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Guillermou's avatar

Interesting report. The link to Dr. Mercola's latest reference indicates that guar gum (GG) [E412], present in both mixtures 2 and 5, has been implicated in its alteration of gut microbiota composition, leading to elevated proinflammatory markers and potential metabolic disturbances in a mouse model. Guar gum feeding increased colonic expression of genes that promote cell proliferation. GG exacerbated DSS-induced colitis, as evidenced by body weight loss, altered colonic crypt architecture, and increased proinflammatory markers, accompanied by decreased anti-inflammatory markers. Furthermore, GG feeding increased colonic expression of genes that promote cell proliferation. Consequently, extensive colonic tumorigenesis was observed in mice fed guar gum.

Guar gum is primarily used as a thickener, emulsifier, and stabilizer in the food industry and other fields. In food, it is used in the production of ice cream, sauces, baked goods, dairy products, and vegetable drinks.

https://www.researchgate.net/publication/386597453_Processed_Dietary_Fiber_Partially_Hydrolyzed_Guar_Gum_Increases_Susceptibility_to_Colitis_and_Colon_Tumorigenesis_in_Mice .(2025)---

As we know, maintaining a stable intestinal barrier is crucial to prevent the entry of various potentially harmful substances and pathogens into the internal environment. The disruption of this barrier is known as "leaky gut" or leaky gut syndrome and appears to be characterized by the release of bacterial metabolites and endotoxins, such as lipopolysaccharide (LPS), into the circulation. This condition, caused mainly by bacterial infections, oxidative stress, a high-fat diet, exposure to alcohol or chronic allergens, and dysbiosis, is closely linked to the development or progression of various systemic metabolic and autoimmune diseases, such as obesity, non-alcoholic fatty liver disease (NAFLD), neurodegeneration, cardiovascular disease, inflammatory bowel disease, and type 1 diabetes mellitus. This article provides a comprehensive analysis of these relationships:

https://link.springer.com/article/10.1007/s11739-023-03374-w (2024)

Carrageenan [E407], a predominant emulsifier in Blend 2, impairs glucose metabolism in mice and exhibited inflammatory properties, which may be involved in the etiology of type 2 diabetes. The role of artificial sweeteners, such as those found in Blend 5, in gut microbiota disturbances has also been suggested. In particular, acesulfame-K [E950] and sucralose [E955] were observed to shape microbial populations and lead to dysbiosis, which in turn may increase glucose intolerance and changes in host physiology in mice. This was supported by the observation of similarities in the microbial populations of consumers of non-caloric artificial sweeteners and patients with type 2 diabetes.

One of the main concerns with artificial sweeteners is their potential impact on hormonal regulation. Certain artificial sweeteners, such as aspartame, undergo metabolic processes that produce methanol, which can be converted into formaldehyde. This process has raised concerns about potential estrogen receptor interactions and hormonal imbalances that could promote the development of breast cancer. The potential link between artificial sweeteners and hormonal disorders in breast cancer has been a topic of growing interest and research. Hormonal disorders, particularly those involving the estrogen and insulin pathways, play a crucial role in the development and progression of breast cancer. Consumption of artificially sweetened beverages is also positively associated with the risk of leukemia and negatively associated with the risk of colorectal cancer, among other cancers.

https://link.springer.com/article/10.1007/s00125-011-2333-z (2015).--

https://www.mdpi.com/2072-6643/16/11/1780 (2024).--

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.988144/full (2022).--

https://www.tandfonline.com/doi/abs/10.1080/15287390802328630 (2024).--

https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.15654 (2021).---

https://www.psiram.com/de/images/9/9a/NatureSue%C3%9FstoffeGewicht.pdf (2025).—

https://www.mdpi.com/2227-9059/12/12/2871 (2024).--

https://www.mdpi.com/2072-6643/14/21/4445 (2022).--

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STH's avatar

Well, I never had a fasting blood glucose above 75 until I got Covid. No shot. Just Covid and my bg is now in the high 80’s. Yes normal, but high for me.

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