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Magnesium threonate increases NMDA receptor signaling, BDNF expression, presynaptic puncta density, and synaptic plasticity in the prefrontal cortex.
Dr. Mercola reported that even raising blood magnesium levels by 300% (known as "induced hypermagnesemia") did not change cerebrospinal fluid levels by more than 19%.
In one study presented, baseline cognitive testing was performed, with the first follow-up tests performed six weeks later.
Then, for 12 weeks, study participants received a randomized daily dose of either placebos or 1,500 to 2,000 milligrams of MgT, based on their body weight. Cognitive tests were repeated at six-week and 12-week intervals in the areas of:
1) Executive Function----
2) Working Memory----
3) Attention----
4) Episodic Memory (ability to recall fleeting events)----
Significantly, the most "surprising" finding is not only that MgT improves performance on individual cognitive tests in older adults with cognitive decline, but that it also reverses brain aging for over nine years.
Studies also show how increasing magnesium concentrations in cultured brain cells from the hippocampus (where memories are stored and retrieved) increases both synaptic density and brain plasticity. The reasons why this is important are twofold:
1) Synaptic density is not only a measure of the structural integrity of brain synapses, but evidence suggests that higher synaptic density results in more efficient cognitive processing.
2) Plasticity is a measure of the speed at which synaptic connections can change with new stimuli; it is essentially learning at the cellular level.
https://www.sciencedirect.com/science/article/abs/pii/S1053811916300404 .----
https://pubmed.ncbi.nlm.nih.gov/22016520/.---
https://articulos.mercola.com/sitios/articulos/archivo/2019/05/27/beneficios-cognitivos-del-treonato-de-magnesio.aspx
Just a personal note, I am finding Magnesium and Zinc are two things if I don't keep up on causes problems. Very much like the Magnesium Threonate but after reflecting on this article am considering swapping out the nighttime Threonate for the Glycinate to help with muscle tightness affecting sleep at times.