We can consider some supplements or foods high in apigenin such as chamomile, parsley, celery, mint and citrus fruits. Apigenin acts against numerous diseases such as cancer, diabetes, cardiovascular diseases, neurodegenerative diseases, non-alcoholic fatty liver disease, and aging. etc., which are related to the overproduction of oxidative stress. The antioxidant mechanism of apigenin includes: inhibition of oxidative enzymes, modulation of redox signaling pathways (NF-kB, Nrf2, MAPK and P13/Akt), reinforcement of enzymatic and non-enzymatic antioxidants, metal chelation and scavenging of free radicals. .
These articles conclude that apigenin is a powerful antioxidant compound to overcome difficulties related to oxidative stress and many other chronic diseases.
A total of 34 studies were included in this review. The included studies revealed that apigenin improved learning, memory, and locomotion activity, exhibited anxiolytic effects, attenuated depressive behavior, and improved sensorimotor and motor coordination, cognitive impairment, and neurobehavioral deficits. Some of the molecular and biochemical mechanisms of apigenin include activation of the signaling pathway; modulation of neurotransmitter levels and monoaminergic, cholinergic, dopaminergic and serotonergic systems; inhibition of proinflammatory cytokine production; and attenuation of oxidative neuronal damage.
Apigenin induces cell growth arrest and apoptotic induction by modulating multiple cell signaling pathways in a broader range of human tumors, including breast, lung, liver, skin, blood, colon, prostate, pancreas, cervical , oral and stomach. Oncogenic protein networks, abnormal cell signaling, and modulation of apoptotic machinery are just a few examples of various molecular interactions and processes that have not yet been thoroughly addressed by scientific research.
The researchers analyzed the action of apigenin on breast cancer cells. Apigenin corrected abnormalities in the RNA and thus prevented the excessive cellular production typical of cancer. The review of the last article provides a general potential of apigenin as a candidate for reducing the risk of cancer metastasis.
The results of this meta-analysis show that apigenin inhibits tumor volume, tumor weight, the number of malignant tumors. This is due to the anti-apoptotic, anti-proliferative and anti-invasive properties of apigenin.
This article aims to review various effects of apigenin in both normal tissues and malignant tumors. Apigenin may have the ability to protect normal cells against genotoxic repercussions following radiotherapy and chemotherapy. Additionally, the inhibitory effects of apigenin on tumors will be discussed.
In this study, the flavones apigenin and genistein, in monotherapy or combined therapy, showed great potential in the treatment of prostate cancer (PCa), including resistant PCa.
Apigenin functions to activate NF-κB which functions as a critical mediator to regulate inflammation crosstalk and cancer initiation and progression, serving as a pharmacological target. Both can regulate apoptosis and the repair pathway associated with DNA damage.
Luteolin (LUT) and apigenin (API) are the most abundant citrus flavones and exhibit more potent biological activity. LUT and API have been shown to have good anticancer activity against CC without the side effects.
We can consider some supplements or foods high in apigenin such as chamomile, parsley, celery, mint and citrus fruits. Apigenin acts against numerous diseases such as cancer, diabetes, cardiovascular diseases, neurodegenerative diseases, non-alcoholic fatty liver disease, and aging. etc., which are related to the overproduction of oxidative stress. The antioxidant mechanism of apigenin includes: inhibition of oxidative enzymes, modulation of redox signaling pathways (NF-kB, Nrf2, MAPK and P13/Akt), reinforcement of enzymatic and non-enzymatic antioxidants, metal chelation and scavenging of free radicals. .
These articles conclude that apigenin is a powerful antioxidant compound to overcome difficulties related to oxidative stress and many other chronic diseases.
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13950 (2022)
https://www.tandfonline.com/doi/full/10.1080/10942912.2023.2236329 (2023).---
https://www.ingentaconnect.com/content/ben/npj/2023/00000013/00000004/art00006 (2023).--
https://www.sciencedirect.com/science/article/abs/pii/S004763742300115X (2024).---
https://www.ingentaconnect.com/content/ben/cnsnddt/2024/00000023/00000004/art00007 (2024).---
A total of 34 studies were included in this review. The included studies revealed that apigenin improved learning, memory, and locomotion activity, exhibited anxiolytic effects, attenuated depressive behavior, and improved sensorimotor and motor coordination, cognitive impairment, and neurobehavioral deficits. Some of the molecular and biochemical mechanisms of apigenin include activation of the signaling pathway; modulation of neurotransmitter levels and monoaminergic, cholinergic, dopaminergic and serotonergic systems; inhibition of proinflammatory cytokine production; and attenuation of oxidative neuronal damage.
https://www.mdpi.com/2227-9059/12/1/178 (2023).---
Apigenin induces cell growth arrest and apoptotic induction by modulating multiple cell signaling pathways in a broader range of human tumors, including breast, lung, liver, skin, blood, colon, prostate, pancreas, cervical , oral and stomach. Oncogenic protein networks, abnormal cell signaling, and modulation of apoptotic machinery are just a few examples of various molecular interactions and processes that have not yet been thoroughly addressed by scientific research.
The researchers analyzed the action of apigenin on breast cancer cells. Apigenin corrected abnormalities in the RNA and thus prevented the excessive cellular production typical of cancer. The review of the last article provides a general potential of apigenin as a candidate for reducing the risk of cancer metastasis.
https://www.pnas.org/doi/full/10.1073/pnas.1303726110 (2017).--
https://www.nature.com/articles/s41419-023-06342-6 (2023).--
https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.14206 (2023).----
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1380194/abstract (2024).--
The results of this meta-analysis show that apigenin inhibits tumor volume, tumor weight, the number of malignant tumors. This is due to the anti-apoptotic, anti-proliferative and anti-invasive properties of apigenin.
www.sciencedirect.com/science/article/abs/pii/S1040842822001755 (2022
This article aims to review various effects of apigenin in both normal tissues and malignant tumors. Apigenin may have the ability to protect normal cells against genotoxic repercussions following radiotherapy and chemotherapy. Additionally, the inhibitory effects of apigenin on tumors will be discussed.
https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13725 (2023)
In this study, the flavones apigenin and genistein, in monotherapy or combined therapy, showed great potential in the treatment of prostate cancer (PCa), including resistant PCa.
Apigenin functions to activate NF-κB which functions as a critical mediator to regulate inflammation crosstalk and cancer initiation and progression, serving as a pharmacological target. Both can regulate apoptosis and the repair pathway associated with DNA damage.
https://www.frontiersin.org/articles/10.3389/fphar.2022.851589/full (2022)
Luteolin (LUT) and apigenin (API) are the most abundant citrus flavones and exhibit more potent biological activity. LUT and API have been shown to have good anticancer activity against CC without the side effects.
https://www.dl.begellhouse.com/journals/2c6306423483e001,7db23e8c052392c3,3d94e5203f933ab4.html (2022)