★ Could This Sunshine Nutrient Be the Missing Link in Colon Cancer Prevention?
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Could This Sunshine Nutrient Be the Missing Link in Colon Cancer Prevention?
New research reveals that low vitamin D levels can raise colorectal cancer risk by up to 58% - especially in older adults. Learn why over 80% of Americans are deficient and how restoring optimal levels may slash your cancer risk and protect your gut.
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And yet the officials; We just don't know what is causing the increasing amounts of colon cancers. Still pushing the sun is deadly, slather on deep, thick coats of chemical sunscreens. Fear the outdoors. Don't drink grass fed raw milk from properly rose healthy cows with a working immune system, drink chemical, antibiotic, hormone, glyphosate contaminated, then actually needed pasteurized fare stripping what nutrients may have left out because if it wasn't, it isn't safe to consume.
The potential of vitamin D for cancer prevention and adjunctive treatment has long been bolstered by several discovered mechanisms involving the regulation of cell growth and differentiation, apoptosis, intercellular contacts, angiogenesis, immune function, and interaction with the gut microbiome. Figure 2 graphically displays the main mechanisms of action of vitamin D. These effects are primarily indirect results through the explained epigenetic and transcriptional changes, which involve the synthesis of transcription factors, chromatin modifiers, noncoding RNA (ncRNA), and microRNAs (miRs), through protein-protein interactions and signaling interference. Furthermore, vitamin D was considered a promising substance to counteract several carcinogenesis-related epigenetic changes, which increase the expression of tumor genes and decrease tumor suppressor genes.
Experiments with colon cancer cells confirmed these results and identified pro-apoptosis targets of VDR. Calcitriol induces the transcription of several pro-apoptotic genes, which encode or interact with Bcl-2 family proteins in ways that enhance mitochondrial membrane permeability and apoptosis. Rapid cell growth and extracellular matrix disruption are addressed by tumor cells with pro-vascularization signaling via VEGF, angiopoietin-1, and platelet-derived growth factor (PDGF) to meet their oxygen needs. An anti-angiogenetic effect of calcitriol was supported in human cancer cells and mice, in which calcitriol decreased VEGF expression and tumor vascularization was observed. Table 1. Meta-analysis of observational studies describing the relative risk of different cancer types according to serum 25(OH)D* concentration.
https://www.mdpi.com/2072-6643/14/21/4512