Great powers of hugs. Oxytocin reduces the expression of proinflammatory cytokines and reduces the infiltration of immune cells. Oxytocin (OT) also stimulates the differentiation of stem cells into cardiomyocyte lineages, as well as the generation of endothelial and smooth muscle cells, promoting angiogenesis. Beneficial actions of oxytocin may include increasing glucose uptake by cardiomyocytes, reducing cardiomyocyte hypertrophy, decreasing oxidative stress, and mitochondrial protection of various cell types. Oxytocin is cardioprotective by reducing inflammatory response and improve cardiovascular and metabolic function. Due to its pleiotropic nature, this peptide demonstrates clear potential for the treatment of cardiovascular pathologies. The role of OT in glucose uptake, pancreatic function, and regulation of body weight balance suggests the involvement of OT in the pathophysiology of diabetes: Accumulating evidence indicates that the hypothalamic-neurohypophysial system is involved in the network. neuroendocrine-immune. Studies suggested that high levels of OT protected against increases in mitochondrial oxygen consumption, ROS production, and release of proinflammatory cytokines seen in stress and hypoxia.
OT is produced in the cardiovascular system and is critical in regulating cardiac and vascular function during early development and adulthood. The main actions of OT include the regulation of chronotropy and inotropy of the heart, as well as the vascular tone of cardiac resistance vessels. OT is also involved in the regulation of blood pressure and body volume through the cardiac-renal axis and the release of NO. In addition to cardiovascular regulation and protection, OT exerts potent antioxidant and anti-inflammatory effects on CMC. In cells, OT targets mitochondria, promoting glucose uptake and reducing the effects of ROS upon reperfusion.
Oxytocin has demonstrated beneficial cardiovascular outcomes in animal models of cardiovascular disease. This study aimed to determine whether chemogenetic activation of hypothalamic oxytocin neurons in animals with obstructive sleep apnea-induced hypertension would reverse or mitigate the progression of autonomic and cardiovascular dysfunction.
Compared with normal breastfeeding, both tellectomy and complete separation were associated with reduced OT and harmful cardiovascular parameters at 1 month postpartum. These results suggest that breastfeeding cessation, not mother-infant interaction, mediates the effects of mother-infant separation on cardiovascular health.
Oxytocin spikes during childbirth cause deep sensations that the mother can remember for a lifetime while the newborn receives oxytocin and endorphins. Oxytocin plays a key role in regulating the processes that ensure both maternal and infant health. the peripartum period. It should always be considered that oxytocin promotes the return to homeostasis and begins the post-stress healing process. Oxytocin and stress pathways behave like Yin Yang systems, controlling each other on a macro and micro level. The two systems have largely been investigated independently. We suggest that these two systems are very closely intertwined and represent two sides of the same coin, balanced like Yin and Yang. Only by taking the two systems together can we fully determine their effects on birth outcomes, maternal health and child well-being.
Great powers of hugs. Oxytocin reduces the expression of proinflammatory cytokines and reduces the infiltration of immune cells. Oxytocin (OT) also stimulates the differentiation of stem cells into cardiomyocyte lineages, as well as the generation of endothelial and smooth muscle cells, promoting angiogenesis. Beneficial actions of oxytocin may include increasing glucose uptake by cardiomyocytes, reducing cardiomyocyte hypertrophy, decreasing oxidative stress, and mitochondrial protection of various cell types. Oxytocin is cardioprotective by reducing inflammatory response and improve cardiovascular and metabolic function. Due to its pleiotropic nature, this peptide demonstrates clear potential for the treatment of cardiovascular pathologies. The role of OT in glucose uptake, pancreatic function, and regulation of body weight balance suggests the involvement of OT in the pathophysiology of diabetes: Accumulating evidence indicates that the hypothalamic-neurohypophysial system is involved in the network. neuroendocrine-immune. Studies suggested that high levels of OT protected against increases in mitochondrial oxygen consumption, ROS production, and release of proinflammatory cytokines seen in stress and hypoxia.
OT is produced in the cardiovascular system and is critical in regulating cardiac and vascular function during early development and adulthood. The main actions of OT include the regulation of chronotropy and inotropy of the heart, as well as the vascular tone of cardiac resistance vessels. OT is also involved in the regulation of blood pressure and body volume through the cardiac-renal axis and the release of NO. In addition to cardiovascular regulation and protection, OT exerts potent antioxidant and anti-inflammatory effects on CMC. In cells, OT targets mitochondria, promoting glucose uptake and reducing the effects of ROS upon reperfusion.
Oxytocin has demonstrated beneficial cardiovascular outcomes in animal models of cardiovascular disease. This study aimed to determine whether chemogenetic activation of hypothalamic oxytocin neurons in animals with obstructive sleep apnea-induced hypertension would reverse or mitigate the progression of autonomic and cardiovascular dysfunction.
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2020.02139/full (2020).--
https://www.ingentaconnect.com/content/wk/hyp/2023/00000080/00000004/art00024 (2023).-
Compared with normal breastfeeding, both tellectomy and complete separation were associated with reduced OT and harmful cardiovascular parameters at 1 month postpartum. These results suggest that breastfeeding cessation, not mother-infant interaction, mediates the effects of mother-infant separation on cardiovascular health.
Oxytocin spikes during childbirth cause deep sensations that the mother can remember for a lifetime while the newborn receives oxytocin and endorphins. Oxytocin plays a key role in regulating the processes that ensure both maternal and infant health. the peripartum period. It should always be considered that oxytocin promotes the return to homeostasis and begins the post-stress healing process. Oxytocin and stress pathways behave like Yin Yang systems, controlling each other on a macro and micro level. The two systems have largely been investigated independently. We suggest that these two systems are very closely intertwined and represent two sides of the same coin, balanced like Yin and Yang. Only by taking the two systems together can we fully determine their effects on birth outcomes, maternal health and child well-being.
https://www.ajog.org/article/S0002-9378(22)01950-0/fulltext (2024).--
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1272270/full (2024).--
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