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Dr. Mercola's Censored Library (Private Membership)

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Just steve's avatar
Just steve
Jan 17Edited

Excellent direction for research! * " Restoring your CKM health is not about treating multiple diseases. " - "it’s rediscovering how to live in alignment with how your biology was designed to generate energy and heal itself." * Our bodies want to be healthy, designed to be healthy - if allowed! Instead of we got a pill for that, and that, and also that. Instead we can pursue Health Building, Dis-Ease Preventing methods, starting with the dinner plate, proper portions of each needed food group coming from Healed Farms using healthy Farming practices.

I'm hungry, what is available today may be just fine for those in full loincloth in deep pristine places, but is a disaster in the 'civilized' throw away consumer world providing empty toxic calories with manipulated colors for the eyes, enhanced for mouth feel, exaggerated taste and aromas.

while also providing quick highs to be followed by lows so as to crave even more of the same. Designed not to build health or prevent Dis-Ease, but to encourage us to over consume, whether deliberate or not - Dis-Ease drivers.

No need for never ending specialist who know more and more about less and less, until they know all there is about next to nothing. The need is to Make Farming Healthy Again. Farm practices to revive healthy living soils to create healthy living foods while encouraging the ability to Farm allowing for people to make an honest living while they provide a critical need - foods that can truly be our medicine.

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Guillermou's avatar
Guillermou
Jan 17Edited

More than one-fifth of adults meet premorbid MetS criteria, and almost one-sixth have MetS with DM and/or ASCVD. In addition to the criteria defining MetS, other medical conditions show an independent association with MetS, highlighting EA for premorbid MetS and HTN, hypercholesterolaemia, HF, and other CKM factors for morbid MetS. Almost two-fifths of people with MetS are at moderate, high or very high risk of CKD, and four-fifths are at high or very high cardiovascular risk. Based on this, we believe that it is necessary to broaden the concept of MetS and conduct further studies on which are the independent risk factors for DM, CVDs, and CKD in order to define a comprehensive disorder such as CKM syndrome.

Cardiovascular-renal-metabolic syndrome (CKM) is characterized by the complex interplay of metabolic, cardiovascular, and renal disorders driven by interacting risk factors, such as obesity, insulin resistance (IR), dysglycemia, atherogenic/metabolic dyslipidemia, and hypertension. These factors and shared pathogenic mechanisms create a cycle of dysfunction in which the presence of one condition substantially increases the negative impact on the others. The relationships between the components of metabolic syndrome, atherosclerotic cardiovascular disease, and chronic kidney disease are causal and mutually influential.

Excess adipose tissue (visceral, dysfunctional) generates subclinical inflammation, decreased adiponectin, increased adipokines and leptin, insulin resistance, and oxidative stress, which, together with the activation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS), leads to endothelial dysfunction (decreased NO bioavailability, impaired relaxation) and maladaptive changes in the heart (diastolic dysfunction → decreased systolic function) and kidneys (hyperfiltration, Na+ retention, glomerular sclerosis, tubulointerstitial fibrosis, proteinuria, decreased GFR).

https://link.springer.com/chapter/10.1007/978-3-032-11445-7_5 (2025).--

https://www.mdpi.com/2227-9059/13/3/590 (2025).--

This chapter focuses on the evolution of cardiovascular-renal-metabolic syndrome from its two initial components (cardio-renal syndrome and cardio-metabolic syndrome) and describes how these conditions converged. Cardio-renal syndrome refers to the interplay between the heart and the kidneys where the dysfunction of one system leads to the dysfunction of the other. Based on the primary insult site (cardiac and renal) and the nature of the dysfunction (acute or chronic), it has been classified into five subtypes. Both reduced cardiac output and increased central venous perfusion are important pathophysiological mechanisms and treatment targets. Cardio-metabolic syndrome represents a chronic and progressive condition marked by interconnected metabolic abnormalities that collectively increase the risk of atherosclerotic cardiovascular disease and type 2 diabetes mellitus. It represents a distinct clinical entity with its own pathophysiology in which dysfunctional adipose tissue, insulin resistance, dyslipidemia, chronic inflammation, and prothrombotic factors play important roles. The interplay between these two entities was formally defined by the American Heart Association in 2023. It has been divided into four stages, ranging from healthy individuals in whom management should focus on prevention to symptomatic cardiovascular disease and kidney disease.

https://link.springer.com/chapter/10.1007/978-3-032-11445-7_2 (2025).--

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