Ginger has a long history of medicinal use dating back 2,500 years. Ginger has been traditionally used since time immemorial for various human ailments in different parts of the world. Some pungent components present in ginger and other zingiberaceae plants have potent antioxidant and anti-inflammatory activities, and some of them exhibit cancer preventive activity. 50% of approved cancer therapeutic agents are derived from natural products and secondly, metabolites from medicinal plants have shown great prospect as a source of anticancer and chemopreventive compounds.
The summarized data from experiments (in vitro or in vivo) and clinical studies, evidenced in the reviews, show that ginger derivatives perpetrate their antitumor action through important mediators, involved in crucial cellular processes, such as cell cycle arrest, the induction of cancer cells. death, imbalance of redox homeostasis, inhibition of cell proliferation, angiogenesis, migration and dissemination of cancer cells.
The anti-cancer properties of ginger are attributed to the presence of certain pungent valinoids viz. [6]-gingerol and [6]-paradol, as well as some other components such as shogaols, zingerone, etc. Several mechanisms have been reported that may be involved in the chemopreventive effects of ginger. The anticancer activity of ginger is attributed to its ability to modulate various signaling molecules such as NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9 , survivin, cIAP-1, XIAP, Bcl-2, caspases and other cell growth regulatory proteins.
Ginger has potential for the daily prevention and clinical treatment of cholerectal cancer. Another benefit of ginger in cancer therapy is its potential to alleviate treatment-related side effects.
In addition to its anti-nausea effects, ginger may also improve
effectiveness of certain chemotherapeutic agents. Research suggests that ginger may sensitize cancer cells to the cytotoxic effects of chemotherapeutic drugs, potentially improving treatment outcomes.
Ginger has a long history of medicinal use dating back 2,500 years. Ginger has been traditionally used since time immemorial for various human ailments in different parts of the world. Some pungent components present in ginger and other zingiberaceae plants have potent antioxidant and anti-inflammatory activities, and some of them exhibit cancer preventive activity. 50% of approved cancer therapeutic agents are derived from natural products and secondly, metabolites from medicinal plants have shown great prospect as a source of anticancer and chemopreventive compounds.
The summarized data from experiments (in vitro or in vivo) and clinical studies, evidenced in the reviews, show that ginger derivatives perpetrate their antitumor action through important mediators, involved in crucial cellular processes, such as cell cycle arrest, the induction of cancer cells. death, imbalance of redox homeostasis, inhibition of cell proliferation, angiogenesis, migration and dissemination of cancer cells.
The anti-cancer properties of ginger are attributed to the presence of certain pungent valinoids viz. [6]-gingerol and [6]-paradol, as well as some other components such as shogaols, zingerone, etc. Several mechanisms have been reported that may be involved in the chemopreventive effects of ginger. The anticancer activity of ginger is attributed to its ability to modulate various signaling molecules such as NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9 , survivin, cIAP-1, XIAP, Bcl-2, caspases and other cell growth regulatory proteins.
Ginger has potential for the daily prevention and clinical treatment of cholerectal cancer. Another benefit of ginger in cancer therapy is its potential to alleviate treatment-related side effects.
In addition to its anti-nausea effects, ginger may also improve
effectiveness of certain chemotherapeutic agents. Research suggests that ginger may sensitize cancer cells to the cytotoxic effects of chemotherapeutic drugs, potentially improving treatment outcomes.
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