In 2020, Dr. Venn-Watson published a key peer-reviewed paper in Nature's Scientific Reports showing that C15:0 is the first essential fatty acid discovered since omega-3, which was over 90 years ago. Essential fatty acids are nutrients that our body needs to stay healthy, but cannot produce, so we must obtain these nutrients from our diet or supplements.
The unexpected discovery of C15:0 (pentadecanoic acid) as essential for maintaining long-term health was made while Dr. Venn-Watson was helping older Navy dolphins. "We found that some dolphins aged at a faster rate than others," shared Dr. Venn-Watson. "It's exciting that when dolphins were given a diet high in C15:0, they not only improved their metabolic and liver health, but also had evidence of slower aging." These two studies were published in the Proceedings of the National Academy of Sciences and PLOS ONE.
Today, more than 70 peer-reviewed studies from prestigious teams around the world have demonstrated the role of C15:0 in supporting long-term human metabolic, cardiac, liver and immune health. Some studies have linked a higher level of C15:0 with longer life.
In fact, pentadecanoic acid is associated with positive health markers such as balanced immunity, heart health, healthy metabolism, and overall cellular health. A recent study showed that people living in high-longevity areas (where more people live longer than the average world population) had higher body levels of C15:0 compared to people living in low-longevity areas. Another large-scale study that followed more than 14,000 people for 14 years showed that those who had more C15:0 in their diet had a lower risk of mortality during the study period.
Unfortunately, as we age, our C15:0 levels decrease and the likelihood of getting enough C15:0 in your diet is quite slim. It is mainly found in full-fat dairy products such as milk and butter.
There are different ways that C15:0 can help, and all of them specifically target well-known characteristics of aging:*
1) Supporting your body at the cellular level. As a tough fatty acid, C15:0 penetrates deep into our cells, strengthening cell membranes to keep them healthy and protect them from damage and fragility.
2) Increases cell stability and helps prevent premature cell degradation. In turn, we age less rapidly than if our cells remained unprotected and vulnerable to damage and stressors.
3) Protect mitochondrial function. Your mitochondria are responsible for cellular energy. Slow mitochondrial function means decreased cellular energy production and increased cellular stress, two major factors of cellular aging. C15:0 helps support mitochondrial function, so your cells' little power plants can continue to produce the energy they should.
4) Helping to maintain cellular homeostasis. Part of cellular aging causes our immune system and metabolism to become unbalanced over time. C15:0 naturally binds to key receptors throughout the body, called PPARs, which help support healthy metabolism and immunity, so your cells stay healthier longer.
Pentadecanoic acid (C15:0) is an odd-chain saturated fatty acid present at trace levels in dairy fat and ruminant meat, as well as in some types of plants and fish. Large prospective cohort studies in humans have shown that higher blood concentrations of C15:0 are associated with lower risks of developing chronic diseases over time, such as type 2 diabetes, cardiovascular disease, and heart failure. Higher dietary intake and circulating concentrations of C15:0 have also been linked to lower mortality and increased longevity, as well as lower risks of chronic inflammation, gestational diabetes, hypertension, nonalcoholic fatty liver disease, as well as nonalcoholic steatohepatitis. less severe and chronic disease. obstructive pulmonary disease.
These studies built on existing literature on the anticancer and antimicrobial properties of C15:0, as well as being the first to demonstrate the potential of C15:0 to help manage depression and autoimmune diseases.
Also another study found that mild weight loss induced by a Mediterranean diet adapted for Asians has multiple beneficial health effects in women with NAFLD. C15:0 supplementation lowers LDL cholesterol and may lead to beneficial changes in the gut microbiome.
To evaluate the potential of C15:0 to improve processes associated with longevity and health, human cell-based molecular phenotyping assays were used to compare C15:0 with three longevity-enhancing candidates: acarbose, metformin, and rapamycin.
C15:0 has the additional benefit over rapamycin and metformin that its associations with health are studied in global meta-analyses of large prospective cohort studies that have been conducted for decades, most of which included healthy patients. individuals; These studies consistently show that people with higher circulating concentrations of C15:0 have a lower risk of aging-related conditions. Given the voluminous literature supporting it, we propose C15:0 as a natural, effective and safe odd-chain saturated fatty acid, with strong evidence that this essential nutrient supports healthy aging and longevity in humans, with activities based in cells that are as good as, or better than, leading prescription therapies for improving longevity. Given the decline in C15:0 levels throughout the population, it is necessary to evaluate the potential effects of C15:0 nutritional deficiencies on our health and longevity.
