The contribution of C-15 saturated fat is very interesting. Pentadecanoic acid (C15:0), an odd-chain saturated fatty acid, has growing evidence of being essential for supporting cardiometabolic and liver health. People with low circulating concentrations of C15:0 have an increased risk of having or developing type 2 diabetes, heart disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis, as well as specific types of cancer. C15:0 is present in 1 to 3% of milk fat, and as a primarily exogenous molecule, circulating C15:0 concentrations reflect dietary C15:0 intake. Epidemiological, in vivo, and in vitro studies support the idea that between 100 and 300 mg of C15:0 per day are needed to effectively achieve and maintain active circulating C15:0 concentrations of 10 to 30 µM.
C15:0 and rapamycin, a leading candidate for a longevity and health enhancement intervention, share numerous clinically relevant activities, including anti-inflammatory, anticancer, antifibrotic, antimicrobial, and mTOR inhibitory activities. Furthermore, as an AMPK activator, C15:0 also exhibits multiple similarities to metformin, particularly at specific doses. Studies consistently show that individuals with higher circulating concentrations of C15:0 have a lower risk of age-related conditions. C15:0 is an essential nutrient that supports healthy aging and longevity in humans, with cell-based activities that are as effective as, or better than, leading prescription therapies for longevity enhancement. Given the decline in C15:0 levels across the population, there is a need to assess the potential effects of C15:0 nutritional deficiencies on our lifespan and longevity.
Three recognized types of cell death have been established: apoptosis, necrosis, and autophagy. Ferroptosis involves the lipid peroxidation of fragile polyunsaturated fatty acids in cell membranes, which combines with abnormal intracellular iron to induce the massive production of reactive oxygen species, resulting in mitochondrial dysfunction and cell death. Ferroptosis has been linked to many age-related diseases in humans, including type 2 diabetes, cardiovascular disease, NAFLD, and neurodegenerative diseases.
Feroptosis requires two triggers: fragile polyunsaturated fatty acids in cell membranes that are susceptible to lipid peroxidation and excess intracellular iron. As Dr. Mercola has reported, PUFA lipid peroxidation is a major contributor to numerous age-related diseases, including metabolic syndrome, NAFLD, cardiovascular disease, and neurodegenerative diseases. Furthermore, dysregulated iron metabolism and direct tissue damage caused by iron overload are increasingly recognized as drivers of type 2 diabetes, NAFLD, cardiovascular disease, and neurodegenerative diseases. When lipid peroxidation is combined with iron overload, the result is ferroptosis, which has far-reaching effects that contribute to the onset and progression of metabolic and related diseases (Figure 1).
While decreased dietary intake of cow's milk fat may explain the decline in circulating C15:0 concentrations in Western countries, changes in dietary fish consumption habits also play a role. As shown in Table 1, C15:0 content varies considerably by fish species, with mullet and catfish having a C15:0 content similar to milk fat. Therefore, changes in the type or amount of fish consumed can influence an individual's circulating C15:0 concentrations.
C15:0 is a recently discovered essential fatty acid that plays a critical role in the physical strengthening of cell membranes and the protection of cells against lipid peroxidation. As part of a cell stability hypothesis, it is proposed that adequate concentrations of C15:0 in cell membranes are needed to prevent ferroptosis, a recently discovered mechanism of cell death involving lipid peroxidation of cell membrane fatty acids and intracellular iron, which has also been linked to type 2 diabetes, cardiovascular disease, and NAFLD.
Based on numerous studies provided in this review, a definition of C15:0 nutritional deficiency is offered (circulating C15:0 ≤ 0.2% of total fatty acids). A description of the pathophysiology behind this C15:0 nutritional deficiency syndrome (cellular fragility syndrome) is provided, explaining how a low level of C15:0 can accelerate the progression of age-related diseases, including dysmetabolic iron overload syndrome, type 2 diabetes, cardiovascular disease, and NAFLD.
