A longevity expert shares his insights on treating chronic health issues by addressing their foundational causes, such as microbiome imbalances and toxicity.
A relevant definition: “Chronic diseases often result due to a buildup of toxicities and a lack nutrition and healing in the body to compensate for them…”
If we lived in a natural environment, without contamination of any kind, eating organic foods and drinking spring water, exercising, taking powerful fruits and vegetables loaded with phytochemicals, enzymes, vitamins and minerals, fermented, etc., the people who lose their health would be you almost don't exist.
Aging is characterized by a progressive loss of physiological integrity, which leads to a deterioration of cellular and mitochondrial functions, as an important risk factor for major human pathologies. These reviews list the factors that represent the common denominators of aging, where mitochondrial dysfunction is basic: genomic instability, telomeric attrition, loss of proteostasis, disabled macroautophagy, epigenetic alterations, nutrient deregulation, cellular senescence, stem cell exhaustion and intercellular communication. altered chronic inflammation and dysbiosis. Very well represented in Fig,1,
This review shows the evidence of the relationship of magnesium with all the characteristics of aging (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient detection, mitochondrial dysfunction, cellular senescence, stem cell exhaustion , altered intercellular communication, disability). autophagy, dysbiosis and chronic inflammation), which can positively affect human health. Vitamin D also seems to confirm the modulating effect on some characteristics of aging and diseases.
Several recent studies highlight multiple trajectories of gut microbiome aging, which depend on the body's microbial communities, particularly within the gut microbiota, the imbalance of which can lead to dysbiosis. Mitochondrial dysfunction is commonly observed in the aging gastrointestinal tract, but the gut-brain axis is emerging as a complex bidirectional pathway, linking the gut microbiota to the brain and also involving mitochondrial function. Mitochondrial dysfunction may contribute to dysbiosis and alter the composition and function of the gut microbiota through various mechanisms, including alteration of host-microbiota crosstalk, metabolic changes, oxidative stress, gut barrier dysfunction, and dysregulation. immune system that contributes to chronic diseases.
NAD+ precursors, such as nicotinamide riboside, nicotinamide mononucleotide and their analogues, have an effect on aging and neurodegenerative diseases. Urolithin A stimulate mitophagy and mitigate neurodegenerative diseases,
This review reports on the therapeutic application of flavonoids in the treatment of chronic diseases, cancers, and neurodegenerative disorders. The citrus flavonoid naringenin has a host of health benefits. Flavonoids such as curcumin, resveratrol, catechin, quercetin and kaempferol have also been studied to exert their anti-aging properties in humans.
In this review, we summarize bioactive compounds from natural food sources that have the potential to extend lifespan and prevent diseases associated with aging. These compounds include polysaccharides, polyphenols, carotenoids, sterols, terpenoids and vitamins, which are abundant in plants, algae, animals and edible fungi.
A relevant definition: “Chronic diseases often result due to a buildup of toxicities and a lack nutrition and healing in the body to compensate for them…”
If we lived in a natural environment, without contamination of any kind, eating organic foods and drinking spring water, exercising, taking powerful fruits and vegetables loaded with phytochemicals, enzymes, vitamins and minerals, fermented, etc., the people who lose their health would be you almost don't exist.
Aging is characterized by a progressive loss of physiological integrity, which leads to a deterioration of cellular and mitochondrial functions, as an important risk factor for major human pathologies. These reviews list the factors that represent the common denominators of aging, where mitochondrial dysfunction is basic: genomic instability, telomeric attrition, loss of proteostasis, disabled macroautophagy, epigenetic alterations, nutrient deregulation, cellular senescence, stem cell exhaustion and intercellular communication. altered chronic inflammation and dysbiosis. Very well represented in Fig,1,
https://www.sciencedirect.com/science/article/pii/S0092867422013770 (2023).--
https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1334261/full (2024).--
This review shows the evidence of the relationship of magnesium with all the characteristics of aging (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient detection, mitochondrial dysfunction, cellular senescence, stem cell exhaustion , altered intercellular communication, disability). autophagy, dysbiosis and chronic inflammation), which can positively affect human health. Vitamin D also seems to confirm the modulating effect on some characteristics of aging and diseases.
https://www.mdpi.com/2072-6643/16/4/496 (2024).--
https://www.mdpi.com/2072-6643/16/6/906 (2024).--
Several recent studies highlight multiple trajectories of gut microbiome aging, which depend on the body's microbial communities, particularly within the gut microbiota, the imbalance of which can lead to dysbiosis. Mitochondrial dysfunction is commonly observed in the aging gastrointestinal tract, but the gut-brain axis is emerging as a complex bidirectional pathway, linking the gut microbiota to the brain and also involving mitochondrial function. Mitochondrial dysfunction may contribute to dysbiosis and alter the composition and function of the gut microbiota through various mechanisms, including alteration of host-microbiota crosstalk, metabolic changes, oxidative stress, gut barrier dysfunction, and dysregulation. immune system that contributes to chronic diseases.
NAD+ precursors, such as nicotinamide riboside, nicotinamide mononucleotide and their analogues, have an effect on aging and neurodegenerative diseases. Urolithin A stimulate mitophagy and mitigate neurodegenerative diseases,
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13942 (2024).--
This review reports on the therapeutic application of flavonoids in the treatment of chronic diseases, cancers, and neurodegenerative disorders. The citrus flavonoid naringenin has a host of health benefits. Flavonoids such as curcumin, resveratrol, catechin, quercetin and kaempferol have also been studied to exert their anti-aging properties in humans.
https://www.liebertpub.com/doi/abs/10.1089/rej.2023.0065 (2024).--
In this review, we summarize bioactive compounds from natural food sources that have the potential to extend lifespan and prevent diseases associated with aging. These compounds include polysaccharides, polyphenols, carotenoids, sterols, terpenoids and vitamins, which are abundant in plants, algae, animals and edible fungi.
https://www.mdpi.com/2218-273X/13/11/1600 (2023).--