><p><strong>Body temperature increase triggers a full immune response &#8212;</strong> During the sauna session, body temperature rose from about 36.4 degrees C (97.5 degrees F) to 38.4 degrees C (101.1 degrees F). That increase acts like flipping a switch. As your temperature climbs, your body moves immune cells into circulation, where they&#8217;re ready to detect and attack threats. The study found that total white blood cells increased significantly.</p></li><li><p><strong>Your immune system deploys in waves &#8212;</strong> Neutrophils and lymphocytes, the first responders, surged immediately and stood down within 30 minutes. A second wave stayed elevated longer, continuing to patrol after the session ended. In simple terms, your body sends out a rapid response team first, then keeps backup forces circulating even after the heat exposure ends. That layered response strengthens your ability to deal with incoming threats.</p></li><li><p><strong>The timing of the response gives you a short-term advantage &#8212;</strong> The most dramatic changes happened immediately after the sauna session, not hours later. If your immune system is already activated and circulating at higher levels, you have a stronger early defense, which is important because infections often take hold quickly.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The fact that some immune cells remained elevated after 30 minutes shows that the effect doesn&#8217;t disappear instantly. Your body stays on alert for a period after the heat exposure ends.</p></li><li><p><strong>Heat affects immune signaling, not just cell counts &#8212;</strong> Beyond cell numbers, the researchers measured 37 different cytokines, which are signaling molecules your immune system uses to communicate.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Only a few changed directly, but there were 18 strong links between body temperature increases and cytokine activity. Think of cytokines as text messages between immune cells. As your temperature rises, those messages increase or shift, coordinating a more organized and effective response.</p></li><li><p><strong>The key mechanism is immune cell mobilization &#8212;</strong> The study makes it clear that sauna heat stress pushes immune cells out of storage areas and into your bloodstream. This process is called mobilization. Instead of waiting in reserve, your immune cells circulate where they can respond faster. That improves surveillance, meaning your body is better prepared to detect infections early and act on them quickly.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Interestingly, heat drove the communication changes (cytokines) and the troop movements (white blood cells) through different pathways. Your body is running two coordinated systems in parallel &#8212; one mobilizing cells, the other tuning how they talk to each other. Together, they create a coordinated immune response triggered by heat.</p></li><li><p><strong>This is a controlled stress that strengthens your defenses &#8212;</strong> The researchers emphasized that this is an acute, short-term response, not chronic <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/07/16/gut-inflammation-and-insulin-resistance.aspx">inflammation</a></strong>. That distinction matters. Chronic elevation of white blood cells signals disease, but a temporary spike like this reflects a healthy activation. Your body treats the heat like a training session. Each exposure reinforces your ability to respond when a real infection shows up.</p></li></ul><h2><strong>The Best Way to Know When You&#8217;ve Had Enough: Monitor Your Core Body Temperature</strong></h2><p>While sauna room temperature and session duration are useful starting points, the most accurate way to optimize your sauna session is to monitor your actual core body temperature using an oral digital thermometer. This personalized approach accounts for individual variations in heat tolerance, body composition, and acclimation status.</p><h2><strong>Why This Method Works</strong></h2><p>Research shows that the <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/08/21/sauna-use-may-help-menopausal-women.aspx">therapeutic benefits of sauna</a></strong> &#8212; including heat shock protein activation, cardiovascular improvements, and enhanced recovery &#8212; are triggered when your core body temperature rises to specific thresholds, not simply by the room temperature or time spent inside.</p><p>Since individual responses to heat vary significantly based on factors like body mass, hydration status, fitness level, and heat acclimation, using a thermometer gives you direct feedback on what matters most: your body&#8217;s actual response.</p><h2><strong>Target Temperature Guidelines</strong></h2><p><strong>Using an oral digital thermometer:</strong></p><ul><li><p><strong>Beginner target &#8212;</strong> Work toward reaching an oral temperature of 100 degrees F (37.8 degrees C)</p></li><li><p><strong>Optimal target &#8212;</strong> Gradually progress to 101 degrees F (38.3 degrees C) for maximum heat shock protein activation</p></li><li><p><strong>Do not exceed &#8212;</strong> 101.5 degrees F oral temperature (38.6 degrees C)</p></li></ul><p>Important note on oral vs. core temperature: Oral temperature typically reads approximately 0.5 to 1 degrees F (0.3 to 0.5 degrees C) lower than true core (rectal) temperature.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a> An oral reading of 101 degrees F corresponds to a core temperature of approximately 101.5 to 102 degrees F (38.6 to 38.9 degrees C) &#8212; the range research associates with robust heat shock protein induction and therapeutic benefits.</p><h2><strong>How to Use This Method</strong></h2><ol><li><p><strong>Take your baseline &#8212;</strong> Before entering the sauna, record your oral temperature (typically 97.5 to 98.6 degrees F / 36.4 to 37 degrees C).</p></li><li><p><strong>Check periodically &#8212;</strong> Keep thermometer out of the sauna as it will prolong its life and give you better measurements. After 10 to 15 minutes in the sauna, or as soon as you feel hot, measure your temperature. Be sure to put thermometer outside the sauna after measuring your temperature.</p></li><li><p><strong>Track your progress &#8212;</strong> First few weeks: Exit when you reach 100 degrees F (37.8 degrees C). After acclimation (2 to 4 weeks of regular use): You may extend sessions until reaching 101 degrees F (38.3 degrees C). Never exceed 101.5 degrees F oral temperature.</p></li><li><p><strong>Listen to your body &#8212;</strong> If you feel dizzy, nauseous, or unwell at any temperature, exit immediately regardless of the thermometer reading.</p></li></ol><h2><strong>The Science Behind These Numbers</strong></h2><ul><li><p><strong>Heat shock proteins (HSPs)</strong> are activated when core temperature reaches approximately 38.5 degrees C (101.3 degrees F) or higher</p></li><li><p>Research shows that time spent with core temperature &#8805;38.5 degrees C correlates with greater HSP72 mRNA expression<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-6" href="#footnote-6" target="_self">6</a></p></li><li><p>Core temperatures above 39.4 degrees C (103 degrees F) approach hyperthermia risk territory<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-7" href="#footnote-7" target="_self">7</a></p></li><li><p>The 101 to 101.5 degrees F oral target keeps you in the therapeutic zone while maintaining a safety margin</p></li></ul><h2><strong>Why This Beats Room Temperature Alone</strong></h2><p>A 175 degrees F traditional sauna may raise one person&#8217;s core temperature to 101 degrees F in 15 minutes while taking another person 25 minutes to reach the same point. Similarly, a 140 degrees F infrared sauna session may be perfectly adequate for one person while insufficient for another. Your oral thermometer tells you what&#8217;s actually happening in your body.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-8" href="#footnote-8" target="_self">8</a></p><h2><strong>Quick Reference Summary</strong></h2><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!4dLT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!4dLT!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png 424w, 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data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:478,&quot;width&quot;:1304,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:47416,&quot;alt&quot;:&quot;quick reference summary&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/195338676?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="quick reference summary" title="quick reference summary" srcset="https://substackcdn.com/image/fetch/$s_!4dLT!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png 424w, https://substackcdn.com/image/fetch/$s_!4dLT!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png 848w, https://substackcdn.com/image/fetch/$s_!4dLT!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png 1272w, https://substackcdn.com/image/fetch/$s_!4dLT!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F063f7366-9565-4937-aa59-ee3fb4e20700_1304x478.png 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h2><strong>How to Trigger a Faster Immune Response Using Sauna Heat</strong></h2><p>Your immune system depends on a combination of factors to function well &#8212; nutrition, sleep, light exposure, movement, and controlled stress among them. Heat is another one of those factors, and it&#8217;s often missing in modern life.</p><p>A meaningful rise in your internal temperature sends a clear message to your body. It tells your immune system to shift into a more active state. This isn&#8217;t about mild warmth. It&#8217;s about a measurable <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/03/14/fever-chills-explained.aspx">increase in body temperature</a></strong> that prompts immune cells to move into circulation, communicate more effectively, and stay ready for incoming threats.</p><p>When that signal is absent, your immune response tends to stay less responsive. Bringing it back into your routine gives your body another tool to stay prepared. The goal is not to rely on heat alone, but to use it alongside other foundational habits so your immune system responds faster and more effectively when it matters.</p><p>A quick note before you start: heat is a stressor, and not every body is ready for it. If you&#8217;re pregnant, managing a heart condition, taking medications that affect circulation or hydration (beta-blockers, diuretics, and stimulants are common ones), or you&#8217;ve recently had alcohol, check with your health care provider first.</p><ol><li><p><strong>Train your immune system by reaching the right temperature &#8212;</strong> Time in a sauna means nothing if your body temperature doesn&#8217;t rise enough. What matters is getting your oral temperature up to at least 100 degrees F, then working toward 101 degrees F as you adapt. That is the range where your immune system shifts into a more active state.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>If you&#8217;re just sitting in heat without reaching that threshold, you&#8217;re not getting the full benefit. Focus on the response inside your body, not the clock on the wall.</p></li><li><p><strong>Use a thermometer to make your sessions precise and personal &#8212;</strong> Your body doesn&#8217;t respond the same way as someone else&#8217;s. That&#8217;s why guessing doesn&#8217;t work. Take your temperature before you go in, then check it after 10 to 15 minutes and again as you heat up. This gives you direct feedback on what your body is doing.