In addition to correcting nutritional deficiencies, there is evidence that optimal circulating C15:0 concentrations (>0.4% to 0.64% of total fatty acids) may support cardiovascular health and long-term longevity. Continued studies, including clinical trials, will help to further test the cellular stability hypothesis and the proposed definition of C15:0 nutritional deficiencies. Given the global decline in dietary C15:0 intake, further studies are needed to better understand the depth and breadth of C15:0 deficiency-driven cellular fragility syndrome in different human populations and how this syndrome may be contributing to the rise in age-related diseases, particularly among younger people.
Early humans pursued their prey slowly but surely for miles and miles until the animal collapsed from heat exhaustion, at which point they harpooned it and ate it for up to a month. This method, called "persistence hunting," was likely practiced by prehistoric hunter-gatherers for nearly two million years. Running long distances was crucial in creating our current upright body shape, according to a new theory. Researchers have suggested that our early ancestors were good endurance runners and that their habit has left its evolutionary mark on our bodies, from our leg joints to our heads.
Aerobic exercise increases the size of the anterior hippocampus. This expansion is linked to improved memory, which mirrors the enhanced learning associated with running activity in animal studies. Greater physical fitness is associated with greater expansion, not only of the hippocampus, but of several other brain regions as well.
Today’s hunter-gatherers offer a window into the level of activity required to live a low-tech life, says Raichlen, who primarily studies the activity levels of the Hadza people in Tanzania, a group of 1,300 who choose to live a hunter-gatherer lifestyle. “We found that the Hadza spend about 75 minutes a day doing moderate to vigorous physical activity,” Raichlen says. “In two days, the Hadza meet the U.S. national weekly activity guidelines.”
The Hadza forage for the same animals and plants that humans have hunted and gathered for millions of years. Importantly, the interplay between humans and microbes that developed here over eons likely shaped aspects of our immune system and made us who we are today. The significance of being in Hadza land was not lost on me.
The high levels of activity and a diet consisting mainly of gathered and hunted foods may be why the Hadza tend to be healthier than Westerners. They also have a relative lack of autoimmune diseases, metabolic diseases, and colon cancer, possibly related to the fact that they have much more diverse gut bacteria than we do, according to researchers at the University of Nevada, Las Vegas.
Analysis of the gut microbiome of extant rural populations in Africa and South America has revealed the presence of a common, potentially commensal spirochete belonging to the genus. These spirochetes have also been detected in extant hunter-gatherers and in 1,000-year-old human coprolites from Mexico, but are essentially absent in healthy, ancestral urban populations. Ancient microbiome sources can reveal the extent to which bacteria commonly considered "pathogenic" in the modern world (e.g., H. pylori) were endemic indigenous organisms in pre-industrial microbiomes.
"In ancient cultures, the foods people ate were very diverse and could support the growth and presence of a more eclectic collection of microbes," said Kostic. “But as people move toward industrialization and a more supermarket-based diet, they lose many nutrients that help maintain a more diverse microbiome.”
Ancient microbiomes also had relatively higher numbers of transposases—transposable elements of DNA sequences that can change location within the genome—than modern industrial microbiomes.
A direct Bullseye hit! An article needing to be copied, left on the nightstand and as many passed out to those who are willing to listen.
Much of medicinal products found their origins in plants. Healing properties wrapped in a package of companion plant substances, fiber. Many were distilled, condensed down stripping out everything else but the strongest compound. Now, much more are synthetic chemical versions meant to address never ending symptoms.
Now to attempt to produce healthy lifestyles with a base of chemical free cleanly grown foods, to address and use Health Builders, Dis-Ease Preventers are attacked by intertwined Mammoth Monopolies. Monopolies with many deep pockets to protect their Monopolies. Having the tools to distract, use Fear Porn, whatnot to continue to convince a public to pay no attention to their actual dismal results. (In the States, the highest costs generating the worst results.)
The real health builders and path to possibly create a long life of quality worth living comes from Local Efforts. Make it Real Locally, Keep it Real Locally. Slick, shiny commercials sell images, not substance. Just Sayn'
Well said, Just. Rockefeller and his evil cronies managed to create a medical-industrial complex that still dominates Western medicine today. John D. Rockefeller controlled 90 percent of U.S. oil production, which allowed him to buy the favor of everyone he needed under his Big Pharma umbrella.
