Mg is involved in virtually all major metabolic and biochemical processes within the cell and is responsible for numerous functions in the body, including bone development, neuromuscular function, signaling pathways, energy storage and transfer, glucose, lipid metabolism. and proteins, DNA and RNA stability and cell proliferation. Enzyme databases currently list more than 600 enzymes with Mg as a cofactor, while another 200 are listed in which Mg can act as an activator. Magnesium has an important role in enzyme activation, membrane function and intracellular signaling. The ion also represents an important cofactor for many enzymes. It is involved in the synthesis and replication of RNA and DNA, as well as the secretion of enzymes and hormones.
Over the past 30 years, several experimental, clinical, and epidemiological studies have shown that chronic magnesium deficiency is associated with and/or amplifies many important diseases. Most of them are known “social pathologies” such as diabetes, osteoporosis and cardiovascular diseases.
In this context, it is important to reiterate that acute hypomagnesemia presents clear clinical characteristics (severe cramps, nystagmus, cardiac arrhythmias, etc.), and is easily detectable. In contrast, subclinical or chronic magnesium deficiency is often underestimated because it reflects reduced levels of magnesium within cells and bones, not extracellular magnesium.
The links focus on five diseases of high social impact in which magnesium deficiency seems to be involved: diabetes mellitus, osteoporosis, cardiovascular diseases, cancer and neurological disorders.
A study highlights the potential of magnesium-rich foods to prevent hypertension, diabetes and hyperlipidemia in American adults. Magnesium supplementation may be effective for the treatment of gestational diabetes without the need for insulin treatment.
Increasing Mg intake could help reduce the risk associated with high hemoglobin glycation associated with diabetes,
Knowing that 80% of the immune system resides in the intestine, magnesium has long been associated with immune responses. It plays a fundamental role in various immune responses by participating in multiple mechanisms. It facilitates the binding of substance P to lymphoblasts, promotes responses of T helper cells, B cells, and macrophages to lymphokines, and facilitates antibody-dependent cytolysis and immune cell adhesion and immunoglobulin synthesis. In addition, it has an important anti-cancer effect. Chronic Mg deficiency leads to increased basal inflammation associated with oxidative stress, related to various age-associated morbidities. The importance of Mg in the immune response against cancer cells and infectious agents and how it regulates inflammation, oxidative stress, cell progression, differentiation and apoptosis.
Mg is involved in virtually all major metabolic and biochemical processes within the cell and is responsible for numerous functions in the body, including bone development, neuromuscular function, signaling pathways, energy storage and transfer, glucose, lipid metabolism. and proteins, DNA and RNA stability and cell proliferation. Enzyme databases currently list more than 600 enzymes with Mg as a cofactor, while another 200 are listed in which Mg can act as an activator. Magnesium has an important role in enzyme activation, membrane function and intracellular signaling. The ion also represents an important cofactor for many enzymes. It is involved in the synthesis and replication of RNA and DNA, as well as the secretion of enzymes and hormones.
Over the past 30 years, several experimental, clinical, and epidemiological studies have shown that chronic magnesium deficiency is associated with and/or amplifies many important diseases. Most of them are known “social pathologies” such as diabetes, osteoporosis and cardiovascular diseases.
In this context, it is important to reiterate that acute hypomagnesemia presents clear clinical characteristics (severe cramps, nystagmus, cardiac arrhythmias, etc.), and is easily detectable. In contrast, subclinical or chronic magnesium deficiency is often underestimated because it reflects reduced levels of magnesium within cells and bones, not extracellular magnesium.
The links focus on five diseases of high social impact in which magnesium deficiency seems to be involved: diabetes mellitus, osteoporosis, cardiovascular diseases, cancer and neurological disorders.
A study highlights the potential of magnesium-rich foods to prevent hypertension, diabetes and hyperlipidemia in American adults. Magnesium supplementation may be effective for the treatment of gestational diabetes without the need for insulin treatment.
Increasing Mg intake could help reduce the risk associated with high hemoglobin glycation associated with diabetes,
https://www.mdpi.com/2072-6643/13/4/1136/htm (2022)
https://www.mdpi.com/2072-6643/14/3/644 (2022)
https://www.nature.com/articles/s41440-023-01439-z (2024).--
https://www.sciencedirect.com/science/article/abs/pii/S0301211523008588 (2024).--
https://link.springer.com/article/10.1007/s12011-023-03727-8 (2024).--
Knowing that 80% of the immune system resides in the intestine, magnesium has long been associated with immune responses. It plays a fundamental role in various immune responses by participating in multiple mechanisms. It facilitates the binding of substance P to lymphoblasts, promotes responses of T helper cells, B cells, and macrophages to lymphokines, and facilitates antibody-dependent cytolysis and immune cell adhesion and immunoglobulin synthesis. In addition, it has an important anti-cancer effect. Chronic Mg deficiency leads to increased basal inflammation associated with oxidative stress, related to various age-associated morbidities. The importance of Mg in the immune response against cancer cells and infectious agents and how it regulates inflammation, oxidative stress, cell progression, differentiation and apoptosis.
https://link.springer.com/article/10.1186/s41043-023-00423-0 (2023).--
INTEGRATIVE OMICS UNCOVERS LOW TUMOROUS MAGNESIUM CONTENT AS A DRIVER FACTOR OF COLORECTAL CANCER
https://www.biorxiv.org/content/10.1101/2024.01.22.576593v1.abstract (2024).--
MAGNESIUM-L-THREONATE TREATS ALZHEIMER’S DESIGN BY MODULATING THE MICROBIOTA-GUT-BRAIN AXIS
https://journals.lww.com/nrronline/fulltext/2024/10000/magnesium_l_threonate_treats_alzheimer_s_disease.29.aspx (2024).--
MAGNESIUM AND HUMAN HEALTH: PERSPECTIVES AND RESEARCH DIRECTIONS
https://downloads.hindawi.com/journals/ije/2018/9041694.pdf (2019).---