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Nitric oxide and betalain are an excellent combination for those suffering from metabolic diseases, hypertension, cardio-cerebrovascular, neurodegenerative, immunological and infectious diseases that are associated with the severity of COVID-19.

Nitric oxide is produced from plant nitrates, rich in polyphenols. Argenine inside the cell, through the action of a cytoplasmic enzyme nitric oxide synthase, gives rise to nitric oxide and another molecule, L-citrulline. High intensity exercise, massage, meditation, probiotics, osteoatic manipulation, intense cold produce NO.

https://www.trainingcor.com/massage-range-of-motion-foam-rolls/

https://www.spandidos-publications.com/ijmm/14/3/443

https://articles.mercola.com/sites/articles/archive/2017/07/17/heart-healthy-foods.aspx

Nitric oxide (NO) production in the body can be increased with foods or supplements containing D3, arginine, citrulline, nitrates, vitamin E and C, Q10, pycnogenol, ginseng, quercetin, capsaicin, grape seed extract, exercise and sun.

https://www.anabolicmen.com/boost-nitric-oxide-naturally/ (Many links to studies):

https://www.ncbi.nlm.nih.gov/pubmed/22088605 .---

https://www.ncbi.nlm.nih.gov/pubmed/22745005 .---

https://www.ncbi.nlm.nih.gov/pubmed/18037769. .---

https://www.ncbi.nlm.nih.gov/pubmed/9809945 .---

https://www.ncbi.nlm.nih.gov/pubmed/22240497 .---

https://www.ncbi.nlm.nih.gov/pubmed/18473744 .---

https://www.anabolicmen.com/garlic-and-vitamin-c/ .---

25 Nitrate Rich Foods, Ranked

https://morningsteel.com/nitric-oxide-foods/ .--

10 Healthy High Arginine Foods

https://www.healthline.com/health/healthy-high-arginine-foods .--

Betalain plays a role in reducing homocysteine ​​levels in the blood, reducing the risk of cardiovascular problems, higher risk for the severity of COVID-19, and Alzheimer's disease.

Betalain and neobetanin that helps reduce glucose levels, increase insulin sensitivity and prevent changes induced by oxidative stress in patients with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153083/ .--

Betalain plays a fundamental role in the synthesis of creatine. The production of creatine helps promote muscle strength and endurance, which can promote lung function. Betaine increases the production of nitric oxide, which also helps optimize the efficiency of the Krebs cycle.

The USDA establishes that beets and spinach are one of the main food sources of betaine, also contained in broccoli, fish Trimethylglycine can be formed from choline by oxidation in the liver, providing a beneficial effect on the cardiovascular system https://www.ars.usda.gov/ARSUserFiles/80400525/Articles/IFT2004_Betaine.pdf.--

https://www.ars.usda.gov/ARSUserFiles/80400525/Data/Choline/Choln02.pdf.--

Betalain is often referred to as a lipotropic factor because it helps the liver process fats (lipids).

http://europepmc.org/abstract/med/12197781 .--

http://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.lb333 .---

The homocysteine ​​pathway: a new target for the treatment of Alzheimer's disease. Homocysteine ​​potentiates beta-amyloid neurotoxicity: role of oxidative stress. Betaine improves memory and cognitive performance

https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.22090 .--

https://www.ncbi.nlm.nih.gov/pubmed/11461960?dopt=Abstract .--

https://link.springer.com/article/10.1007/s11064-017-2397-3 .--

NO activates the p53 response pathway, known as the gatekeeper of the genome, the list of known functions of p53 includes regulatory roles in cell cycle arrest, apoptosis, angiogenesis, DNA repair, and cellular senescence. Promotes exercise-induced mitochondrial biogenesis

http://www.pnas.org/content/100/1/143.short.--

https://link.springer.com/article/10.1007/s40279-013-0127-9 .--

Lactobacilli can use nitrate and nitrite to generate nitric oxide, with immunomodulatory and antibacterial properties. Dietary supplementation with lactobacilli and nitrate resulted in increased ON in the small intestine and cecum.

https://www.sciencedirect.com/science/article/pii/S0891584906004229

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