It was then that Rockefeller injected $100 million into the General Board of Education to END all studies of natural medicine (anything holistic) in the 150 medical schools in the United States and permanently establish only the study and practice (in hospitals) of prescribing pharmaceutical drugs that alleviate the symptoms of illnesses and disorders, but never cure anything. He even called the whole movement "a pill for an ailment." Patients then and now who regularly take prescription medications are the sickest people on the planet, and they typically die from chronic and preventable diseases 10, 20, even 30 years before their normal life expectancy.
It was 1910. I said goodbye to healthy eating, clean water, and all knowledge about the power of proper nutrition. And just like that, the medical-pharmaceutical industrial complex was created and consolidated. Any competition or negative reaction from natural medicine enthusiasts would be eliminated and labeled "quackery."
Half of the medical schools in the United States were forced to close. These were schools that wanted to continue offering training in nutrition, chiropractic, homeopathy, holistic, functional, integrative medicine, and osteopathy. If you violated the linear approach of this new medical regime, you went to jail and lost your medical license. It was that simple.
And the future is a continuation of this. The health of the planet is at stake. The world's powerful have devised a perverse agenda called "One Health" that threatens to enslave the planet under the tyranny of food and medicine.
A "twist of the screw," to quote Tracy Thurman of the Brownstone Institute, on the old adage "Let food be thy medicine," One Health is a full-scale attack on food, medicine, and life itself. It will hand control of everything that sustains health to globalist eugenicists who want to eliminate the world's population.
According to Thurman, the plan is to strip ordinary citizens of all control over food and medicine. "Doctors" will prescribe food for people and won't even consider buying dietary supplements for them.
“Think about the brainwashing most doctors underwent during the pandemic and their refusal to recommend basic health supplements, sunlight, vitamin D, or effective early treatment, instead leaving their patients at the mercy of remdesivir, ventilators, and mRNA injections. If you don’t like the idea of prescribing cricket food and vaccine lettuce, this agenda should shock you.”
Behind the One Health plot are the usual suspects. Billionaire eugenicist Bill Gates, of course, backs the plan, as do the World Health Organization (WHO), the World Bank, the Rockefeller Foundation, the CDC, the FDA, the NIH, the USDA, and “every other Covid culprit you can imagine,” Thurman says.
Another spot on Bullseye hit, this time coming from Gui! Thanks Gui! Rockefeller, the Ringleader, Circus Master who inserted himself in all the intertwined Monopolies all of a hundred years ago. This is why when attempting to deal with any of the monopolies, what is under the radar for most is we are being flanked by all the other monopolies at the same time. How do get a real Health Building System in place when we have an Octopus reaching out in all directions strangling all?
Because so much is intertwined, a bit of a sidebar; How do we get Glyphosate destroying our health out of the environment when Finance, Oil, Chemicals, the Ag system and more are off on the sides attacking. Its a system of systems to have been built over a century and allowed for better than fifty years to become so dominant to remove Glyphosate over night, and there would be little to no food for the majority. It has been by design. Currently though, this may become a moot point to disappear as the repercussions of the Global Systems have had the rug pulled out from under it all due to the events in the Gulf.
Lots of information on how an individual can go off grid, but little if any for how does an extended family or a combination of extended families go off grid? How does a neighborhood, a community go off grid? How do we protect and keep what we may have to work with when Gates, others, Blackrock, Vanguard and State Street are gobbling lands and resources up?
Actually humans did not evolve - not ever.
We were created. Everything about us is according to design and with purpose.
Everything that exists requires a "maker."
Evolution simply means "change."
We observe only two kinds of change in the world:
that which is according to inherent genetic potential
and that which is manipulated in a lab.
Macro evolution is impossible.
Functional complexity does not arise from disorder by chance.
