A study found that one of the world's most common knee surgeries worked no better than placebo surgery for chronic meniscus tears and often led to worse long-term joint damage.
Yes, Jinc, 👍👌A comprehensive review of national and international research findings indicates that exercise therapy is the preferred treatment method for restoring knee joint function, followed by physiotherapy and other treatments. Age is a widely recognized risk factor for the development of knee osteoarthritis (OAR) among experts and academics. As people age, the risk of developing OAR also increases. This may be related to the greater vulnerability of knee joints in the elderly, such as decreased muscle strength, ligament laxity around the knee joint, and wear and tear of articular cartilage. Under the influence of these factors, the stability of the knee joint is reduced. Research by Chinese academic Wang indicates that approximately 48.7% of people aged 50 to 60 have OAR, the prevalence rate is 62.2% among people aged 60 to 70, and 63.1% among people over 70. Furthermore, the incidence of osteoarthritis of the knee (OAR) is higher in women than in men. Studies have shown that the radiographic prevalence of OAR in women is approximately 3.5 times higher than in men, and the prevalence of symptomatic OAR is 5.2 times higher in women than in men, with women being significantly more affected than men.<sup>12</sup> This may be related to hormonal fluctuations in women and the practice of squatting to urinate.
Traditional Chinese Medicine (TCM) offers a variety of treatment methods for osteoarthritis of the knee (OAR) and boasts numerous success stories. The main therapeutic approaches include acupuncture, tuina (Chinese therapeutic massage), needle therapy, and the use of Chinese herbal medicine.
Patients with osteoarthritis of the knee (OAR) may also utilize physiotherapy methods during the treatment process, which primarily include ultrasound therapy, pulsed electromagnetic field therapy, laser therapy, and whole-body vibration therapy, among others. https://www.sciencedirect.com/science/article/pii/S0972978X24004185 (2025)
Osteoarthritis (OA) is becoming one of the most common joint conditions due to increased life expectancy, representing a significant socioeconomic and public health problem. OA is characterized by inflammation and progressive destruction of articular cartilage, affecting any joint, although it is most common in the knee, hip, spine, and interphalangeal joints, causing pain, functional limitations, and a reduced quality of life.
Gelatin is probably the most common form of gelatin on the market, but no biological function for joint health has been described. However, it has excellent physical and mechanical properties, such as low solubility and ease of handling, mainly because it is composed of a mixture of peptides with different molecular weights. Therefore, gelatin is widely used in the manufacture of various food systems, such as capsules and films.
Hydrolyzed collagens are composed of amino acids and peptides of varying lengths (including dipeptides and tripeptides) that resist intracellular hydrolysis, preventing their degradation by peptidases and systemic hydrolytic enzymes. Thus, hydrolyzed collagen peptides have high bioavailability, allowing them to reach the bloodstream, accumulate in cartilage tissue, and induce the synthesis of extracellular matrix (ECM) in cartilage, stimulating chondrocytes.
The differences in the mechanisms of action described for native and hydrolyzed collagens could theoretically justify a possible combination of both types of collagen to explore their complementary effects.
Type II collagen (the main protein of articular cartilage) has been shown to be a potential source of autoantigens in osteoarthritis (OA). Consequently, oral tolerance to type II collagen could theoretically have a positive impact on controlling inflammation in OA. In fact, the efficacy of oral administration of low doses of native type II collagen has been demonstrated in animal models of osteoarthritis (OA), such as the monoiodoactetate-induced (MIA) rat model of OA. In this model, oral administration of native chicken type II collagen (1 to 10 mg/kg) reduced joint pain and decreased plasma concentrations of inflammatory cytokines (TNFα, IL-1β) and C2C levels.
Hydrolyzed collagen has been shown to contain biologically active peptides that can reach joint tissues and exert chondroprotective effects. Preclinical and clinical studies have demonstrated the safety and efficacy of ingredients containing native type II collagen or hydrolyzed collagen. However, available research suggests a clear link between the chemical composition/structure of collagen ingredients and their mechanism of action/efficacy.
Yes, Jinc, 👌bothshare virtually the same amino acid profile (rich in glycine, proline, and hydroxyproline), so they provide similar components as building blocks for the body. The main difference lies in ease of use and absorption rate: hydrolyzed collagen does not alter the texture of beverages and is absorbed more easily, while gelatin provides the gelling effect characteristic of traditional cooking.
