Methylene blue (MB), as the first completely artificial drug, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria and methemoglobinemia, the antioxidant properties of MB have recently drawn attention to this century-old drug. Mitochondrial dysfunction in aging is systemic affecting many different tissues, including the brain and skin. This leads to increased oxidative stress and results in subsequent phenotypes in age-related conditions. MB can circumvent the activity of Complex I/III in mitochondria and decrease oxidative stress. MB easily crosses the blood-brain barrier, which makes it a promising candidate for neurodegenerative pathologies.
Methylene blue, a versatile drug used in the treatment and diagnosis of methemoglobinemia, is promising in the prevention of possible brain damage oxidative stress of iron deposits. It can act by inhibiting the Fenton reaction and reducing the production of hydroxyl radicals. By reducing, methylene blue can mitigate iron-induced neurotoxicity in neurodegenerative diseases.
In addition, methylene blue provides a protective effect on neurons and astrocytes in neurodegenerative diseases. metabolic The ability to cross the blood-brain barrier and accumulate in the brain with low toxicity and high affinity for both neuronal and cancerous tissues
In these studies against Parkinson's disease, MB restored dopamine depletion. MB is a potent inducer of BDNF and its downstream signaling pathways, suggesting that BDNF could be a key contributor to the beneficial effects. These results indicate that MB protects neurons against MPTP neurotoxicity by inducing BDNF, which represents MB as a possible modulatory agent in Parkinson's disease. The restoration of mitochondrial complex activity and ATP levels, and the attenuation of oxidative stress. In addition, we demonstrated that MB induced antioxidant molecules and activated the Nrf2 pathway.
Many seniors are given antibiotics, which disrupt their microbiome. Methylene blue (MB) was used for many decades at a dose of 65 mg per day and was even sold in pharmacies as Urolene Blue. (UTI). Many seniors are given antibiotics, which disrupt their microbiome. The kidneys excrete MB into the bladder, where it reaches very high concentrations over time and becomes a potent oxidative stress that kills virtually any pathogen in the bladder. Plus, it has the added "side effect" of improving brain health and reducing dementia. It is reprehensible medical negligence not to use methylene blue in urinary infections in the elderly. It is clearly the safest and most effective drug of choice.
The use of MB is associated with a reduction in the chance of contracting C-19 infection and mortality, and can be used as a safe, effective, inexpensive and readily available treatment option with minimal side effects for the clinical management of COVID-19.
In an article by Dr. Mihalcea explains that these abnormal clots appear to consist of amyloid or prion proteins: A serious concern with the gummy clots that develop in people's blood vessels is that they cannot be dissolved with conventional anticoagulants. Interestingly, however, the hydrogels seem to bind very strongly to the methylene blue (MB) molecule, and MB can be excreted through the kidneys.
Methylene blue (MB), as the first completely artificial drug, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria and methemoglobinemia, the antioxidant properties of MB have recently drawn attention to this century-old drug. Mitochondrial dysfunction in aging is systemic affecting many different tissues, including the brain and skin. This leads to increased oxidative stress and results in subsequent phenotypes in age-related conditions. MB can circumvent the activity of Complex I/III in mitochondria and decrease oxidative stress. MB easily crosses the blood-brain barrier, which makes it a promising candidate for neurodegenerative pathologies.
https://www.mdpi.com/2073-4409/10/12/3379/htm (2021).---
https://www.degruyter.com/document/doi/10.1515/revneuro-2024-0007/html (2024).--
https://openurl.ebsco.com/EPDB%3Agcd%3A12%3A23620172/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A176577925&crl=c (2024).--
Methylene blue, a versatile drug used in the treatment and diagnosis of methemoglobinemia, is promising in the prevention of possible brain damage oxidative stress of iron deposits. It can act by inhibiting the Fenton reaction and reducing the production of hydroxyl radicals. By reducing, methylene blue can mitigate iron-induced neurotoxicity in neurodegenerative diseases.
https://www.sciencedirect.com/science/article/abs/pii/S0306987724000422 (2024).--
In addition, methylene blue provides a protective effect on neurons and astrocytes in neurodegenerative diseases. metabolic The ability to cross the blood-brain barrier and accumulate in the brain with low toxicity and high affinity for both neuronal and cancerous tissues
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871783/ (2021)
In these studies against Parkinson's disease, MB restored dopamine depletion. MB is a potent inducer of BDNF and its downstream signaling pathways, suggesting that BDNF could be a key contributor to the beneficial effects. These results indicate that MB protects neurons against MPTP neurotoxicity by inducing BDNF, which represents MB as a possible modulatory agent in Parkinson's disease. The restoration of mitochondrial complex activity and ATP levels, and the attenuation of oxidative stress. In addition, we demonstrated that MB induced antioxidant molecules and activated the Nrf2 pathway.
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2018.32.1_supplement.553.8 (2018)
https://www.sciencedirect.com/science/article/abs/pii/S000629522100335X (2021)
Many seniors are given antibiotics, which disrupt their microbiome. Methylene blue (MB) was used for many decades at a dose of 65 mg per day and was even sold in pharmacies as Urolene Blue. (UTI). Many seniors are given antibiotics, which disrupt their microbiome. The kidneys excrete MB into the bladder, where it reaches very high concentrations over time and becomes a potent oxidative stress that kills virtually any pathogen in the bladder. Plus, it has the added "side effect" of improving brain health and reducing dementia. It is reprehensible medical negligence not to use methylene blue in urinary infections in the elderly. It is clearly the safest and most effective drug of choice.
https://takecontrol.substack.com/p/methylene-blue-health-benefits (2024).--
The use of MB is associated with a reduction in the chance of contracting C-19 infection and mortality, and can be used as a safe, effective, inexpensive and readily available treatment option with minimal side effects for the clinical management of COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127079/ (2024).--
In an article by Dr. Mihalcea explains that these abnormal clots appear to consist of amyloid or prion proteins: A serious concern with the gummy clots that develop in people's blood vessels is that they cannot be dissolved with conventional anticoagulants. Interestingly, however, the hydrogels seem to bind very strongly to the methylene blue (MB) molecule, and MB can be excreted through the kidneys.
https://drtesslawrie.substack.com/p/rubbery-clots-and-prion-like-proteins?utm_source=%2Fsearch%2Fprions&utm_medium=reader2 (16/04/2024)