Linking to the PPARalpha-promoted obesity mechanism, synthetic ligands for PPARα, collectively known as peroxisome proliferators, are a perfect tool to study PPARα function. The most striking effect of administering peroxisome proliferators to rodents is a dramatic enlargement of the liver. Prolonged treatment with peroxisome proliferators causes enlargement and formation of liver tumors, indicating a role for PPARα in hepatocyte proliferation and/or the cell cycle. PPARγ has also attracted the attention of almost every medical specialty, including diabetes, gastroenterology, dermatology, oncology, and cardiology. PPARγ has also attracted a lot of interest among researchers studying obesity. PPARγ is not only highly expressed in adipose tissue, but also plays a very important role in adipogenesis.
In vitro and in vivo studies on apigenin, arjunolic acid, astaxanthin, berberine, resveratrol, vaticanol C, hispidulin, ginsenoside Rb3 and genistein showed significant effects on CVD complications by targeting PPAR-α. This review provides information on various natural products that may work to prevent CVD by targeting the PPAR-α receptor along with their detailed mechanism.
Several evidences support the use of silymarin, berberine, curcumin, Nigella sativa, Ascophyllum nodosum and Fucus vesiculosus, vitamin E, coenzyme Q10 and Omega-3 are effective against obesity, hepatic steatosis, type 2 Diabetes Mellitus.
Patients with diabetes have a prevalence of MAFLD two to three times higher than patients without diabetes. Inadequate fat deposits in the liver cause alterations in energy metabolism and the inflammatory state, generating insulin resistance. Due to this chronic hyperinsulinemia, patients with diabetes tend to accumulate more fat in the liver. In these patients, the severity, morbidity, progression, and liver-related mortality associated with MAFLD are much higher.
There is numerous evidence that highlights the use of therapies such as incretins or the use of inhibitors of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) and PPARalpha or other similar therapies that, by helping existing therapies for pathologies such as diabetes, hypertension, insulin resistance, with great progress in the prevention and reduction of cardiometabolic risk. This review provided an overview of current therapeutic strategies that are expected to help in the treatment and prevention of MAFLD.
We didn't evolve from some cosmic fart. The assertion the world is millions of years old is unprovable and frankly defies common sense. God created the world by his spoken word in 6 days and He rested on the 7th.
People who don't read His words or who want to be their own 'gods' strive to reduce his power and His design for the world because they consciously or subconsciously know they are defying His will, so they rationalize away His power..
Even ungodly geneticists have figured out we all came from one man, Adam. God made man first. He said, 'let us make man in our image... - and boom! Man was made. And He called him Adam..' Then He made Eve by causing her to fall asleep and taking a rib out of Adam.
Adam was a child of God and we are all Adam. When Eve was tempted in the garden and took the fruit of the tree of the knowledge of good and evil, and Adam took of the fruit, we were all condemned. Death entered into the world from that moment. That's why the bible often says 'man' or 'mankind' when referring to people. The apostle Paul said we are all Adam.
So we are all under the curse, and we are powerless to correct this problem on our own. It's only by faith in the Lord Jesus Christ who left his heavenly throne above to walk a perfect sin free life and laid it down on the cross to take away God's wrath. We are saved by grace, through faith in the finished work of Christ on the cross. Jesus took our punishment for us. God is holy, and when he sees we are covered by the blood of the Lamb(Jesus), our sins are forgiven and forgotten. But we must keep the faith until the end and never deny it. that means there are times when we will suffer persecution, even death to prevent being coerced to deny the Lord. Satan came for to steal, to kill and to destroy. His goal is to steal us from the Lord. He will try to get people to deny the Lord. This is a bridge we may never cross as it will have eternal, catastrophic consequences.
God made it all, and it didn't take a cosmic fart billions of years for it to happen.
I left a similar (but shorter response) earlier, and was banned from Mercola articles for doing so. At least I presume this was the reason for the ban, as it is my only recent comment. I see my comment has been deleted. Apparently asserting that God created the system we live in does not align with community standards at Mercola. I have followed Mercola for 10 yrs. It was an automated message with no right of reply, or question and no explanation of what in fact are the 'community guidelines' or how I breached them, or with what comment, or statement. To say I am utterly shocked at behaviour I would have expected from the psychopathic elite, coming instead from Mercola, is an understatement. I am leaving this response here because there is simply no other recourse. It will likely be deleted like the other comment.
In my opinion, All mammals did not evolve from the same source. The first sentence in this presentation is a turn off that dismisses our creation. I’m surprised & disappointed to see this shared.
In 2020, Dr. Venn-Watson published a key peer-reviewed paper in Nature's Scientific Reports showing that C15:0 is the first essential fatty acid discovered since omega-3, which was over 90 years ago. Essential fatty acids are nutrients that our body needs to stay healthy, but cannot produce, so we must obtain these nutrients from our diet or supplements.
