Midwestern Doctor's research on DMSO is extraordinary. An interesting piece of news:
A NEW FINDING ABOUT A NATURAL COMPOUND OPENS THE DOOR TO INNOVATIVE THERAPIES FOR ALZHEIMER'S.
Scientists at the National University of Singapore have identified a metabolite present in the body as a potential tool to restore neuronal functions affected by the disease and delay cognitive decline.
According to a new study published in Aging Cell, calcium alpha-ketoglutarate (CaAKG), a metabolite naturally produced by the human body, has been identified as a potential tool to restore brain functions impaired by Alzheimer's.
This advance opens the door to potentially safer and more accessible therapeutic strategies to combat age-related cognitive decline.
A medicinal plant with ancestral uses in Brazil has shown effectiveness against arthritis in scientific research.
The study demonstrated that a natural metabolite can restore synaptic plasticity, key to memory and learning (Illustrative Image Infobae).
Brian K. Kennedy, from the Department of Biochemistry and chair of the Translational Research Program on Healthy Longevity (TRP), stated: “The research suggests that safe, natural compounds like CaAKG could one day complement existing approaches to protecting the brain and slowing memory loss.”
“Since AKG is already present in our bodies, focusing on these pathways could offer fewer risks and greater accessibility. This could provide us with a powerful new strategy to delay cognitive decline and promote healthy brain aging,” he noted.
The research team from the Yong Loo Lin School of Medicine at the National University of Singapore demonstrated that CaAKG can restore functionality to key neuronal processes altered in patients with Alzheimer's disease.
The compound, previously studied for its role in healthy aging, showed positive results in restoring synaptic plasticity, considered fundamental for learning and memory formation, a function severely impaired in this disease.
CaAKG allowed for the recovery of associative memory, one of the first abilities typically lost in the early stages of Alzheimer's, and restored synaptic retrieval, a mechanism that enables the brain to link events and form complex memories. Furthermore, it enhanced autophagy, the brain's natural system for eliminating harmful proteins, crucial for maintaining neuronal health.
The research indicates that CaAKG promotes the strengthening of connections between neurons by activating L-type calcium channels and calcium-permeable AMPA receptors, which are important for neuronal flexibility.
It also prevents the overload of NMDA receptors, frequently affected by the accumulation of amyloid protein, a hallmark of the disease. This multifaceted action suggests that CaAKG contributes both to maintaining basic memory function and to supporting more complex learning abilities.
Since AKG levels naturally decline with age, replenishing this metabolite could be a less risky and more accessible way to promote healthy brain aging.
Calcium alpha-ketoglutarate (Ca-AKG) is a compound formed by combining calcium and alpha-ketoglutarate (AKG), a key intermediate in the Krebs cycle (citric acid cycle), the process responsible for energy generation in aerobic organisms. First identified by Hans Adolf Krebs in 1937, this cycle oxidizes nutrients to produce ATP, the body's primary energy source.
Ca-AKG combines the benefits of calcium, essential for bone health, with AKG, a crucial component in metabolic pathways that influence cellular energy, aging, and longevity. Compared to regular AKG, the calcium form (Ca-AKG) offers greater stability and bioavailability, making it the preferred choice in advanced longevity formulations.
Ca-AKG A study by the Buck Institute for Aging Research revealed that AKG extended lifespan by 12% to 16% and healthy lifespan by 40% to 52%. Mice not only lived longer, but also remained healthier and disease-free for a longer period.
Aging animals: AKG significantly reduced hair graying in aged animals.
Alpha-ketoglutarate (AKG) plays a vital role in cellular health, metabolism, and the regulation of aging. As we age, AKG levels decline, contributing to metabolic dysfunction and increased susceptibility to age-related diseases.
Research suggests that calcium alpha-ketoglutarate (Ca-AKG) supplementation may extend lifespan, improve metabolic flexibility, and promote youthful cellular function.
AKG influences aging at the level epigenetics helps regulate which genes are activated or silenced.