The contribution of C-15 saturated fat is very interesting. Pentadecanoic acid (C15:0), an odd-chain saturated fatty acid, has growing evidence of being essential for supporting cardiometabolic and liver health. People with low circulating concentrations of C15:0 have an increased risk of having or developing type 2 diabetes, heart disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis, as well as specific types of cancer. C15:0 is present in 1 to 3% of milk fat, and as a primarily exogenous molecule, circulating C15:0 concentrations reflect dietary C15:0 intake. Epidemiological, in vivo, and in vitro studies support the idea that between 100 and 300 mg of C15:0 per day are needed to effectively achieve and maintain active circulating C15:0 concentrations of 10 to 30 µM.
C15:0 and rapamycin, a leading candidate for a longevity and health enhancement intervention, share numerous clinically relevant activities, including anti-inflammatory, anticancer, antifibrotic, antimicrobial, and mTOR inhibitory activities. Furthermore, as an AMPK activator, C15:0 also exhibits multiple similarities to metformin, particularly at specific doses. Studies consistently show that individuals with higher circulating concentrations of C15:0 have a lower risk of age-related conditions. C15:0 is an essential nutrient that supports healthy aging and longevity in humans, with cell-based activities that are as effective as, or better than, leading prescription therapies for longevity enhancement. Given the decline in C15:0 levels across the population, there is a need to assess the potential effects of C15:0 nutritional deficiencies on our lifespan and longevity.
https://www.mdpi.com/2072-6643/15/21/4607 (2023).--
Three recognized types of cell death have been established: apoptosis, necrosis, and autophagy. Ferroptosis involves the lipid peroxidation of fragile polyunsaturated fatty acids in cell membranes, which combines with abnormal intracellular iron to induce the massive production of reactive oxygen species, resulting in mitochondrial dysfunction and cell death. Ferroptosis has been linked to many age-related diseases in humans, including type 2 diabetes, cardiovascular disease, NAFLD, and neurodegenerative diseases.
Feroptosis requires two triggers: fragile polyunsaturated fatty acids in cell membranes that are susceptible to lipid peroxidation and excess intracellular iron. As Dr. Mercola has reported, PUFA lipid peroxidation is a major contributor to numerous age-related diseases, including metabolic syndrome, NAFLD, cardiovascular disease, and neurodegenerative diseases. Furthermore, dysregulated iron metabolism and direct tissue damage caused by iron overload are increasingly recognized as drivers of type 2 diabetes, NAFLD, cardiovascular disease, and neurodegenerative diseases. When lipid peroxidation is combined with iron overload, the result is ferroptosis, which has far-reaching effects that contribute to the onset and progression of metabolic and related diseases (Figure 1).
While decreased dietary intake of cow's milk fat may explain the decline in circulating C15:0 concentrations in Western countries, changes in dietary fish consumption habits also play a role. As shown in Table 1, C15:0 content varies considerably by fish species, with mullet and catfish having a C15:0 content similar to milk fat. Therefore, changes in the type or amount of fish consumed can influence an individual's circulating C15:0 concentrations.
C15:0 is a recently discovered essential fatty acid that plays a critical role in the physical strengthening of cell membranes and the protection of cells against lipid peroxidation. As part of a cell stability hypothesis, it is proposed that adequate concentrations of C15:0 in cell membranes are needed to prevent ferroptosis, a recently discovered mechanism of cell death involving lipid peroxidation of cell membrane fatty acids and intracellular iron, which has also been linked to type 2 diabetes, cardiovascular disease, and NAFLD.
Based on numerous studies provided in this review, a definition of C15:0 nutritional deficiency is offered (circulating C15:0 ≤ 0.2% of total fatty acids). A description of the pathophysiology behind this C15:0 nutritional deficiency syndrome (cellular fragility syndrome) is provided, explaining how a low level of C15:0 can accelerate the progression of age-related diseases, including dysmetabolic iron overload syndrome, type 2 diabetes, cardiovascular disease, and NAFLD.
