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Exercise increases levels of powerful brain chemicals such as serotonin, dopamine and norepinephrine, which may help mitigate some of the effects of stress and create new neurons, including those that release the calming neurotransmitter GABA. In addition, it increases the levels of anandamide, and endocannabinoid that acts against pain and depression. For the synthesis of neurotransmitters: SAMe, folic acid, B12, B6 and tryptophan. serotonin supply had improved. Methylation is essential for many functions in the body, including the production of neurotransmitters. SAMe, folic acid, B12 and B6 required.

SAMe helps the production of creatine, glutathione, taurine, L-carnitine, and melatonin. An insufficiency of sunshine and vitamin D is associated with seasonal depression, and its ability to control inflammation. Insulin resistance is associated with depression. Ancestral diet, and blood sugar regulation: berberine, chromium and green coffee extract. Blood zinc levels are associated with mood and depression. Antioxidant effects of lipoic acid, NAC curcumin and selenium help fight free radicals. Hypericum perforatum is a medicinal herb used to treat depressive, neurological and psychiatric disorders.

People who develop active strategies focused on solving problems have lower levels of anxiety and depression. On the contrary, subjects who are focused on their negative emotions do not use these activities to distract themselves from their emotions, do not use strategies to solve the problem, and present a high risk of severe and prolonged depressive episodes. Research links depression to metabolic phenomena, including inflammation, insulin resistance, and oxidative stress. The relationship between chronic stress, depression and anxiety is complex, but incredibly powerful.

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