In my CBS Chicago interview, I explained that your body already contains detox systems that work continuously through your liver, skin, kidneys, and digestive tract, but processed foods, seed oils, and dehydration overload those pathways and slow recovery.
And also a good dose of happiness to accompany all of Dr. Mercola's good advice. Albert Schweitzer, the Nobel Peace Prize-winning physician and philosopher, said that "happiness is also good health and a bad memory." A bad memory can be useful for forgetting past disappointments and maintaining healthy optimism, but nothing affects our moment-to-moment satisfaction as much as the condition of our bodies. A common cold is as depressing as it is painful and uncomfortable. Schweitzer also famously said, "Every patient carries his own doctor within." He couldn't have been more right about how our bodies are designed to heal themselves and how they work to keep us functioning at our best, even at the most minute level. Arguably, no one works harder to keep us healthy (and therefore happy) than our mitochondria.
Our mitochondria keep our neurons firing, our muscles flexing, and our hearts beating. In short, they keep us alive. Even if you don't feel it, these microscopic powerhouses are constantly producing the cellular energy we need to function at the most basic level.
1) Increase energy levels
2) Keep blood sugar levels under control
3) Using NAD to boost cellular energy to support healthy mitochondrial function and overall health as we age.
We have many "doctors" in our lives who support our mitochondria and can infuse us with joy and health:
1) Doctor Nature: sunshine, air, and pure water
2) Doctor Healthy Nutrition and Fasting
3) Doctor Physical Activity with Rest and Good Posture
4) Doctor Joy-Supported Mindset
The feeling of joy comes from the activity of the nervous system, specifically our neurotransmitters. These transmitters carry chemicals throughout our body, including the feel-good chemicals mentioned in the previous paragraph, also known as "joy" chemicals. When you have a high concentration of these chemicals in your system, your physical health improves. Better sleep, improved digestion, weight loss, and a stronger immune system are just some of the benefits of a happy mood. When you feel happy, your circulatory system may respond by flushing your cheeks and raising your body temperature—it's the face of happiness.
A few more Doctors' Gui, Detox what we spend our money on, detox before the checkout counter, detox as many toxic fare we can along with the Ultra Processed Calories.
We do the best we can with what we have and if we can improve then do so. Purchase as much quality as possible. Heirloom or Heritage quality goods nearly automatically eliminates much of the plastic junk. Purchasing quality goods that will last much longer if taking care of than the mountains of plastic, chemical junk meant to be repeat mindless, chase a style or trend shuts down feeding landfills, plugging up the world around us, and ourselves internally.
When possible, Make it Real Locally, Make it Locally and Keep it Real. This keeps basic needs, staples in shorter, more stable supply lines instead of the whole nation waiting for goods to be delivered from thousands of miles away. Also cutting down the toxins from shipping or the situations where a product is shut off like the current lettuce problem.
Just adding something else. Liver detoxification is fundamental. This includes hormonal and digestive health (including histamine breakdown) and supports kidney health. The liver detoxifies primarily through a phased process: In Phase I, lipophilic toxins are transformed into reactive molecules through reduction, oxidation, and hydrolysis, catalyzed by P-450 enzymes. In Phase II, the toxins transformed in Phase I are conjugated with other molecules to create a water-soluble compound that is eliminated mainly through bile or urine. Phase III is elimination. The liver filters 1.5 liters of blood per minute, eliminating 99% of the bacteria and toxins that arrive from the intestine via the portal vein.
---1. SULFATION. This is a very important pathway because a large portion of estrogens and their derivatives are detoxified through it. It consists of the binding of a toxin with a sulfate group activated by ATP. Foods and supplements containing taurine, MSM, B6, and B12 are good contributors in this phase. Nrf2 regulation in cells is supported by R-lipoic acid, polyphenols, and sulfur-based compounds from cruciferous vegetables and allium.
