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Long-term studies in animal models have also shown that diets based on high-GI starches promote weight gain, visceral adiposity, and higher concentrations of lipogenic enzymes than isoenergetic, macronutrient- and micronutrient-controlled diets with a Low GI starch. In a study of healthy pregnant women, a high-GI diet was associated with higher term weight than a nutrient-balanced, low-GI diet. In a study of diet and complications of type 1 diabetes, overall dietary GI was an independent predictor of waist circumference in men. Functional foods have been studied as a means to improve weight control in those who lead a healthy lifestyle. Functional foods have been evaluated for their effectiveness as therapies for obesity in two ways: first are foods that reduce appetite and increase pleasure, and another are foods that increase thermogenesis. Nutraceutical therapies are currently being widely investigated as potential treatments for obesity and weight loss. Low-glycemic carbohydrates, chromium, and green tea extract are among the substances that have been shown to promote weight loss.

A high dietary GI is associated with increased odds of NAFLD in subjects with T2DM. Studies also indicate that high glycemic index and glycemic load were associated with an increased risk of mortality from CVD and stroke.

https://www.sciencedirect.com/science/article/pii/S000291652305829X (2002).-

https://www.scielo.br/j/aem/a/6Gz5X9S6JPdg3BXt36kWkpd/ (2015).—

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1228072/ful (2023).--l

https://www.sciencedirect.com/science/article/abs/pii/S0261561423002728 (2023).--

https://www.taylorfrancis.com/chapters/edit/10.1201/9781003395737-5/functional-foods-management-weight-loss-obesity-khemchand-surana-ashwini-shelke-tushar-lokhande-sunil-mahajan (2024) .--

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Tambien considerar la resistencia a la insulina y la obesidad. Las dietas ricas en índice glucemco (IG) y carga glucemica y GL pueden inducir o exacerbar la RI, mientras que las dietas bajas en IG y GL parecen aumentar la sensibilidad a la insulina y mejorar el control glucémico. Estos resultados positivos pueden atribuirse a interacciones directas con la homeostasis de la insulina y la glucosa o a efectos indirectos a través de una mejor composición corporal y control del peso.

https://www.mdpi.com/2072-6643/16/3/399 (2024).--

El consumo de granada redujo significativamente la glucosa en sangre en ayunas (FBG) y la insulina en ayunas. El consumo de granada redujo significativamente la hemoglobina A1c y la evaluación del modelo homeostático para la resistencia a la insulina. Según la FBG inicial, los pacientes con prediabetes y diabetes tuvieron más mejoras después de la ingesta de granada.

https://www.sciencedirect.com/science/article/abs/pii/S1871402124000018 (2024).-

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