As we age, epigenetic dysregulation occurs:
Some genes that should be inactive become active.
Protective genes, such as those involved in cancer suppression, may be deactivated.
This imbalance accelerates cellular aging and disease progression.
A key enzyme in epigenetic regulation is TET (ten-eleven translocation), which contributes to reprogramming the epigenome toward a more youthful state. However, TET enzymes require both AKG and vitamin C to function properly.
Most AKG supplements contain simple alpha-ketoglutarate, which:
• Is rapidly absorbed and excreted even more rapidly, limiting its longevity benefits.
• Lacks sustained effects on cellular metabolism and mitochondrial health.
On the other hand, calcium alpha-ketoglutarate (Ca-AKG):
• Provides longer-lasting effects due to its gradual absorption.
• More efficiently supports energy production, epigenetic regulation, and detoxification.
AKG is a crucial intermediate metabolite in the TCA cycle and plays a fundamental role in maintaining skeletal muscle health. AKG not only participates in energy metabolism but also plays a crucial role in regulating muscle protein synthesis and degradation, oxidative stress, and nitrogen metabolism. Therefore, AKG supplementation shows considerable potential for improving skeletal muscle regeneration, preventing muscle atrophy, and enhancing athletic performance.
In skeletal muscle regeneration, AKG supports the repair process following muscle injury by promoting muscle stem cell (MuSC) proliferation and regulating macrophage polarization. AKG supplementation has demonstrated positive effects in treating age-related muscle damage. Furthermore, AKG effectively mitigates muscle atrophy induced by chronic diseases, surgery, and inflammation by regulating protein synthesis pathways, such as the mTOR pathway.
In athletic performance, AKG supplementation has shown promise in improving strength and endurance, as well as reducing fatigue, especially during high-intensity exercise or in hypoxic environments. However, research indicates that different dosage regimens and durations of AKG supplementation can produce variable results. Therefore, further research is needed to optimize the dosage and timing of AKG administration to maximize its potential in exercise physiology.
A Medical System Foundation built by the son of a snake oil salesman so clever as to last for over a century, aped and mimicked by the members of the Global Monopolies. Billions thrown away on Alzheimer drugs and treatments very likely a Dis-Ease fueled by multiple, many layers of not only other med's, but Ag practices, Ultra Processed Foods, Industry. Just one income stream after another to consolidate and moved all in the one same direction, increasing financial wealth to further control and create even more to move in one way and one way only. Health itself be damned.
DMSO on its own or working with other natural compounds just keeps revealing how much has been missing in our ability to have an actual Health Sustaining - Dis-Ease Prevention System. A real system would be costing the Individual and Social Treasury pennies compared to a only patented medicines allowed Monopoly we have today.
Tag all this along with todays third article about creating Healthy Soil Life. As someone who started with basically dead sand. Incapable of even growing peas, onions or radishes. As early on it was recommended by family farm members, the standard 5-10-10 was thrown on and yes while stuff would grow, it would not improve to the degree those with better soil could produce. On top of it all, being dead sand, any fertilizer, amendments would just leach away. By the way, the end result of many decades of heavy fertilizer use is dead sand with any nutrients leaching away. The discovery and move to Organic Gardening improved soil structure and the switch to organic fertilizers was an improvement but using green manures, cover crops to bulk up soil structure, dampen the weeds and hold those organic fertilizers was a greater improvement. Then experimenting with Eden Gardening jumped things even further. Now the move has been to use No to Little Till in wide rows with Eden Gardening in the walkways and are making fast, welcomed results. These efforts, (along with Biochar,) allow the additives todays stay in place - end the leaching. End the constant financial drain and exposures to toxic ag chemicals. The additives in todays third article give the needed nutrients to feed the soil microbes to make Healthy Living Soil to create Health Living Foods. No need to eat Ze Bugs and Worms, Ze Bugs and Worms can feed our soils and in turn create Healthy Living Foods and Thriving Bodies. Just Sayn'