The unexpected discovery of C15:0 (pentadecanoic acid) as essential for maintaining long-term health was made while Dr. Venn-Watson was helping older Navy dolphins. "We found that some dolphins aged at a faster rate than others," shared Dr. Venn-Watson. "It's exciting that when dolphins were given a diet high in C15:0, they not only improved their metabolic and liver health, but also had evidence of slower aging." These two studies were published in the Proceedings of the National Academy of Sciences and PLOS ONE.
Today, more than 70 peer-reviewed studies from prestigious teams around the world have demonstrated the role of C15:0 in supporting long-term human metabolic, cardiac, liver and immune health. Some studies have linked a higher level of C15:0 with longer life.
In fact, pentadecanoic acid is associated with positive health markers such as balanced immunity, heart health, healthy metabolism, and overall cellular health. A recent study showed that people living in high-longevity areas (where more people live longer than the average world population) had higher body levels of C15:0 compared to people living in low-longevity areas. Another large-scale study that followed more than 14,000 people for 14 years showed that those who had more C15:0 in their diet had a lower risk of mortality during the study period.
Unfortunately, as we age, our C15:0 levels decrease and the likelihood of getting enough C15:0 in your diet is quite slim. It is mainly found in full-fat dairy products such as milk and butter.
There are different ways that C15:0 can help, and all of them specifically target well-known characteristics of aging:*
1) Supporting your body at the cellular level. As a tough fatty acid, C15:0 penetrates deep into our cells, strengthening cell membranes to keep them healthy and protect them from damage and fragility.
2) Increases cell stability and helps prevent premature cell degradation. In turn, we age less rapidly than if our cells remained unprotected and vulnerable to damage and stressors.
3) Protect mitochondrial function. Your mitochondria are responsible for cellular energy. Slow mitochondrial function means decreased cellular energy production and increased cellular stress, two major factors of cellular aging. C15:0 helps support mitochondrial function, so your cells' little power plants can continue to produce the energy they should.
4) Helping to maintain cellular homeostasis. Part of cellular aging causes our immune system and metabolism to become unbalanced over time. C15:0 naturally binds to key receptors throughout the body, called PPARs, which help support healthy metabolism and immunity, so your cells stay healthier longer.
https://www.discoverc15.com/resources/ .---
https://fatty15.com/blogs/news/what-causes-aging-and-can-it-be-slowed (2023).---
https://www.prweb.com/releases/could-a-saturated-fat-be-the-missing-link-in-longevity-research--896455758.html (2023).--
Pentadecanoic acid (C15:0) is an odd-chain saturated fatty acid present at trace levels in dairy fat and ruminant meat, as well as in some types of plants and fish. Large prospective cohort studies in humans have shown that higher blood concentrations of C15:0 are associated with lower risks of developing chronic diseases over time, such as type 2 diabetes, cardiovascular disease, and heart failure. Higher dietary intake and circulating concentrations of C15:0 have also been linked to lower mortality and increased longevity, as well as lower risks of chronic inflammation, gestational diabetes, hypertension, nonalcoholic fatty liver disease, as well as nonalcoholic steatohepatitis. less severe and chronic disease. obstructive pulmonary disease.
These studies built on existing literature on the anticancer and antimicrobial properties of C15:0, as well as being the first to demonstrate the potential of C15:0 to help manage depression and autoimmune diseases.
Also another study found that mild weight loss induced by a Mediterranean diet adapted for Asians has multiple beneficial health effects in women with NAFLD. C15:0 supplementation lowers LDL cholesterol and may lead to beneficial changes in the gut microbiome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135213/ (2022).—
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268778 (2022).---
https://www.sciencedirect.com/science/article/pii/S0002916523662859 (2024).--
To evaluate the potential of C15:0 to improve processes associated with longevity and health, human cell-based molecular phenotyping assays were used to compare C15:0 with three longevity-enhancing candidates: acarbose, metformin, and rapamycin.
C15:0 has the additional benefit over rapamycin and metformin that its associations with health are studied in global meta-analyses of large prospective cohort studies that have been conducted for decades, most of which included healthy patients. individuals; These studies consistently show that people with higher circulating concentrations of C15:0 have a lower risk of aging-related conditions. Given the voluminous literature supporting it, we propose C15:0 as a natural, effective and safe odd-chain saturated fatty acid, with strong evidence that this essential nutrient supports healthy aging and longevity in humans, with activities based in cells that are as good as, or better than, leading prescription therapies for improving longevity. Given the decline in C15:0 levels throughout the population, it is necessary to evaluate the potential effects of C15:0 nutritional deficiencies on our health and longevity.
