Me too, but since 2000. Never di much but have avottle of 12 year old scotch havn't touched over 40 years. I just have to work on adding choline supplements in addition to free range chcken eggs and more exercise, I have type 2 diabetes since 2000. This article really got me thinking. Would like to make it to 94, 10 years to go!
Foods and nutrients influence the microbiome in different ways. For example, a Western diet high in processed fats and sugars reduces microbial diversity, produces dysbiosis, and impairs cognition by triggering chronic low-grade inflammation. Diet interacts with the host's genetics and microbiota, with physiological consequences that can protect or harm the brain. Interindividual variations in absorption, metabolism, and excretion that reflect differences in lifestyle, genetics, microbiome, and demographics will influence how the system responds to different nutrient combinations.
The additive effects of the combination of DHA, uridine, choline, folate, vitamin B12, vitamin B6, vitamin E, vitamin C, and selenium promote synaptogenesis to counteract the synaptic loss that occurs in cognitive decline and AD. These ingredients may act through several synergistic mechanisms, including, but not limited to, providing precursors for the Kennedy cycle, reducing homocysteine levels, and increasing cerebral blood flow and perfusion.
Uridine monophosphate (5'-uridylic acid or UMP) is a nootropic recommended by neurologists. Various studies have shown it to boost mood, cognitive function, learning, and memory. Uridine monophosphate:
1) Supports RNA construction and is therefore responsible for protein synthesis in the body
2) Increases brain neurotransmitter levels
3) Reduces stress
4) Increases learning ability and memory
This pyrimidine nucleoside can be found in various foods we consume in our diet. In supplementation, the phosphate group increases its bioavailability and helps it cross the blood-brain barrier. It functions as a precursor for brain synapses and phospholipids in nerve cell membranes, improving cholinergic functions and, finally, supporting the liver and mitochondria.
The main foods where it is found are:
1) Sugarcane extract
2) Vegetables, such as broccoli or tomatoes
3) Liver
4) Beer (preferably non-alcoholic)
5) Breast milk
6) Barley
It has been proven that uridine supplementation increases choline levels in the brain. Choline is necessary for the production of alpha-tidylcholine (AP), a precursor to acetylcholine, the essential neurotransmitter in the brain.
As a nootropic, the body absorbs it in the gastrointestinal tract and liver. In the brain, its active properties include acting as an important building block, enhancing the growth of neurites (neuronal projections that facilitate connections with other neurons), and improving various aspects of cognition. It also plays an important role in carbohydrate metabolism and cell rejuvenation, and promotes synapse formation. The brain controls and coordinates virtually the entire human body. Thoughts, actions, memory, feelings, and movements depend on what can be classified as the most critical organ in the human body, and what also differentiates it from other living beings.
Uridine monophosphate is beneficial for brain plasticity because it promotes or assists the formation of synapses. It activates P2Y2 receptors, which aid in neuronal development, regeneration, and synaptic protein synthesis. Uridine monophosphate stimulates neurite outgrowth, giving them a unique role in the integration of neuronal and glial cellular circuits.
Memory depends primarily on brain plasticity, which is associated with the ability to convert experiences into memories. The addition of UMP enhances memory, specifically verbal and logical memory.
Choline is an essential nutrient that plays a role in membrane phospholipid synthesis, critical for cellular functions, and is the primary source of methyl donors relevant for epigenetic modifications of the genome. It is also the precursor of the neurotransmitter acetylcholine.
Choline is present in a wide range of biological systems, the dysregulation of which is associated with various disorders, including metabolic syndrome, non-alcoholic fatty liver disease, obesity, microbial dysbiosis, celiac disease, neurological disease, and inflammatory muscle diseases, as well as chronic cardiovascular and renal diseases, among others. Genetic predispositions and gender may influence individual variation in choline requirements and, therefore, susceptibility to choline deficiency-induced fatty liver disease. Choline is a precursor for the synthesis of phospholipids, such as phosphatidylcholine and sphingomyelin, and a precursor for the synthesis of the neurotransmitter acetylcholine. Betaine is an osmolyte in addition to its function as a methyl group donor. Homocysteine is converted to methionine by acquiring a methyl group. Folate can donate a methyl group to homocysteine; alternatively, choline is converted to betaine, which can donate a methyl group to homocysteine. Extensive epidemiological research has identified low folate intake as a risk factor for neural tube defects, cardiovascular disease, and several cancers. Higher choline intake is associated with a lower risk of neural tube defects independent of folate intake. Maternal Choline Supplementation During Pregnancy to Promote Mental Health in Offspring
Elevated plasma total homocysteine (tHcy) concentrations are a risk factor for cardiovascular disease, dementia, Alzheimer's disease, some cancers, and mortality. Many studies have found that intakes of folic acid and vitamins B-6 and B-12, nutrients involved in methyl group metabolism, predict tHcy concentrations. Choline and betaine intakes also predict tHcy concentrations.
