Great research on the benefits of CO2. We need to increase CO2 to reduce lactate and promote mitochondrial function. The presence of lactic acid in our tissues is very significant because it is a cause of biological diseases. Its presence manifests itself in arthritis, heart disease, diabetes, neurological diseases and cancer. Lactate increases blood viscosity, mimics stress and causes inflammation. Lactate contributes to diabetes by inhibiting the ability to oxidize glucose. It promotes the migration of endothelial cells, with an increase in vascular permeability factor (VPF or vascular endothelial growth factor, VEGF) and can lead to the breakdown of the "blood-brain barrier". If there is too much lactate, glycolytic ATP production slows down. The cell with defective respiration will die. The ability of lactic acid to displace carbon dioxide. in its effects on the blood coagulation system. Lactate contributes to intravascular coagulation and increases the tendency of red blood cells to clump together, forming a "blood sludge," and makes red blood cells more rigid, increasing blood viscosity and impairing circulation in small vessels. .
Factors that reduce stress hormones increase carbon dioxide and help reduce circulating free fatty acids, lactate and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), fruit (to reduce cortisol, adrenaline and free fatty acids), salt (to reduce adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis. Dietary protein should not provide excess tryptophan, due to tryptophan's role as a serotonin precursor that increases inflammation and glycolysis.
The brain has a high rate of metabolism and governs the metabolism of other tissues, including their consumption of oxygen and production of carbon dioxide or lactic acid. Within a particular species, the rate of oxygen consumption increases. in proportion to brain size, rather than body weight. Among very different species, the role of the brain in metabolism is even more obvious, since the resting metabolic rate corresponds to the size of the brain.
Strenuous exercise combined with fasting not only directly triggers lactate and ammonia production and endotoxin absorption.
With the increase in lactate and nitric oxide, mitochondrial respiration is weakened, precipitating the secretion of adaptive stress hormones. Prolonged stress also decreases carbon dioxide and increases lactate, while increasing fat utilization.
Methionine restriction has many protective effects, including increasing average (42%) and maximum (44%) longevity. The age-accelerating effect of methionine could be related to the alteration of methylation balance, inappropriately suppressing cellular activity. In addition to its effect on methyl stores, methionine inhibits thyroid function and damages mitochondria.
There are several specific signals produced by lactate that can promote growth. and other characteristics of cancer, and it happens that aspirin antagonizes those: HIF, NF-kappaB, the kinase cascades, cyclin D1 and heme oxygenase.
Great research on the benefits of CO2. We need to increase CO2 to reduce lactate and promote mitochondrial function. The presence of lactic acid in our tissues is very significant because it is a cause of biological diseases. Its presence manifests itself in arthritis, heart disease, diabetes, neurological diseases and cancer. Lactate increases blood viscosity, mimics stress and causes inflammation. Lactate contributes to diabetes by inhibiting the ability to oxidize glucose. It promotes the migration of endothelial cells, with an increase in vascular permeability factor (VPF or vascular endothelial growth factor, VEGF) and can lead to the breakdown of the "blood-brain barrier". If there is too much lactate, glycolytic ATP production slows down. The cell with defective respiration will die. The ability of lactic acid to displace carbon dioxide. in its effects on the blood coagulation system. Lactate contributes to intravascular coagulation and increases the tendency of red blood cells to clump together, forming a "blood sludge," and makes red blood cells more rigid, increasing blood viscosity and impairing circulation in small vessels. .
Factors that reduce stress hormones increase carbon dioxide and help reduce circulating free fatty acids, lactate and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), fruit (to reduce cortisol, adrenaline and free fatty acids), salt (to reduce adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis. Dietary protein should not provide excess tryptophan, due to tryptophan's role as a serotonin precursor that increases inflammation and glycolysis.
The brain has a high rate of metabolism and governs the metabolism of other tissues, including their consumption of oxygen and production of carbon dioxide or lactic acid. Within a particular species, the rate of oxygen consumption increases. in proportion to brain size, rather than body weight. Among very different species, the role of the brain in metabolism is even more obvious, since the resting metabolic rate corresponds to the size of the brain.
Strenuous exercise combined with fasting not only directly triggers lactate and ammonia production and endotoxin absorption.
With the increase in lactate and nitric oxide, mitochondrial respiration is weakened, precipitating the secretion of adaptive stress hormones. Prolonged stress also decreases carbon dioxide and increases lactate, while increasing fat utilization.
Methionine restriction has many protective effects, including increasing average (42%) and maximum (44%) longevity. The age-accelerating effect of methionine could be related to the alteration of methylation balance, inappropriately suppressing cellular activity. In addition to its effect on methyl stores, methionine inhibits thyroid function and damages mitochondria.
There are several specific signals produced by lactate that can promote growth. and other characteristics of cancer, and it happens that aspirin antagonizes those: HIF, NF-kappaB, the kinase cascades, cyclin D1 and heme oxygenase.
https://raypeat.com/articles/articles/lactate.shtml .------
https://raypeat.com/articles/aging/tryptophan-serotonin-aging.shtml .----
https://raypeat.com/articles/articles/co2.shtml,....
https://raypeat.com/articles/articles/protective-co2-aging.shtml .----
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001920RR (2021).---
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16058 (2021).---
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207018/ (2022).---
https://www.sciencedirect.com/science/article/abs/pii/S1535610823000090 (2023).--