Garlic supplements have been shown to be effective in lowering blood pressure in hypertensive patients, similar to standard first-line antihypertensive medications and without the side effects. Garlic has shown promise in improving cardiovascular health by reducing arterial stiffness, elevated cholesterol levels, and blood "stickiness." In addition, the prebiotic properties of garlic increase intestinal microbial richness and diversity. Meta-analysis of 12 trials and 553 hypertensive participants confirmed that garlic supplements reduce systolic blood pressure.

Vitamin B12 status plays an important role in blood pressure responsiveness to garlic. https://www.spandidos-publications.com/10.3892/etm.2019.8374?text=fulltext#  (2020).----- 1.- Garlic activates nitric oxide, which leads to vasodilation. Garlic-derived polysulfides improve endothelial nitric oxide (NO) regulation, which induces smooth muscle cell relaxation, vasodilation, and BP reduction. with supplements of organic sulfur compounds derived from garlic. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250/  (2014).--- https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.289  (2023).---- 2.- Sulfur is linked to the methylation pathway, and both require several cofactors, such as vitamin B12, folic acid, vitamin B2 and vitamin B6.

Deficiencies in cofactors, such as vitamin B12, may explain the individual blood pressure responsiveness to garlic observed in our clinical trials. 3. Improves the intestinal microbiota, with microbial richness and diversity that significantly reduces blood pressure that was accompanied by a decrease in acetate and butyrate-producing bacteria. Elevated BP is associated with gut microbiota dysbiosis.

The gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), lipopolysaccharides (LPS), and trimethylamine N-oxide (TMAO), affect hypertension and atherosclerosis. It was shown that hypertensive patients have a lower abundance of SCFA-producing microbiota and a higher abundance of gram-negative bacteria, which are a source of LPS. https://www.nature.com/articles/s41467-020-18871-1  (2020).-- https://www.mdpi.com/2072-6643/12/10/2982  (2020).-- https://www.sciencedirect.com/science/article/abs/pii/S0006295222003963  (2022).-- https://www.mdpi.com/2076-3417/12/19/9673  (2022).-- Garlic can reduce blood pressure, waist circumference, body mass index, LDL-C, triglycerides, and inflammatory markers.

It can also increase HDL-c levels and can improve cardiovascular parameters such as coronary artery calcium, microcirculation, epicardial and periaortic adipose tissue, low-attenuation plaque, carotid intima-media thickness; and carotid intima-media thickness. The genus Allium (are rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer activity, preventive of cardiovascular and heart diseases, anti-inflammatory, anti-obesity, anti-diabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, etc.

Numerous Scientific works reveal the positive effect of organosulfur compounds from plants of the Allium genus on the immune system and inflammatory processes. https://www.tandfonline.com/doi/abs/10.1080/10408398.2022.2043821  (2022).---- https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7729  (2023).-- https://www.sciencedirect.com/science/article/abs/pii/S0378874123008280  (2023).--

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Prolonged aging of garlic in dilute alcohol, without heat, produces unique and potent compounds, including S-allylcysteine and other S-allyl compounds. These sulfur-based components have powerful oxidant-reducing qualities. The aging process can also produce other beneficial compounds. In addition to the collective findings of the 2016 review, more recent studies on the cardioprotective effects of aged garlic extract have revealed notable results. One of the most compelling effects of aged garlic extract is its ability to help reverse early heart disease. It does this by removing the buildup of deadly plaque on the walls of your arteries.

In a randomized, double-blind study, researchers gave patients with metabolic syndrome (ages 40 to 75) a placebo or 2,400 mg of aged garlic extract daily. They then tested their coronary arteries (those that supply blood to the heart) for plaque. A follow-up examination one year later showed that those who took garlic experienced a slower buildup of total plaque compared to the placebo group. Most impressively, regression of the “low attenuation” plate occurred. https://www.lifeextension.com/magazine/2018/10/aged-garlic-reduces-heart-disease-risk-factors

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