Apr 20, 2023·edited Apr 20, 2023

As Dr. Mercola establishes in this relevant article, the methionine/glycine ratio is essential. Inflammation is a common factor in cancer, cardiovascular disease, and diabetes, as well as arthritis and other inflammatory diseases.

Studies establish an inverse association of plasma glycine levels between patients with insulin resistance and diabetes, cardiovascular disease, and cancer. This suggests that low blood glycine levels can lead to a hyperinflammatory state, predisposing the body to a spectrum of chronic diseases including cancer.

Plasma glycine levels in human populations, while may be adequate for the biochemical functions of glycine, including protein synthesis, may not be sufficient for the cellular physiological role of glycine in membrane voltage stabilization, cell activation. in macrophages and other cells.

Glycine comprises one-third of the mole fraction of collagen, and it is postulated that such chronic diseases have been on the rise because the consumption of glycine-rich bone and connective tissues has declined in recent decades.

Amino acid metabolism suggests a more complex relationship between glycine and methionine, the latter of which is abundant in muscle meats. Specifically, glycine is the only substrate for glycine-N-methyltransferase, which comprises the only major pathway of methionine clearance. Triggered by the absorption of a methionine-rich meal, elimination of excess methionine requires two to three molar equivalents of glycine per mole of methionine. Therefore, it could be hypothesized that high consumption of methionine-rich, glycine-poor muscle meats without the connective tissues as staple foods causes a net reduction in plasma glycine levels.

This hypothesis among the participants of the EPIC study in the United Kingdom. Carnivores consuming high methionine and low glycine intake had the lowest plasma glycine levels than other diets.

Observational studies, a clinical trial in Mexico City a decade ago reported the reversal of type 2 diabetes with the consumption of 15 g/day of supplemental glycine for 90 days. Glycine decreases proinflammatory cytokines and increases interferon-γ in patients with type 2 diabetes.

Observationally, the inverse association of type 2 diabetes and prediabetes with plasma glycine has been abundantly documented, as evidenced by the recent SRMA of 46 studies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839172/ (2016)-----

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859380/ (2016).-----

https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/bmc.3893 (2017).-----

https://www.jbc.org/article/S0021-9258(17)30753-6/fulltext (2009).---

https://www.nature.com/articles/ejcn2015144 (2015).---

https://link.springer.com/article/10.1007/BF03346417 (2008).----

https://www.bmj.com/content/360/bmj.k134/rr-1 (2018).---

Glycine administration modulates dietary amino acid levels especially methionine, which may increase healthy lifespan in mice and provide a basis for further investigation of the effects of diet on aging and old-age diseases.

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12953 (2019)


https://www.mdpi.com/2076-3921/11/1/154 (2022)

Glycine supplementation improves various components of the metabolic syndrome, such as diabetes, obesity, hyperlipidemia, and hypertension. In the future, the use of glycine may have a significant clinical impact in the treatment of patients with metabolic syndrome.

https://link.springer.com/article/10.1007/s40618-021-01720-3 (2022)

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition

https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.372 (2021)


https://www.sciencedirect.com/science/article/pii/S2213231722000854 (2022)


https://www.sciencedirect.com/science/article/pii/S2212877820301800 (2021)

Higher levels of glycine, glutamine, betaine, indolepropionate, and (phosphatidylcholines) were associated with a lower risk of type 2 diabetes.

https://diabetesjournals.org/care/article/45/4/1013/144892/Metabolomics-and-Type-2-Diabetes-Risk-An-Updated (2022)

Glycine is synthesized from serine, threonine, choline, and hydroxyproline through interorgan metabolism primarily involving the liver and kidneys. The main pathway is glycine synthesis is a serine cleavage reaction that yields two different products: a glycine molecule plus a C1 unit carried by tetrahydrofolate for other metabolic processes. Metabolism requires much more glycine than C1 units. The amount of glycine available from synthesis, around 3 g/day, together with that from the diet, may be below the amount needed for all metabolic uses, including collagen synthesis by 10 g per day. day for a person of 70 kg. This result supports that glycine is a semi-essential amino acid.

http://www.ncbi.nlm.nih.gov/pubmed/20093739 .---

http://www.ncbi.nlm.nih.gov/pubmed/19179765 .---


Glycine also plays a role in the transmission of nerve signals and the removal of toxins from the body. Glycine stimulates the production of serotonin, the "feel good" hormone that helps elevate mood, improve sleep, and improve memory. Glycine is anti-inflammatory and antioxidant, both of which are properties that reduce the risk of heart disease. Therefore, some researchers have looked at the connection between glycine and heart disease.


https://www.healthline.com/nutrition/glycine .-----

Glyphosate in particular is working synergistically with most other factors to increase toxic effects. Glyphosate causes insidious damage through its action as an amino acid analogue of glycine, and that this interferes with natural protective mechanisms against other exposures.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6695815/ (2019)

Glycine also plays an important role in fighting inflammation, as explained by Dr. Mercola in the article "Glycine Suppresses Oxidative Damage by Inhibiting Superoxide NOX Production and Raising NADPH Levels," and is used in the detoxification process. As a result of glyphosate toxicity, many people do not have sufficient glycine levels for efficient detoxification.

NADPH is used as a reducing reservoir of electrons that serves to recharge antioxidants once they are oxidized. NADPH is also needed to produce steroid hormones and fats.

To prevent many chronic diseases, we need to find a way to inhibit or modulate NOX. Such strategies include avoiding fructose, practicing nutritional ketosis, and taking spirulina, niacin, glycine, and collagen supplements.

Glycine might be beneficial in preventing or treating metabolic syndrome, diabetic complications, and cardiac hypertrophy, as well as fatty liver disorders.

https://articulos.mercola.com/sitios/articulos/archivo/2022/04/01/que-son-la-nadph-y-la-nox.aspx (2022)


https://www.nutritionvalue.org/foods_by_Glycine_content.html .----

https://wholefoodcatalog.info/nutrient/glycine/foods/ .----

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Trying to find a supplement that accomplishes a dose of 10-12 g per day. What should I buy? The servings for most are in mg or ug….so I would have to take many many pills. Dr. Mercola…..what do you take?

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I am trying to do the same! The best one I found has 1000 mg per serving.

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Vital Nutrients has Glycine Powder. 4 grams per teaspoon.

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Thank you!!

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PureBulk glycine comes in powder. No addatives and tastes somewhat like sugar. Easy and great price!

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So then have to get the NAC separately I take it. Then wonder how much of that one should take

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PureBulk was suggested on an earlier thread. I ordered some. No additives and great price!

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Can we just take a glutathione supplement instead?

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If I purchase the L-Glycine in the Mercola store, I would have to take 40 capsules per day. That would be ridiculous!

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Apr 25, 2023·edited Apr 25, 2023

There were 92 comments on this article on the day it was posted, a few days ago, now there are 8 including my comment now. There were a lot of good information and good questions.

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Shoots I wonder why

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would "magnesium glycinate" help with obtaining glycine?

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Dr Mercola, a company call neumi is selling a product that is an oral rinse and swallow to deliver glutathione systemically through nano particle technology, which started to raise red flags to me as I heard of that being in the mRNA vaccines and does not seem safe, any thoughts on this?

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