https://www.mdpi.com/2072-6643/15/21/4607 (2024)
Linking to the PPARalpha-promoted obesity mechanism, synthetic ligands for PPARα, collectively known as peroxisome proliferators, are a perfect tool to study PPARα function. The most striking effect of administering peroxisome proliferators to rodents is a dramatic enlargement of the liver. Prolonged treatment with peroxisome proliferators causes enlargement and formation of liver tumors, indicating a role for PPARα in hepatocyte proliferation and/or the cell cycle. PPARγ has also attracted the attention of almost every medical specialty, including diabetes, gastroenterology, dermatology, oncology, and cardiology. PPARγ has also attracted a lot of interest among researchers studying obesity. PPARγ is not only highly expressed in adipose tissue, but also plays a very important role in adipogenesis.
https://www.sciencedirect.com/science/article/abs/pii/S0014299902014310 (2002).---
In vitro and in vivo studies on apigenin, arjunolic acid, astaxanthin, berberine, resveratrol, vaticanol C, hispidulin, ginsenoside Rb3 and genistein showed significant effects on CVD complications by targeting PPAR-α. This review provides information on various natural products that may work to prevent CVD by targeting the PPAR-α receptor along with their detailed mechanism.
https://link.springer.com/article/10.1007/s11010-023-04755-7 (2024).---
Several evidences support the use of silymarin, berberine, curcumin, Nigella sativa, Ascophyllum nodosum and Fucus vesiculosus, vitamin E, coenzyme Q10 and Omega-3 are effective against obesity, hepatic steatosis, type 2 Diabetes Mellitus.
Patients with diabetes have a prevalence of MAFLD two to three times higher than patients without diabetes. Inadequate fat deposits in the liver cause alterations in energy metabolism and the inflammatory state, generating insulin resistance. Due to this chronic hyperinsulinemia, patients with diabetes tend to accumulate more fat in the liver. In these patients, the severity, morbidity, progression, and liver-related mortality associated with MAFLD are much higher.
There is numerous evidence that highlights the use of therapies such as incretins or the use of inhibitors of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) and PPARalpha or other similar therapies that, by helping existing therapies for pathologies such as diabetes, hypertension, insulin resistance, with great progress in the prevention and reduction of cardiometabolic risk. This review provided an overview of current therapeutic strategies that are expected to help in the treatment and prevention of MAFLD.
https://www.frontiersin.org/articles/10.3389/fnut.2024.1355732/full (2024).--
We didn't evolve from some cosmic fart. The assertion the world is millions of years old is unprovable and frankly defies common sense. God created the world by his spoken word in 6 days and He rested on the 7th.
People who don't read His words or who want to be their own 'gods' strive to reduce his power and His design for the world because they consciously or subconsciously know they are defying His will, so they rationalize away His power..
Even ungodly geneticists have figured out we all came from one man, Adam. God made man first. He said, 'let us make man in our image... - and boom! Man was made. And He called him Adam..' Then He made Eve by causing her to fall asleep and taking a rib out of Adam.
Adam was a child of God and we are all Adam. When Eve was tempted in the garden and took the fruit of the tree of the knowledge of good and evil, and Adam took of the fruit, we were all condemned. Death entered into the world from that moment. That's why the bible often says 'man' or 'mankind' when referring to people. The apostle Paul said we are all Adam.
So we are all under the curse, and we are powerless to correct this problem on our own. It's only by faith in the Lord Jesus Christ who left his heavenly throne above to walk a perfect sin free life and laid it down on the cross to take away God's wrath. We are saved by grace, through faith in the finished work of Christ on the cross. Jesus took our punishment for us. God is holy, and when he sees we are covered by the blood of the Lamb(Jesus), our sins are forgiven and forgotten. But we must keep the faith until the end and never deny it. that means there are times when we will suffer persecution, even death to prevent being coerced to deny the Lord. Satan came for to steal, to kill and to destroy. His goal is to steal us from the Lord. He will try to get people to deny the Lord. This is a bridge we may never cross as it will have eternal, catastrophic consequences.
God made it all, and it didn't take a cosmic fart billions of years for it to happen.
Thank you Matt!
I left a similar (but shorter response) earlier, and was banned from Mercola articles for doing so. At least I presume this was the reason for the ban, as it is my only recent comment. I see my comment has been deleted. Apparently asserting that God created the system we live in does not align with community standards at Mercola. I have followed Mercola for 10 yrs. It was an automated message with no right of reply, or question and no explanation of what in fact are the 'community guidelines' or how I breached them, or with what comment, or statement. To say I am utterly shocked at behaviour I would have expected from the psychopathic elite, coming instead from Mercola, is an understatement. I am leaving this response here because there is simply no other recourse. It will likely be deleted like the other comment.
This has left such a sour taste in my mouth.
I just left a similar response. Waiting to see if I’m banned next. Totally agree with you
In my opinion, All mammals did not evolve from the same source. The first sentence in this presentation is a turn off that dismisses our creation. I’m surprised & disappointed to see this shared.