---2. CONJUGATION. This involves the addition of an amino acid to the compound to be deactivated. The main amino acid in this pathway is taurine (taurine conjugation: responsible for eliminating bile acids, for example, tanocholic acid). Glycine is the next most important: less important in the detoxification of bile acids but helpful in detoxifying petrochemical derivatives (for example, solvents). The other conjugable amino acids (ornithine, cysteine, arginine, and glutamine) are not as relevant. Taurine, NAC, glycine, ornithine, and B6 are effective in this stage.
---3. CONJUGATION (GST): The compound conjugated in this pathway is glutathione, composed of cysteine, glycine, and glutamic acid. It eliminates heavy metals, aromatic hydrocarbon compounds, polycyclic organophosphates, epoxides, paracetamol, etc.
Nutrients that help increase glutathione:
1. Milk thistle. 2. Undenatured whey protein. 3. Sulfur-rich foods: cabbage and allium. 4. NAC (acetylcysteine). 5. Alpha-lipoic acid. 6. Methylation (vitamins B6, B9, B12, and biotin). 7. Selenium. 8. Vitamins C and E. 9. Beef liver.
In one study, biotin, choline, milk thistle extract, N-acetyl L-cysteine, alpha-lipoic acid, broccoli concentrate, green tea, and turmeric extract were administered. Plasma glutathione levels increased by 74 percent at the end of the study.
4. METHYLATION. This involves the addition of a methyl group to the molecules to be eliminated. SAMe is a good methyl group donor molecule. Choline, lecithin, and vitamin B12 help in this stage. Estrogens are removed from circulation through three pathways: sulfation, methylation, and glucuronidation.
5. GLUCURONIDATION. Glucuronidation involves the combination of the toxin with glucuronic acid. Bilirubin, resulting from the degradation of the heme group of hemoglobin, is eliminated by glucuronidation. Artichoke, desmodium, cruciferous vegetables, and allium help in this stage.
6. ACETYLATION. Acetylation is a reaction that introduces an acetyl group, whose cofactors are vitamins B2 and B5. It helps eliminate toxins such as benzodiazepines, histamine, and aromatic amines.
And also a good dose of happiness to accompany all of Dr. Mercola's good advice. Albert Schweitzer, the Nobel Peace Prize-winning physician and philosopher, said that "happiness is also good health and a bad memory." A bad memory can be useful for forgetting past disappointments and maintaining healthy optimism, but nothing affects our moment-to-moment satisfaction as much as the condition of our bodies. A common cold is as depressing as it is painful and uncomfortable. Schweitzer also famously said, "Every patient carries his own doctor within." He couldn't have been more right about how our bodies are designed to heal themselves and how they work to keep us functioning at our best, even at the most minute level. Arguably, no one works harder to keep us healthy (and therefore happy) than our mitochondria.
Our mitochondria keep our neurons firing, our muscles flexing, and our hearts beating. In short, they keep us alive. Even if you don't feel it, these microscopic powerhouses are constantly producing the cellular energy we need to function at the most basic level.
1) Increase energy levels
2) Keep blood sugar levels under control
3) Using NAD to boost cellular energy to support healthy mitochondrial function and overall health as we age.
We have many "doctors" in our lives who support our mitochondria and can infuse us with joy and health:
1) Doctor Nature: sunshine, air, and pure water
2) Doctor Healthy Nutrition and Fasting
3) Doctor Physical Activity with Rest and Good Posture
4) Doctor Joy-Supported Mindset
The feeling of joy comes from the activity of the nervous system, specifically our neurotransmitters. These transmitters carry chemicals throughout our body, including the feel-good chemicals mentioned in the previous paragraph, also known as "joy" chemicals. When you have a high concentration of these chemicals in your system, your physical health improves. Better sleep, improved digestion, weight loss, and a stronger immune system are just some of the benefits of a happy mood. When you feel happy, your circulatory system may respond by flushing your cheeks and raising your body temperature—it's the face of happiness.
A few more Doctors' Gui, Detox what we spend our money on, detox before the checkout counter, detox as many toxic fare we can along with the Ultra Processed Calories.
