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It seems most reasonable to think that optimal digestive regulation means that the frequency with which you empty your intestines should be the same times you eat.

Chronic constipation (CH) is a major health problem. The global prevalence of constipation is estimated to be 14% (rising to 25% in people over 65 years of age), with women being affected more frequently. Constipation is one of the most prevalent conditions seen in primary care practice and is among the most common indications in the United States for referral to a gastroenterologist. Colorectal cancer is the second most common cause of cancer-related death in the United States and the seventh most common cause of death among industrialized nations. Since about two-thirds of the world's cases occur in developed countries, CR cancer is predominantly a disease of Westernized countries.

There are statistically positive associations of chronic diarrhea or constipation with breast and colon cancer, CVD, risks of all-cause mortality, and CVD mortality. Particularly in participants younger than 60 years, in addition to the positive correlations of chronic diarrhea with three major chronic diseases and the risk of all-cause mortality, chronic constipation also contributed to an elevated risk of CVD mortality. Regarding markers of inflammation, an elevated level of DII or CRP was significantly associated with a higher prevalence of abnormal intestinal health and major chronic diseases, and a higher risk of mortality.

The ability of probiotics to modulate the gut microbiome population, strengthen the intestinal barrier, and modulate the immune system along with their antioxidant properties have encouraged research into probiotic therapy in many gastrointestinal conditions. Diet and lifestyle changes and the use of probiotics appear to play an important role in relieving constipation and effectively relieving diarrhea by suppressing the germs involved. This review aims to describe how probiotic bacteria and the use of specific strains could interfere and provide benefits as an associated treatment for diarrhea and constipation.

Patients with chronic constipation are associated with a significantly higher prevalence and incidence of colorectal cancer and benign colorectal neoplasia than comparable patients without chronic constipation. These risks increase with the severity of chronic constipation.

https://www.sciencedirect.com/science/article/pii/S1047279722002265 (2022).---

https://www.mdpi.com/2076-2607/11/9/2177 (2023).---

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