An interesting article: DONALD RUMSFELD AND THE STRANGE HISTORY OF ASPARTAME. “Donald Rumsfeld, the "knowns and unknowns" guy who remarkably executed some of the worst decisions in American foreign policy and got a medal for it…… Dr. John Olney, who founded the field of neuroscience called excitotoxicity, attempted to stop the approval of aspartame with Attorney James Turner back in 1996. The FDA's own toxicologist, Dr. Adrian Gross told Congress that without a shadow of a doubt, aspartame can cause brain tumors and brain cancer and that it violated the Delaney Amendment, which forbids putting anything in “food that is known to cause cancer….”
CHD remembers attorney James Turner, who died January 25 at age 81, who was a consumer advocate and champion in the fight against chemical sweeteners. Turner and Olney filed formal objections to the FDA and questioned the validity of some of the key safety evidence for aspartame that the manufacturer, Searle, had submitted to the FDA. Turner and Olney highlighted evidence that aspartame was causing brain damage, brain tumors, seizures, and changes in animal brain chemistry and therefore , may have the potential to affect pregnant women and young children.
This research employed network toxicology and molecular docking techniques to examine the potential carcinogenic effects and mechanisms of aspartame. Aspartame has the potential to affect several cancer-related proteins, increasing risks by interfering with biomolecular function. The patterns of action and pathways of action of aspartame-related agents are similar to the mechanisms of known carcinogenic pathways, further supporting the scientific hypothesis of their potential carcinogenicity.
A total of 32 studies were reviewed that demonstrated the effects of spartame on monoamine deficiencies, oxidative stress, and cognitive changes. Results: Multiple studies demonstrated decreased brain dopamine, decreased brain norepinephrine, increased oxidative stress, increased lipid peroxidation, and decreased memory function in rodents after esoarthame use.
This systematic review sheds light on how excessive consumption of artificially sweetened beverages can affect multiple organ systems, and associations have been made with mental health burden, delays in childhood neurodevelopment, cardiac remodeling, worsening of retinopathy in diabetics, incidental end-stage renal disease, non-Hodgkin lymphoma and multiple myeloma in men, rheumatoid arthritis in women, hip fractures, dental erosion, increases in breath alcohol concentration when used in alcoholic beverages, and cellular aging accelerated.
An interesting article: DONALD RUMSFELD AND THE STRANGE HISTORY OF ASPARTAME. “Donald Rumsfeld, the "knowns and unknowns" guy who remarkably executed some of the worst decisions in American foreign policy and got a medal for it…… Dr. John Olney, who founded the field of neuroscience called excitotoxicity, attempted to stop the approval of aspartame with Attorney James Turner back in 1996. The FDA's own toxicologist, Dr. Adrian Gross told Congress that without a shadow of a doubt, aspartame can cause brain tumors and brain cancer and that it violated the Delaney Amendment, which forbids putting anything in “food that is known to cause cancer….”
https://www.huffpost.com/entry/donald-rumsfeld-and-the-s_b_805581 .-----
CHD remembers attorney James Turner, who died January 25 at age 81, who was a consumer advocate and champion in the fight against chemical sweeteners. Turner and Olney filed formal objections to the FDA and questioned the validity of some of the key safety evidence for aspartame that the manufacturer, Searle, had submitted to the FDA. Turner and Olney highlighted evidence that aspartame was causing brain damage, brain tumors, seizures, and changes in animal brain chemistry and therefore , may have the potential to affect pregnant women and young children.
https://childrenshealthdefense.org/defender/chd-remembers-james-turner-food-safety-advocate/ (2022).-
This research employed network toxicology and molecular docking techniques to examine the potential carcinogenic effects and mechanisms of aspartame. Aspartame has the potential to affect several cancer-related proteins, increasing risks by interfering with biomolecular function. The patterns of action and pathways of action of aspartame-related agents are similar to the mechanisms of known carcinogenic pathways, further supporting the scientific hypothesis of their potential carcinogenicity.
https://www.nature.com/articles/s41598-024-62461-w (2024)
ASPARTAME-INDUCED COGNITIVE DYSFUNCTION: UNVEILING ROLE OF MICROGLIA-MEDIATED NEUROINFLAMMATION AND MOLECULAR REMEDIATION.—
https://www.sciencedirect.com/science/article/abs/pii/S1567576924008154 (2024).--
A total of 32 studies were reviewed that demonstrated the effects of spartame on monoamine deficiencies, oxidative stress, and cognitive changes. Results: Multiple studies demonstrated decreased brain dopamine, decreased brain norepinephrine, increased oxidative stress, increased lipid peroxidation, and decreased memory function in rodents after esoarthame use.
https://www.tandfonline.com/doi/abs/10.1080/1028415X.2023.2228561 (2024).--
This systematic review sheds light on how excessive consumption of artificially sweetened beverages can affect multiple organ systems, and associations have been made with mental health burden, delays in childhood neurodevelopment, cardiac remodeling, worsening of retinopathy in diabetics, incidental end-stage renal disease, non-Hodgkin lymphoma and multiple myeloma in men, rheumatoid arthritis in women, hip fractures, dental erosion, increases in breath alcohol concentration when used in alcoholic beverages, and cellular aging accelerated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891650/ (2023)
ASPARTAME INTAKE IMPAIRS MALE REPRODUCTIVE FUNCTION: ROLE OF MITOCHONDRIAL DYSFUNCTION
https://cdn.nutrition.org/article/S2475-2991(24)01209-5/fulltext (2024).--
ASPARTAME INTAKE DELAYED PUBERTY ONSET IN FEMALE OFFSPRING RATS AND GIRLS
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.202300270 (2024).--