Thank you so much for a tour de force of dementia, with such clarity and loaded with helpful, clear and concise information, and practical easy to use solutions. What I read in dozens of books, you have reduced to a few paragraphs.
Worldwide there are more than 50 million people living with Alzheimer's disease or other dementias. By 2050, rates could exceed 150 million. Controlling diabetes, high blood pressure, obesity, smoking, sedentary lifestyle, depression, cognitive inactivity, and social isolation and other environmental factors could potentially prevent the disease.
Modern diets, containing a high proportion of ultra-processed foods produce a high level of AGEs, cause deleterious effects leading to a multitude of intracellular and extracellular signaling and inflammatory pathways. The formation of advanced glycation products, by reaction of sugar molecules with proteins and other biomolecules, produces endothelial damage in the brain, which can result in cognitive impairment, strokes and neurodegenerative diseases such as Alzheimer's disease. The effects of hyperglycemia, including excessive glucose entry into cells independent of insulin, can induce oxidative stress and a secondary innate immunity-dependent inflammatory response, which can damage CNS cells, thereby promoting neurodegeneration and dementia. . Furthermore, long-term hyperglycemia can promote brain insulin resistance, which in turn can promote the accumulation of Aβ aggregates and tau hyperphosphorylation. This dysfunction is known as "type 3 diabetes."
Modifications in lifestyle, such as physical activity and caloric restriction, also in the entire process of digestion, absorption and metabolism by polyphenols, amino acids, carnosine, Benfotiamine and other new antiglycation agents such as carnosine. ….and always present curcumin, ubiquinol, PQQ, NAD +. Omega 3, Acetyl-L-Carnitine, R-lipoic, NAC, resveratrol, green tea, ginkgo Biloba, grape seed extract, B complex, vitamaa E, D and magnesium to prevent Alzheimer's.
Supplementation with the NAD+ precursor nicotinamide riboside improves cognitive function and restores brain plasticity and preserves cognitive health in a variety of disease contexts, with the strongest evidence presented for Alzheimer's disease and other forms of of dementia. The main findings are summarized in Table 1 of the last link.
Thank you so much for a tour de force of dementia, with such clarity and loaded with helpful, clear and concise information, and practical easy to use solutions. What I read in dozens of books, you have reduced to a few paragraphs.
Worldwide there are more than 50 million people living with Alzheimer's disease or other dementias. By 2050, rates could exceed 150 million. Controlling diabetes, high blood pressure, obesity, smoking, sedentary lifestyle, depression, cognitive inactivity, and social isolation and other environmental factors could potentially prevent the disease.
Modern diets, containing a high proportion of ultra-processed foods produce a high level of AGEs, cause deleterious effects leading to a multitude of intracellular and extracellular signaling and inflammatory pathways. The formation of advanced glycation products, by reaction of sugar molecules with proteins and other biomolecules, produces endothelial damage in the brain, which can result in cognitive impairment, strokes and neurodegenerative diseases such as Alzheimer's disease. The effects of hyperglycemia, including excessive glucose entry into cells independent of insulin, can induce oxidative stress and a secondary innate immunity-dependent inflammatory response, which can damage CNS cells, thereby promoting neurodegeneration and dementia. . Furthermore, long-term hyperglycemia can promote brain insulin resistance, which in turn can promote the accumulation of Aβ aggregates and tau hyperphosphorylation. This dysfunction is known as "type 3 diabetes."
http://europepmc.org/abstract/med/27350397 (2017).----
https://www.sciencedirect.com/science/article/pii/S0261561423002571 (2023),---
https://www.mdpi.com/1422-0067/24/12/10069 (2023).---
https://n.neurology.org/content/there-may-be-brain-origin-advanced-glycation-end-products-causing-accelerated-cognitive (2023).--
https://www.mdpi.com/2072-6643/15/2/405 (2023).---
https://www.mdpi.com/1422-0067/24/12/9881 (2023).---
https://www.mdpi.com/2073-4409/12/13/1684 (2023).--.
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.16286 (2024).--
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1348410/full (2024).--
Modifications in lifestyle, such as physical activity and caloric restriction, also in the entire process of digestion, absorption and metabolism by polyphenols, amino acids, carnosine, Benfotiamine and other new antiglycation agents such as carnosine. ….and always present curcumin, ubiquinol, PQQ, NAD +. Omega 3, Acetyl-L-Carnitine, R-lipoic, NAC, resveratrol, green tea, ginkgo Biloba, grape seed extract, B complex, vitamaa E, D and magnesium to prevent Alzheimer's.
https://www.mdpi.com/1422-0067/24/12/9881 (2023).---
https://www.sciencedirect.com/science/article/abs/pii/S0141813023027095?via%3Dihub (2023).---
https://www.mdpi.com/2076-3921/12/5/1008 (2023)
https://www.future-science.com/doi/abs/10.4155/fmc-2022-0040 (2023)
Supplementation with the NAD+ precursor nicotinamide riboside improves cognitive function and restores brain plasticity and preserves cognitive health in a variety of disease contexts, with the strongest evidence presented for Alzheimer's disease and other forms of of dementia. The main findings are summarized in Table 1 of the last link.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876637/ (2023)
https://www.mdpi.com/2072-6643/14/15/3231 (2023)
Some neuropathological characteristics of its development have been related to the high concentration of some metal cations such as aluminum and iron.
https://pubs.acs.org/doi/full/10.1021/acsomega.2c06939# (2023).---
https://www.tandfonline.com/doi/abs/10.1080/01480545.2022.2065291 (2023).--
https://link.springer.com/article/10.1007/s12011-023-03599-y (2023).---
Blood test can identify dementia risk 10 years before diagnosis, study says
BLOOD TEST CAN IDENTIFY DEMENTIA RISK 10 YEARS BEFORE DIAGNOSIS
https://www.theepochtimes.com/health/blood-test-can-identify-dementia-risk-10-years-before-diagnosis-study-5586497?utm_source=Health&src_src=Health&utm_campaign=health-2024-02-17&src_cmp= health-2024-02-17&utm_medium=email&est=AAAAAAAAAAAAAAAAAZvc5ZxIWyJCav5MJs2RQB%2Fp5xE4iNpMohY3crZKzXA1NC7ep (2024)