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Once you see how quickly you reach 100 degrees F or higher, you can adjust your sauna sessions with confidence. This is how you turn sauna use into a targeted tool instead of a random habit.</p></li><li><p><strong>Stay in the heat until you hit your target, not just until you feel uncomfortable &#8212;</strong> Discomfort is not the signal. Temperature is. If you step out too early, before your body reaches that immune-activating range, you cut the process short. Stay in long enough to reach your target temperature, then exit. That&#8217;s where the immune cell mobilization begins. If you feel dizzy or unwell, get out immediately. Otherwise, let your body complete the response you&#8217;re trying to trigger.</p></li><li><p><strong>Repeat sessions consistently to build a faster baseline response &#8212;</strong> One session wakes your immune system up. Repetition trains it. When you expose your body to this heat signal a few times each week, your system becomes more efficient at mobilizing immune cells quickly. Over time, your body learns to respond faster and more effectively. If you go long stretches without this stimulus, that responsiveness fades. Consistency is what turns a short-term boost into a lasting advantage.</p></li><li><p><strong>Support cellular energy so your immune system has the fuel to respond &#8212;</strong> Heat triggers the response, but energy powers it. If your cells struggle to produce energy, your immune system can&#8217;t mobilize effectively. Make sure you&#8217;re getting enough <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/25/hidden-health-benefit-of-carbohydrates.aspx">carbohydrates</a></strong> to support cellular energy, keep protein intake strong with a focus on collagen-rich foods, and avoid <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/02/16/seed-oils-and-heart-disease-connection.aspx">seed oils</a></strong>, including soybean, corn, sunflower, safflower, and canola oils, that interfere with mitochondrial function.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>When your energy systems are working efficiently, your immune response becomes faster, stronger, and more reliable every time you use heat as a trigger.</p></li></ol><h2><strong>FAQs About Sauna Bathing and Your Immune System</strong></h2><p><strong>Q: How does sauna heat help my immune system respond faster?</strong></p><p><strong>A: </strong>When your body temperature rises during a sauna session, it triggers your immune system to shift into a more active state. Immune cells move out of storage and into your bloodstream, where they&#8217;re better positioned to detect and attack pathogens. At the same time, communication between those cells becomes more coordinated, helping your body respond quickly when a threat appears.</p><p><strong>Q: What temperature do I need to reach to activate this response?</strong></p><p><strong>A: </strong>The key is not just sitting in heat but raising your internal temperature. An oral temperature of about 100 degrees F is a starting point, with stronger effects closer to 101 degrees F. This range signals your body to activate immune defenses. Going beyond 101.5 degrees F is not recommended &#8212; that&#8217;s the edge of the therapeutic window, and pushing further raises your risk of heat illness without added benefit.</p><p><strong>Q: How quickly does my immune system respond during a sauna session?</strong></p><p><strong>A: </strong>The response happens fast. In the research, immune cells increased immediately after a single 30-minute session and some stayed elevated for at least 30 minutes afterward. That means your immune system becomes more alert while you&#8217;re still in the heat and remains on standby for a short period after you finish.</p><p><strong>Q: Do I need to use a sauna regularly to see benefits?</strong></p><p><strong>A: </strong>One session activates your immune system, but repeated sessions train it. When you use a sauna several times per week, your body becomes more efficient at mobilizing immune cells quickly. This improves your baseline response, so your immune system reacts faster when you encounter an infection.</p><p><strong>Q: Is heat the only factor that affects my immune system?</strong></p><p><strong>A: </strong>No. Your immune system depends on multiple factors, including nutrition, sleep, movement, and light exposure. Heat is one important signal that many people lack. When you combine regular sauna use with strong foundational habits, your immune system becomes more responsive and better prepared to handle infections.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/mitochondrial-roots-of-fatty-liver&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/mitochondrial-roots-of-fatty-liver"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467">Temperature March 31, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467">Temperature March 31, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467">Temperature March 31, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467">Temperature March 31, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-5" href="#footnote-anchor-5" class="footnote-number" contenteditable="false" target="_self">5</a><div class="footnote-content"><p><a href="https://www.ncbi.nlm.nih.gov/books/NBK331/">National Library of Medicine, Clinical Methods, Temperature</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-6" href="#footnote-anchor-6" class="footnote-number" contenteditable="false" target="_self">6</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5083671/">Cell Stress Chaperones. 2016 Aug 11;21(6):1021&#8211;1035</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-7" href="#footnote-anchor-7" class="footnote-number" contenteditable="false" target="_self">7</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12705364/">Front Physiol. 2025 Dec 2;16:1700342</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-8" href="#footnote-anchor-8" class="footnote-number" contenteditable="false" target="_self">8</a><div class="footnote-content"><p><a href="https://www.tandfonline.com/doi/full/10.1080/23328940.2017.1384089">Temperature November 10, 2017</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★What Determines How Clearly You See?]]></title><description><![CDATA[Vitamin A and thyroid hormone work together during eye development to build the tiny region of your retina responsible for your sharpest vision.]]></description><link>https://takecontrol.substack.com/p/may-22-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-22-2026-take-control-nl</guid><pubDate>Fri, 22 May 2026 04:01:08 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/143366ed-425e-47b6-8307-41a1943dda2f_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260522_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp" width="220" height="55" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260522_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw" fetchpriority="high"></picture><div></div></div></a></figure></div><h2><strong>&#9733; </strong>TOP STORY</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2026/04/22/vitamin-a-thyroid-hormone-good-eyesight.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260522_TC">What Determines How Clearly You See?</a></h4><p>It comes down to a tightly controlled process deep inside your eye - one that depends on specific signals working in perfect sequence to produce sharp, detailed vision.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/22/vitamin-a-thyroid-hormone-good-eyesight.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260522_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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loading="lazy"></picture><div></div></div></a></figure></div><h2><strong>&#128200;</strong> TRENDING NEWS</h2><h4><a href="https://articles.mercola.com/sites/articles/archive/2024/05/21/lifestyle-and-dietary-changes.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2HL&amp;utm_campaign=20260522_TC">These 7 &#8216;Metabolic Boosters&#8217; Make You Burn Calories Faster</a></h4><p>If you want to lose weight without eating like a bird (which is not sustainable and will negatively impact your metabolism in the long run), master these 7 &#8216;metabolism-boosting&#8217; habits first, so you can eat more calories and shed more pounds.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2024/05/21/lifestyle-and-dietary-changes.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art2Bttn&amp;utm_campaign=20260522_TC" data-component-name="Image2ToDOM"><div 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href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4HL&amp;utm_campaign=20260522_TC">Breaking News: What You Need to Know</a></h4><p>Up-to-date info on the latest health-related news happening in the world.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260522_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, 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src="https://substackcdn.com/image/fetch/$s_!lvIC!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/7be433da-4164-4a37-85d0-809db9977342_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3609,&quot;alt&quot;:&quot;read more&quot;,&quot;title&quot;:&quot;read more&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://blogs.mercola.com/sites/vitalvotes/default.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art4Bttn&amp;utm_campaign=20260522_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="read more" title="read more" srcset="https://substackcdn.com/image/fetch/$s_!lvIC!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!lvIC!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7be433da-4164-4a37-85d0-809db9977342_750x25.png 848w, 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Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Can You Prevent the Hunched Back of Kyphosis?]]></title><description><![CDATA[A hunched back can develop gradually as weak muscles, poor posture, and declining bone strength place increasing strain on the spine over time.]]></description><link>https://takecontrol.substack.com/p/kyphosis</link><guid isPermaLink="false">https://takecontrol.substack.com/p/kyphosis</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Fri, 22 May 2026 03:33:52 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/e71af1bb-6afc-48d9-b3df-401d3521520f_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!ZCYu!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!ZCYu!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!ZCYu!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/b2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:27020,&quot;alt&quot;:&quot;kyphosis&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/195613680?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="kyphosis" title="kyphosis" srcset="https://substackcdn.com/image/fetch/$s_!ZCYu!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!ZCYu!