Discover how NAD+ deficiency drives muscle wasting in cancer and chronic illness, and learn simple strategies to restore cellular energy and rebuild strength.
It is essential to follow the nicotinamide dosage recommended by Dr. Mercola. Mitochondrial dysfunction is caused by poor nutrition, highly processed and pesticide-contaminated food, high sugar and additive loads, vaccines, fluoridated and contaminated water, stress, etc. Nicotinamide can improve mitochondrial quality by promoting autophagy. This effect has been observed in human cells, maintaining normal mitochondrial function, an essential factor in chronic diseases and aging. NAD acts as a cofactor in several oxidation-reduction (redox) reactions and is a substrate for various non-redox enzymes. NAD is fundamental for a variety of cellular processes, including energy metabolism, cell signaling, and epigenetics. NAD homeostasis appears to be of paramount importance for health and longevity, and its dysregulation is associated with multiple diseases.
Dysregulation of CD38, a glycoprotein found on the surface of many immune cells, leads to changes in NAD homeostasis and contributes to the pathophysiology of multiple conditions. In fact, in animal models, the development of infectious diseases, autoimmune disorders, fibrosis, metabolic diseases, and age-related diseases, including cancer, heart disease, and neurodegeneration, are associated with altered CD38 enzyme activity.
Ingestion of NMN has been shown to improve age-related diseases and likely delay death. Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is implicated in a broad spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes.
Furthermore, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Accumulating evidence suggests that NAM plays a role in cancer chemoprevention and therapy. Phase III clinical trials have demonstrated the efficacy of NAM in chemoprevention for head and neck, laryngeal, and bladder cancers, incorporating their results into clinical practice. More references are available in the links.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23673 (2024).--- NAD+ may have immunomodulatory properties in inflammation. Nicotinamide as a precursor of NAD+ contributes to the immune response and inflammatory conditions, with particular attention to multiple sclerosis, inflammatory bowel diseases, and inflammation.
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15477 (2022).-- Short telomeres are a defining characteristic of disorders of telomere biology (TBD). Patients with TBD often experience bone marrow failure. Nicotinamide improves body weight loss and enhances telomere integrity and reduces systemic inflammation induced by telomere dysfunction. Furthermore, nicotinamide alleviated villous atrophy and inflammation in the small intestine. Taken together, NAD constitutes a therapeutic strategy for improving aspects of health compromised by telomere shortening.
Muscle strength enhancing, anti cancer, natural immune system supporter, positive mental, emotional health, provider for our bodies to fully engage in Life; The Gut is increasing being realized as the foundation our best health, Dis-Ease preventer. If the memory is working thought to be such to prevent cancers all of one hundred years ago and then promptly shuttled to the bottom of the pile.
Now with more and proper focus, more once unknown mechanisms and what feeds them to support this Foundation are coming to light.
Maybe Just Me, but it seems so much of what is needed to feed these processes does more than feed our own personal health but in turn heals so much or what we find troublesome, wrong with life today. Better foods call for better Farm Practices, Land Management, Food Distribution, and scrapping such nonsense as Fruit Loops being at the top of a Food Pyramid claiming it is the best to consume for health. Cleaning out dyes, toxic compounds interfering with proper practices, scrapped in favor for as many "units" as possible, touched by as few human hands as possible for the most Profit$ for the fewest individuals.
You always recommend sunlight as a wellness therapy. What do you recommend for those living in northern climates where there is little sunlight during the winter months? Is red-light therapy a good alternative? Infrared sauna?
thank you, good points
most health problems come from vaccines, however
in the USA, unlike any other nation, live viruses and bacteria are in there
Very good information!’ Many thanks!😊
It is essential to follow the nicotinamide dosage recommended by Dr. Mercola. Mitochondrial dysfunction is caused by poor nutrition, highly processed and pesticide-contaminated food, high sugar and additive loads, vaccines, fluoridated and contaminated water, stress, etc. Nicotinamide can improve mitochondrial quality by promoting autophagy. This effect has been observed in human cells, maintaining normal mitochondrial function, an essential factor in chronic diseases and aging. NAD acts as a cofactor in several oxidation-reduction (redox) reactions and is a substrate for various non-redox enzymes. NAD is fundamental for a variety of cellular processes, including energy metabolism, cell signaling, and epigenetics. NAD homeostasis appears to be of paramount importance for health and longevity, and its dysregulation is associated with multiple diseases.
Dysregulation of CD38, a glycoprotein found on the surface of many immune cells, leads to changes in NAD homeostasis and contributes to the pathophysiology of multiple conditions. In fact, in animal models, the development of infectious diseases, autoimmune disorders, fibrosis, metabolic diseases, and age-related diseases, including cancer, heart disease, and neurodegeneration, are associated with altered CD38 enzyme activity.
Ingestion of NMN has been shown to improve age-related diseases and likely delay death. Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is implicated in a broad spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes.
Furthermore, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Accumulating evidence suggests that NAM plays a role in cancer chemoprevention and therapy. Phase III clinical trials have demonstrated the efficacy of NAM in chemoprevention for head and neck, laryngeal, and bladder cancers, incorporating their results into clinical practice. More references are available in the links.
https://www.liebertpub.com/doi/abs/10.1089/ars.2017.7445 (2018).---
https://pubmed.ncbi.nlm.nih.gov/19473119/ (2018).—
https://www.mdpi.com/2218-273X/10/3/477 (2020).--
https://pubmed.ncbi.nlm.nih.gov/35138178/ (2022).---
https://www.nature.com/articles/s41537-023-00357-w (2023).--
https://www.mdpi.com/1420-3049/28/16/6078 (2023).--
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917541/ (2024).--
https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23673 (2024).--- NAD+ may have immunomodulatory properties in inflammation. Nicotinamide as a precursor of NAD+ contributes to the immune response and inflammatory conditions, with particular attention to multiple sclerosis, inflammatory bowel diseases, and inflammation.
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15477 (2022).-- Short telomeres are a defining characteristic of disorders of telomere biology (TBD). Patients with TBD often experience bone marrow failure. Nicotinamide improves body weight loss and enhances telomere integrity and reduces systemic inflammation induced by telomere dysfunction. Furthermore, nicotinamide alleviated villous atrophy and inflammation in the small intestine. Taken together, NAD constitutes a therapeutic strategy for improving aspects of health compromised by telomere shortening.
https://link.springer.com/article/10.1007/s11357-023-00752-2 (2023).---
I am a paid subscriber why am I on your free list?
Muscle strength enhancing, anti cancer, natural immune system supporter, positive mental, emotional health, provider for our bodies to fully engage in Life; The Gut is increasing being realized as the foundation our best health, Dis-Ease preventer. If the memory is working thought to be such to prevent cancers all of one hundred years ago and then promptly shuttled to the bottom of the pile.
Now with more and proper focus, more once unknown mechanisms and what feeds them to support this Foundation are coming to light.
Maybe Just Me, but it seems so much of what is needed to feed these processes does more than feed our own personal health but in turn heals so much or what we find troublesome, wrong with life today. Better foods call for better Farm Practices, Land Management, Food Distribution, and scrapping such nonsense as Fruit Loops being at the top of a Food Pyramid claiming it is the best to consume for health. Cleaning out dyes, toxic compounds interfering with proper practices, scrapped in favor for as many "units" as possible, touched by as few human hands as possible for the most Profit$ for the fewest individuals.
You always recommend sunlight as a wellness therapy. What do you recommend for those living in northern climates where there is little sunlight during the winter months? Is red-light therapy a good alternative? Infrared sauna?