No you can get it pretty easily. Amazon sells it, search for progesterone powder. There are various sources now and then of USP progesterone. I keep mine in the freezer so it can last indefinitely.
However, the best progesterone is Progest-E by Kenogen. I buy mine from Long Natural Health. It contains vitamin E, progesterone and fully saturated oils and works great.
The so-called “chromanol” head is the fundamental unit of vitamin E, and is also the site of antioxidant activity. Vitamin E is made up of four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta).
The slight difference between tocotrienols and tocopherols is in the unsaturated side chain which has three double bonds in its farnesyl isoprenoid tail. Tocotrienols are natural compounds found in walnuts, pumpkin seeds, sea buckthorn, broccoli, cereal bran and other foods that, due to their omega 6 content, we must consider the total intake of omega 6 because the evidence that supports the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties as reported by Dr. Mercola.
Dr. Lester Packer of the University of California/Berkeley reports tocotrienol's superior antioxidant capacity is attributed to its greater flexibility, allowing greater mobility to cover a greater surface area of cell membranes.
Tocotrienols safely address all three areas of atherogenic dyslipidemia: reduction in triglyceride levels, moderate increase in HDL cholesterol. Additionally, there is evidence in animal studies that tocotrienol reduces blood pressure, arterial plaques, adhesion molecules, and blood sugar, all signs of metabolic syndrome.
"Tocotrienols exhibit very different health benefits than tocopherols, and in most cases these activities are superior for human use," says biochemist Bharat B. Aggarwal, PhD, of MD Anderson Cancer Center. from the University of Texas at Houston, where he and his team study curcumin, resveratrol, tocotrienols and other natural compounds that could help us beat cancer. “We now know that different isomers of tocotrienols exhibit different activities. “While alpha-tocotrienol is highly effective in the brain for cerebral ischemia, gamma and delta tocotrienol exhibit greater anticancer and anti-inflammatory activities.”
There is groundbreaking research showing that tocotrienols can improve and often cure fatty liver disease, improve end-stage liver disease, and protect liver function.
Tocotrienols protect neurons, prevent neuronal cell death, inhibit cholesterol and beneficially alter its fractions, and dampen inappropriate inflammation.
Tocotrienol lowers cholesterol by regulating and decreasing the enzyme responsible for its production in the liver and this is a safe route to address cholesterol compared to statins with their harmful side effects.
Vitamin E and especially tocotrienols control inflammatory mechanisms and markers, including the reduction of atherogenic lipoprotein, also inhibiting the adhesion of sticky molecules present in the first stage of atherosclerosis.
Bacterial infections contribute to the body's inflammatory response and tocotrienols have been shown to reduce infection by chlamydia, a bacteria found in atherosclerotic tissue, and exacerbate inflammation. In summary, tocotrienols promote arterial health. δ-Tocotrienol in combination with resveratrol improves cardiometabolic risk factors and biomarkers in patients with metabolic syndrome
Some studies found that vitamin E affects certain transcription factors, such as nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that induces the expression of many antioxidant enzymes. Vitamin E supplementation increases antioxidant activity in the musculoskeletal system, slowing the progression of osteoarthritis, and may also inhibit the NFκB pathway, suppressing inflammation
Compared to tocopherols, some studies indicate that tocotrienols may be more potent antioxidants; although this is not supported by all studies. Regardless of which antioxidants are the most effective, tocotrienols clearly play an important role in cellular metabolism. For example, while all vitamin E vitamers can scavenge free radicals, tocotrienols are thought to be better scavengers due to uniform distribution within membranes, a large number of double bonds, and higher efficiency of the redox cycle. A study was conducted that examined the ability of vitamin E to increase endogenous antioxidants in healthy older adults (50–55 years) by supplementation with α-tocopherol or a tocotrienol-rich fraction, compared to a placebo. Compared to baseline levels, six months of tocotrienol-rich supplements significantly increased superoxide dismutase levels in the entire population; α-Tocopherol, however, had no impact on this measure. When examined by gender, women had significant increases in both superoxide dismutase and glutathione peroxidase after six months of supplementation with a tocotrienol-rich fraction. α-Tocopherol only had a significant impact when examining the ratio of reduced glutathione to oxidized glutathione in women; tocotrienol-rich fractions also significantly affected this measure.