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb2f0faab-e0ea-43a1-a449-4a6d36b69906_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>A hunched back develops gradually as weak muscles, poor posture, and declining bone strength allow gravity to pull your spine forward over time</p></li><li><p>Up to 40% of adults over 60 experience significant spinal curvature, and the angle worsens steadily with each decade if you don&#8217;t intervene</p></li><li><p>Simple daily habits like sitting hunched over devices and skipping upper-back training accelerate the process long before you notice visible changes</p></li><li><p>Targeted exercises that strengthen your back, core, and posterior chain help retrain your body to hold proper alignment and reduce strain on your spine</p></li><li><p>Consistent posture resets, proper sleep support, and weight-bearing activity work together to slow or reverse early-stage spine changes and protect long-term mobility</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, 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srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>You may have caught a glimpse of yourself in a store window and barely recognized the person staring back &#8212; shoulders rolled forward, head jutting ahead of your body, upper back curving where it used to stand tall. That gradual hunch has a name: kyphosis. And it&#8217;s far more common, and far more preventable, than most people realize.</p><p>Kyphosis is a condition characterized by an excessive forward curve in your upper spine, meaning your back rounds and your posture shifts into a hunched position. The first signs are often rounded shoulders, a forward head, or stiffness in your upper back. In more advanced stages, it brings pain, fatigue, and even breathing difficulty as the curve compresses your lungs.</p><p>The Cleveland Clinic notes that severe forms affect up to 20% to 40% of adults over age 60, and the angle of the spine increases by about 3 degrees each decade.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> By the time the mirror shows you a hunched back, the curve has usually been forming for a decade or more. Another layer makes this even more relevant. Poor posture and weak back muscles accelerate the process.</p><p>Hours spent sitting, looking down at devices, or neglecting upper-back strength shift your spine forward long before any diagnosis appears. Over time, these daily habits combine with bone loss and aging to reshape your posture. This raises a direct question: if the curve builds gradually from these factors, what specific changes actually slow it down or stop it from worsening?</p><div id="youtube2-vy38iDZp-bQ" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;vy38iDZp-bQ&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/vy38iDZp-bQ?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Daily Habits Shape Your Spine More Than You Think</strong></h2><p>A report by Harvard Health Publishing examined how lifestyle, aging, and bone health interact to drive the forward <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/07/01/curved-back-kyphosis.aspx">curvature of your spine</a></strong>.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> Instead of framing kyphosis as something that suddenly appears, the report shows it builds step by step through structural changes in your bones, discs, and muscles. When you understand what drives the curve, you gain control over slowing it down.</p><ul><li><p><strong>Bone loss sets the stage for structural damage &#8212;</strong> The report highlights osteoporosis as a major driver, where low bone density weakens the vertebrae and leads to small compression fractures in the front of the spine.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Imagine a stack of marshmallows where the front edges slowly get squashed flat while the back stays full; your spine tilts forward as a result. That&#8217;s what compression fractures do to vertebrae. These micro-fractures are usually painless, which is precisely the problem; your spine is reshaping itself months or years before you notice anything is wrong.</p></li><li><p><strong>Aging discs reduce your spine&#8217;s ability to stay upright &#8212;</strong> Over time, the discs between your vertebrae dry out and lose cushioning, which reduces their ability to absorb force and maintain spacing.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This explains why height loss occurs with age and why your upper back begins to round forward under constant pressure from gravity. Think of these discs as the shock absorbers in a car. When they wear out, every bump and load travels straight up the frame; only in this case, the frame is your spine, and the cumulative damage shows up as a forward curve.</p></li><li><p><strong>Posture habits either reinforce or fight the curve &#8212;</strong> <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/04/05/postural-restoration.aspx">Poor posture</a></strong> and prolonged sitting accelerate the forward bend of your spine. Spending hours hunched over devices trains your body into that position. In contrast, maintaining an upright posture keeps your head aligned over your spine, reducing strain and slowing structural changes. This gives you a simple daily metric to track: how often you correct your posture throughout the day.</p></li><li><p><strong>Muscle strength determines whether your spine holds its position &#8212;</strong> Weak upper-back, neck, and core muscles fail to support proper posture, which allows your spine to collapse forward more easily. Many people train the front of their body &#8212; chest and arms &#8212; while neglecting the muscles that keep them upright. That imbalance pulls your posture forward and locks in the curve over time.</p></li><li><p><strong>Simple daily behaviors create long-term structural change &#8212;</strong> The guidance includes breaking up long periods of sitting every 30 minutes, using supportive chairs, and avoiding prolonged forward bending positions. Each of these actions reduces continuous stress on your spine.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Certain movements increase risk and need to be avoided. Exercises that repeatedly bend the spine forward, such as toe touches or sit-ups, increase the risk of vertebral fractures in people with low bone density. Adding weight while bending forward amplifies that risk even further. Avoiding these movements removes a major source of stress on already vulnerable bones.</p></li></ul><h2><strong>Severity and Progression Determine Your Real Risk</strong></h2><p>Kyphosis becomes clinically significant when the curve in your spine exceeds 50 degrees, compared to a normal range of 20 to 45 degrees.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> There are multiple forms, including postural, structural, congenital, and age-related hyperkyphosis. Each type behaves differently.</p><p>For example, postural kyphosis is often related to habits and tends to remain flexible, while structural forms involve actual changes in bone shape that don&#8217;t correct with simple posture adjustments. This distinction matters because your strategy depends on which type you&#8217;re dealing with. One responds quickly to daily changes. The other requires long-term management.</p><ul><li><p><strong>Severity directly impacts how your body functions &#8212;</strong> Mild cases often stay cosmetic, meaning they affect appearance more than physical health. However, as the curve increases, it begins to interfere with normal movement and organ function. Severe cases lead to <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/06/12/back-pain-nonsurgical-solutions.aspx">back pain</a></strong>, fatigue, balance issues, and even lung compression that affects breathing.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Mild kyphosis is a warning sign. Severe kyphosis is a daily limitation. The window between them is where your choices matter most. The earlier you address the curve, the less likely it interferes with basic functions like walking or breathing.</p></li><li><p><strong>Diagnosis relies on simple but revealing physical tests &#8212;</strong> Health care providers often use a forward bending test, where you bend at the waist while they observe the curve of your spine. This test reveals how pronounced the curvature is and whether it worsens when you move. Imaging like X-rays confirms the angle.</p></li><li><p><strong>Treatment decisions depend on multiple personal factors &#8212;</strong> Age, overall health, curve severity, and symptoms all influence treatment choices. Mild cases often rely on exercise and physical therapy. More advanced cases often require bracing or surgery.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Physical therapy focuses on strengthening the muscles that support your spine and improving flexibility in tight areas. Pain relief strategies and posture correction play a role as well. These approaches aim to reduce strain and improve alignment so your body moves more efficiently.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Procedures like spinal fusion physically realign and stabilize the vertebrae when the curve becomes extreme or causes serious symptoms. This involves joining bones together to hold your spine in a straighter position. Surgery can straighten a spine, but it can&#8217;t change the habits that bent it in the first place. Without daily reinforcement, even the most successful procedures lose ground over time.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Lifestyle adjustments &#8212; how you sit, stand, and carry weight &#8212; remain essential for maintaining results. This creates a simple but powerful system you can follow: monitor posture, adjust movement, and stay consistent. Your spine remembers what you did yesterday. Every hour spent slumped over a phone reinforces the curve; every posture reset, every set of rows, pulls you back the other way.</p></li></ul><h2><strong>Targeted Movement Patterns Change How Your Spine Functions</strong></h2><p>Knowing where you fall on this spectrum is useful, but it&#8217;s not enough. Whether your curve is mild or pronounced, the same fundamental truth applies: your spine responds to how you move it. That&#8217;s where targeted exercise enters the picture.</p><p>Physical therapy and targeted exercise are central tools for improving posture and reducing symptoms associated with spinal curvature. Instead of relying on passive treatments, the focus shifts to active movement that strengthens and stabilizes your body. This puts you in control of how your spine functions day to day.</p><ul><li><p><strong>Standing rows train the muscles that pull your shoulders back &#8212;</strong> One of the key exercises is the standing row, which strengthens the upper-back muscles responsible for keeping your shoulders from rolling forward.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a></p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Attach a resistance band at waist height, pull your elbows back, and squeeze your shoulder blades together. That motion directly counters the rounded posture that leads to a hunched back. When done regularly, this movement retrains your body to hold a more upright position without constant effort.</p></li><li><p><strong>Shoulder extensions reinforce alignment and chest opening &#8212;</strong> Another recommended movement uses a resistance band anchored overhead, where you pull your arms down to your sides while squeezing your shoulder blades together.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This strengthens the muscles that stabilize your spine and opens your chest, which reverses the tight, forward-pulled position many people develop from sitting. You&#8217;re not just building strength here; you&#8217;re restoring balance between the front and back of your body.