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The liver is the main organ responsible for maintaining nutrient homeostasis in the body. The liver ensures a constant supply of oxidizable substrates, plays a key role in the transformation of exogenous compounds, as it contains a variety of xenobiotic biotransforming enzymes involved in oxidation, reduction, hydrolysis and conjugation. The liver's regenerative capacity is another notable characteristic of this organ. Magnesium deficiency is also associated with oxidative stress in different tissues and organs, affecting the survival of hepatocytes through apoptosis induced by oxidative stress, it is related to an acceleration of cellular senescence, which causes the Magnesium supplementation is a beneficial approach to preventing aging. Maintaining an adequate diet that consumes rich sources of magnesium, as summarized in Table 1, can help in the prevention of age-related liver disorders and, meanwhile, in maintaining liver homeostasis to avoid the development of liver pathologies.

https://www.sciencedirect.com/science/article/pii/S2161831323003149 (2023).--

Magnesium deficiency is commonly associated with liver disease and may result from poor nutrient absorption, increased urinary secretion, low serum albumin concentration, or hormonal inactivation. In turn, low magnesium content in serum and liver tissue can lead to the progression of these diseases, due to an alteration in mitochondrial function, defective protein kinase C (PKC) translocation, inflammatory responses, oxidative stress or disorders. metabolic. Additionally, magnesium supplementation may improve liver function in certain liver diseases. Magnesium supplementation may not only preserve liver function, but also slow the progression of liver disease and reduce associated mortality.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861788/ (2019).----

https://www.mdpi.com/2072-6643/13/1/142 (2021).--

Micronutrients implicated in nonalcoholic fatty liver disease and fatty liver disease (NAFLD) are zinc, copper, iron, selenium, magnesium, vitamins A, C, D and E, and carotenoids. The proposed mechanisms of action are its antioxidant, antifibrotic, immunomodulatory and lipoprotective effects. Excess iron has been reported to play a role in the severity of NAFLD.

https://www.sciencedirect.com/science/article/pii/S2666149723000051 (2023).--

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