A recently published study by the Environmental Working Group revealed that 80% of Americans tested positive for this pesticide, which is found in many foods.
To consider the synergy of pesticides and toxic substances in the environment and in food in the development of chronic and degenerative diseases. Exposure to pesticides causes many health disorders. Mixed exposure to pesticides is an important issue for human and environmental health.
In this study, the cytotoxicity of chlormequat pirimiphos-methyl, glyphosate, tebuconazole, chlorpyrifos-methyl, deltamethrin and the mixture of these six pesticides has been determined. We further investigated the role of oxidative stress, total oxidant status (TOS), lactate dehydrogenase (LDH) and TOS antioxidant defense mechanism, total glutathione (GSH) levels with the observed cytotoxicity. Results: Pesticide mixtures reduced total antioxidant status (TAS) and GSH level and increased cellular reactive oxygen species (ROS) generation, respectively with a significant contribution of oxidative stress to cytotoxicity during exposure to the mixture. of pesticides.
This study reported that clormequat chloride at 5 mg/kg body weight not only affects embryonic growth in rats, but also has additional impacts on postnatal health.
Globally, 30% of suicide deaths are caused by self-intoxication with pesticides. Deaths due to intentional or suicidal ingestion of plant growth regulators are rare. In Sri Lanka it is used during the cultivation of vegetables, fruits and floriculture. There are four case reports and a case series of seven patients with acute poisoning reported previously. Ten of these eleven cases have been fatal. One was after inhalation and the others after ingestion of chlormequat chloride. The clinical characteristics of acute poisoning are cholinergic crisis, cardiac arrest, acute pulmonary edema, respiratory failure and death, mainly within an hour after ingestion. In four cases atropine was used. Death occurred within the day of exposure in all fatal cases.
To consider the synergy of pesticides and toxic substances in the environment and in food in the development of chronic and degenerative diseases. Exposure to pesticides causes many health disorders. Mixed exposure to pesticides is an important issue for human and environmental health.
In this study, the cytotoxicity of chlormequat pirimiphos-methyl, glyphosate, tebuconazole, chlorpyrifos-methyl, deltamethrin and the mixture of these six pesticides has been determined. We further investigated the role of oxidative stress, total oxidant status (TOS), lactate dehydrogenase (LDH) and TOS antioxidant defense mechanism, total glutathione (GSH) levels with the observed cytotoxicity. Results: Pesticide mixtures reduced total antioxidant status (TAS) and GSH level and increased cellular reactive oxygen species (ROS) generation, respectively with a significant contribution of oxidative stress to cytotoxicity during exposure to the mixture. of pesticides.
https://dergipark.org.tr/en/pub/iujp/issue/63480/881724 (2021).----
This study reported that clormequat chloride at 5 mg/kg body weight not only affects embryonic growth in rats, but also has additional impacts on postnatal health.
https://www.sciencedirect.com/science/article/abs/pii/S0300483X20301736 (2020).-----
PIRG DELIVERS MORE THAN 10,000 SIGNATURES CALLING ON EPA TO REJECT A TOXIC PESTICIDE.
https://pirg.org/updates/pirg-delivers-more-than-10000-signatures-calling-on-epa-to-reject-a-toxic-pesticide/ (2023).----
Globally, 30% of suicide deaths are caused by self-intoxication with pesticides. Deaths due to intentional or suicidal ingestion of plant growth regulators are rare. In Sri Lanka it is used during the cultivation of vegetables, fruits and floriculture. There are four case reports and a case series of seven patients with acute poisoning reported previously. Ten of these eleven cases have been fatal. One was after inhalation and the others after ingestion of chlormequat chloride. The clinical characteristics of acute poisoning are cholinergic crisis, cardiac arrest, acute pulmonary edema, respiratory failure and death, mainly within an hour after ingestion. In four cases atropine was used. Death occurred within the day of exposure in all fatal cases.
https://www.safetylit.org/citations/index.php?fuseaction=citations.viewdetails&citationIds[]=citjournalarticle_527245_7 (2018).---