Just plain DMSO?...or used with another topical so that the DMSO helps get it deeper into the joint for best efficacy? And if so, what would that other topical be? Thanks.
If you go to the “A Midwestern Doctor” substack (Guillermou posted the link) there are numerous articles on DMSO. Also, Robert Yoho has compiled all the articles into a book for easier referencing.
But to answer your question, yes, DMSO does help other compounds to penetrate through the skin. But actually DMSO on its own has wonderful curative powers. Also, Red Light Therapy (Photonic Health) as an additional therapy can be quite beneficial. My 13 year old dog had a ligament issue on her hind leg and the combo of DMSO and RLT had her back to normal in a month.
Hi, Thank you for your reply. I just had a few more questions, if you wouldn't mind answering. What brand & strength DMSO did you use for your doggie? Also, how exactly did you apply the DMSO to your dogs ligament?
And what type of device, & brand, red light therapy did you purchase & use for your doggie?
One of my senior cats has pretty bad arthritis, so I was hoping both those therapies might help her. I also give her a homeopathic for joint issues, Dasuquin for her joints, as well as another herbal medicinal neuro/joint supplement, and also CBD 2x's per day.
The dmsostore has a roll on that I used on our baby...me too. Very convenient.
HerbalMana has DMSO in a gel. Various blends.
dmso.store has an abundance of options. I'm using one in my eyes. Based in Canada.
For the RLT: https://photonichealth.com has multiple options. I got the small mat. These are also human approved. I use it too. The hand held light looks to be very practical.
I am not surprised to hear this. Let's avoid surgery.
Yes, Jinc, 👍👌A comprehensive review of national and international research findings indicates that exercise therapy is the preferred treatment method for restoring knee joint function, followed by physiotherapy and other treatments. Age is a widely recognized risk factor for the development of knee osteoarthritis (OAR) among experts and academics. As people age, the risk of developing OAR also increases. This may be related to the greater vulnerability of knee joints in the elderly, such as decreased muscle strength, ligament laxity around the knee joint, and wear and tear of articular cartilage. Under the influence of these factors, the stability of the knee joint is reduced. Research by Chinese academic Wang indicates that approximately 48.7% of people aged 50 to 60 have OAR, the prevalence rate is 62.2% among people aged 60 to 70, and 63.1% among people over 70. Furthermore, the incidence of osteoarthritis of the knee (OAR) is higher in women than in men. Studies have shown that the radiographic prevalence of OAR in women is approximately 3.5 times higher than in men, and the prevalence of symptomatic OAR is 5.2 times higher in women than in men, with women being significantly more affected than men.<sup>12</sup> This may be related to hormonal fluctuations in women and the practice of squatting to urinate.
Traditional Chinese Medicine (TCM) offers a variety of treatment methods for osteoarthritis of the knee (OAR) and boasts numerous success stories. The main therapeutic approaches include acupuncture, tuina (Chinese therapeutic massage), needle therapy, and the use of Chinese herbal medicine.
Patients with osteoarthritis of the knee (OAR) may also utilize physiotherapy methods during the treatment process, which primarily include ultrasound therapy, pulsed electromagnetic field therapy, laser therapy, and whole-body vibration therapy, among others. https://www.sciencedirect.com/science/article/pii/S0972978X24004185 (2025)
Osteoarthritis (OA) is becoming one of the most common joint conditions due to increased life expectancy, representing a significant socioeconomic and public health problem. OA is characterized by inflammation and progressive destruction of articular cartilage, affecting any joint, although it is most common in the knee, hip, spine, and interphalangeal joints, causing pain, functional limitations, and a reduced quality of life.
Gelatin is probably the most common form of gelatin on the market, but no biological function for joint health has been described. However, it has excellent physical and mechanical properties, such as low solubility and ease of handling, mainly because it is composed of a mixture of peptides with different molecular weights. Therefore, gelatin is widely used in the manufacture of various food systems, such as capsules and films.
