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Guillermou's avatar
Guillermou
8d

We find great medicine with DMSO, if applied with due experience, against many pain-related diseases, including cancer. In contrast, corticosteroids, such as glucocorticoids (GCs), have immunosuppressive effects, and their long-term use is associated with a possible increased risk of cancer, especially for certain types such as lung and liver cancer. In multivariate Cox regression analysis, the risk of cancer among long-term GC users was 1.23 times higher than that of unexposed individuals. In competing risks analyses, the risk of liver cancer and lung cancer was 1.46 times and 1.52 times higher in long-term GC users than in unexposed individuals, respectively.

Prolonged glucocorticoid signaling inhibits wound healing, triggering a feedback loop with increased release of damage-associated molecular patterns (DAMPs), which increase inflammation and further promote tissue damage. Simultaneously, they suppress antitumor surveillance by CD8+ T lymphocytes. Similarly, they suppress antitumor immunity in the tumor microenvironment and promote the expression of immune checkpoint proteins. However, their effects are compounded by increased psychological stress, exogenous steroid treatment, and local steroidogenesis by tumor-infiltrating immune cells. Furthermore, they can directly promote tumor cell survival by suppressing apoptosis and promoting tumor cell growth. Glucocorticoids are also commonly coadministered with chemotherapy to reduce negative side effects such as nausea and edema and to improve appetite and energy. Similar to the negative effects of elevated endogenous glucocorticoids, corticosteroid treatment is associated with reduced antitumor immune responses, tumor treatment resistance, and increased metastasis. In North Jutland County, Denmark, we investigated whether the use of oral glucocorticoids was associated with an increased risk of developing basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), and non-Hodgkin lymphoma (NHL). From the Danish Cancer Registry, we identified 5,422 cases of BCC, 935 cases of SCC, 983 cases of MM, and 481 cases of NHL during 1989–2003.

The use of corticosteroids (CSs) is associated with numerous side effects affecting several systems. Metabolically, they can lead to hyperglycemia, hypertension, and weight gain. Endocrinologically, they increase the risk of Cushing's syndrome and can cause adrenal insufficiency. Gastrointestinally, CSs promote the development of gastritis and peptic ulcers and increase the risk of gastrointestinal bleeding, particularly when combined with nonsteroidal anti-inflammatory drugs (NSAIDs). Cardiovascularly, they elevate blood pressure and increase the risk of heart disease. The risk of hypertension increases approximately twofold in patients treated with CS, regardless of treatment duration. Furthermore, CS use has been reported to increase the risk of coronary artery disease, ischemic heart disease, heart failure, and even sudden death.

Elevated glucose and glutamine metabolism, altered vitamin D levels, and microbiome alterations are some of the key factors contributing to these long-term adverse outcomes of corticosteroids (CS). Approaches such as appropriate diet, fasting, and vitamin D supplementation have shown promise in providing benefits similar to CS while mitigating the risks associated with mechanisms identified as contributing to tumor progression. This perspective underscores the need to reevaluate the use of CS in oncology care and advocates for further research to find safer and more effective therapeutic strategies.

https://aacrjournals.org/cancerpreventionresearch/article-abstract/13/12/1017/47287/Long-Term-Glucocorticoid-Use-and-Cancer-Risk-A?redirectedFrom=fulltext (2020).—

https://www.nature.com/articles/6604796 (2008).-

https://pmc.ncbi.nlm.nih.gov/articles/PMC10151568/ (2023).—

https://pmc.ncbi.nlm.nih.gov/articles/PMC11979161/ (2025).--

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Just steve's avatar
Just steve
8dEdited

Yet despite the history of how Opioids were marketed, pushed though known to be addictive, made billions on misery and grief, but also just one more play with symptoms and give partial relief but generating other symptoms: An industry known to promote treatments for years if not decades only to be seen for what they were and then when it can no longer be ignored, Pharma fined huge fines. Huge fines, but seen is oh well, just the costs of doing business, let's rinse and repeat.

Despite this, lately after sharing DMSO information to see the person immediately pop out the 'Smart Phone' and Google it to see the Expert's, Officials, Authorities condemn GMSO as quackery. Blind trust in those who are eating our health, our lives, our birthrights.

Why do people hit themselves in the head? Maybe because when they stop, it feels so good, but only if they stop in time. Just Sayn'

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