In these reviews the evidence supports the idea that acute and chronic stressors influence various aspects of mitochondrial biology and that chronic exposure to stress can lead to molecular and functional recalibrations between mitochondria. Limitations of current studies in animals and humans are discussed. The maladaptive mitochondrial changes that characterize this subcellular state of stress are called mitochondrial allostatic load.
Findings resulting from psychosomatic medicine, psychoneuroimmunology, and psychoneuroendocrinology have demonstrated that psychosocial experiences and life exposures influence subcellular processes, including immune activation/suppression, oncogenic behavior, regulation of gene expression, telomere maintenance and epigenetic processes.
In addition to energy production, mitochondria perform multiple essential functions that influence gene expression within the cell nucleus and physiological regulation throughout the organism. In particular, mitochondria are the main producers of reactive oxygen species (ROS) within the cell, which perform signaling and other life-sustaining functions at low levels, but can cause oxidative stress when they overcome defense mechanisms. antioxidants, play a key role in neurodegenerative processes and in the pathophysiology of stress. Stress and aging, namely cellular metabolic activity, DNA damage, telomere length, cellular senescence and inflammatory response patterns. Mitochondrial function and dynamics have been implicated in many different aspects of social behavior, as well as behavioral changes related to anxiety and stress. However, mitochondrial changes could be i) a primary driving force of variation in social behavior, or rather ii) a secondary effect of another underlying (neuro)biological difference,
A decrease in systemic NAD+ levels is a crucial factor in the deterioration of the organism in aging and in conditions such as diabetes and obesity, non-alcoholic fatty liver disease, kidney injury, impaired renal muscle function and sarcopenia, glaucoma, ischemia injury -reperfusion, vascular dysfunction, cognitive impairment
There is evidence to support that mitochondrial function/dysfunction mediates the relationship between prenatal and postnatal stress and neurodevelopmental outcomes in infants. There are links between preserved functioning of these neural systems under stress and neuroplasticity, immunoregulation, composition of the gut microbiome and the integrity of the intestinal barrier and the blood-brain barrier. Chronic stress is recognized for its comprehensive impact on various aspects of physical and mental health, including cardiovascular well-being, immune system function, cognitive performance, sleep quality, and overall quality of life. Table A2 of the last link examines the relationship between chronic stress (CSI) and various occupations.
Table 5 presents a comprehensive analysis of socioeconomic/behavioral and health-related variables in relation to CSI Indicator risk. A key socioeconomic and behavioral observation is the notable disparity in CSI risk
In these reviews the evidence supports the idea that acute and chronic stressors influence various aspects of mitochondrial biology and that chronic exposure to stress can lead to molecular and functional recalibrations between mitochondria. Limitations of current studies in animals and humans are discussed. The maladaptive mitochondrial changes that characterize this subcellular state of stress are called mitochondrial allostatic load.
Findings resulting from psychosomatic medicine, psychoneuroimmunology, and psychoneuroendocrinology have demonstrated that psychosocial experiences and life exposures influence subcellular processes, including immune activation/suppression, oncogenic behavior, regulation of gene expression, telomere maintenance and epigenetic processes.
In addition to energy production, mitochondria perform multiple essential functions that influence gene expression within the cell nucleus and physiological regulation throughout the organism. In particular, mitochondria are the main producers of reactive oxygen species (ROS) within the cell, which perform signaling and other life-sustaining functions at low levels, but can cause oxidative stress when they overcome defense mechanisms. antioxidants, play a key role in neurodegenerative processes and in the pathophysiology of stress. Stress and aging, namely cellular metabolic activity, DNA damage, telomere length, cellular senescence and inflammatory response patterns. Mitochondrial function and dynamics have been implicated in many different aspects of social behavior, as well as behavioral changes related to anxiety and stress. However, mitochondrial changes could be i) a primary driving force of variation in social behavior, or rather ii) a secondary effect of another underlying (neuro)biological difference,
A decrease in systemic NAD+ levels is a crucial factor in the deterioration of the organism in aging and in conditions such as diabetes and obesity, non-alcoholic fatty liver disease, kidney injury, impaired renal muscle function and sarcopenia, glaucoma, ischemia injury -reperfusion, vascular dysfunction, cognitive impairment
There is evidence to support that mitochondrial function/dysfunction mediates the relationship between prenatal and postnatal stress and neurodevelopmental outcomes in infants. There are links between preserved functioning of these neural systems under stress and neuroplasticity, immunoregulation, composition of the gut microbiome and the integrity of the intestinal barrier and the blood-brain barrier. Chronic stress is recognized for its comprehensive impact on various aspects of physical and mental health, including cardiovascular well-being, immune system function, cognitive performance, sleep quality, and overall quality of life. Table A2 of the last link examines the relationship between chronic stress (CSI) and various occupations.
Table 5 presents a comprehensive analysis of socioeconomic/behavioral and health-related variables in relation to CSI Indicator risk. A key socioeconomic and behavioral observation is the notable disparity in CSI risk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901654/ (2018).----
https://www.annualreviews.org/doi/abs/10.1146/annurev-publhealth-040119-094239 (2020).----
https://www.scie.ncedirect.com/science/article/pii/S1568163721002543 (2022).---
https://karger.com/dne/article/44/6/438/835327 (2022).--
https://www.sciencedirect.com/science/article/pii/S0889159122001477 (2022)
https://www.nature.com/articles/s43587-022-00191-2 (2022).---
https://www.sciencedirect.com/science/article/pii/S0959438822001696 (2023)
https://europepmc.org/article/med/38483288 (2024).--
https://www.mdpi.com/1660-4601/21/3/302 (2024).--
A Christians advice. Enter into His rest. Let go and let God.