The Gut's Role in Parkinson's Disease

Parkinson's disease is a progressive neurological disorder.

STORY AT-A-GLANCE

• Intestinal hyperpermeability may trigger alpha-synuclein protein aggregation around enteric nerves, resulting in gastrointestinal symptoms long before the neurological symptoms of Parkinson’s disease appears

• Increased expression of alpha-synuclein proteins inhibits the release of neurotransmitters, but at normal levels the proteins accel…