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The best vitamin D is that obtained from the sun. Solar radiation produces anti-inflammatory, analgesic, and modulating effects. It stimulates cells and regulates the production of hormones and neurotransmitters. We absorb between 25-30% of solar photons through the skin.

The sun's rays produce two types of sulfur: cholesterol sulfate and vitamin D3 sulfate. Healthy cholesterol and sulfur levels also depend largely on vitamin D levels. Stephanie Seneff tells us that cholesterol and sulfur are oxidized after exposure to sunlight and transformed into vitamin D3.

Cholesterol sulfate deficiency can cause glucose intolerance, fat cells store more fat to fuel muscles, and excess fat accumulates, causing obesity and metabolic disorders that cause multiple pathologies, including cancer. Red blood cells produce cholesterol sulfate, and this molecule protects red blood cells from disintegration.

Growing evidence demonstrates that the immune system and skeletal muscle interact, modulating each other's function. In this context, vitamin D appears capable of integrating and converging certain biomolecular signaling toward protective anti-inflammatory effects. Therefore, vitamin D regulation appears to be even more critical at the intersection of signaling between the immune system and muscle, rather than at the individual tissue level, opening up new opportunities for clinical applications to improve health. This article focuses on the interaction between the immune system and skeletal muscle as a multifaceted target for vitamin D in health and disease, after reviewing the main regulatory roles of vitamin D in these systems separately.

Furthermore, vitamin D exhibits anti-inflammatory properties by inhibiting proinflammatory cytokines implicated in the pathophysiology of metabolic dysfunction (MASLD). Experimental evidence suggests that the immunomodulatory effects of vitamin D extend to the liver, reducing inflammation and oxidative stress, key factors in MASLD, and the likelihood of hepatocyte damage and fibrosis. Understanding the complex interplay between vitamin D and MASLD provides a basis for exploring targeted therapeutic strategies and preventive interventions. Given that vitamin D deficiency is a modifiable risk factor, addressing this nutritional concern may be beneficial in mitigating the burden of MASLD and associated metabolic disorders such as fatty liver disease.

https://www.mdpi.com/2076-3417/10/16/5592 (2020).--

https://www.mdpi.com/1422-0067/25/9/4901 (2024).-

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