We do the best we can with what we have and if we can improve then do so. Purchase as much quality as possible. Heirloom or Heritage quality goods nearly automatically eliminates much of the plastic junk. Purchasing quality goods that will last much longer if taking care of than the mountains of plastic, chemical junk meant to be repeat mindless, chase a style or trend shuts down feeding landfills, plugging up the world around us, and ourselves internally.
When possible, Make it Real Locally, Make it Locally and Keep it Real. This keeps basic needs, staples in shorter, more stable supply lines instead of the whole nation waiting for goods to be delivered from thousands of miles away. Also cutting down the toxins from shipping or the situations where a product is shut off like the current lettuce problem.
Just adding something else. Liver detoxification is fundamental. This includes hormonal and digestive health (including histamine breakdown) and supports kidney health. The liver detoxifies primarily through a phased process: In Phase I, lipophilic toxins are transformed into reactive molecules through reduction, oxidation, and hydrolysis, catalyzed by P-450 enzymes. In Phase II, the toxins transformed in Phase I are conjugated with other molecules to create a water-soluble compound that is eliminated mainly through bile or urine. Phase III is elimination. The liver filters 1.5 liters of blood per minute, eliminating 99% of the bacteria and toxins that arrive from the intestine via the portal vein.
---1. SULFATION. This is a very important pathway because a large portion of estrogens and their derivatives are detoxified through it. It consists of the binding of a toxin with a sulfate group activated by ATP. Foods and supplements containing taurine, MSM, B6, and B12 are good contributors in this phase. Nrf2 regulation in cells is supported by R-lipoic acid, polyphenols, and sulfur-based compounds from cruciferous vegetables and allium.
---2. CONJUGATION. This involves the addition of an amino acid to the compound to be deactivated. The main amino acid in this pathway is taurine (taurine conjugation: responsible for eliminating bile acids, for example, tanocholic acid). Glycine is the next most important: less important in the detoxification of bile acids but helpful in detoxifying petrochemical derivatives (for example, solvents). The other conjugable amino acids (ornithine, cysteine, arginine, and glutamine) are not as relevant. Taurine, NAC, glycine, ornithine, and B6 are effective in this stage.
---3. CONJUGATION (GST): The compound conjugated in this pathway is glutathione, composed of cysteine, glycine, and glutamic acid. It eliminates heavy metals, aromatic hydrocarbon compounds, polycyclic organophosphates, epoxides, paracetamol, etc.
Nutrients that help increase glutathione:
1. Milk thistle. 2. Undenatured whey protein. 3. Sulfur-rich foods: cabbage and allium. 4. NAC (acetylcysteine). 5. Alpha-lipoic acid. 6. Methylation (vitamins B6, B9, B12, and biotin). 7. Selenium. 8. Vitamins C and E. 9. Beef liver.
In one study, biotin, choline, milk thistle extract, N-acetyl L-cysteine, alpha-lipoic acid, broccoli concentrate, green tea, and turmeric extract were administered. Plasma glutathione levels increased by 74 percent at the end of the study.
4. METHYLATION. This involves the addition of a methyl group to the molecules to be eliminated. SAMe is a good methyl group donor molecule. Choline, lecithin, and vitamin B12 help in this stage. Estrogens are removed from circulation through three pathways: sulfation, methylation, and glucuronidation.
5. GLUCURONIDATION. Glucuronidation involves the combination of the toxin with glucuronic acid. Bilirubin, resulting from the degradation of the heme group of hemoglobin, is eliminated by glucuronidation. Artichoke, desmodium, cruciferous vegetables, and allium help in this stage.
6. ACETYLATION. Acetylation is a reaction that introduces an acetyl group, whose cofactors are vitamins B2 and B5. It helps eliminate toxins such as benzodiazepines, histamine, and aromatic amines.
https://askthescientists.com/qa/liver-detoxification-pathways/
https://www.integrativefamilypractice.com/blog/liver-detoxification
https://regenerahealth.com/blog/detoxificacion-hepatica-fases/
https://integrative.ca/blog/3-phases-detoxification
https://www.drlamcoaching.com/blog/liver-detox-phases-what-to-expect/