Transgenic fats loaded with omega 6 are a poison to your health. Obesity and diabetes are terrible consequences of the current diet loaded with linoleic acid.
Blood levels of BDNF are lower in humans with obesity and type 2 diabetes. BDNF regulates glucose and energy metabolism and prevents β-cell exhaustion. Reduced levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. BDNF may be useful in the prevention and treatment of several diseases, including diabetes. This review summarizes the current understanding of the role of BDNF in several neurodegenerative diseases, as well as the underlying molecular mechanism. The evidence reviewed in this article indicates that deficiency in BDNF signaling may play a role in the pathophysiology of Alzheimer's disease and Parkinson's disease.
Brain-derived neurotrophic factor (BDNF) is associated with emotional and cognitive functioning and is considered a transdiagnostic biomarker of mental disorders. The lowest BDNF in subjects with insomnia.
Probiotics may be effective in raising BDNF levels in patients with depression and neurological disorders, and a combination of Lactobacillus and Bifidobacterium appears to show greater efficacy than either supplement alone. Scientists are investigating whether the following dietary factors can increase or decrease BDNF levels:
Curcumin also increased BDNF synthesis in the hippocampus in hypothyroid rats. Curcumin is a natural polyphenolic compound that has great potential for the prevention and treatment of age-related disorders by regulating and activating the expression of neuronal protective proteins such as BDNF.
Short-chain fatty acids, such as butyrate, contribute to the upregulation of brain-derived neurotrophic factor (BDNF), and intestinal dysbiosis results in reduced levels of BDNF, which could affect neuronal development and synaptic plasticity. Increased intestinal permeability causes an influx of gut microbial components such as lipopolysaccharides, and the resulting systemic inflammation can lead to neuroinflammation in the central nervous system.
Neuroinflammation induced by microglial and astrocyte polarizations may contribute to neurodegeneration and cognitive impairment. Polyunsaturated fatty acid DHA improved cognitive decline associated with aging by regulating glial polarization in correlation with changes in astrocytes, the precursor of brain-derived neurotrophic factor.
Transgenic fats loaded with omega 6 are a poison to your health. Obesity and diabetes are terrible consequences of the current diet loaded with linoleic acid.
Blood levels of BDNF are lower in humans with obesity and type 2 diabetes. BDNF regulates glucose and energy metabolism and prevents β-cell exhaustion. Reduced levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. BDNF may be useful in the prevention and treatment of several diseases, including diabetes. This review summarizes the current understanding of the role of BDNF in several neurodegenerative diseases, as well as the underlying molecular mechanism. The evidence reviewed in this article indicates that deficiency in BDNF signaling may play a role in the pathophysiology of Alzheimer's disease and Parkinson's disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697050/ (2015).---
https://www.mdpi.com/1422-0067/23/12/6827 (2022).---
Brain-derived neurotrophic factor (BDNF) is associated with emotional and cognitive functioning and is considered a transdiagnostic biomarker of mental disorders. The lowest BDNF in subjects with insomnia.
https://www.sciencedirect.com/science/article/abs/pii/S1087079222001514 (2023).---
Probiotics may be effective in raising BDNF levels in patients with depression and neurological disorders, and a combination of Lactobacillus and Bifidobacterium appears to show greater efficacy than either supplement alone. Scientists are investigating whether the following dietary factors can increase or decrease BDNF levels:
https://www.tandfonline.com/doi/abs/10.1080/1028415X.2022.2110664 (2023).---
Curcumin also increased BDNF synthesis in the hippocampus in hypothyroid rats. Curcumin is a natural polyphenolic compound that has great potential for the prevention and treatment of age-related disorders by regulating and activating the expression of neuronal protective proteins such as BDNF.
https://www.ingentaconnect.com/content/wk/bepha/2022/00000033/00000007/art00004 (2022).---
https://www.ingentaconnect.com/content/ben/cmc/pre-prints/content-37278037 (2024).---
Short-chain fatty acids, such as butyrate, contribute to the upregulation of brain-derived neurotrophic factor (BDNF), and intestinal dysbiosis results in reduced levels of BDNF, which could affect neuronal development and synaptic plasticity. Increased intestinal permeability causes an influx of gut microbial components such as lipopolysaccharides, and the resulting systemic inflammation can lead to neuroinflammation in the central nervous system.
https://www.mdpi.com/1422-0067/23/3/1172 (2022).----
Neuroinflammation induced by microglial and astrocyte polarizations may contribute to neurodegeneration and cognitive impairment. Polyunsaturated fatty acid DHA improved cognitive decline associated with aging by regulating glial polarization in correlation with changes in astrocytes, the precursor of brain-derived neurotrophic factor.
https://www.mdpi.com/1660-3397/21/7/398 (2023).-----