</p></li><li><p><strong>Planks build the core stability your spine depends on &#8212;</strong> The plank is highlighted as both a core-strengthening and weight-bearing exercise. You hold your body in a straight line while supporting your weight through your arms and toes. This teaches your core muscles to stabilize your spine during movement and daily activity. A stronger core reduces the load placed on your back and helps maintain alignment throughout the day.</p></li><li><p><strong>The Superman exercise builds full posterior strength &#8212;</strong> Lying face down and lifting your arms and legs off the ground trains the muscles along your entire back chain.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a> This movement improves your ability to extend your spine and resist forward collapse. It also reinforces coordination between your upper and lower body, which supports better posture during daily activity.</p></li><li><p><strong>Chest-opening movements reduce tightness that pulls you forward &#8212;</strong> Exercises like raising your arms into a &#8220;Y&#8221; position while standing upright help stretch tight chest muscles and activate your upper back. Tight chest muscles often pull your shoulders forward, so releasing that tension allows your spine to return to a more neutral position.</p></li><li><p><strong>Foam rolling improves mobility in the upper spine &#8212;</strong> Using a foam roller across your mid-back helps loosen stiff tissues and improve movement in the thoracic spine &#8212; the 12 vertebrae running from the base of your neck to your lower ribs. This increases your ability to extend your back and maintain better posture. When your spine moves more freely, it becomes easier to hold an upright position without strain.</p></li></ul><h2><strong>Fix the Root Causes Driving Your Spine Forward</strong></h2><p>Your spine doesn&#8217;t suddenly collapse into a hunched position. It shifts because the muscles that hold you upright weaken, your daily posture reinforces a forward bend, and your structure loses support over time. That means the solution starts with rebuilding strength, retraining posture, and removing the stress that keeps pulling you forward. When you focus on those root causes, your body begins to correct itself.</p><ol><li><p><strong>Train your posterior chain to restore alignment &#8212;</strong> This is where <strong><a href="https://articles.mercola.com/sites/articles/archive/2023/06/18/foundation-training-back-pain-relief.aspx">Foundation Training</a></strong> comes in. It was developed to strengthen your posterior chain and restore natural alignment by teaching your core and back to work together in coordinated movement patterns. Your posterior chain is the connected web of muscles running from the base of your skull down through your back, glutes, hamstrings, and calves that work together to keep you upright.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Even 10 minutes a day helps decompress your spine, reduce low back discomfort, and retrain your posture so standing upright feels natural again. To build on that foundation, include a few short sessions each week that target:</p><ul><li><p>Spinal extension and back strength using movements like weighted lifts and bird-dogs</p></li><li><p>Chest and shoulder mobility with foam rolling and wall angels</p></li><li><p>Core and pelvic stability through dead bugs and glute bridges</p></li><li><p>Balance and sensory feedback with heel-to-toe walks and single-leg stands</p></li></ul></li><li><p><strong>Reset your posture throughout the day &#8212;</strong> Fixing posture is a practice that works best when done repeatedly. Every 30 minutes, pause and bring your head back over your shoulders, lift your chest, and gently pull your shoulder blades down and back. If you sit for long stretches, this becomes your most important habit. Each reset reinforces the position you want your body to hold automatically.</p></li><li><p><strong>Remove the daily habits that reinforce the curve &#8212;</strong> Long hours hunched over a screen or phone train your spine into a forward position. Raise your screen to eye level, use a chair with strong back support, and break up sitting time often. If your routine keeps you seated most of the day, consider a standing desk to help remove the constant pressure that pushes your spine out of alignment.</p></li><li><p><strong>Strengthen the structural support of your spine &#8212;</strong> Your vertebrae need strength to resist compression. Walking is the minimum effective dose for bone-loading; progressive resistance training &#8212; squats, deadlifts, and overhead carries &#8212; helps strengthen the vertebrae themselves.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Pair that with <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/09/27/nutrients-for-aging-bones.aspx">bone-supportive nutrition</a></strong>: pastured egg yolks and hard cheeses for vitamin K2, sensible sun exposure for vitamin D, liposomal magnesium, and enough high-quality protein to maintain the muscle that anchors your skeleton.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Aim for roughly 0.8 grams per pound of lean body mass per day, or 1.76 grams per kilogram, with approximately one-third of that coming from collagen-rich sources like bone broth, slow-cooked meats with connective tissue, or a quality collagen supplement. If you&#8217;re older or have risk factors for bone loss, this step becomes central. <strong><a href="https://articles.mercola.com/sites/articles/archive/2026/05/30/osteoporosis-in-men-over-50.aspx">Strong bones</a></strong> give your spine the ability to hold its shape under load.</p></li><li><p><strong>Support your spine even while you sleep &#8212;</strong> Your posture doesn&#8217;t stop when you go to bed. Your sleep position either reinforces alignment or works against it. Use a <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/04/19/sleep-posture-cervical-spine-health.aspx">cervical pillow</a></strong> that supports the natural curve of your neck without pushing your head too far forward. This keeps your head aligned with your spine and prevents that forward-head position from becoming your default.</p></li></ol><p>Most early kyphosis responds well to the strategies above, but don&#8217;t hesitate to see a doctor if you notice the curve worsening quickly, develop new back pain, lose more than an inch of height, experience changes in your breathing, or feel numbness or tingling in your arms or legs. These signal that your spine may need more than self-care.</p><h2><strong>FAQs About Kyphosis</strong></h2><p><strong>Q: What is kyphosis and how do I know if I have it?</strong></p><p><strong>A: </strong>Kyphosis is an excessive forward curve in your upper spine that makes your back appear rounded or hunched. You usually notice early signs like rounded shoulders, a forward head position, or stiffness in your upper back. In more advanced cases, it leads to pain, fatigue, and even breathing difficulty as the curve presses on your lungs.</p><p><strong>Q: What causes a hunched back as I age?</strong></p><p><strong>A: </strong>The most common drivers include bone loss from osteoporosis, weakening of the spinal discs, and poor posture habits over time. Sitting for long hours, looking down at devices, and neglecting upper-back strength all reinforce a forward curve. These factors build on each other slowly, which is why the condition often goes unnoticed until it becomes visible.</p><p><strong>Q: Is kyphosis preventable or reversible?</strong></p><p><strong>A: </strong>You can slow, stop, or even improve early-stage kyphosis by addressing the root causes. Strengthening your back and core muscles, maintaining upright posture throughout the day, and supporting bone health all play a direct role. Postural forms respond quickly to these changes, while structural forms require more consistent long-term effort.</p><p><strong>Q: What exercises help fix or prevent kyphosis?</strong></p><p><strong>A: </strong>Targeted movements that strengthen your posterior chain and improve mobility are the most effective. These include standing rows, planks, bird-dogs, foam rolling, chest-opening exercises, and Foundation Training movements. These exercises retrain your body to hold proper alignment and reduce the forward pull on your spine over time.</p><p><strong>Q: What happens if kyphosis is left untreated?</strong></p><p><strong>A: </strong>If the curve continues to progress, it moves beyond appearance and starts affecting how your body functions. You may develop chronic back pain, balance issues, reduced mobility, and in severe cases, breathing problems due to lung compression. The earlier you take action, the easier it is to prevent these complications and maintain long-term spinal health.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/sauna-bathing&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/sauna-bathing"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://my.clevelandclinic.org/health/diseases/17671-kyphosis">Cleveland Clinic, Kyphosis</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.health.harvard.edu/bones-and-joints/can-you-prevent-the-hunched-back-of-kyphosis">Harvard Health Publishing March 13, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://my.clevelandclinic.org/health/diseases/17671-kyphosis">Cleveland Clinic, Kyphosis</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://www.health.harvard.edu/bones-and-joints/can-you-prevent-the-hunched-back-of-kyphosis">Harvard Health Publishing March 13, 2026</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-5" href="#footnote-anchor-5" class="footnote-number" contenteditable="false" target="_self">5</a><div class="footnote-content"><p><a href="https://www.healthline.com/health/exercise-fitness/kyphosis-exercises">Healthline, Kyphosis Exercises to Treat a Rounded Upper Back</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★The Missing Link Between Sleep and Resilience]]></title><description><![CDATA[Sleep deprivation suppresses melatonin, triggering inflammation and weakening immunity. Learn how to rebuild melatonin naturally to restore immune resilience.]]></description><link>https://takecontrol.substack.com/p/may-21-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-21-2026-take-control-nl</guid><pubDate>Thu, 21 May 2026 04:01:17 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/d21f8f90-584b-4ef3-bc93-75c21de9dd46_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260521_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 848w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1272w, https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!U5uG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp" width="220" height="55" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:55,&quot;width&quot;:220,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3394,&quot;alt&quot;:&quot;MERCOLA header logo&quot;,&quot;title&quot;:&quot;MERCOLA header logo&quot;,&quot;type&quot;:&quot;image/webp&quot;,&quot;href&quot;:&quot;https://www.mercola.com/?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=headerlogo&amp;utm_campaign=20260521_TC&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/167881678?