The authors suggest that this higher ratio of reduced glutathione to oxidized glutathione indicates better cellular health, as a lower ratio is associated with chronic diseases such as diabetes, high blood pressure, and Alzheimer's disease. While males showed similar patterns, the impact was not significant
After absorption in the small intestine, vitamin E is transported within chylomicrons through the lymphatic system and is finally absorbed by the liver. The liver again secretes mainly α-tocopherol, to be transported through the bloodstream within various lipoproteins. From these lipoproteins, γ-tocopherol accumulates in specific tissues such as skin, muscle, and adipose tissue, while less is available in plasma, γ-tocopherol and its metabolites (e.g., 13′ -carboxychromanol) appear to have important anti-inflammatory effects by blocking cyclooxygenases (COX-1 and COX-2) which in turn block prostaglandin production, as well as by inhibiting 5-lipoxygenase (5-LOX) activity. Furthermore, due to structural differences, γ-tocopherol is able to trap electrophiles that α-tocopherol cannot. Therefore, it is superior to α-tocopherol in detoxifying nitrogen dioxide, peroxynitrite and copper-zinc superoxide dismutase, thereby protecting mitochondrial function.
This review article examines the potential of tocotrienols, a class of vitamin E compounds with antioxidant and anti-inflammatory activity, to improve aging-related cardiovascular diseases and their associated morbidities. In particular, the potential of tocotrienols to improve inflammation, dyslipidemia, and mitochondrial dysfunction in aging-related cardiovascular diseases is discussed. a class of vitamin E compounds with antioxidant and anti-inflammatory activity.
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality and atherosclerosis is the common root of most CVDs. Oxidative stress. Thus, strategies for the prevention and treatment of cardiovascular events had oxidative changes as a potential target. Natural . All tocopherols and tocotrienols are potent antioxidants with lipoperoxyl radical-scavenging activities. In addition, α-tocopherol possesses also anti-inflammatory as well as anti-atherothrombotic effects by modulating platelet and coagulation system. Experimental and in vitro studies described molecular and cellular signaling pathways regulated by vitamin E regulated by antithrombotic and antioxidant properties.
This review focuses on the impact of vitamin E on the atherothrombotic process and describes the results of experimental studies.
The anti-inflammatory effects of δ-tocotrienol, quercetin, riboflavin, on serum TNF-α and NO levels have been reported for the first time. Furthermore, all treatments except dexamethasone resulted in lower serum levels of total cholesterol, LDL cholesterol, and triglycerides. The mechanism for this inhibition appears to be decreased proteolytic degradation of the P-IB protein due to proteasome inhibition, resulting in decreased translocation of activated NF-κB to the nucleus and depressed transcription of expression. TNF-α and iNOS genes. The impact of the above compounds increased on these parameters when combined with δ-tocotrienol.
Furthermore, these results also indicated that intravenously administered tocotrienols inhibited acute platelet-mediated thrombus formation and collagen- and ADP-induced platelet aggregation. δ-Tocotrienol, riboflavin and quercetin inhibit NO production in macrophages.
Included in this review are 32 eligible meta-analyses with four sources of vitamin E and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheezing or asthma in children was corroborated with consistent evidence. Suggestive evidence was suggested for seven outcomes on endothelial function (supplementary vitamin E): serum C-reactive protein (CRP) concentrations (supplementary vitamin E), cervical cancer, esophageal cancer, cervical intraepithelial neoplasia, pancreatic cancer, and cancer. colorectal; all of them showed a protective effect consistent with the source of vitamin E. In conclusion, this work has indicated that vitamin E protects several particular health outcomes
In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes. Additionally, short-term interventions with vitamin E have resulted in lower fasting blood glucose levels in these patients.
I listened to podcast and recall hearing Dr. Mercola mention they were going to discuss CO2, and also his concerns with methylene blue, but then I never heard those discussions. Can someone point me to where in the podcast (or transcript) those were discussed?
I suspect you saw the second part of the interview came out later in another podcast episode. For anyone following along, that episode and accompanying article is here: https://takecontrol.substack.com/p/co2-benefits
No you can get it pretty easily. Amazon sells it, search for progesterone powder. There are various sources now and then of USP progesterone. I keep mine in the freezer so it can last indefinitely.
However, the best progesterone is Progest-E by Kenogen. I buy mine from Long Natural Health. It contains vitamin E, progesterone and fully saturated oils and works great.
yeah this stuff is awesome for every problem. I put it on bug bites even. Heals wounds really fast. Women can use it 20 days on and 10 days off.
The so-called “chromanol” head is the fundamental unit of vitamin E, and is also the site of antioxidant activity. Vitamin E is made up of four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta).
The slight difference between tocotrienols and tocopherols is in the unsaturated side chain which has three double bonds in its farnesyl isoprenoid tail. Tocotrienols are natural compounds found in walnuts, pumpkin seeds, sea buckthorn, broccoli, cereal bran and other foods that, due to their omega 6 content, we must consider the total intake of omega 6 because the evidence that supports the hypothesis that omega-6 PUFAs have proadipogenic and prolipogenic properties as reported by Dr. Mercola.
