★ Could This Be the Most Undiagnosed Condition in America?
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Could This Be the Most Undiagnosed Condition in America?
It doesn't show up in your labs. It doesn't hurt. But the damage builds until energy crashes, fat piles up, and your health breaks down - often without a single warning sign.
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Where would we start? As whispers how thousands of chemicals are allowed not just in our foods, but we are surrounded in a toxic sea. How do our livers stand a chance? Tylenol long promoted as a safe pain killer because it is light on the stomach, less apt to cause ulcers, can severely damage the liver in quick and short order. Interacts with other chem's, and is easy for people to overdose as it is often added to many over the counter meds and easy to miss when taking more than one med. How much is going on when there is so much not just in our foods, but across the environment, so many have a long shelf life, don't break down.
Choline is an essential nutrient that plays a role in membrane phospholipid synthesis, critical for cellular functions, and is the primary source of methyl donors relevant for epigenetic modifications of the genome. It is also the precursor of the neurotransmitter acetylcholine.
Choline is present in a wide range of biological systems, the dysregulation of which is associated with various disorders, including metabolic syndrome, non-alcoholic fatty liver disease, obesity, microbial dysbiosis, celiac disease, neurological disease, and inflammatory muscle diseases, as well as chronic cardiovascular and renal diseases, among others. Genetic predispositions and gender may influence individual variation in choline requirements and, therefore, susceptibility to choline deficiency-induced fatty liver disease. Choline is a precursor for the synthesis of phospholipids, such as phosphatidylcholine and sphingomyelin, and a precursor for the synthesis of the neurotransmitter acetylcholine. Betaine is an osmolyte in addition to its function as a methyl group donor. Homocysteine is converted to methionine by acquiring a methyl group. Folate can donate a methyl group to homocysteine; alternatively, choline is converted to betaine, which can donate a methyl group to homocysteine. Extensive epidemiological research has identified low folate intake as a risk factor for neural tube defects, cardiovascular disease, and several cancers. Higher choline intake is associated with a lower risk of neural tube defects independent of folate intake. Maternal Choline Supplementation During Pregnancy to Promote Mental Health in Offspring
Elevated plasma total homocysteine (tHcy) concentrations are a risk factor for cardiovascular disease, dementia, Alzheimer's disease, some cancers, and mortality. Many studies have found that intakes of folic acid and vitamins B-6 and B-12, nutrients involved in methyl group metabolism, predict tHcy concentrations. Choline and betaine intakes also predict tHcy concentrations.
Furthermore, choline exhibits protective effects against cardiovascular disorders, including arrhythmias, cardiac hypertrophy, and ischemia/reperfusion (I/R)-induced vascular injury by inhibiting the ROS-mediated calmodulin-/Ca 2+ -dependent protein kinase II pathway. Citicoline acts as a myocardial protector against I/R injury by inhibiting mitochondrial permeability transition. Choline has also been shown to improve cardiovascular damage by slowing the progression of hypertension and improving heart function.
https://lpi.oregonstate.edu/mic/other-nutrients/choline .----
https://europepmc.org/article/PMC/2430728 (2016).----
https://scholar.google.es/scholar?as_ylo=2022&q=Choline+benefits&hl=es&as_sdt=0,5 (2022).---
https://www.mdpi.com/2072-6643/14/2/364 (2022).----
https://www.frontiersin.org/articles/10.3389/fnut.2023.1179807/full (2023.---)
https://onlinelibrary.wiley.com/doi/abs/10.1111/eip.13426 (2023).---
https://www.frontiersin.org/articles/10.3389/fendo.2023.1148166/full (2023).----
https://www.mdpi.com/2072-6643/15/13/2900 (2023).---