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="MERCOLA header logo" title="MERCOLA header logo" srcset="https://substackcdn.com/image/fetch/$s_!U5uG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b434caa-234c-4727-b740-5ab419101997_220x55.webp 424w, 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href="https://articles.mercola.com/sites/articles/archive/2026/04/21/melatonin-sleep-deprivation-immune-dysregulation.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1HL&amp;utm_campaign=20260521_TC">The Missing Link Between Sleep and Resilience</a></h4><p>Researchers are now connecting disrupted nights to a deeper breakdown in how your body manages stress, inflammation, and defense - and it centers on one overlooked factor.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://articles.mercola.com/sites/articles/archive/2026/04/21/melatonin-sleep-deprivation-immune-dysregulation.aspx?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=art1Bttn&amp;utm_campaign=20260521_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" 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Save now and stay focused.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/category/1098/1/brain-memory-health?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Bttn&amp;utm_campaign=20260521_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3647,&quot;alt&quot;:&quot;shop now&quot;,&quot;title&quot;:&quot;shop now&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/category/1098/1/brain-memory-health?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Bttn&amp;utm_campaign=20260521_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/184393155?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="shop now" title="shop now" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><div><hr></div><p><em><strong>Disclaimer:</strong> The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Study Reveals Bile as Reservoir for Microplastics in Humans]]></title><description><![CDATA[Microplastics have been found in every human bile sample tested, showing that your body is likely actively storing them in a key digestive fluid.]]></description><link>https://takecontrol.substack.com/p/bile-microplastics</link><guid isPermaLink="false">https://takecontrol.substack.com/p/bile-microplastics</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Thu, 21 May 2026 03:33:49 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/9900aac8-b1b7-4bb5-bc46-d8403471f578_773x434.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!KiA6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!KiA6!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!KiA6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/c99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:18412,&quot;alt&quot;:&quot;bile microplastics&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/194767905?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="bile microplastics" title="bile microplastics" srcset="https://substackcdn.com/image/fetch/$s_!KiA6!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!KiA6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc99fd50a-a811-4da6-b513-afda2dae98c2_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Microplastics have been found in every human bile sample tested, showing that your body is likely actively storing them in a key digestive fluid</p></li><li><p>Higher levels of microplastics are linked to gallstones, meaning everyday plastic exposure connects directly to a condition that causes pain, inflammation, and digestive disruption</p></li><li><p>These particles are large enough to interact with your cells, where they interfere with energy production and slow down your body&#8217;s ability to repair and function</p></li><li><p>Repeated exposure drives your cells into premature aging, creating a cycle of inflammation and tissue damage that builds over time without obvious early symptoms</p></li><li><p>Simple daily changes like avoiding plastic food contact, filtering your water, and improving indoor air quality reduce how much plastic enters your body and lowers what accumulates in your bile</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, 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class="image-caption">Advertisement</figcaption></figure></div><p>Microplastics are no longer just polluting oceans and rivers; they&#8217;re accumulating inside your body. A 2026 study published in Environmental Science and Ecotechnology found plastic particles inside human bile, revealing that your body&#8217;s own waste-processing fluid is acting as a collection site for these contaminants.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> What researchers uncovered goes beyond simple exposure.</p><p>The evidence points to cellular damage, including energy failure at the mitochondrial level and premature aging of tissue that lines your bile ducts. This is not a problem to ignore and hope resolves on its own. Once plastics settle into bile, your body has limited ability to flush them without targeted support. That reality is exactly why I wrote &#8220;<strong><a href="https://joyhousepublishing.com/microplasticscure#preorder-now">Microplastics Cure: Total Body Cleanse</a></strong>,&#8221; which comes out soon.</p><p>The book goes deeper into how this invisible exposure affects your long-term health, why your body struggles to clear plastics once they accumulate, and what you can do to lower your burden and strengthen your natural defenses. Understanding how microplastics reach your bile, and what they do once trapped there, starts with a closer look at how researchers uncovered this hidden reservoir inside the human body.</p><div id="youtube2-6Xk1qRYRTys" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;6Xk1qRYRTys&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/6Xk1qRYRTys?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>Plastic Is Accumulating Where Your Body Processes Waste</strong></h2><p>For the Environmental Science and Ecotechnology study, researchers investigated whether <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/07/microplastic-in-the-brain.aspx">microplastics</a></strong> collect inside human bile, a fluid your liver produces to break down fats and carry waste out of your body. Bile is a key pathway your body uses to process and eliminate toxins. Scientists analyzed bile samples using advanced detection methods that identify both the type and amount of plastic present.</p><ul><li><p><strong>Every participant carried measurable plastic inside their bile &#8212;</strong> The study examined bile from 14 adults undergoing gallbladder surgery and found microplastics in every single sample tested. Six different plastic types showed up, with polyethylene terephthalate (PET) making up 68.05% and polyethylene (PE) accounting for 27.11% of the total. These are the same plastics used in water bottles, food packaging, and containers you encounter daily.</p></li><li><p><strong>People with gallstones had more plastic buildup &#8212;</strong> Participants with <strong><a href="https://articles.mercola.com/sites/articles/archive/2023/11/13/gallbladder-digestive-issues.aspx">gallstones</a></strong> showed significantly higher concentrations of microplastics in their bile compared to those without. Gallstones form when substances like cholesterol harden inside the gallbladder, leading to pain, nausea, and digestive issues. The fact that higher plastic levels appear in this group signals a direct connection between environmental exposure and a physical condition you can feel and experience.</p></li><li><p><strong>The particles are large enough to interfere with your cells &#8212;</strong> Most of the detected microplastics ranged from 20 to 50 micrometers in size, large enough for these particles to interact directly with cells rather than pass through unnoticed. This size range increases the likelihood that plastics become embedded in tissues or disrupt normal cellular processes instead of being easily flushed out.</p></li><li><p><strong>Your daily habits influence how much plastic builds up &#8212;</strong> The study tracked lifestyle factors such as bottled water use and takeout consumption among participants. A noticeable portion reported frequent plastic bottle use and regular exposure to packaged food. While the sample size is small, it reflects a pattern you can recognize in your own life &#8212; repeated, low-level exposure that adds up over time rather than a single large event.</p></li></ul><h2><strong>How Plastics Disrupt Bile and Damage Your Cells</strong></h2><p>The researchers explained that bile is part of your body&#8217;s waste removal system.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> Its unique composition, rich in fats and bile salts, attracts and binds to plastic particles. This means once microplastics enter your system, bile becomes a place where they collect instead of being quickly eliminated.</p><ul><li><p><strong>Plastic buildup disrupts normal bile function &#8212;</strong> When microplastics accumulate, they interfere with how bile flows and how its components stay balanced. Bile needs the right mix of cholesterol, acids, and pigments to function properly. Disruption leads to crystallization, which is the first step in gallstone formation. In simple terms, plastic interferes with your body&#8217;s ability to keep this fluid stable.</p></li><li><p><strong>Chronic exposure damages the energy systems inside your cells &#8212;</strong> The study exposed human bile duct cells to low doses of microplastics over several days to simulate real-world exposure. Researchers observed <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/08/20/microplastics-liver-mitochondria-damage.aspx">mitochondrial dysfunction</a></strong>, meaning the parts of your cells responsible for producing energy began to fail. When your cells lose energy efficiency, every process slows down &#8212; repair, detox, and communication all suffer.</p></li><li><p><strong>Damaged cells enter a state of premature aging &#8212; </strong>Scientists identified a process called <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/13/how-aging-cells-help-or-hinder-healing.aspx">senescence</a></strong> in the exposed cells, which means the cells stop working properly but don&#8217;t die off. Instead, they release inflammatory signals that damage nearby healthy cells. This creates a ripple effect, where one damaged cell influences others, accelerating tissue decline over time.</p></li><li><p><strong>Melatonin showed a measurable protective effect &#8212;</strong> When researchers introduced <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/10/03/melatonin-for-migraines.aspx">melatonin</a></strong>, a compound your body produces naturally, they observed preserved mitochondrial function and reduced cellular damage. In plain terms, melatonin helped keep the cells&#8217; energy systems running and slowed the aging process triggered by plastic exposure. This finding highlights a clear mechanism &#8212; oxidative stress &#8212; as a key driver of the damage.</p></li></ul><h2><strong>Reduce Your Plastic Burden to Protect Your Bile</strong></h2><p>What this means in practical terms is that every day your bile sits loaded with plastic particles, the cells lining your bile ducts are aging faster than they should, and you won&#8217;t feel it until the damage has accumulated. But the exposure pattern that drives this is largely within your control.</p><p>Microplastics build up because they enter your system daily and your bile traps them instead of clearing them efficiently. That gives you two clear targets: reduce what comes in and support how your body moves and eliminates those particles. When you focus on both, you shift the entire trajectory.