Researchers found that a naturally occurring compound called geranylgeraniol (GG) reduced diabetic nerve pain by 35% in rats even without significantly improving blood sugar control.
I'm glad to know that geranylgeraniol is found in small amounts in foods such as tomatoes, carrots, olives, and some cereals, and that the body uses it to produce geranylgeranyl pyrophosphate (GGPP), a molecule necessary for:
1) mitochondrial function,
2) cell repair,
3) various proteins involved in neuron survival.
Tomatoes are one of the best-known plant sources of geranylgeraniol (GG), although its concentration is relatively low and depends on the variety and ripeness. GG belongs to the isoprenoid family, the same metabolic pathway that produces carotenoids like lycopene. In addition to geranylgeraniol, tomatoes provide: lycopene (very abundant, especially in cooked tomatoes), phytoene and phytofluene, vitamin C, polyphenols, and flavonoids.
Although there are few studies quantifying GG in foods, experts consider these options to be the most favorable:
🍅 Very ripe tomatoes.
🍅 Traditionally grown tomatoes with good flavor (they tend to contain more bioactive compounds).
🍅 Crushed or concentrated tomatoes.
🍅 Tomato sauce cooked with extra virgin olive oil, which also improves the absorption of fat-soluble carotenoids.
Recent scientific reviews continue to consider that the treatment of diabetic neuropathy is based primarily on:
A review published in 2026 proposes that geranylgeraniol could be an important regulator of aging because it:
1) improves mitochondrial function;
2) promotes autophagy (cellular recycling);
3) reduces chronic inflammation;
4) participates in the synthesis of coenzyme Q10;
5) may improve insulin sensitivity;
6) It may support cognitive function.
Experimental studies show that GGOH can:
1) inhibit the growth of some tumor cells;
2) induce apoptosis (programmed cell death of cancer cells);
3) reduce cancer-associated inflammation.
The results are particularly interesting in models of liver, breast, prostate, and colon cancer.
The liver uses geranylgeraniol to produce a molecule called geranylgeranoic acid, which appears to act as a liver protectant. This metabolic pathway decreases with age, and some researchers believe this could contribute to the development of liver cancer and other liver disorders.
Some experimental studies suggest that it may:
1) protect neurons;
2) improve mitochondrial function in the brain;
3) support processes related to memory and learning.
Its potential usefulness in diseases such as Alzheimer's or Parkinson's remains a research hypothesis. As Dr. Mercola reports, statins reduce the production of several compounds derived from the mevalonate pathway, including geranylgeraniol. Researchers are studying whether supplementation with geranylgeraniol could help reduce certain side effects, such as muscle discomfort or mitochondrial dysfunction.
Apologies, Just the Gut Speaking, as Gui mentions in his comment, stands to reason being as the Brain is a complicated collection of Nerves and in recent years Alzheimer's is being called a type of diabetes of the brain. That GG and Butyrate healing and supporting the gut would have connections there too. Just stopping compounds the Gut is designed to keep offenders out of the body goes a long way preventing constant, starving of needed nutrients, compounds and yet, never ending corrosion of the body functions, plus erosion of the Blood Brain Barrier caused by toxic compounds never meant to be there in the first place.
Maintaining a healthy Gut does more than allow it to function properly so the microbes can process necessary nutrients so those same functions can run at their best potential, but this shows how the Gut, Immune, Brain System connection expressed by ancient cultures is very Real.
We get a double whammy drowning in a Toxic Sea attacking not only from the outside of the body, but also in the inside, affecting our physical, mental, emotional bodies and Brain.
We possibly should also take note so many pesticides work by attacking the nerve function of insects. It is folly to expect they would not attack our nervous system too.
Just, his mind has a strong focus on the culture of true health, 👍👌 particularly regarding neurodegenerative diseases. One of the most researched areas is the gut-brain axis, the bidirectional communication system between the gut and the central nervous system. The microbiome, influenced by fiber, can synthesize neurotransmitters and modulate inflammation, affecting cognitive functions and neurodegenerative processes.
Gut dysbiosis (an imbalanced microbiota) has been linked to an increased risk of Alzheimer's, Parkinson's, ALS, and other diseases through chronic inflammation and immune system dysfunction.
Microorganisms ferment fiber, generating short-chain fatty acids (SCFAs), which strengthen the integrity of the intestinal barrier and reduce permeability, thus promoting systemic inflammatory responses. They also modulate neurogenic inflammation and the activation of microglia, a key component in the progression of neurodegenerative diseases. SCFAs such as butyrate can have anti-inflammatory and protective effects on neurons in experimental models. A study published in Nutrients links adequate fiber intake with improved memory and reduced cognitive decline in older adults, highlighting its role in brain health and potential prevention of neurodegeneration.
The mechanisms by which fiber may influence neurodegeneration include:
--Modulation of systemic and brain inflammation through short-chain fatty acids (SCFAs) and the gut microbiota.
--Improvement of the intestinal and blood-brain barriers, reducing the passage of toxins and endotoxins that activate neuroinflammatory processes.
--Interaction with the immune system, influencing the activation of glial cells and the production of pro-inflammatory cytokines.
I'm glad to know that geranylgeraniol is found in small amounts in foods such as tomatoes, carrots, olives, and some cereals, and that the body uses it to produce geranylgeranyl pyrophosphate (GGPP), a molecule necessary for:
1) mitochondrial function,
2) cell repair,
3) various proteins involved in neuron survival.