Dr. Lester Packer of the University of California/Berkeley reports tocotrienol's superior antioxidant capacity is attributed to its greater flexibility, allowing greater mobility to cover a greater surface area of cell membranes.
Tocotrienols safely address all three areas of atherogenic dyslipidemia: reduction in triglyceride levels, moderate increase in HDL cholesterol. Additionally, there is evidence in animal studies that tocotrienol reduces blood pressure, arterial plaques, adhesion molecules, and blood sugar, all signs of metabolic syndrome.
"Tocotrienols exhibit very different health benefits than tocopherols, and in most cases these activities are superior for human use," says biochemist Bharat B. Aggarwal, PhD, of MD Anderson Cancer Center. from the University of Texas at Houston, where he and his team study curcumin, resveratrol, tocotrienols and other natural compounds that could help us beat cancer. “We now know that different isomers of tocotrienols exhibit different activities. “While alpha-tocotrienol is highly effective in the brain for cerebral ischemia, gamma and delta tocotrienol exhibit greater anticancer and anti-inflammatory activities.”
There is groundbreaking research showing that tocotrienols can improve and often cure fatty liver disease, improve end-stage liver disease, and protect liver function.
Tocotrienols protect neurons, prevent neuronal cell death, inhibit cholesterol and beneficially alter its fractions, and dampen inappropriate inflammation.
Tocotrienol lowers cholesterol by regulating and decreasing the enzyme responsible for its production in the liver and this is a safe route to address cholesterol compared to statins with their harmful side effects.
Vitamin E and especially tocotrienols control inflammatory mechanisms and markers, including the reduction of atherogenic lipoprotein, also inhibiting the adhesion of sticky molecules present in the first stage of atherosclerosis.
Bacterial infections contribute to the body's inflammatory response and tocotrienols have been shown to reduce infection by chlamydia, a bacteria found in atherosclerotic tissue, and exacerbate inflammation. In summary, tocotrienols promote arterial health. δ-Tocotrienol in combination with resveratrol improves cardiometabolic risk factors and biomarkers in patients with metabolic syndrome
https://www.clinicaleducation.org/resources/reviews/the-next-generation-vitamin-e-how-tocotrienols-benefit-the-heart-brain-and-liver/ (2021).---
https://www.womenfitness.net/tocotrienols/ (2021).---
https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.11345 (2022).---
https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1873 (2022).----
https://www.sciencedirect.com/science/article/pii/S2405457722005198 (2022).---
https://aacrjournals.org/cancerpreventionresearch/article-abstract/15/4/233/682296/Tocotrienol-is-the-Most-Potent-Vitamin-E-Form-in (2022).----
https://www.mdpi.com/2072-6643/15/4/834 (2023).----
https://www.liebertpub.com/doi/abs/10.1089/met.2022.0052 (2023).---
https://www.sciencedirect.com/science/article/abs/pii/S2405457723000347 (2023).----
Some studies found that vitamin E affects certain transcription factors, such as nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that induces the expression of many antioxidant enzymes. Vitamin E supplementation increases antioxidant activity in the musculoskeletal system, slowing the progression of osteoarthritis, and may also inhibit the NFκB pathway, suppressing inflammation
Compared to tocopherols, some studies indicate that tocotrienols may be more potent antioxidants; although this is not supported by all studies. Regardless of which antioxidants are the most effective, tocotrienols clearly play an important role in cellular metabolism. For example, while all vitamin E vitamers can scavenge free radicals, tocotrienols are thought to be better scavengers due to uniform distribution within membranes, a large number of double bonds, and higher efficiency of the redox cycle. A study was conducted that examined the ability of vitamin E to increase endogenous antioxidants in healthy older adults (50–55 years) by supplementation with α-tocopherol or a tocotrienol-rich fraction, compared to a placebo. Compared to baseline levels, six months of tocotrienol-rich supplements significantly increased superoxide dismutase levels in the entire population; α-Tocopherol, however, had no impact on this measure. When examined by gender, women had significant increases in both superoxide dismutase and glutathione peroxidase after six months of supplementation with a tocotrienol-rich fraction. α-Tocopherol only had a significant impact when examining the ratio of reduced glutathione to oxidized glutathione in women; tocotrienol-rich fractions also significantly affected this measure.