Furthermore, choline exhibits protective effects against cardiovascular disorders, including arrhythmias, cardiac hypertrophy, and ischemia/reperfusion (I/R)-induced vascular injury by inhibiting the ROS-mediated calmodulin-/Ca 2+ -dependent protein kinase II pathway. Citicoline acts as a myocardial protector against I/R injury by inhibiting mitochondrial permeability transition. Choline has also been shown to improve cardiovascular damage by slowing the progression of hypertension and improving heart function.
Where would we start? As whispers how thousands of chemicals are allowed not just in our foods, but we are surrounded in a toxic sea. How do our livers stand a chance? Tylenol long promoted as a safe pain killer because it is light on the stomach, less apt to cause ulcers, can severely damage the liver in quick and short order. Interacts with other chem's, and is easy for people to overdose as it is often added to many over the counter meds and easy to miss when taking more than one med. How much is going on when there is so much not just in our foods, but across the environment, so many have a long shelf life, don't break down.
You've hit the bull's-eye. Nearly 99 percent of food chemicals introduced since 2000 have been greenlit for use by food and chemical companies instead of being properly reviewed by the Food and Drug Administration. Many of these widely used chemicals are associated with significant health risks, including an increased risk of cancer, developmental harm, and hormonal disruption.
These chemicals end up in what we eat, thanks to a legal loophole that allows foods to be classified as "generally recognized as safe." Food and chemical companies have exploited this loophole for decades: instead of the FDA determining which food chemicals are safe to consume, manufacturers decide.
We start with Doc's article and begin doing what we can to counter the effects of junk foods, toxic pollution in our environment! Problem is, can I undo harm done over the years before I saw this? We just have to do our best, help educate others to help themselves. Try to counter the effects of all being shoved down us. Wish I had known this in 2000, would be in better shape now. I did stop Tylenol, and by association, stopped other over the counter drugs along with big pharma drugs.
Choline was in the news as containing heavy metals. Please advise. Husband has cirrhosis caused by medications, epidurals, cortisone…. Etc. labs came back normal so he thinks he’s healed. Am worried this is false info, he has a bad diet.
Many are in the same boat, having believed the FDA/big pharma's lies. Only hope is convincing ourselves, loved ones that they lied to us. Help him change his diet by only cooking clean, healthy foods like organic, sugar free. That freed me of terminal lymphoma (3 months to live) in 2000. If he can't/won't make the decision himself, do it for him. When his health starts to improve, maybe he can then see for himself. Also, prayer doesn't hurt!
Who knew!?! Thank you for sharing this information with us! Looking forward to hearing more about this topic.
I’m very happy I have been alcohol-free for over a year
Me too, but since 2000. Never di much but have avottle of 12 year old scotch havn't touched over 40 years. I just have to work on adding choline supplements in addition to free range chcken eggs and more exercise, I have type 2 diabetes since 2000. This article really got me thinking. Would like to make it to 94, 10 years to go!
Foods and nutrients influence the microbiome in different ways. For example, a Western diet high in processed fats and sugars reduces microbial diversity, produces dysbiosis, and impairs cognition by triggering chronic low-grade inflammation. Diet interacts with the host's genetics and microbiota, with physiological consequences that can protect or harm the brain. Interindividual variations in absorption, metabolism, and excretion that reflect differences in lifestyle, genetics, microbiome, and demographics will influence how the system responds to different nutrient combinations.
The additive effects of the combination of DHA, uridine, choline, folate, vitamin B12, vitamin B6, vitamin E, vitamin C, and selenium promote synaptogenesis to counteract the synaptic loss that occurs in cognitive decline and AD. These ingredients may act through several synergistic mechanisms, including, but not limited to, providing precursors for the Kennedy cycle, reducing homocysteine levels, and increasing cerebral blood flow and perfusion.
