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Guillermou's avatar

Interesting report. Neurotropic B vitamins play crucial roles as coenzymes and more in the nervous system. In particular, vitamins B1, B6, and B12 contribute essentially to maintaining a healthy nervous system. Their importance is highlighted by many neurological diseases related to deficiencies in one or more of these vitamins, but they can improve certain neurological conditions even without a proven deficiency.

Evidence suggests that a significant proportion of the population suffers from deficiencies and insufficiencies of one or more of these neurotropic B vitamins. The importance of B vitamins in the context of nerve function is underscored by the numerous neurological diseases, depression, beriberi, seizures, subacute combined degeneration of the spinal cord, or peripheral neuropathy (PN), which are related to a deficiency of one or more of these neurotropic B vitamins. Table 1 provides an overview of the main implications of the overlap of important biochemical pathways for the nervous system, pointing to a synergistic effect as a logical consequence of these overlaps.

https://onlinelibrary.wiley.com/doi/full/10.1111/cns.13207 (2019)---

Vitamin B1 acts as an antioxidant, vitamin B6 balances nerve metabolism, and vitamin B12 maintains myelin sheaths. The presence of vitamins B1, B6, and B12 paves the way for the next important regeneration by supporting the development of new cell structures. Furthermore, vitamin B1 facilitates the use of carbohydrates for energy production, while vitamin B12 promotes the survival and remyelination of nerve cells. A deficiency in these vitamins will contribute to permanent nerve degeneration and pain, eventually leading to peripheral neuropathy.

https://www.hindawi.com/journals/bmri/2021/9968228/ (2021)

This research reported a significant relationship between dietary intake of vitamins B1, B2, B3, B9, and B complex and COVID-19. Higher intake of vitamin B5 could reduce the likelihood of COVID-19 by 47%, and moderate intake of vitamin B12 had a protective effect against COVID-19.

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/abs/association-between-b-vitamins-and-the-risk-of-covid19/ABB34ACDBF78F044643BC6417F844AB1 (2022).----

B12 deficiency is estimated to affect around 40% of people over 60 years of age, although more recent studies suggest that this figure may very well be as high as 70%, particularly in older people with cognitive impairment or chronic illnesses. Taking vitamin B12 along with vitamin C can reduce the amount of vitamin B12 available in the body. To avoid this interaction, take vitamin C two or more hours after taking the vitamin B12 supplement.

B12 deficiency is estimated to affect around 40% of people over 60 years of age, although more recent studies suggest that this figure may very well be as high as 70%, especially in older people with cognitive impairment or chronic illnesses. Taking vitamin B12 along with vitamin C can reduce the amount of vitamin B12 available in the body. To avoid this interaction, take vitamin C two or more hours after taking the vitamin B12 supplement.

https://www.mayoclinic.org/es-es/drugs-supplements-vitamin-b12/art-20363663 (2021).----

Vitamin B12 deficiency can cause: Alzheimer's disease, dementia, cognitive impairment and memory loss, multiple sclerosis and other neurological disorders, mental illness, cardiovascular disease, learning or developmental disorders in children, autism spectrum disorder, autoimmune disease and immune dysregulation, gut dysbiosis, fatty liver disease, and cancer. Among pregnant women, breastfeeding women, and young children, the effects of vitamin B12 deficiency can be particularly devastating.

https://link.springer.com/article/10.1186/s41936-020-00148-0 (2020).----

https://www.frontiersin.org/articles/10.3389/fnut.2020.00083/full (2020).---

https://www.mdpi.com/2227-9032/11/7/958 (2023) https://www.frontiersin.org/articles/10.3389/fnut.2023.1015046/full (2023).-----

https://joe.bioscientifica.com/view/journals/joe/256/2/JOE-22-0158.xml (2023)

Rob's avatar

Outstanding article, as usual from the Dr.

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