Tomatoes are one of the best-known plant sources of geranylgeraniol (GG), although its concentration is relatively low and depends on the variety and ripeness. GG belongs to the isoprenoid family, the same metabolic pathway that produces carotenoids like lycopene. In addition to geranylgeraniol, tomatoes provide: lycopene (very abundant, especially in cooked tomatoes), phytoene and phytofluene, vitamin C, polyphenols, and flavonoids.
Although there are few studies quantifying GG in foods, experts consider these options to be the most favorable:
🍅 Very ripe tomatoes.
🍅 Traditionally grown tomatoes with good flavor (they tend to contain more bioactive compounds).
🍅 Crushed or concentrated tomatoes.
🍅 Tomato sauce cooked with extra virgin olive oil, which also improves the absorption of fat-soluble carotenoids.
Recent scientific reviews continue to consider that the treatment of diabetic neuropathy is based primarily on:
1) good metabolic control,
2) physical exercise,
3) supplements with moderate evidence, such as certain B vitamins when a deficiency exists. https://onlinelibrary.wiley.com/doi/10.1111/jns.70124?utm_source=chatgpt.com (2026)
https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1680031/full?utm_source=chatgpt.com (2025)
https://pubmed.ncbi.nlm.nih.gov/41759582/ (2026)
A review published in 2026 proposes that geranylgeraniol could be an important regulator of aging because it:
1) improves mitochondrial function;
2) promotes autophagy (cellular recycling);
3) reduces chronic inflammation;
4) participates in the synthesis of coenzyme Q10;
5) may improve insulin sensitivity;
6) It may support cognitive function.
Experimental studies show that GGOH can:
1) inhibit the growth of some tumor cells;
2) induce apoptosis (programmed cell death of cancer cells);
3) reduce cancer-associated inflammation.
The results are particularly interesting in models of liver, breast, prostate, and colon cancer.
The liver uses geranylgeraniol to produce a molecule called geranylgeranoic acid, which appears to act as a liver protectant. This metabolic pathway decreases with age, and some researchers believe this could contribute to the development of liver cancer and other liver disorders.
Some experimental studies suggest that it may:
1) protect neurons;
2) improve mitochondrial function in the brain;
3) support processes related to memory and learning.
Its potential usefulness in diseases such as Alzheimer's or Parkinson's remains a research hypothesis. As Dr. Mercola reports, statins reduce the production of several compounds derived from the mevalonate pathway, including geranylgeraniol. Researchers are studying whether supplementation with geranylgeraniol could help reduce certain side effects, such as muscle discomfort or mitochondrial dysfunction.
https://www.sciencedirect.com/science/article/pii/S0022227526000350?utm_source=chatgpt.com (2026)
https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1680031/full?utm_source=chatgpt.com (2025)
https://link.springer.com/article/10.1007/s10787-025-02069-2?utm_source=chatgpt.com (2025)
https://link.springer.com/article/10.1186/s13098-026-02113-3?utm_source=chatgpt.com (2026)
Apologies, Just the Gut Speaking, as Gui mentions in his comment, stands to reason being as the Brain is a complicated collection of Nerves and in recent years Alzheimer's is being called a type of diabetes of the brain. That GG and Butyrate healing and supporting the gut would have connections there too. Just stopping compounds the Gut is designed to keep offenders out of the body goes a long way preventing constant, starving of needed nutrients, compounds and yet, never ending corrosion of the body functions, plus erosion of the Blood Brain Barrier caused by toxic compounds never meant to be there in the first place.
Maintaining a healthy Gut does more than allow it to function properly so the microbes can process necessary nutrients so those same functions can run at their best potential, but this shows how the Gut, Immune, Brain System connection expressed by ancient cultures is very Real.
We get a double whammy drowning in a Toxic Sea attacking not only from the outside of the body, but also in the inside, affecting our physical, mental, emotional bodies and Brain.
We possibly should also take note so many pesticides work by attacking the nerve function of insects. It is folly to expect they would not attack our nervous system too.
Just, his mind has a strong focus on the culture of true health, 👍👌 particularly regarding neurodegenerative diseases. One of the most researched areas is the gut-brain axis, the bidirectional communication system between the gut and the central nervous system. The microbiome, influenced by fiber, can synthesize neurotransmitters and modulate inflammation, affecting cognitive functions and neurodegenerative processes.
Gut dysbiosis (an imbalanced microbiota) has been linked to an increased risk of Alzheimer's, Parkinson's, ALS, and other diseases through chronic inflammation and immune system dysfunction.
Microorganisms ferment fiber, generating short-chain fatty acids (SCFAs), which strengthen the integrity of the intestinal barrier and reduce permeability, thus promoting systemic inflammatory responses. They also modulate neurogenic inflammation and the activation of microglia, a key component in the progression of neurodegenerative diseases. SCFAs such as butyrate can have anti-inflammatory and protective effects on neurons in experimental models. A study published in Nutrients links adequate fiber intake with improved memory and reduced cognitive decline in older adults, highlighting its role in brain health and potential prevention of neurodegeneration.
The mechanisms by which fiber may influence neurodegeneration include:
--Modulation of systemic and brain inflammation through short-chain fatty acids (SCFAs) and the gut microbiota.
--Improvement of the intestinal and blood-brain barriers, reducing the passage of toxins and endotoxins that activate neuroinflammatory processes.
--Interaction with the immune system, influencing the activation of glial cells and the production of pro-inflammatory cytokines.
--Production of neurotransmitters and neuromodulators by gut bacteria that can affect emotions, memory, and neuronal behavior. https://revistamedica.com/aumento-bacterias-proinflamatorias-enfermedades-neurodegenerativas/?utm_source=chatgpt.com (2025).-
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1432659/full?utm_source=chatgpt.com (2024).-
https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1771904/full?utm_source=chatgpt.com (2026).--