Uridine and choline act synergistically with DHA to increase phosphatidylcholine formation; there is a compelling rationale for combining these nutrients. A multinutrient enriched with uridine, choline, and DHA developed to support brain function has been evaluated in randomized controlled trials covering a spectrum of dementia from mild cognitive impairment to moderate AD. https://www.cambridge.org/core/journals/nutrition-research-reviews/article/multinutrient-interventions-and-cognitive-ageing-are-we-barking-up-the-right-tree/EB20249CDC8BE6308A54DCB490ED7D64 (2022)
https://link.springer.com/article/10.1007/s40120-020-00227-y (2020)
Uridine monophosphate (5'-uridylic acid or UMP) is a nootropic recommended by neurologists. Various studies have shown it to boost mood, cognitive function, learning, and memory. Uridine monophosphate:
1) Supports RNA construction and is therefore responsible for protein synthesis in the body
2) Increases brain neurotransmitter levels
3) Reduces stress
4) Increases learning ability and memory
This pyrimidine nucleoside can be found in various foods we consume in our diet. In supplementation, the phosphate group increases its bioavailability and helps it cross the blood-brain barrier. It functions as a precursor for brain synapses and phospholipids in nerve cell membranes, improving cholinergic functions and, finally, supporting the liver and mitochondria.
The main foods where it is found are:
1) Sugarcane extract
2) Vegetables, such as broccoli or tomatoes
3) Liver
4) Beer (preferably non-alcoholic)
5) Breast milk
6) Barley
It has been proven that uridine supplementation increases choline levels in the brain. Choline is necessary for the production of alpha-tidylcholine (AP), a precursor to acetylcholine, the essential neurotransmitter in the brain.
As a nootropic, the body absorbs it in the gastrointestinal tract and liver. In the brain, its active properties include acting as an important building block, enhancing the growth of neurites (neuronal projections that facilitate connections with other neurons), and improving various aspects of cognition. It also plays an important role in carbohydrate metabolism and cell rejuvenation, and promotes synapse formation. The brain controls and coordinates virtually the entire human body. Thoughts, actions, memory, feelings, and movements depend on what can be classified as the most critical organ in the human body, and what also differentiates it from other living beings.
Uridine monophosphate is beneficial for brain plasticity because it promotes or assists the formation of synapses. It activates P2Y2 receptors, which aid in neuronal development, regeneration, and synaptic protein synthesis. Uridine monophosphate stimulates neurite outgrowth, giving them a unique role in the integration of neuronal and glial cellular circuits.
Memory depends primarily on brain plasticity, which is associated with the ability to convert experiences into memories. The addition of UMP enhances memory, specifically verbal and logical memory.
https://nootropicsexpert.com/uridine-monophosphate/ (2022).----
https://focussupplements.co.uk/es/2021/11/12/supplements-to-maximise-brain-health/ (2021).----
https://www.institutovalencianodeozonoterapia.com/papel-de-los-nucleotidos-en-la-recuperacion-de-la-neuropatia-periferica/ (2022).---
https://web.mit.edu/dick/www/pdf/1010.pdf (2022).---
Thank you, as always, you added more tools to help my health!
Choline is an essential nutrient that plays a role in membrane phospholipid synthesis, critical for cellular functions, and is the primary source of methyl donors relevant for epigenetic modifications of the genome. It is also the precursor of the neurotransmitter acetylcholine.
