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Dorlis Lee Grote's avatar
Dorlis Lee Grote
Feb 28

Many possible sources BUT once again, stay away from highly processed foods and you are ahead of the game! In a sense, getting Lymphoma in 2000 was beneficial for me, I eliminated all processed foods from my diet, went into remission and kept toxic foods out of my diet! No more, easy to eat foods, just old fashioned home cooked so I can control what goes into my food! More work for me, but less cost in healthcare!

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Guillermou
Feb 28Edited

As Dr. Mercola reports, the primary dietary determinant of FGF-23 is absorbed phosphorus.

In the meta-analysis, “Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis,” Journal of the American Society of Nephrology (2018), FGF-23 negatively regulates renal proximal tubular sodium-phosphate cotransport function in the kidney, enhancing urinary phosphate excretion and reducing vitamin D1-α hydroxylation, leading to decreased intestinal calcium and phosphate absorption.<sup>12</sup> However, FGF-23 may have Klotho-independent actions in other tissues, including the heart,<sup>13</sup> and may contribute to the etiology of structural heart disease in patients with chronic kidney disease.

Prospective studies relating blood levels of FGF-23 to the following were analyzed: Myocardial infarction, Stroke, Heart failure, Cardiovascular mortality, All-cause mortality, and Non-cardiovascular mortality.

Comparing the highest vs. lowest tertile of FGF-23: Relative risk (RR)

Myocardial infarction: 1.33

Stroke: 1.26

Heart failure: 1.48

Cardiovascular mortality: 1.42

All-cause mortality: 1.70

Non-cardiovascular mortality: 1.52

https://pmc.ncbi.nlm.nih.gov/articles/PMC6050929/

When asked, ChatGPT-PRO confirmed that not all phosphorus from food is absorbed equally.

Phosphorus by Food Type

Dairy, meat, fish: 60–80%

Whole grains, legumes: 30–50%

Phosphate additives (processed foods): 90–100%

Industrial phosphate additives (E-338, E-339, E-340…) are the biggest contributors to FGF-23 levels.

Dietary factors that increase FGF-23

Ultra-processed foods, cola drinks (phosphoric acid), processed meats, processed cheeses, processed meats.

Iron deficiency can increase FGF-23.

Kidney health is important: Adequate hydration, avoid protein overload.

Fiber: Improves gut microbiota → may modulate mineral metabolism. Decreased Klotho (protective protein)

This study, “Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study,” confirmed the previously observed positive correlation between serum FGF-23 levels and cardiovascular (CV) disease severity and revealed a negative correlation between serum Klotho levels and CV severity in patients with chronic kidney disease (CKD). Klotho acts as a protective factor against CV severity in patients with CKD, while FGF-23 acts as a risk factor for CV severity. Serum levels of Klotho and FGF-23 are potential predictors of CV severity in patients with CKD. Furthermore, our results showed that age, history of CVD, and history of diabetes were independent predictors of CV severity in patients with CKD, and these predictors were positively correlated with CV severity. Furthermore, given that the development of cardiovascular disease (CVD) is closely linked to chronic inflammation, our study incorporated certain nonspecific inflammation-related factors, such as procalcitonin, C-reactive protein, SIRI, and ferritin, to explore the relationship between these factors and CVD severity.

https://link.springer.com/article/10.1007/s11255-025-04475-5 (2025)

Certain genes should also be considered. Klotho, a naturally occurring human protein, has great potential to delay these age-related diseases. Exercise is linked to the longevity gene Klotho. Membrane Klotho acts through (FGF)-23 and regulates nitric oxide produced in the endothelium. Inactivity accelerates aging and its consequences, and is suggested as one of the main reasons for the increase in disease and mortality. The circulating s-klotho response has been shown to depend on the level of aerobic fitness: s-Klotho values ​​were significantly higher in trained individuals compared to untrained individuals. The significant and positive associations between exercise-induced changes in s-Klotho and 1,25(OH)2 levels and those observed in memory outcomes suggest that these factors may be potentially related to exercise-induced memory improvements in middle-aged adults.

https://pdfs.semanticscholar.org/3499/02f79e6cef77bd5b6785cc392a5455438f0d.pdf (2015).---

https://www.ingentaconnect.com/contentone/ben/cas/2018/00000011/00000002/art00005 (2018).---

https://shapeamerica.tandfonline.com/doi/abs/10.1080/02640414.2019.1626048#.Xj2w92j0lRY (2019).----

https://www.nature.com/articles/s41598-022-22123-1 (2022).---

https://www.frontiersin.org/articles/10.3389/fresc.2021.807123/full (2022).—

https://www.cjmb.org/uploads/pdf/pdf_CJMB_591.pdf (2023).--

https://onlinelibrary.wiley.com/doi/full/10.1111/sms.14519 (2023)

Cognitive decline, kidney failure, diabetes, and cancer are believed to be associated with the body's production of the Klotho protein. Klotho deficiency exhibits an aging phenotype. Klotho has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been attributed to exercise and physical activity, helping to regenerate muscle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060456/ (2014).

https://www.nature.com/articles/tp201581 (2015).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176932/ (2015).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592833/ (2017).

https://www.mdpi.com/2227-9059/10/3/705 (2022) ---

https://www.mdpi.com/2076-3921/12/2/239 (2023).-

Klotho's mechanisms of action are multiple and complex, but the main ones include:

1. Natural antioxidant: Klotho inhibits the insulin receptor/IGF-1 pathway, decreasing the production of free radicals. This reduces the oxidative damage that harms cells over time.

2. Anti-inflammatory: It modulates factors such as NF-κB, reducing chronic low-grade inflammation, one of the main drivers of aging.

3. Vascular and renal protection: The protein helps maintain the elasticity of blood vessels and protects kidney function, two key factors in preventing cardiovascular disease.

These effects make it an ideal candidate for strategies that aim not only to live longer, but to live better.

Although there is still no approved oral Klotho supplement, researchers are exploring ways to activate it indirectly. You can adopt strategies that promote its natural expression: strength training, efficient sleep, maintaining optimal vitamin D levels, and controlling sugar intake are factors that have been indirectly linked to healthy levels of Klotho protein.

Science suggests that, in the not-too-distant future, we could see therapies based on this protein as part of protocols for men who want to maximize their longevity, not just adding years to their lives, but life to their years.

https://www.menshealth.com/es/nutricion-dietetica/a64684141/proteina-kioto-longevidad-vivir-mas-mejor/

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