In addition to correcting nutritional deficiencies, there is evidence that optimal circulating C15:0 concentrations (>0.4% to 0.64% of total fatty acids) may support cardiovascular health and long-term longevity. Continued studies, including clinical trials, will help to further test the cellular stability hypothesis and the proposed definition of C15:0 nutritional deficiencies. Given the global decline in dietary C15:0 intake, further studies are needed to better understand the depth and breadth of C15:0 deficiency-driven cellular fragility syndrome in different human populations and how this syndrome may be contributing to the rise in age-related diseases, particularly among younger people.
https://www.mdpi.com/2218-1989/14/7/355 (2024).--
Early humans pursued their prey slowly but surely for miles and miles until the animal collapsed from heat exhaustion, at which point they harpooned it and ate it for up to a month. This method, called "persistence hunting," was likely practiced by prehistoric hunter-gatherers for nearly two million years. Running long distances was crucial in creating our current upright body shape, according to a new theory. Researchers have suggested that our early ancestors were good endurance runners and that their habit has left its evolutionary mark on our bodies, from our leg joints to our heads.
Aerobic exercise increases the size of the anterior hippocampus. This expansion is linked to improved memory, which mirrors the enhanced learning associated with running activity in animal studies. Greater physical fitness is associated with greater expansion, not only of the hippocampus, but of several other brain regions as well.
Today’s hunter-gatherers offer a window into the level of activity required to live a low-tech life, says Raichlen, who primarily studies the activity levels of the Hadza people in Tanzania, a group of 1,300 who choose to live a hunter-gatherer lifestyle. “We found that the Hadza spend about 75 minutes a day doing moderate to vigorous physical activity,” Raichlen says. “In two days, the Hadza meet the U.S. national weekly activity guidelines.”
The Hadza forage for the same animals and plants that humans have hunted and gathered for millions of years. Importantly, the interplay between humans and microbes that developed here over eons likely shaped aspects of our immune system and made us who we are today. The significance of being in Hadza land was not lost on me.
The high levels of activity and a diet consisting mainly of gathered and hunted foods may be why the Hadza tend to be healthier than Westerners. They also have a relative lack of autoimmune diseases, metabolic diseases, and colon cancer, possibly related to the fact that they have much more diverse gut bacteria than we do, according to researchers at the University of Nevada, Las Vegas.
Analysis of the gut microbiome of extant rural populations in Africa and South America has revealed the presence of a common, potentially commensal spirochete belonging to the genus. These spirochetes have also been detected in extant hunter-gatherers and in 1,000-year-old human coprolites from Mexico, but are essentially absent in healthy, ancestral urban populations. Ancient microbiome sources can reveal the extent to which bacteria commonly considered "pathogenic" in the modern world (e.g., H. pylori) were endemic indigenous organisms in pre-industrial microbiomes.
"In ancient cultures, the foods people ate were very diverse and could support the growth and presence of a more eclectic collection of microbes," said Kostic. “But as people move toward industrialization and a more supermarket-based diet, they lose many nutrients that help maintain a more diverse microbiome.”
Ancient microbiomes also had relatively higher numbers of transposases—transposable elements of DNA sequences that can change location within the genome—than modern industrial microbiomes.
https://www.nature.com/articles/nature03052.(2004) .-----
https://archive.unews.utah.edu/news_releases/how-running-made-us-human/.(2005).----
https://link.springer.com/chapter/10.1007/978-1-4020-9980-9_8 (2009).---
https://royalsocietypublishing.org/doi/full/10.1098/rstb.2014.0064 (2015).---
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312737/ (2015).---
https://www.nature.com/articles/ncomms4654 (2015).---
https://edition.cnn.com/2017/07/05/health/hunter-gatherer-diet-tanzania-the-conversation/index.html (2017).--
https://link.springer.com/article/10.1007/s00018-021-04060-w (2022).--
A direct Bullseye hit! An article needing to be copied, left on the nightstand and as many passed out to those who are willing to listen.
Much of medicinal products found their origins in plants. Healing properties wrapped in a package of companion plant substances, fiber. Many were distilled, condensed down stripping out everything else but the strongest compound. Now, much more are synthetic chemical versions meant to address never ending symptoms.
Now to attempt to produce healthy lifestyles with a base of chemical free cleanly grown foods, to address and use Health Builders, Dis-Ease Preventers are attacked by intertwined Mammoth Monopolies. Monopolies with many deep pockets to protect their Monopolies. Having the tools to distract, use Fear Porn, whatnot to continue to convince a public to pay no attention to their actual dismal results. (In the States, the highest costs generating the worst results.)