Choline is present in a wide range of biological systems, the dysregulation of which is associated with various disorders, including metabolic syndrome, non-alcoholic fatty liver disease, obesity, microbial dysbiosis, celiac disease, neurological disease, and inflammatory muscle diseases, as well as chronic cardiovascular and renal diseases, among others. Genetic predispositions and gender may influence individual variation in choline requirements and, therefore, susceptibility to choline deficiency-induced fatty liver disease. Choline is a precursor for the synthesis of phospholipids, such as phosphatidylcholine and sphingomyelin, and a precursor for the synthesis of the neurotransmitter acetylcholine. Betaine is an osmolyte in addition to its function as a methyl group donor. Homocysteine is converted to methionine by acquiring a methyl group. Folate can donate a methyl group to homocysteine; alternatively, choline is converted to betaine, which can donate a methyl group to homocysteine. Extensive epidemiological research has identified low folate intake as a risk factor for neural tube defects, cardiovascular disease, and several cancers. Higher choline intake is associated with a lower risk of neural tube defects independent of folate intake. Maternal Choline Supplementation During Pregnancy to Promote Mental Health in Offspring
Elevated plasma total homocysteine (tHcy) concentrations are a risk factor for cardiovascular disease, dementia, Alzheimer's disease, some cancers, and mortality. Many studies have found that intakes of folic acid and vitamins B-6 and B-12, nutrients involved in methyl group metabolism, predict tHcy concentrations. Choline and betaine intakes also predict tHcy concentrations.
Furthermore, choline exhibits protective effects against cardiovascular disorders, including arrhythmias, cardiac hypertrophy, and ischemia/reperfusion (I/R)-induced vascular injury by inhibiting the ROS-mediated calmodulin-/Ca 2+ -dependent protein kinase II pathway. Citicoline acts as a myocardial protector against I/R injury by inhibiting mitochondrial permeability transition. Choline has also been shown to improve cardiovascular damage by slowing the progression of hypertension and improving heart function.
https://lpi.oregonstate.edu/mic/other-nutrients/choline .----
https://europepmc.org/article/PMC/2430728 (2016).----
https://scholar.google.es/scholar?as_ylo=2022&q=Choline+benefits&hl=es&as_sdt=0,5 (2022).---
https://www.mdpi.com/2072-6643/14/2/364 (2022).----
https://www.frontiersin.org/articles/10.3389/fnut.2023.1179807/full (2023.---)
https://onlinelibrary.wiley.com/doi/abs/10.1111/eip.13426 (2023).---
https://www.frontiersin.org/articles/10.3389/fendo.2023.1148166/full (2023).----
https://www.mdpi.com/2072-6643/15/13/2900 (2023).---
Where would we start? As whispers how thousands of chemicals are allowed not just in our foods, but we are surrounded in a toxic sea. How do our livers stand a chance? Tylenol long promoted as a safe pain killer because it is light on the stomach, less apt to cause ulcers, can severely damage the liver in quick and short order. Interacts with other chem's, and is easy for people to overdose as it is often added to many over the counter meds and easy to miss when taking more than one med. How much is going on when there is so much not just in our foods, but across the environment, so many have a long shelf life, don't break down.
You've hit the bull's-eye. Nearly 99 percent of food chemicals introduced since 2000 have been greenlit for use by food and chemical companies instead of being properly reviewed by the Food and Drug Administration. Many of these widely used chemicals are associated with significant health risks, including an increased risk of cancer, developmental harm, and hormonal disruption.
These chemicals end up in what we eat, thanks to a legal loophole that allows foods to be classified as "generally recognized as safe." Food and chemical companies have exploited this loophole for decades: instead of the FDA determining which food chemicals are safe to consume, manufacturers decide.
Some of the worst offenders on the market, EWG's Dirty Dozen Guide to Food Chemicals shows you which chemicals in food to avoid at https://www.ewg.org/consumer-guides/ewgs-dirty-dozen-guide-food-chemicals-top-12-avoid.
We start with Doc's article and begin doing what we can to counter the effects of junk foods, toxic pollution in our environment! Problem is, can I undo harm done over the years before I saw this? We just have to do our best, help educate others to help themselves. Try to counter the effects of all being shoved down us. Wish I had known this in 2000, would be in better shape now. I did stop Tylenol, and by association, stopped other over the counter drugs along with big pharma drugs.
Choline was in the news as containing heavy metals. Please advise. Husband has cirrhosis caused by medications, epidurals, cortisone…. Etc. labs came back normal so he thinks he’s healed. Am worried this is false info, he has a bad diet.
Many are in the same boat, having believed the FDA/big pharma's lies. Only hope is convincing ourselves, loved ones that they lied to us. Help him change his diet by only cooking clean, healthy foods like organic, sugar free. That freed me of terminal lymphoma (3 months to live) in 2000. If he can't/won't make the decision himself, do it for him. When his health starts to improve, maybe he can then see for himself. Also, prayer doesn't hurt!