</p><ol><li><p><strong>Cut off the biggest source of exposure first &#8212; plastic food and drink contact &#8212;</strong> If you drink from plastic bottles, store food in plastic containers, or heat food in plastic, that&#8217;s a constant source of exposure. Research has found that a single liter of bottled water can contain thousands of microplastic particles, and heating plastic dramatically increases release.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> <a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a> Switch to glass or stainless steel for water and food storage.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Don&#8217;t microwave in plastic, as even containers labeled &#8220;microwave safe&#8221; still release particles at elevated temperatures. Use glass or ceramic dishes instead. Replace plastic cutting boards with wood or bamboo alternatives, which don&#8217;t shed synthetic fragments into your food. Every plastic contact point you remove means fewer particles circulating into your bile.</p></li><li><p><strong>Change how you handle takeout and packaged foods &#8212;</strong> Takeout meals sit in plastic or foam containers, often while still hot, which accelerates leaching. Transfer hot food to glass or ceramic immediately upon arrival; don&#8217;t eat directly from the container. Even better, cook most of your food at home to avoid takeout meals as much as possible.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>When buying groceries, choose unpackaged produce over pre-wrapped options. Avoid single-serve plastic-wrapped snacks when whole food alternatives are available.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>If you use <strong><a href="https://articles.mercola.com/sites/articles/archive/2023/11/23/tea-bags-contain-plastic.aspx">tea bags</a></strong>, switch to loose-leaf tea, since many commercial tea bags are made with or sealed using plastic and release billions of micro- and nanoplastic particles when steeped in hot water. These are small, daily habits, but the cumulative reduction is significant when you consider how many meals per week involve plastic contact.</p></li><li><p><strong>Support bile flow so your body clears waste more efficiently &#8212;</strong> Your bile is a transport system for waste. When it stagnates, buildup increases. You want steady bile movement. Eat <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/01/20/benefits-of-bitters.aspx">bitter foods</a></strong> like arugula, dandelion greens, artichokes, and citrus. These stimulate bile flow by triggering cholecystokinin, a hormone that causes your gallbladder to contract and release bile.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>While increased bile flow hasn&#8217;t been directly studied as a microplastic clearance strategy, the principle of keeping bile cycling rather than stagnant reduces the window for accumulation. Also include soluble fiber from foods like apples and root vegetables, which binds to bile acids in your gut and promotes their excretion rather than recirculation.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Stay well-hydrated with plenty of filtered water daily, since bile is mostly water and thickens when you&#8217;re dehydrated. Include healthy fats from sources like grass fed butter, ghee, and tallow to trigger natural gallbladder contractions. <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/04/12/choline-prostate-cancer.aspx">Choline-rich foods</a></strong> such as pastured eggs and grass fed liver support your liver&#8217;s ability to produce bile in the first place. The goal is to keep bile thin, flowing, and actively cycling waste out of your body instead of storing it.</p></li><li><p><strong>Filter your water and rethink your daily fluid sources &#8212;</strong> If your main hydration comes from tap or bottled water, you&#8217;re getting a steady stream of microplastics. Municipal treatment plants don&#8217;t remove microplastics effectively. Look for a high-quality water filtration system specifically designed to target fine particulates, including microplastics at the submicron level.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Not all filters are equal; standard pitcher filters and refrigerator filters have pore sizes thousands of times too large to catch the smallest particles.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>When evaluating systems, check whether they&#8217;re tested and certified for microplastic removal, and prioritize units with the finest filtration capability your budget allows. Store all filtered water in glass, and don&#8217;t refill plastic bottles, which continue to leach. This single change eliminates thousands of plastic particles from what you consume every day.</p></li><li><p><strong>Reduce airborne plastic exposure inside your home &#8212;</strong> Microplastics are in the <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/02/08/airborne-microplastics-health-problems.aspx">air you breathe</a></strong>. Indoor air often contains higher concentrations of airborne microplastics than outdoor air because synthetic carpets, polyester clothing and bedding, vinyl flooring, and household dust continuously shed tiny fibers. You inhale and swallow these throughout the day.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Use an air purifier with HEPA filtration, which captures 99.97% of particles down to 0.3 microns, well within the range of most airborne microplastic fibers and fragments. Place it in rooms where you spend the most time, particularly your bedroom. Vacuum regularly with a HEPA-filtered vacuum so settled fibers don&#8217;t become airborne again. Replace synthetic carpeting with hardwood, tile, or natural fiber rugs when possible.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Choose clothing and bedding made from natural fabrics like cotton, linen, or wool over polyester and nylon. Even your home furnishings matter; synthetic upholstery and curtains shed fibers constantly. Reducing your airborne load directly reduces what <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/09/08/microplastics-lung-cancer-risk.aspx">accumulates in your lungs</a></strong>, your gut, and ultimately your bile.</p></li><li><p><strong>Support your body&#8217;s defenses against microplastic-driven oxidative damage &#8212; </strong>Even after reducing exposure, some microplastics will still reach your system. The study found that melatonin preserved mitochondrial function and reduced cellular damage caused by microplastic exposure.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Your mitochondria actually produce 95% of your body&#8217;s melatonin. This process depends on your exposure to natural sunlight.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-5" href="#footnote-5" target="_self">5</a> Near-infrared light penetrates deep into your skin and switches on an enzyme inside your mitochondria that drives mitochondrial melatonin production, also known as subcellular melatonin. Melatonin acts as a potent antioxidant that neutralizes reactive oxygen species, the primary mechanism through which microplastics damage cells.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Support your body&#8217;s own melatonin production by maintaining a consistent sleep schedule, sleeping in total darkness, and getting morning sunlight exposure. Beyond melatonin, other antioxidant-rich foods like berries, green tea, and cruciferous vegetables provide additional protection against the oxidative stress that microplastics generate. The goal is to build internal resilience so the particles that do get through cause less damage.</p></li></ol><h2><strong>FAQs About Microplastics in Bile</strong></h2><p><strong>Q: What are microplastics and how do they end up in bile?</strong></p><p><strong>A: </strong>Microplastics are tiny plastic particles from packaging, bottled water, and synthetic materials that enter your body through food, water, and air. The research shows your bile, a fluid that helps digest fats and remove waste, attracts and collects these particles instead of clearing them efficiently.</p><p><strong>Q: Why does it matter that microplastics build up in bile?</strong></p><p><strong>A: </strong>Bile plays a key role in digestion and waste removal. When plastics accumulate, they disrupt its balance and flow. This interference contributes to gallstone formation, which is linked to symptoms like abdominal pain, nausea, and digestive problems. Over time, this disruption places ongoing stress on your liver and gallbladder.</p><p><strong>Q: How do microplastics damage my cells?</strong></p><p><strong>A: </strong>The study showed that even low, repeated exposure damages mitochondria, the parts of your cells that produce energy. When these structures fail, your cells lose efficiency and shift into a state called senescence, where they stop functioning properly and release inflammatory signals that harm nearby tissue.</p><p><strong>Q: Are some people at higher risk for microplastic buildup?</strong></p><p><strong>A: </strong>Individuals with gallstones had higher levels of microplastics in their bile compared to those without. Daily habits also play a major role. Frequent use of plastic bottles, packaged foods, and takeout increases your exposure, which raises the amount that accumulates in your body over time.</p><p><strong>Q: What can I do to reduce my exposure and protect my body?</strong></p><p><strong>A: </strong>You can lower your burden by removing everyday sources of plastic contact, such as bottled water, plastic food storage, and packaged meals. Filtering your water, improving indoor air quality, and supporting bile flow through diet all help reduce how much plastic enters and stays in your system. These steps directly reduce what builds up in your bile and limit the damage to your cells.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/kyphosis&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/kyphosis"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.sciencedirect.com/science/article/pii/S2666498426000311">Environmental Science and Ecotechnology May 2026, Volume 31, 100686</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.sciencedirect.com/science/article/pii/S2666498426000311">Environmental Science and Ecotechnology May 2026, Volume 31, 100686</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://www.nih.gov/news-events/nih-research-matters/plastic-particles-bottled-water">National Institutes of Health January 23, 2024</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12845809/">Toxics. 2026 Jan 20;14(1):94</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-5" href="#footnote-anchor-5" class="footnote-number" contenteditable="false" target="_self">5</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8621753/">Int J Mol Sci. 2021 Nov 19;22(22):12494</a></p></div></div>]]></content:encoded></item><item><title><![CDATA[★The Overlooked Formula That Changes Everything]]></title><description><![CDATA[A modest daily upgrade - more sleep, five minutes of exercise, less sitting, and a better diet can extend your lifespan.]]></description><link>https://takecontrol.substack.com/p/may-20-2026-take-control-nl</link><guid isPermaLink="false">https://takecontrol.substack.com/p/may-20-2026-take-control-nl</guid><pubDate>Wed, 20 May 2026 04:01:32 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/ba089cec-cf9b-4594-b13a-8501814ce3aa_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" 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The phytocannabinoids and terpenes in whole hemp oil concentrate may play a key role.