Iodine deficiency can increase your risk of chronic diseases like hypothyroidism. Find out how to optimize your dietary intake of this essential mineral here.
Pregnant women, breastfeeding women and children are particularly affected by iodine deficiency. It leads to thyroid diseases and metabolic and developmental disorders, as well as other diseases, including oncological diseases. Correcting an iodine deficiency potentially reduces the chance of developing malignant tumors. Urinary iodine levels should be monitored more frequently and an increase in iodine salt levels should be considered. Research suggests that there is a link between iodine deficiency and human mammary gland disease. Molecular iodine has a beneficial effect on fibrotic breast disease. Women suffering from breast cancer show a significant decrease in iodine excretion.
Previous studies show that iodine deficiency also produces hyperplasia of breast tissue and its hypertrophy, as well as perialveolar and ductal fibrosis. The impact of thyroid diseases on the development of breast cancer is well documented. Abnormal thyroid function may promote breast cancer through the action of thyroid hormones and their stimulation of the v3 integrin receptor that induces mitogen-activated protein kinase (MAPK) activity and receptor pathway response. estrogen; the interaction of TSH and TSH-stimulating antibodies in the course of Graves' disease at extra thyroid TSH receptors (TSH-R) located in the breast tissue; and the action of an increased concentration of prolactin (PRL) that accompanies primary hypothyroidism.
Iodine deficiency may also be associated with an increased risk of developing stomach cancer. It is hypothesized that iodine deficiency (or excess) may be a risk factor for gastric cancer and atrophic gastritis. This effect of iodides on the gastric mucosa may be due to the antioxidant activity and antagonism of iodide inhibitors such as nitrates, thiocyanates and salt, which are risk factors for gastric carcinogenesis.
Tissue iodine levels, determined by the Foss method based on the Sandell-Kolt-Hoff reaction, were lower in gastric cancer tissue compared to surrounding normal tissue. There was a positive correlation between iodine levels in gastric cancer tissue and surrounding normal tissue. Therefore, iodine deficiency may be one of the factors behind the increased incidence of gastric cancer. https://www.mdpi.com/2072-6643/14/11/2209 (2022) Iodine is an anticancer and fluoride prevents its benefits. The role that the oxidation of iodide to iodine (organification) plays in thyroid hormonegenesis is well established.
Iodine deficiency can produce oxidative stress conditions with high TSH producing a level of H 2 O 2,. These cytotoxic effects appear to depend on the status of antioxidant enzymes and may only be evident in selenium-deficient conditions where the activity of selenium-containing antioxidant enzymes is altered. The Japanese experience may indicate a protective effect against breast cancer for a diet containing iodine-rich seaweed. Similarly, thyroid autoimmunity may also be associated with a better prognosis. https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.5520190304 (2008)
Pregnant women, breastfeeding women and children are particularly affected by iodine deficiency. It leads to thyroid diseases and metabolic and developmental disorders, as well as other diseases, including oncological diseases. Correcting an iodine deficiency potentially reduces the chance of developing malignant tumors. Urinary iodine levels should be monitored more frequently and an increase in iodine salt levels should be considered. Research suggests that there is a link between iodine deficiency and human mammary gland disease. Molecular iodine has a beneficial effect on fibrotic breast disease. Women suffering from breast cancer show a significant decrease in iodine excretion.
Previous studies show that iodine deficiency also produces hyperplasia of breast tissue and its hypertrophy, as well as perialveolar and ductal fibrosis. The impact of thyroid diseases on the development of breast cancer is well documented. Abnormal thyroid function may promote breast cancer through the action of thyroid hormones and their stimulation of the v3 integrin receptor that induces mitogen-activated protein kinase (MAPK) activity and receptor pathway response. estrogen; the interaction of TSH and TSH-stimulating antibodies in the course of Graves' disease at extra thyroid TSH receptors (TSH-R) located in the breast tissue; and the action of an increased concentration of prolactin (PRL) that accompanies primary hypothyroidism.
Iodine deficiency may also be associated with an increased risk of developing stomach cancer. It is hypothesized that iodine deficiency (or excess) may be a risk factor for gastric cancer and atrophic gastritis. This effect of iodides on the gastric mucosa may be due to the antioxidant activity and antagonism of iodide inhibitors such as nitrates, thiocyanates and salt, which are risk factors for gastric carcinogenesis.
Tissue iodine levels, determined by the Foss method based on the Sandell-Kolt-Hoff reaction, were lower in gastric cancer tissue compared to surrounding normal tissue. There was a positive correlation between iodine levels in gastric cancer tissue and surrounding normal tissue. Therefore, iodine deficiency may be one of the factors behind the increased incidence of gastric cancer. https://www.mdpi.com/2072-6643/14/11/2209 (2022) Iodine is an anticancer and fluoride prevents its benefits. The role that the oxidation of iodide to iodine (organification) plays in thyroid hormonegenesis is well established.
Iodine deficiency can produce oxidative stress conditions with high TSH producing a level of H 2 O 2,. These cytotoxic effects appear to depend on the status of antioxidant enzymes and may only be evident in selenium-deficient conditions where the activity of selenium-containing antioxidant enzymes is altered. The Japanese experience may indicate a protective effect against breast cancer for a diet containing iodine-rich seaweed. Similarly, thyroid autoimmunity may also be associated with a better prognosis. https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.5520190304 (2008)