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Great cardiovascular remedies. Also quercetin is a flavonoid that exists largely in the daily diet and in various vegetables, fruits and plants, including onion, asparagus and berries, buckwheat and broccoli and as a supplement. Quercetin has become a potential therapeutic agent in cardiovascular diseases (CVD) in recent decades. Experimental studies including in vitro methods and in vivo animal models mainly describe the following effects of quercetin: (1) antihypertensive, (2) hypolipidemic, (3) hypoglycemic, (4) antiatherosclerotic, and (5) cardioprotective (suppressed cardiotoxicity). .

Quercetin may exert beneficial effects on arrhythmias by affecting cardiac ion channels, calcium homeostasis, gap junction and mitochondrial channels to inhibit mitochondrial oxidative stress and by suppressing cardiac fibrosis, inflammation, modulating autophagy and apoptosis. , improving ischemia and reperfusion injury. antiarrhythmia, heart failure, blood pressure regulation and intestinal microbiota.

Pharmacological studies also showed that quercetin exhibited biopharmacological activities such as antioxidant, antiplatelet aggregation, antiosteoporosis, antiaging and inhibition of cell proliferation, which can be used in the treatment of lymphoma, autoimmune diseases, neurological diseases, cancer, etc.

The reviews discuss the effects of quercetin: (1) antihypertensive, (2) hypolipidemic, (3) hypoglycemic, (4) antiatherosclerotic, and (5) cardioprotective (suppressed cardiotoxicity). From a clinical point of view, there are studies and meta-analyses in humans that imply its beneficial effects on glycemic and lipid parameters.

Quercetin through Nrf2 modulates mitochondria, apoptosis and autophagy, which reinforces the potential for non-communicable diseases. At the molecular level, it interacts mainly with sirtuins and modulates numerous signaling pathways, which contributes to its therapeutic effects.

Quercetin has also been used alone or in combination for the treatment of various diseases, including malignant tumors, autoimmune diseases, viral diseases, periodontal disease, and metabolic diseases.

https://www.sciencedirect.com/science/article/pii/S0753332222008368 (2022).-----

https://www.nature.com/articles/s41598-022-13911-w (2022).----

https://www.mdpi.com/1424-8247/15/8/1019 (2022)

https://www.mdpi.com/2076-3921/12/2/258 (2023)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694509/ (2023).—

https://www.hindawi.com/journals/jfbc/2023/8459095/ (2023).—

https://www.mdpi.com/1424-8247/16/7/1020 (2023).--

https://link.springer.com/article/10.1007/s00217-023-04368-w (2024).--

https://www.sciencedirect.com/science/article/pii/S2095177923003039 (2024).--

https://www.mdpi.com/2072-6643/16/5/735 (2024).--

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.8168 (2024).--

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.8177 (2024).--

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