</p><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/product/2916/organic-hemp-oil-concentrate-1-fl-oz-3-bottles?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Bttn&amp;utm_campaign=20260520_TC" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png" width="750" height="25" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/cee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:25,&quot;width&quot;:750,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:3647,&quot;alt&quot;:&quot;shop now&quot;,&quot;title&quot;:&quot;shop now&quot;,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/product/2916/organic-hemp-oil-concentrate-1-fl-oz-3-bottles?utm_source=takecontrol&amp;utm_medium=email&amp;utm_content=dpe2Bttn&amp;utm_campaign=20260520_TC&quot;,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/184393155?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="shop now" title="shop now" srcset="https://substackcdn.com/image/fetch/$s_!EFrx!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 424w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 848w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1272w, https://substackcdn.com/image/fetch/$s_!EFrx!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fcee7b7f4-0b12-4e5d-a3c4-7446c396e5b5_750x25.png 1456w" sizes="100vw" loading="lazy"></picture><div></div></div></a></figure></div><div><hr></div><p><em><strong>Disclaimer:</strong> The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.</em></p><p>Mercola.com, 125 SW 3rd Place, Suite 205, Cape Coral, FL 33991<br>US Number: (877) 985-2695 | Intl Number: 1 (239) 599-9500<br>&#169; 1997-2026 Dr. Joseph Mercola. All Rights Reserved.</p><p>*These statements have not been evaluated by the Food and Drug Administration.</p><p>These products are not intended to diagnose, treat, cure, or prevent any disease.</p>]]></content:encoded></item><item><title><![CDATA[Can Spending Time in Nature Improve Your Diet?]]></title><description><![CDATA[Spending time in nature shifts your food preferences so you naturally choose healthier, whole foods without relying on willpower.]]></description><link>https://takecontrol.substack.com/p/spending-time-in-nature-eating-habits</link><guid isPermaLink="false">https://takecontrol.substack.com/p/spending-time-in-nature-eating-habits</guid><dc:creator><![CDATA[Dr. Joseph Mercola]]></dc:creator><pubDate>Wed, 20 May 2026 03:33:37 GMT</pubDate><enclosure url="https://substack-post-media.s3.amazonaws.com/public/images/e0b12fcf-04dc-4abf-8fa5-a4c1a062695f_840x600.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!TZHm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!TZHm!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!TZHm!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg" width="773" height="434" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:434,&quot;width&quot;:773,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:36293,&quot;alt&quot;:&quot;spending time in nature eating habits&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://takecontrol.substack.com/i/194498193?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="spending time in nature eating habits" title="spending time in nature eating habits" srcset="https://substackcdn.com/image/fetch/$s_!TZHm!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 424w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 848w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!TZHm!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F93aef87c-217c-436e-a171-ff6fc0e5e827_773x434.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>STORY AT-A-GLANCE</strong></h3><ul><li><p>Spending time in nature shifts your food preferences so you naturally choose healthier, whole foods without relying on willpower</p></li><li><p>Even short, daily exposure to natural environments improves diet quality, making simple habits like walking outside highly effective</p></li><li><p>Nature doesn&#8217;t reduce how much you eat but changes what you want to eat, steering you away from processed foods toward real nourishment</p></li><li><p>Exposure to nature increases how much you value your health in the moment, which directly influences better food decisions</p></li><li><p>Using nature as a daily routine or pre-meal reset helps break stress-driven eating patterns and makes healthy eating easier to sustain</p></li></ul><div class="captioned-image-container"><figure><a class="image-link image2" target="_blank" href="https://www.mercolamarket.com/pages/top-products-supplements" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg" width="1272" height="254" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/d5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:254,&quot;width&quot;:1272,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:115080,&quot;alt&quot;:&quot;Visit Mercola Market&quot;,&quot;title&quot;:&quot;Visit Mercola Market&quot;,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:&quot;https://www.mercolamarket.com/pages/top-products-supplements&quot;,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="Visit Mercola Market" title="Visit Mercola Market" srcset="https://substackcdn.com/image/fetch/$s_!IkIO!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 424w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 848w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!IkIO!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5e21c70-47b5-432d-a6eb-93ee605e4a0d_1272x254.jpeg 1456w" sizes="100vw"></picture><div></div></div></a><figcaption class="image-caption">Advertisement</figcaption></figure></div><p>Most people treat diet as a matter of willpower &#8212; choosing the right foods, resisting the wrong ones, and grinding through discipline until something sticks. But two studies found that one of the most powerful ways to improve what you eat has nothing to do with meal plans, calorie counting, or self-control. It starts with stepping outside, and the shift begins in as little as 20 minutes.</p><p>Spending time in nature recalibrates your nutritional instincts from the inside out. It shifts what your brain actually wants when you sit down to eat. The processed foods that normally feel irresistible start to lose their pull, and whole, nourishing options become what you reach for instead.</p><p>Rather than focusing on dieting or restriction, nature supports your body returning to a preference for real food. The effect doesn&#8217;t require hours of hiking or a move to the countryside. All it takes is simply stepping outdoors and letting natural surroundings reshape your dietary choices from the ground up.</p><div id="youtube2-4NRUvwsA3aY" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;4NRUvwsA3aY&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/4NRUvwsA3aY?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div><h2><strong>More Time Outdoors Reshapes Your Eating Habits</strong></h2><p>A study published in Social Science &amp; Medicine looked at how often and how long people <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/03/20/the-20-5-3-nature-prescription.aspx">spend time in nature</a></strong>, then measured how that lined up with the quality of their diet.<sup><a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-1" href="#footnote-1" target="_self">1</a></sup> The researchers surveyed 300 adults across the U.S. and followed up with in-depth interviews to get the full picture &#8212; not just what people were eating, but what was driving those choices.</p><ul><li><p><strong>People who spent more time in nature consistently ate better &#8212;</strong> The study included adults from different backgrounds, income levels, and lifestyles, which makes the findings harder to dismiss as a niche result. The pattern was clear: the more often someone interacted with nature and the longer they stayed in it, the higher their diet quality scores and the more closely they followed sustainable eating habits.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Put simply, the more time you spend around nature, the more likely you are to reach for whole foods over processed ones.</p></li><li><p><strong>Both how often you get outside and how long you stay matter &#8212;</strong> The study measured frequency and duration separately, and both independently improved diet quality. That&#8217;s good news because it means you don&#8217;t need weekend-long hiking trips to see a difference. Even short, regular contact with nature starts to shift your food decisions.</p></li><li><p><strong>Not all types of nature exposure work the same way &#8212;</strong> The researchers broke it into three categories: indirect (like seeing trees through a window), incidental (passing through a park on your way somewhere), and intentional (activities like <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/11/06/gardening-mental-health-quality-of-life.aspx">gardening</a></strong> or going for a walk in the woods). Indirect exposure on its own didn&#8217;t show a strong link to better eating, but incidental and intentional exposure did.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>The takeaway is that passively looking at nature isn&#8217;t enough. You get more out of nature when you physically move through it or actively engage with it.</p></li><li><p><strong>Your mental state plays a big role in how much your diet improves &#8212;</strong> People with better mental well-being got even stronger benefits from time in nature. When your stress levels drop, your food choices tend to follow. That connection helps explain why stress eating feels so automatic and why changing your surroundings helps break the cycle.</p></li><li><p><strong>Nature directly reduces stress-driven eating and impulsive food choices &#8212;</strong> Participants called being in nature a &#8220;stress reliever&#8221; and said it helped them feel calmer and more grounded. When that stress lifted, so did the pull toward quick, processed food options. One person put it this way &#8212; being in nature made their mind &#8220;less concerned&#8221; about easy ways to satisfy cravings.</p></li><li><p><strong>Feeling connected to nature shifts what you want to eat &#8212;</strong> The study measured what researchers call &#8220;nature relatedness,&#8221; and people who scored higher in that area had better diet quality and ate more fruits and vegetables. When you feel genuinely connected to nature, processed food starts to feel out of step with everything else. Your preferences shift on their own without you having to force anything.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Getting involved with where your food comes from also changes your choices automatically. Gardening and buying from local sources came up again and again in interviews. Participants said that growing or sourcing their own food made them value it more and naturally lean toward higher-quality options. It creates a feedback loop; the more hands-on you are with your food, the less you have to rely on discipline to eat well.</p></li></ul><h2><strong>Nature Changes What You Want, Not How Hard You Try</strong></h2><p>A study published in Communications Psychology looked at how being exposed to natural environments changes food choices in the moment, and more importantly, why.