The authors suggest that this higher ratio of reduced glutathione to oxidized glutathione indicates better cellular health, as a lower ratio is associated with chronic diseases such as diabetes, high blood pressure, and Alzheimer's disease. While males showed similar patterns, the impact was not significant
After absorption in the small intestine, vitamin E is transported within chylomicrons through the lymphatic system and is finally absorbed by the liver. The liver again secretes mainly α-tocopherol, to be transported through the bloodstream within various lipoproteins. From these lipoproteins, γ-tocopherol accumulates in specific tissues such as skin, muscle, and adipose tissue, while less is available in plasma, γ-tocopherol and its metabolites (e.g., 13′ -carboxychromanol) appear to have important anti-inflammatory effects by blocking cyclooxygenases (COX-1 and COX-2) which in turn block prostaglandin production, as well as by inhibiting 5-lipoxygenase (5-LOX) activity. Furthermore, due to structural differences, γ-tocopherol is able to trap electrophiles that α-tocopherol cannot. Therefore, it is superior to α-tocopherol in detoxifying nitrogen dioxide, peroxynitrite and copper-zinc superoxide dismutase, thereby protecting mitochondrial function.
https://www.mdpi.com/2227-9717/10/6/1222 (2022)
This review article examines the potential of tocotrienols, a class of vitamin E compounds with antioxidant and anti-inflammatory activity, to improve aging-related cardiovascular diseases and their associated morbidities. In particular, the potential of tocotrienols to improve inflammation, dyslipidemia, and mitochondrial dysfunction in aging-related cardiovascular diseases is discussed. a class of vitamin E compounds with antioxidant and anti-inflammatory activity.
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0244-4 (2018)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality and atherosclerosis is the common root of most CVDs. Oxidative stress. Thus, strategies for the prevention and treatment of cardiovascular events had oxidative changes as a potential target. Natural . All tocopherols and tocotrienols are potent antioxidants with lipoperoxyl radical-scavenging activities. In addition, α-tocopherol possesses also anti-inflammatory as well as anti-atherothrombotic effects by modulating platelet and coagulation system. Experimental and in vitro studies described molecular and cellular signaling pathways regulated by vitamin E regulated by antithrombotic and antioxidant properties.
This review focuses on the impact of vitamin E on the atherothrombotic process and describes the results of experimental studies.
https://www.sciencedirect.com/science/article/abs/pii/S089158492100825X (2022)
The anti-inflammatory effects of δ-tocotrienol, quercetin, riboflavin, on serum TNF-α and NO levels have been reported for the first time. Furthermore, all treatments except dexamethasone resulted in lower serum levels of total cholesterol, LDL cholesterol, and triglycerides. The mechanism for this inhibition appears to be decreased proteolytic degradation of the P-IB protein due to proteasome inhibition, resulting in decreased translocation of activated NF-κB to the nucleus and depressed transcription of expression. TNF-α and iNOS genes. The impact of the above compounds increased on these parameters when combined with δ-tocotrienol.
Furthermore, these results also indicated that intravenously administered tocotrienols inhibited acute platelet-mediated thrombus formation and collagen- and ADP-induced platelet aggregation. δ-Tocotrienol, riboflavin and quercetin inhibit NO production in macrophages.
https://europepmc.org/article/med/36626569 (2022)
Included in this review are 32 eligible meta-analyses with four sources of vitamin E and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheezing or asthma in children was corroborated with consistent evidence. Suggestive evidence was suggested for seven outcomes on endothelial function (supplementary vitamin E): serum C-reactive protein (CRP) concentrations (supplementary vitamin E), cervical cancer, esophageal cancer, cervical intraepithelial neoplasia, pancreatic cancer, and cancer. colorectal; all of them showed a protective effect consistent with the source of vitamin E. In conclusion, this work has indicated that vitamin E protects several particular health outcomes
https://www.mdpi.com/2072-6643/15/15/3301 (2023)
This study shows that taking vitamin E can reduce the risk of Parkinson's disease and play a preventive role.
https://www.tandfonline.com/doi/abs/10.1080/1028415X.2023.2192561 (2023)
In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes. Additionally, short-term interventions with vitamin E have resulted in lower fasting blood glucose levels in these patients.
https://nutritionj.biomedcentral.com/articles/10.1186/s12937-023-00840-1 (2023)
Just to confirm you can take both Pregnenolone and progesterone? And the dosage is 30-50mg of each, even when taking both?
Same question - are both recommended to be taken or only progesterone?
I listened to podcast and recall hearing Dr. Mercola mention they were going to discuss CO2, and also his concerns with methylene blue, but then I never heard those discussions. Can someone point me to where in the podcast (or transcript) those were discussed?
I suspect you saw the second part of the interview came out later in another podcast episode. For anyone following along, that episode and accompanying article is here: https://takecontrol.substack.com/p/co2-benefits