Amen to Gui and Steve! Back to basics, old fashioned, native understanding of how the earth works, how a balance of all things natural actually works! YES, it does not improve the finances of pharma companies, chemical additives for soil. BUT it makes a healthy soil and me! I live on a rocky bluff with clay soil. I still get beautiful flowers, great veggies. All I do is let leaf litter stay in the winter, break down, nourish the soil, add a bit of mature manure from a neighbor's horse, cow, goat. I started a compost pit and then add that to the soil in my gardens and for potted plants! My only problem now is Honeysuckle Bush brought here from Japan as an ornamental for landscaping that is taking over everything! Conservation department spends thousands trying to get rid of it. It spreads by roots, seed and smothers native plants, provides little food for wildlife! Then they apply RoundUp, other chemicals to kill it. They also kill native plants, bees, other pollinators and people, including myself. In 2000 I was diagnosed with Lymphoma, given 3 months, go home and plan your funeral. A never ending viscious cycle of chemicals doing very little to help life, a lot to destroy life that helps no one but chemical, pharma! I went into remission from lymphoma because I prayed for healing, wisdom and went organic. One year later I was in remission, have been since then. Modern medicine puts down DMSO, I swear by it for almost every ache, pain I have. Again, nature is best! I have a wild garden full of mother nature's medicines! I collected seed, cuttings from the wild and planted what many call a messy, ugly garden. I call t my medicine garden.
Midwestern Doctor's research on DMSO is extraordinary. An interesting piece of news:
A NEW FINDING ABOUT A NATURAL COMPOUND OPENS THE DOOR TO INNOVATIVE THERAPIES FOR ALZHEIMER'S.
Scientists at the National University of Singapore have identified a metabolite present in the body as a potential tool to restore neuronal functions affected by the disease and delay cognitive decline.
According to a new study published in Aging Cell, calcium alpha-ketoglutarate (CaAKG), a metabolite naturally produced by the human body, has been identified as a potential tool to restore brain functions impaired by Alzheimer's.
This advance opens the door to potentially safer and more accessible therapeutic strategies to combat age-related cognitive decline.
A medicinal plant with ancestral uses in Brazil has shown effectiveness against arthritis in scientific research.
The study demonstrated that a natural metabolite can restore synaptic plasticity, key to memory and learning (Illustrative Image Infobae).
Brian K. Kennedy, from the Department of Biochemistry and chair of the Translational Research Program on Healthy Longevity (TRP), stated: “The research suggests that safe, natural compounds like CaAKG could one day complement existing approaches to protecting the brain and slowing memory loss.”
“Since AKG is already present in our bodies, focusing on these pathways could offer fewer risks and greater accessibility. This could provide us with a powerful new strategy to delay cognitive decline and promote healthy brain aging,” he noted.
The research team from the Yong Loo Lin School of Medicine at the National University of Singapore demonstrated that CaAKG can restore functionality to key neuronal processes altered in patients with Alzheimer's disease.
The compound, previously studied for its role in healthy aging, showed positive results in restoring synaptic plasticity, considered fundamental for learning and memory formation, a function severely impaired in this disease.
CaAKG allowed for the recovery of associative memory, one of the first abilities typically lost in the early stages of Alzheimer's, and restored synaptic retrieval, a mechanism that enables the brain to link events and form complex memories. Furthermore, it enhanced autophagy, the brain's natural system for eliminating harmful proteins, crucial for maintaining neuronal health.
The research indicates that CaAKG promotes the strengthening of connections between neurons by activating L-type calcium channels and calcium-permeable AMPA receptors, which are important for neuronal flexibility.
It also prevents the overload of NMDA receptors, frequently affected by the accumulation of amyloid protein, a hallmark of the disease. This multifaceted action suggests that CaAKG contributes both to maintaining basic memory function and to supporting more complex learning abilities.