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-2" href="#footnote-2" target="_self">2</a> Instead of assuming people made better choices because they were more focused or less tired, the researchers tested those explanations directly and found they didn&#8217;t hold up.</p><ul><li><p><strong>People chose different foods without eating less &#8212;</strong> The study compared people exposed to nature scenes with those who saw urban or neutral settings, then tracked both what they picked and how much they ate. People who saw nature didn&#8217;t eat less; they just picked better food. This reflects a natural pull toward higher-quality options without any sense of restriction.</p></li><li><p><strong>Nature made people prioritize health more when choosing food &#8212;</strong> The researchers found that exposure to nature increased how important participants considered their own health at the moment they made food decisions. This shift reflected a change in internal motivation. In simple terms, after seeing nature, people placed more value on nourishing their body, and that directly changed the type of food they chose, without reducing how much they ate.</p></li><li><p><strong>Nature steers you toward real food, not diet food &#8212;</strong> One of the most interesting findings was how people responded to different kinds of &#8220;healthy&#8221; options. Nature exposure increased the preference for natural, whole foods while actually decreasing interest in &#8220;diet&#8221; or &#8220;light&#8221; snack products.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This isn&#8217;t a weight-loss switch flipping &#8212; it&#8217;s a nourishment switch. Your brain stops asking &#8220;what&#8217;s lighter?&#8221; and starts asking &#8220;what&#8217;s real?&#8221; You start favoring real food over processed substitutes, even the ones marketed as better-for-you.</p></li><li><p><strong>Cities don&#8217;t make your choices worse; nature just makes them better &#8212;</strong> The researchers compared nature exposure to both urban views and neutral settings like closed curtains. There was no real difference between how people ate in urban versus neutral environments. Nature is the active ingredient here. It lifts your choices above the baseline rather than cities dragging them down.</p></li><li><p><strong>Time in nature also improves your gut health directly &#8212;</strong> The benefits of getting outside go beyond what you choose to eat; they extend to what&#8217;s happening inside your digestive system. Spending time outdoors exposes you to a wide range of beneficial bacteria from soil, plants, and air that can increase the diversity of your <strong><a href="https://articles.mercola.com/sites/articles/archive/2025/01/17/how-gut-bacteria-modulate-stress-responses.aspx">gut microbiome</a></strong>.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-3" href="#footnote-3" target="_self">3</a> In one study, urban preschoolers who took part in a 10-week outdoor nature program showed measurable improvements in gut microbial diversity.<a class="footnote-anchor" data-component-name="FootnoteAnchorToDOM" id="footnote-anchor-4" href="#footnote-4" target="_self">4</a></p></li></ul><h2><strong>Spend Time in Nature to Upgrade Your Diet</strong></h2><p>Your food choices reflect what your brain values in the moment. When you feel disconnected, stressed, or mentally drained, your brain defaults to quick, processed options. When you <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/02/20/ecotherapy.aspx">reconnect with nature</a></strong>, your internal priorities quietly rearrange themselves. You start valuing nourishment over convenience. That&#8217;s the lever you want to use. Instead of forcing better habits, change the environment that drives those habits.</p><ol><li><p><strong>Build a daily &#8220;nature exposure minimum&#8221; that&#8217;s easy to reach &#8212;</strong> Set a non-negotiable baseline such as 20 to 30 minutes outside every day. Keep it simple so you follow through. A <strong><a href="https://articles.mercola.com/sites/articles/archive/2024/07/26/outdoor-walks.aspx">daily walk</a></strong>, sitting in your yard, or even standing near trees works. The key is consistency. When you repeat this each day, your brain starts to associate your normal routine with a higher value placed on your health, which shifts your food choices without effort.</p></li><li><p><strong>Use nature right before meals as a reset trigger &#8212;</strong> If you tend to grab whatever is easiest when you&#8217;re hungry, build a five- to 10-minute outdoor pause into your routine before lunch or dinner. Step outside, walk to the nearest tree-lined street, or simply stand in your yard or on your balcony. Don&#8217;t check your phone; let your attention settle on what&#8217;s around you.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>This kind of direct, intentional nature contact (not just glancing through a window) is what shifts food preferences. By the time you walk back inside, the pull toward processed convenience food is typically measurably weaker, and whole-food options feel more appealing. Think of it as resetting your palate before you sit down to eat by letting your environment do the work for you.</p></li><li><p><strong>Turn your meals into a &#8220;natural alignment&#8221; habit &#8212;</strong> After your outdoor time, eat something that matches the simplicity of what you just experienced. If you walked past a garden, come inside and build your plate around fresh vegetables, not a frozen dinner. If you sat near trees or water, reach for whole fruit. The principle is straightforward: processed food feels out of place after time in nature, so lean into that instinct instead of fighting it.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>Over time, this pairing strengthens the connection between being outdoors and choosing real food, until the preference becomes automatic. The less you have to think about what to eat, the more sustainable the change becomes.</p></li><li><p><strong>Add one hands-on nature activity each week &#8212;</strong> If you&#8217;re disconnected from where your food comes from, your choices stay abstract. Gardening, visiting a farmers market, or buying directly from local farms changes that. When you see and interact with real food sources, your appreciation increases, and processed food loses its appeal. This builds long-term change without relying on willpower.</p></li><li><p><strong>Track your &#8220;nature streak&#8221; instead of your diet &#8212;</strong> Calorie tracking puts your attention on restriction. Tracking your nature streak puts it on a behavior that makes better eating a side effect. Each day you spend at least 20 minutes outside, mark it &#8212; a check on a wall calendar, a tally on a notecard, or a simple habit tracker. The method doesn&#8217;t matter as long as it&#8217;s visible enough to create a sense of momentum.</p><div class="preformatted-block" data-component-name="PreformattedTextBlockToDOM"><label class="hide-text" contenteditable="false">Text within this block will maintain its original spacing when published</label><pre class="text"></pre></div><p>As your streak grows, so does the cumulative effect on your food preferences. The pull toward processed food starts to feel less automatic, and whole-food meals begin to feel like the obvious choice rather than the disciplined one. If you break the streak, don&#8217;t reset to zero, just start a new one. The goal isn&#8217;t perfection; it&#8217;s making nature contact your default, so better eating follows without you having to manage it.</p></li></ol><h2><strong>FAQs About Nature and Your Diet</strong></h2><p><strong>Q: How does spending time in nature actually improve my diet?</strong></p><p><strong>A: </strong>Time in nature shifts what your brain values in the moment. Instead of relying on discipline, your internal priorities change. You start placing more importance on nourishing your body, which leads you to choose whole, unprocessed foods more often without forcing it.</p><p><strong>Q: Do you need long hikes or major lifestyle changes to see results?</strong></p><p><strong>A: </strong>No. Research shows that both how often you get outside and how long you stay matter, but even short, regular exposure makes a difference. Simple activities like walking through a park or sitting outside daily start to shift your food choices over time.</p><p><strong>Q: Does nature make you eat less or just eat better?</strong></p><p><strong>A: </strong>Nature changes the type of food you choose, not the amount you eat. People exposed to natural environments didn&#8217;t reduce how much they ate. Instead, they consistently chose higher-quality foods, especially whole, nourishing options.</p><p><strong>Q: Why does stress affect your food choices so much?</strong></p><p><strong>A: </strong>When you feel stressed or mentally drained, your brain defaults to quick, processed foods. Time in nature reduces that stress response, which weakens the pull toward those foods. As your mental state improves, your food choices naturally follow.</p><p><strong>Q: Is this about dieting or weight loss?</strong></p><p><strong>A: </strong>No. Nature doesn&#8217;t trigger a dieting mindset. It shifts your preference toward real, whole foods and away from processed &#8220;diet&#8221; products. The focus becomes nourishment, not restriction or calorie counting, which makes the changes easier to maintain long term.</p><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://takecontrol.substack.com/p/bile-microplastics&quot;,&quot;text&quot;:&quot;NEXT ARTICLE >>&quot;,&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://takecontrol.substack.com/p/bile-microplastics"><span>NEXT ARTICLE &gt;&gt;</span></a></p><p><em><strong>Disclaimer</strong>: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked.</em></p><p><em>The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. The subscription fee being requested is for access to the articles and information posted on this site, and is not being paid for any individual medical advice.</em></p><p><em>If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.</em></p><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-1" href="#footnote-anchor-1" class="footnote-number" contenteditable="false" target="_self">1</a><div class="footnote-content"><p><a href="https://www.sciencedirect.com/science/article/pii/S0277953626000894">Social Science &amp; Medicine March 2026, Volume 393, 119014</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-2" href="#footnote-anchor-2" class="footnote-number" contenteditable="false" target="_self">2</a><div class="footnote-content"><p><a href="https://www.nature.com/articles/s44271-024-00072-x">Communications Psychology April 2, 2024</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-3" href="#footnote-anchor-3" class="footnote-number" contenteditable="false" target="_self">3</a><div class="footnote-content"><p><a href="https://www.uclahealth.org/news/article/time-spent-outdoors-helpful-gut-microbiome">UCLA Health January 21, 2025</a></p></div></div><div class="footnote" data-component-name="FootnoteToDOM"><a id="footnote-4" href="#footnote-anchor-4" class="footnote-number" contenteditable="false" target="_self">4</a><div class="footnote-content"><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7738543/">Sci Rep. 2020 Dec 15;10:21993</a></p></div></div>]]></content:encoded></item></channel></rss>