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Coenzyme Q-10 increases adenosine tryposisphate levels by preventing the loss of the adenine nucleotide pool of cardiac cells. Additionally, coenzyme Q-10 has demonstrated activity in the prevention of lipid peroxidation and an indirect stabilizer of lipid peroxidation. calcium channels to reduce calcium overload. Coenzyme Q-10 has been authorized for treatment. of congestive heart failure, against ischemia and reperfusion injury in animal studies. CoQ 10 affects the function of all cells in the body, making it essential for the health of all tissues and organs. CoQ 10 also functions as an intracellular antioxidant at the mitochondrial level, which perhaps explains its benefit in neurodegenerative diseases, male infertility, periodontal disease, cardiovascular diseases, diabetes mellitus, cancer, asthma, kidney failure, migraine, and immunity.

In Fig. 1 Mechanism of action of Coenzyme Q10.

https://themedicon.com/pdf/medicalsciences/MCMS-04-121.pdf (2023)

In this systematic review, a total of 154 articles were analyzed to evaluate the metabolic effects of coenzyme Q10, magnesium and vitamin D on cardiovascular diseases. It was concluded that magnesium plays a fundamental role in the metabolism of glucose, insulin and glycemic homeostasis, in the synthesis of adenosine triphosphate, proteins and nucleic acids. Vitamin D plays an important role in innate and adaptive immune responses, cell cycle, and metabolic processes, as demonstrated by the reported relationship between its deficiency and the prevalence of immune-mediated disorders, cancer, and cardiometabolic diseases. Coenzyme Q10 exerts an important antioxidant protective action. The clinical studies carried out demonstrated that pathologies such as acute myocardial infarction, arterial hypertension, statin-induced myopathies, physical fatigue inherent to physical exercise, male infertility, preeclampsia, Parkinson's disease, periodontal diseases and migraines had low plasma concentrations of Q10. Additionally, Coenzyme Q10 reduces the amount of lipid peroxide found in atherosclerotic lesions. Thus, Q10 protects the lipids present in cell membranes, as well as plasma lipoproteins.

https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/259

(2023)

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