Since AKG levels naturally decline with age, replenishing this metabolite could be a less risky and more accessible way to promote healthy brain aging.
https://www.infobae.com/salud/ciencia/2025/12/30/alzheimer-un-nuevo-hallazgo-sobre-un-compuesto-natural-abre-la-puerta-a-terapias-innovadoras/
Calcium alpha-ketoglutarate (Ca-AKG) is a compound formed by combining calcium and alpha-ketoglutarate (AKG), a key intermediate in the Krebs cycle (citric acid cycle), the process responsible for energy generation in aerobic organisms. First identified by Hans Adolf Krebs in 1937, this cycle oxidizes nutrients to produce ATP, the body's primary energy source.
Ca-AKG combines the benefits of calcium, essential for bone health, with AKG, a crucial component in metabolic pathways that influence cellular energy, aging, and longevity. Compared to regular AKG, the calcium form (Ca-AKG) offers greater stability and bioavailability, making it the preferred choice in advanced longevity formulations.
Ca-AKG A study by the Buck Institute for Aging Research revealed that AKG extended lifespan by 12% to 16% and healthy lifespan by 40% to 52%. Mice not only lived longer, but also remained healthier and disease-free for a longer period.
Aging animals: AKG significantly reduced hair graying in aged animals.
Alpha-ketoglutarate (AKG) plays a vital role in cellular health, metabolism, and the regulation of aging. As we age, AKG levels decline, contributing to metabolic dysfunction and increased susceptibility to age-related diseases.
Research suggests that calcium alpha-ketoglutarate (Ca-AKG) supplementation may extend lifespan, improve metabolic flexibility, and promote youthful cellular function.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30417-4?uuid=uuid%3Af3daf0de-5f1a-4830-88e4-39fd8e815cd8
https://www.biorxiv.org/content/10.1101/779157v1
https://www.sciencedirect.com/science/article/pii/S053155652300075X
https://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(21)00266-6
AKG influences aging at the level epigenetics helps regulate which genes are activated or silenced.
As we age, epigenetic dysregulation occurs:
Some genes that should be inactive become active.
Protective genes, such as those involved in cancer suppression, may be deactivated.
This imbalance accelerates cellular aging and disease progression.
A key enzyme in epigenetic regulation is TET (ten-eleven translocation), which contributes to reprogramming the epigenome toward a more youthful state. However, TET enzymes require both AKG and vitamin C to function properly.
https://www.sciencedirect.com/science/article/pii/S0021925820355010#:~:text=%CE%B1%2DKetoglutarate%20is%20an%20important,are%20involved%20in%20DNA%20demethylation
AKG plays a crucial role in stem cell health, ensuring that tissues continue to regenerate efficiently as we age.
It supports the maintenance and differentiation of stem cells.
It helps repair and regenerate tissues.
It contributes to bone and intestinal metabolism.
https://pubmed.ncbi.nlm.nih.gov/25487152/
https://www.biomolther.org/journal/view.html?uid=575&vmd=Full
Most AKG supplements contain simple alpha-ketoglutarate, which:
• Is rapidly absorbed and excreted even more rapidly, limiting its longevity benefits.
• Lacks sustained effects on cellular metabolism and mitochondrial health.
On the other hand, calcium alpha-ketoglutarate (Ca-AKG):
• Provides longer-lasting effects due to its gradual absorption.
• More efficiently supports energy production, epigenetic regulation, and detoxification.
AKG is a crucial intermediate metabolite in the TCA cycle and plays a fundamental role in maintaining skeletal muscle health. AKG not only participates in energy metabolism but also plays a crucial role in regulating muscle protein synthesis and degradation, oxidative stress, and nitrogen metabolism. Therefore, AKG supplementation shows considerable potential for improving skeletal muscle regeneration, preventing muscle atrophy, and enhancing athletic performance.
In skeletal muscle regeneration, AKG supports the repair process following muscle injury by promoting muscle stem cell (MuSC) proliferation and regulating macrophage polarization. AKG supplementation has demonstrated positive effects in treating age-related muscle damage. Furthermore, AKG effectively mitigates muscle atrophy induced by chronic diseases, surgery, and inflammation by regulating protein synthesis pathways, such as the mTOR pathway.
