★ Study Reveals This Vegetable Lowers Your Colon Cancer Risk by 17%
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Broccoli contains glucoraphine, sulforaphane, selenium, and isothiocyanates. It is high in vitamin C and dietary fiber. Indole-3-carbinol is also abundant in broccoli. These components found in broccoli possess a number of anticancer qualities and benefits, making them extremely popular. Broccoli is widely used to treat various types of cancer, as well as other neurological diseases. The phytochemical and medicinal potential of broccoli is currently being reviewed. The medicinal potential of broccoli has been discussed in relation to its use in treating cancer, diabetes, and other major diseases. Broccoli sprouts contain sulforaphane, which has the potential to treat neurological conditions such as Parkinson's and Alzheimer's diseases. It is a good source of health benefits, promoting compounds such as glucosinolates, flavonoids, hydroxycinnamic acid, and vitamins, according to a comprehensive literature review. Furthermore, broccoli is a nutrient with a wide range of beneficial effects, including antioxidant, anticancer, hepatoprotective, anti-obesity, and antidiabetic properties.
https://www.thepharmajournal.com/archives/2023/vol12issue6/PartH/12-5-545-230.pdf (2023).
Epidemiological evidence suggests that broccoli consumption is inversely associated with the risk of developing cancer in various sites, including the prostate, breast, stomach, and colon. The epidemiological links between broccoli consumption and cancer-preventive benefits in humans have been supported by small-scale laboratory and clinical studies. These protective effects have been largely attributed to isothiocyanates, including sulforaphane.
The primary mechanism of broccoli is believed to be the Nrf2-mediated induction of carcinogen-detoxifying/antioxidant enzymes that stimulate the neutralization/elimination of carcinogens and their reactive metabolites or enhance the physiological defense against oxidative DNA damage. Other mechanisms have been identified, and the list is expanding to cover almost all processes of carcinogenesis. In addition to its effects on signal transduction mediated by oncogenes or tumor suppressor genes, epigenetic regulation is also important in cancer chemoprevention with sulforaphane. It is interesting to note that sulforaphane induces epigenetic regulation of Nrf2 expression, presumably by promoting demethylation of the gene's promoter.
https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.61 (2021).----
https://www.mdpi.com/2072-6694/13/19/4796 (2021).---
https://www.sciencedirect.com/science/article/pii/S0753332223015184 (2023).----
https://link.springer.com/article/10.1007/s12032-023-02211-6 (2023).---
https://www.mdpi.com/1422-0067/24/8/6979 (2023).---