Hydrolyzed collagens are composed of amino acids and peptides of varying lengths (including dipeptides and tripeptides) that resist intracellular hydrolysis, preventing their degradation by peptidases and systemic hydrolytic enzymes. Thus, hydrolyzed collagen peptides have high bioavailability, allowing them to reach the bloodstream, accumulate in cartilage tissue, and induce the synthesis of extracellular matrix (ECM) in cartilage, stimulating chondrocytes.
The differences in the mechanisms of action described for native and hydrolyzed collagens could theoretically justify a possible combination of both types of collagen to explore their complementary effects.
Type II collagen (the main protein of articular cartilage) has been shown to be a potential source of autoantigens in osteoarthritis (OA). Consequently, oral tolerance to type II collagen could theoretically have a positive impact on controlling inflammation in OA. In fact, the efficacy of oral administration of low doses of native type II collagen has been demonstrated in animal models of osteoarthritis (OA), such as the monoiodoactetate-induced (MIA) rat model of OA. In this model, oral administration of native chicken type II collagen (1 to 10 mg/kg) reduced joint pain and decreased plasma concentrations of inflammatory cytokines (TNFα, IL-1β) and C2C levels.
Hydrolyzed collagen has been shown to contain biologically active peptides that can reach joint tissues and exert chondroprotective effects. Preclinical and clinical studies have demonstrated the safety and efficacy of ingredients containing native type II collagen or hydrolyzed collagen. However, available research suggests a clear link between the chemical composition/structure of collagen ingredients and their mechanism of action/efficacy.
https://www.mdpi.com/2072-6643/15/6/1332 (2023).--
https://pubmed.ncbi.nlm.nih.gov/39212129/ (2025)
https://keele-repository.worktribe.com/output/1230539 (2025)
https://www.tandfonline.com/doi/full/10.1080/09581596.2025.2588891 (2026)
https://assets.cureus.com/uploads/review_article/pdf/485824/20260621-42594-h9o4oy.pdf (2026)
"Collagen" is probably the most common form of gelatin on the market, right Gui?
Yes, Jinc, 👌bothshare virtually the same amino acid profile (rich in glycine, proline, and hydroxyproline), so they provide similar components as building blocks for the body. The main difference lies in ease of use and absorption rate: hydrolyzed collagen does not alter the texture of beverages and is absorbed more easily, while gelatin provides the gelling effect characteristic of traditional cooking.
DMSO to the rescue.
https://www.midwesterndoctor.com/p/dmso-is-a-miraculous-therapy-for
Just plain DMSO?...or used with another topical so that the DMSO helps get it deeper into the joint for best efficacy? And if so, what would that other topical be? Thanks.
If you go to the “A Midwestern Doctor” substack (Guillermou posted the link) there are numerous articles on DMSO. Also, Robert Yoho has compiled all the articles into a book for easier referencing.
But to answer your question, yes, DMSO does help other compounds to penetrate through the skin. But actually DMSO on its own has wonderful curative powers. Also, Red Light Therapy (Photonic Health) as an additional therapy can be quite beneficial. My 13 year old dog had a ligament issue on her hind leg and the combo of DMSO and RLT had her back to normal in a month.
Hope this helps
Hi, Thank you for your reply. I just had a few more questions, if you wouldn't mind answering. What brand & strength DMSO did you use for your doggie? Also, how exactly did you apply the DMSO to your dogs ligament?
And what type of device, & brand, red light therapy did you purchase & use for your doggie?
One of my senior cats has pretty bad arthritis, so I was hoping both those therapies might help her. I also give her a homeopathic for joint issues, Dasuquin for her joints, as well as another herbal medicinal neuro/joint supplement, and also CBD 2x's per day.
Thanking you in advance for your reply. 😀
Sorry for the late reply. There are 4 reliable sources for DMSO. I have not used Jacob but they have a very strong background in the use of DMSO.
https://dmsostore.com
https://jacoblab.com/?v=0b3b97fa6688
https://dmso.store/all-products/
https://herbalmana.com
The dmsostore has a roll on that I used on our baby...me too. Very convenient.
HerbalMana has DMSO in a gel. Various blends.
dmso.store has an abundance of options. I'm using one in my eyes. Based in Canada.
For the RLT: https://photonichealth.com has multiple options. I got the small mat. These are also human approved. I use it too. The hand held light looks to be very practical.
Have fun shopping.