Interesting aspects and excellent recommendations. The analysis of the lives of healthy centenarians gives us some clues to achieve a healthy old age, such as the following:---
1) Stay physically active.---
2) Take care of social relationships, express love to loved ones and have a helpful attitude.---
3) Promote attitudes of commitment, responsibility, honesty and perseverance throughout life.---
4) Set realistic short/medium term objectives and strive to achieve them.
5) Establish order and certain habits in daily life, so that daily demands do not overwhelm us.--
6) Keep your mind active, even exploring new areas of knowledge and learning (painting, writing, etc.). Try to solve problems that are progressively more difficult.
7) Practice gratitude, being aware of all the good in life.--
8) Enjoy, learning to identify and exploit positive daily experiences.--
9) Develop skills that allow us to accept negative and stressful events ---as part of life.
Aging is largely defined as a gradual and progressive time-dependent decline in cellular and organ functions of living organisms, leading to increased susceptibility to chronic diseases, including cancer and death. Senescent cells are involved in a series of biological functions, from embryogenesis to aging. An excessive accumulation of senescent cells is associated with a decrease in regenerative capacity and chronic inflammation and mitochondrial dysfunction, characterized by a reduced oxidative capacity and the consequent increase in oxidative damage, contributes decisively and significantly to diseases and biological aging. .
Studies are investigating foods and substances that promote longevity. These include some phytonutrients hydroxytyrosol, epigallocatechin gallate, resveratrol, fisetin, berberine, apigenin, quercetin and curcumin and minerals such as magnesium and selenium also present in foods. Some of them also have senolytic effects, which promote the apoptosis of defective cells that accumulate over the years (senescent cells) and alter normal metabolism. Nicotinamide (an excellent compound known to increase levels of sirtuins, called the “longevity proteins”).
There is increasing evidence that supplementation with some natural compounds can mimic calorie restriction, protecting mitochondrial function, reducing inflammation, chronic diseases and cancer.
Interesting aspects and excellent recommendations. The analysis of the lives of healthy centenarians gives us some clues to achieve a healthy old age, such as the following:---
1) Stay physically active.---
2) Take care of social relationships, express love to loved ones and have a helpful attitude.---
3) Promote attitudes of commitment, responsibility, honesty and perseverance throughout life.---
4) Set realistic short/medium term objectives and strive to achieve them.
5) Establish order and certain habits in daily life, so that daily demands do not overwhelm us.--
6) Keep your mind active, even exploring new areas of knowledge and learning (painting, writing, etc.). Try to solve problems that are progressively more difficult.
7) Practice gratitude, being aware of all the good in life.--
8) Enjoy, learning to identify and exploit positive daily experiences.--
9) Develop skills that allow us to accept negative and stressful events ---as part of life.
10) Practice meditation
https://www.iflscience.com/the-8-psychological-traits-associated-with-living-past-100-71700 (2023).--
https://www.vogue.com/article/10-expert-tips-on-how-to-live-a-longer-healthier-life (2024).--
141 BENEFITS OF MEDITATION.--
https://eocinstitute.org/meditation/10-key-brain-regions-upgraded-with-meditation-2/ (2023).--
Aging is largely defined as a gradual and progressive time-dependent decline in cellular and organ functions of living organisms, leading to increased susceptibility to chronic diseases, including cancer and death. Senescent cells are involved in a series of biological functions, from embryogenesis to aging. An excessive accumulation of senescent cells is associated with a decrease in regenerative capacity and chronic inflammation and mitochondrial dysfunction, characterized by a reduced oxidative capacity and the consequent increase in oxidative damage, contributes decisively and significantly to diseases and biological aging. .
Studies are investigating foods and substances that promote longevity. These include some phytonutrients hydroxytyrosol, epigallocatechin gallate, resveratrol, fisetin, berberine, apigenin, quercetin and curcumin and minerals such as magnesium and selenium also present in foods. Some of them also have senolytic effects, which promote the apoptosis of defective cells that accumulate over the years (senescent cells) and alter normal metabolism. Nicotinamide (an excellent compound known to increase levels of sirtuins, called the “longevity proteins”).
There is increasing evidence that supplementation with some natural compounds can mimic calorie restriction, protecting mitochondrial function, reducing inflammation, chronic diseases and cancer.
https://www.mdpi.com/1422-0067/23/24/16219 (2022).---
https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.129 (2022).---
https://www.sciencedirect.com/science/article/abs/pii/S092422442200108X (2022).----
https://www.mdpi.com/2073-4409/12/6/915 (2023).---
https://www.sciencedirect.com/science/article/pii/S1568163723001022 (2023).----
https://www.mdpi.com/1424-8247/15/12/1528 (2022).---
https://www.mdpi.com/1424-8247/16/2/196 (2023).---
https://www.tandfonline.com/doi/full/10.1080/10942912.2023.2236329 (2023).---
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929829/ (2024).—
https://www.ingentaconnect.com/content/ben/ctmc/2024/00000024/00000002/art00005 (2024).--
https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnae010/7631421?login=false (2024).--