The real health builders and path to possibly create a long life of quality worth living comes from Local Efforts. Make it Real Locally, Keep it Real Locally. Slick, shiny commercials sell images, not substance. Just Sayn'
Well said, Just. Rockefeller and his evil cronies managed to create a medical-industrial complex that still dominates Western medicine today. John D. Rockefeller controlled 90 percent of U.S. oil production, which allowed him to buy the favor of everyone he needed under his Big Pharma umbrella.
It was then that Rockefeller injected $100 million into the General Board of Education to END all studies of natural medicine (anything holistic) in the 150 medical schools in the United States and permanently establish only the study and practice (in hospitals) of prescribing pharmaceutical drugs that alleviate the symptoms of illnesses and disorders, but never cure anything. He even called the whole movement "a pill for an ailment." Patients then and now who regularly take prescription medications are the sickest people on the planet, and they typically die from chronic and preventable diseases 10, 20, even 30 years before their normal life expectancy.
It was 1910. I said goodbye to healthy eating, clean water, and all knowledge about the power of proper nutrition. And just like that, the medical-pharmaceutical industrial complex was created and consolidated. Any competition or negative reaction from natural medicine enthusiasts would be eliminated and labeled "quackery."
Half of the medical schools in the United States were forced to close. These were schools that wanted to continue offering training in nutrition, chiropractic, homeopathy, holistic, functional, integrative medicine, and osteopathy. If you violated the linear approach of this new medical regime, you went to jail and lost your medical license. It was that simple.
https://www.theepochtimes.com/health/rockefeller-medicine-a-poisonous-illusion-4510429
And the future is a continuation of this. The health of the planet is at stake. The world's powerful have devised a perverse agenda called "One Health" that threatens to enslave the planet under the tyranny of food and medicine.
A "twist of the screw," to quote Tracy Thurman of the Brownstone Institute, on the old adage "Let food be thy medicine," One Health is a full-scale attack on food, medicine, and life itself. It will hand control of everything that sustains health to globalist eugenicists who want to eliminate the world's population.
According to Thurman, the plan is to strip ordinary citizens of all control over food and medicine. "Doctors" will prescribe food for people and won't even consider buying dietary supplements for them.
“Think about the brainwashing most doctors underwent during the pandemic and their refusal to recommend basic health supplements, sunlight, vitamin D, or effective early treatment, instead leaving their patients at the mercy of remdesivir, ventilators, and mRNA injections. If you don’t like the idea of prescribing cricket food and vaccine lettuce, this agenda should shock you.”
Behind the One Health plot are the usual suspects. Billionaire eugenicist Bill Gates, of course, backs the plan, as do the World Health Organization (WHO), the World Bank, the Rockefeller Foundation, the CDC, the FDA, the NIH, the USDA, and “every other Covid culprit you can imagine,” Thurman says.
https://brownstone.org/articles/the-one-health-agenda/ (2024).
Another spot on Bullseye hit, this time coming from Gui! Thanks Gui! Rockefeller, the Ringleader, Circus Master who inserted himself in all the intertwined Monopolies all of a hundred years ago. This is why when attempting to deal with any of the monopolies, what is under the radar for most is we are being flanked by all the other monopolies at the same time. How do get a real Health Building System in place when we have an Octopus reaching out in all directions strangling all?
Because so much is intertwined, a bit of a sidebar; How do we get Glyphosate destroying our health out of the environment when Finance, Oil, Chemicals, the Ag system and more are off on the sides attacking. Its a system of systems to have been built over a century and allowed for better than fifty years to become so dominant to remove Glyphosate over night, and there would be little to no food for the majority. It has been by design. Currently though, this may become a moot point to disappear as the repercussions of the Global Systems have had the rug pulled out from under it all due to the events in the Gulf.
Lots of information on how an individual can go off grid, but little if any for how does an extended family or a combination of extended families go off grid? How does a neighborhood, a community go off grid? How do we protect and keep what we may have to work with when Gates, others, Blackrock, Vanguard and State Street are gobbling lands and resources up?