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Coffee is a complex beverage that contains more than 1000 described phytochemicals, which are responsible for its pleasant flavor, aroma and health-promoting properties. The five most abundant bioactive components in green coffee are (I) caffeine, which has been positioned by numerous studies as a protective agent of cell membranes against oxidative damage, with anticancer activity and anti-inflammatory effects; (II) polyphenols, which can cause a variety of important bioactivities with beneficial effects on human health; (III) trigonelline, which has hypoglycemic, neuroprotective, antitumor (antiinvasive), antibacterial, and antiviral activities; (IV) Chlorogenic acids, the most important class of polyphenols, which can be grouped into caffeoylquinic acids, feruloylquinic acids and di-caffeoylquinic acids, all of which are known to have powerful antioxidant, anticancer, anti-inflammatory, antibacterial, antipyretic effects , hepatoprotective and neuroprotective and can help prevent retinal degeneration, obesity and hypertension; and (V) cafestol and kahweol, the main diterpenes in coffee that have demonstrated anti-inflammatory, hepatoprotective, anticancer (inducing tumor cell apoptosis and antiangiogenesis), antidiabetic, and antiosteoclastogenic activities.

the improvement of blood pressure, plasma lipids and body weight (thus contributing to the improvement of the risk components of the Metabolic Syndrome) and benefits for cognitive functions.

https://www.hindawi.com/journals/omcl/2021/4420479/  (2021) https://www.tandfonline.com/doi/abs/10.1080/10408398.2021.1948817  (2023) https://www.sciencedirect.com/science/article/abs/pii/B9780128238110000067  (2023)

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