Endometriosis is an inflammatory pathological process characterized by lesions of endometrium-like tissue outside the uterus, commonly in the pelvic peritoneum and ovaries. The condition can present with debilitating symptoms (dysmenorrhea, acyclic pelvic pain, dysuria, dyschezia, chronic fatigue) that have considerable adverse impacts on quality of life, including an increased risk of infertility. It is estimated that endometriosis affects 10% of women of reproductive age, which is equivalent to 190 million women worldwide.
In the present meta-analysis, we confirmed that endometriosis was associated with a 1.9-fold increased risk of ovarian cancer compared to women without endometriosis.
Endometriosis was also associated with a very small (4%) but statistically significant risk of breast cancer. Endometriosis was associated with a 39% increased risk of thyroid cancer with little heterogeneity identified between studies. The strongest association observed was a highly significant 32% lower risk of cervical cancer for women with endometriosis compared to those without endometriosis.
Patients with endometrial cancer and endometriosis were significantly younger. Additionally, patients with endometrial cancer and endometriosis had fewer pregnancies and births. In the analysis of synchronous ovarian cancer, the percentage of dual primary cancers was higher in patients with endometriosis. The association of early-onset endometrial cancer with endometriosis is an important finding that cannot be ignored clinically.
Gene ontology, gene set enrichment analysis, and immune infiltration analysis further confirmed the immune-related functions, pathways, and relationship between iron metabolism and ovarian cancer. This study highlights the potential of targeting iron metabolism in preventing potential ovarian cancer and in further exploring endometriosis and endometriosis-relevant ovarian cancer therapies. The association between endometriosis and iron homeostasis disorder is becoming clearer, mainly reflected by extensive ferritin staining of local macrophages, significant increase in erythrocytes, and increased ferritin gene expression. transferrin receptor. High levels of iron can cause inflammation, oxidative stress and lipid peroxidation, and the iron-binding protein hemoglobin is an additional potential danger factor.
Endometriosis is an inflammatory pathological process characterized by lesions of endometrium-like tissue outside the uterus, commonly in the pelvic peritoneum and ovaries. The condition can present with debilitating symptoms (dysmenorrhea, acyclic pelvic pain, dysuria, dyschezia, chronic fatigue) that have considerable adverse impacts on quality of life, including an increased risk of infertility. It is estimated that endometriosis affects 10% of women of reproductive age, which is equivalent to 190 million women worldwide.
In the present meta-analysis, we confirmed that endometriosis was associated with a 1.9-fold increased risk of ovarian cancer compared to women without endometriosis.
Endometriosis was also associated with a very small (4%) but statistically significant risk of breast cancer. Endometriosis was associated with a 39% increased risk of thyroid cancer with little heterogeneity identified between studies. The strongest association observed was a highly significant 32% lower risk of cervical cancer for women with endometriosis compared to those without endometriosis.
https://academic.oup.com/humupd/article/27/2/393/5986656?login=false (2020)
Patients with endometrial cancer and endometriosis were significantly younger. Additionally, patients with endometrial cancer and endometriosis had fewer pregnancies and births. In the analysis of synchronous ovarian cancer, the percentage of dual primary cancers was higher in patients with endometriosis. The association of early-onset endometrial cancer with endometriosis is an important finding that cannot be ignored clinically.
https://www.mdpi.com/2072-6694/15/23/5635 (2023).---
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1193123/full (2023).--
Gene ontology, gene set enrichment analysis, and immune infiltration analysis further confirmed the immune-related functions, pathways, and relationship between iron metabolism and ovarian cancer. This study highlights the potential of targeting iron metabolism in preventing potential ovarian cancer and in further exploring endometriosis and endometriosis-relevant ovarian cancer therapies. The association between endometriosis and iron homeostasis disorder is becoming clearer, mainly reflected by extensive ferritin staining of local macrophages, significant increase in erythrocytes, and increased ferritin gene expression. transferrin receptor. High levels of iron can cause inflammation, oxidative stress and lipid peroxidation, and the iron-binding protein hemoglobin is an additional potential danger factor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101319/ (2023).---