Mg is involved in virtually all major metabolic and biochemical processes within the cell and is responsible for numerous functions in the body, including bone development, neuromuscular function, signaling pathways, energy storage and transfer, glucose, lipid metabolism. and proteins, DNA and RNA stability and cell proliferation. Total body magnesium content is approximately 24 g in a normal human adult. The total body magnesium of an adult is approximately 25 g, of which 50-60% is in the bones, and the remaining 40-50% is in the soft tissues, with less than 1% present in the blood. Enzyme databases currently list more than 600 enzymes with Mg as a cofactor, while another 200 are listed in which Mg can act as an activator. Magnesium has an important role in enzyme activation, membrane function and intracellular signaling. The ion also represents an important cofactor for many enzymes. It is involved in the synthesis and replication of RNA and DNA, as well as the secretion of enzymes and hormones [
Over the past 30 years, several experimental, clinical, and epidemiological studies have shown that chronic magnesium deficiency is associated with and/or amplifies many important diseases. Most of them are known “social pathologies” such as diabetes, osteoporosis and cardiovascular diseases.
Growing scientific evidence supports the view that low magnesium intake could induce changes in biochemical signaling pathways, increasing the risk of disease over time. Among some works that focus on the social impact of magnesium deficiency, a recent study is worth highlighting. It states that subclinical magnesium deficiency increases the risk of numerous types of cardiovascular diseases.
In this context, it is important to reiterate that acute hypomagnesemia presents clear clinical characteristics (severe cramps, nystagmus, cardiac arrhythmias, etc.), and is easily detectable.
The links focus on five diseases of high social impact in which magnesium deficiency seems to be involved: diabetes mellitus, osteoporosis, cardiovascular diseases, cancer and neurological disorders.
wApproximately 48% of the US population has been shown to consume less than the Estimated Average Requirement (EAR), while three-quarters do not meet the Recommended Daily Allowance (RDA)
Recent systematic reviews of randomized controlled trials illustrate inverse relationships of magnesium supplementation with circulating CRP levels, with larger effect magnitudes among individuals with elevated inflammatory status. It has also been
Magnesium has a known "calcium channel blocking" effect: the mineral can inhibit the entry of calcium (Ca+2) into immunocompetent cells, limiting the activation of nuclear factor-κB (NF-κB), cytokine production and resulting systemic inflammation. Covid-19 and “vaccines” cause cardiovascular damage. The metabolism of vitamin D depends on magnesium as a cofactor.
A recent retrospective observational investigation of COVID-19 patients found significantly fewer hospitalized patients aged ≥50 years receiving daily oral supplements of vitamin D 3 (1000 IU), magnesium (150 mg), and vitamin B12 (500 μg) for up to 14 days They did not require subsequent oxygen therapy compared to controls. which may explain the relationship between Mg and lung outcomes of COVID-19.
Mg is involved in virtually all major metabolic and biochemical processes within the cell and is responsible for numerous functions in the body, including bone development, neuromuscular function, signaling pathways, energy storage and transfer, glucose, lipid metabolism. and proteins, DNA and RNA stability and cell proliferation. Total body magnesium content is approximately 24 g in a normal human adult. The total body magnesium of an adult is approximately 25 g, of which 50-60% is in the bones, and the remaining 40-50% is in the soft tissues, with less than 1% present in the blood. Enzyme databases currently list more than 600 enzymes with Mg as a cofactor, while another 200 are listed in which Mg can act as an activator. Magnesium has an important role in enzyme activation, membrane function and intracellular signaling. The ion also represents an important cofactor for many enzymes. It is involved in the synthesis and replication of RNA and DNA, as well as the secretion of enzymes and hormones [
Over the past 30 years, several experimental, clinical, and epidemiological studies have shown that chronic magnesium deficiency is associated with and/or amplifies many important diseases. Most of them are known “social pathologies” such as diabetes, osteoporosis and cardiovascular diseases.
Growing scientific evidence supports the view that low magnesium intake could induce changes in biochemical signaling pathways, increasing the risk of disease over time. Among some works that focus on the social impact of magnesium deficiency, a recent study is worth highlighting. It states that subclinical magnesium deficiency increases the risk of numerous types of cardiovascular diseases.
In this context, it is important to reiterate that acute hypomagnesemia presents clear clinical characteristics (severe cramps, nystagmus, cardiac arrhythmias, etc.), and is easily detectable.
The links focus on five diseases of high social impact in which magnesium deficiency seems to be involved: diabetes mellitus, osteoporosis, cardiovascular diseases, cancer and neurological disorders.
https://www.mdpi.com/2072-6643/13/4/1136/htm (2022).--
https://www.mdpi.com/2072-6643/14/3/644 (2022)..---
wApproximately 48% of the US population has been shown to consume less than the Estimated Average Requirement (EAR), while three-quarters do not meet the Recommended Daily Allowance (RDA)
Recent systematic reviews of randomized controlled trials illustrate inverse relationships of magnesium supplementation with circulating CRP levels, with larger effect magnitudes among individuals with elevated inflammatory status. It has also been
Magnesium has a known "calcium channel blocking" effect: the mineral can inhibit the entry of calcium (Ca+2) into immunocompetent cells, limiting the activation of nuclear factor-κB (NF-κB), cytokine production and resulting systemic inflammation. Covid-19 and “vaccines” cause cardiovascular damage. The metabolism of vitamin D depends on magnesium as a cofactor.
A recent retrospective observational investigation of COVID-19 patients found significantly fewer hospitalized patients aged ≥50 years receiving daily oral supplements of vitamin D 3 (1000 IU), magnesium (150 mg), and vitamin B12 (500 μg) for up to 14 days They did not require subsequent oxygen therapy compared to controls. which may explain the relationship between Mg and lung outcomes of COVID-19.
https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1785971 (2021).-___
https://link.springer.com/article/10.1007/s00394-021-02704-y (2022).---
https://link.springer.com/article/10.1007/s12011-022-03124-7 (2023)