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We can enhance the activity of cocoa with a resveratrol (RES) supplement and foods rich in flavonols and RES present in berries and grapes rich in polyphenols with known anti-apoptotic, antioxidant and anti-inflammatory effects. In many studies, RES has been found to have many potential health benefits, such as cardioprotective, artipertensive, neurological, antiplatelet, hypoglycemic, and anticancer. . Recently published literature has shown that RES defend against some neurodegenerative diseases and obesity, in addition to being effective in the treatment of osteoporosis in postmenopausal women and ensuring a low risk against breast cancer,

RES replacement therapy has been shown to be potentially effective for stroke, high blood pressure, diabetes mellitus, and heart failure. Additionally, RES has been shown to improve myocardial hypertrophy, mitochondrial dysfunction, fatty acid oxidation, and cardiac dysfunction.

The antihypertensive effects of RES are mediated by AMP-activated protein kinase (AMPK) and SIRT-1. Activation of SIRT-1 and AMPK increases the expression and activity of endothelial nitric oxide synthase (eNOS), resulting in the production of nitric oxide (NO). NO produced by vascular endothelial cells relaxes vascular smooth muscle and dilates blood vessels, lowering blood pressure. Resveratrol supplementation in hypoglycemic therapy improves glucose control and reduces blood pressure

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