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The group from the Higher Council for Scientific Research (CEBAS-CSIC) identified the production of urolithins (AU) for the first time in the world. In new research a secret anti-aging ingredient is hiding in the intestine. UAs, molecules that are produced naturally in the intestine when foods rich in polyphenols are consumed, such as pomegranates and berries such as strawberries, raspberries, blackberries, etc. Urolithins are a kind of intestinal microbiota metabolites of ellagitannins (ET) and ellagic acid (EA) with potent in vivo biological activity.

The effect of UA on aging and age-related diseases was found to be mediated by activating mitophagy, improving mitochondrial function, and reducing inflammation and mitochondrial function.

Other mechanisms of action have been proposed for UA, such as the activation of the Ahr/Nrf2 pathway and its response to antioxidant, anti-inflammatory stress, dysbiosis and intestinal permeability, cancer, neurodegenerative, mitochondrial protection, muscle performance. metabolic, cardiovascular, degenerative diseases and regulation of genetic expressions.

https://www.sciencedirect.com/science/article/abs/pii/B9780443189517000177 (2024).--

https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.3777 (2024).----

https://www.itjfs.com/index.php/ijfs/article/view/2459 (2024).---

https://www.mdpi.com/2072-6643/14/17/3494/htm (2022).---

https://www.tandfonline.com/doi/abs/10.1080/10408398.2022.2036693 (2023).--

https://www.mdpi.com/2072-6643/15/20/4441 (2023).-

https://www.mdpi.com/2076-3921/12/7/1479 (2023).--

https://www.sciencedirect.com/science/article/pii/S0098299722000541 (2023).--

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085614/ (2023).--

https://www.mdpi.com/2072-6643/15/18/3884 (2023)

This study reports that ellagic acid (EA) and urolithins can exert preventive and curative effects on cardiovascular diseases with negligible side effects and possibly regulate the imbalance of lipid metabolism, the production of pro-inflammatory factors, the proliferation of muscle cells vascular smoothing, cardiomyocyte apoptosis, endothelial cell dysfunction. This can potentially lead to the prevention and improvement of atherosclerosis, hypertension, myocardial infarction, cardiac fibrosis, cardiomyopathy, cardiac arrhythmias, and cardiotoxicities in vivo. Several molecules and signaling pathways are associated with their therapeutic actions, including phosphatidylinositol 3-kinase/protein kinase B, mitogen-activated protein kinase, NF-κB, nuclear factor erythroid-2 related factor 2, sirtuin1, miRNA, and extracellular signal-regulated kinase 1/2.

https://www.sciencedirect.com/science/article/abs/pii/S0944711323002283 (2023).----

This review focused on the role of intestinal bacteria in the conversion of ellagitannins to urolithins. According to the results of in vitro and in vivo studies, the health benefits of urolithins, including antioxidant, anti-inflammatory, anticancer, anti-obesity, anti-diabetic, anti-aging, cardiovascular protective, neuroprotective, kidney protective and muscle mass protective effects

https://pubmed.ncbi.nlm.nih.gov/35959701/ (2024).---

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