In athletic performance, AKG supplementation has shown promise in improving strength and endurance, as well as reducing fatigue, especially during high-intensity exercise or in hypoxic environments. However, research indicates that different dosage regimens and durations of AKG supplementation can produce variable results. Therefore, further research is needed to optimize the dosage and timing of AKG administration to maximize its potential in exercise physiology.
https://www.mdpi.com/2072-6643/16/22/3968
A Medical System Foundation built by the son of a snake oil salesman so clever as to last for over a century, aped and mimicked by the members of the Global Monopolies. Billions thrown away on Alzheimer drugs and treatments very likely a Dis-Ease fueled by multiple, many layers of not only other med's, but Ag practices, Ultra Processed Foods, Industry. Just one income stream after another to consolidate and moved all in the one same direction, increasing financial wealth to further control and create even more to move in one way and one way only. Health itself be damned.
DMSO on its own or working with other natural compounds just keeps revealing how much has been missing in our ability to have an actual Health Sustaining - Dis-Ease Prevention System. A real system would be costing the Individual and Social Treasury pennies compared to a only patented medicines allowed Monopoly we have today.
Tag all this along with todays third article about creating Healthy Soil Life. As someone who started with basically dead sand. Incapable of even growing peas, onions or radishes. As early on it was recommended by family farm members, the standard 5-10-10 was thrown on and yes while stuff would grow, it would not improve to the degree those with better soil could produce. On top of it all, being dead sand, any fertilizer, amendments would just leach away. By the way, the end result of many decades of heavy fertilizer use is dead sand with any nutrients leaching away. The discovery and move to Organic Gardening improved soil structure and the switch to organic fertilizers was an improvement but using green manures, cover crops to bulk up soil structure, dampen the weeds and hold those organic fertilizers was a greater improvement. Then experimenting with Eden Gardening jumped things even further. Now the move has been to use No to Little Till in wide rows with Eden Gardening in the walkways and are making fast, welcomed results. These efforts, (along with Biochar,) allow the additives todays stay in place - end the leaching. End the constant financial drain and exposures to toxic ag chemicals. The additives in todays third article give the needed nutrients to feed the soil microbes to make Healthy Living Soil to create Health Living Foods. No need to eat Ze Bugs and Worms, Ze Bugs and Worms can feed our soils and in turn create Healthy Living Foods and Thriving Bodies. Just Sayn'
Amen to Gui and Steve! Back to basics, old fashioned, native understanding of how the earth works, how a balance of all things natural actually works! YES, it does not improve the finances of pharma companies, chemical additives for soil. BUT it makes a healthy soil and me! I live on a rocky bluff with clay soil. I still get beautiful flowers, great veggies. All I do is let leaf litter stay in the winter, break down, nourish the soil, add a bit of mature manure from a neighbor's horse, cow, goat. I started a compost pit and then add that to the soil in my gardens and for potted plants! My only problem now is Honeysuckle Bush brought here from Japan as an ornamental for landscaping that is taking over everything! Conservation department spends thousands trying to get rid of it. It spreads by roots, seed and smothers native plants, provides little food for wildlife! Then they apply RoundUp, other chemicals to kill it. They also kill native plants, bees, other pollinators and people, including myself. In 2000 I was diagnosed with Lymphoma, given 3 months, go home and plan your funeral. A never ending viscious cycle of chemicals doing very little to help life, a lot to destroy life that helps no one but chemical, pharma! I went into remission from lymphoma because I prayed for healing, wisdom and went organic. One year later I was in remission, have been since then. Modern medicine puts down DMSO, I swear by it for almost every ache, pain I have. Again, nature is best! I have a wild garden full of mother nature's medicines! I collected seed, cuttings from the wild and planted what many call a messy, ugly garden. I call t my medicine garden.