I take higher doses Niacin and notice my skin and vision improves and there is less hair in my brush. Eating enough protein helps with my hair as well.
I have taken suggested dosage of niacinimide but I don’t see the same benefits. Maybe didn’t use long enough. Thankful for the article! 🙏
The potential impact of the link between gut microbiota and NAD+ metabolites on overall health is noteworthy. Although the microorganisms that inhabit the intestine play a role in the metabolism of NAD+ and its metabolites, NMN and NR also affect the composition of the intestinal microbiota, reversing dysbiosis and promoting beneficial effects both at the intestinal and extraintestinal levels.
Furthermore, it is worth mentioning the role of the microbiota in the synthesis of NAD+. Unlike mammals, bacteria present in the intestine have enzymes that convert NMN into nicotinic acid mononucleotide (NAMN) through a deamidation process. After that, NAMN follows the Preiss-Handler pathway to the synthesis of NAD+.
Clinical trials have reported that a single oral dose of NMN (100 to 500 mg) was metabolized safely and effectively in healthy subjects. . Although NAM has been shown to be effective in increasing NAD+ in tissues, it also exerts an inhibitory effect on the activity of sirtuin and PARP. This could lead to a reduction in DNA and protein methylation and, as a consequence, alter gene expression patterns and protein activity, since DNA methylation in gene promoter regions is generally associated with transcriptional repression.
Proposed as a nutraceutical to prevent age-related physiological decline, NMN has been shown to improve diabetes and Alzheimer's disease, improve aerobic capacity, and exhibit cardio- and vasoprotective actions. It inhibits inflammation and reduces oxidative stress, preventing arterial and endothelial dysfunction and protecting against heart failure, ischemia and reperfusion.
As Guillermou stated NAM is a neuroprotective. My son has MTHFR. Evidence says I have it too. We take L-Merhylfolate every day. MTHFR people need it every day. Kudos for Gary Brecka, the first person I heard Finally Say Everyone on this planet needs to take L-Methyfolate and stop taking folic acid.
I’m saying that, be sure to take the above supplement so all your other supplements such as NAM can work effectively. God bless
Several studies have shown that nicotinamide (NAM) could offer benefit in various diseases and pathological conditions. NAM is a neuroprotective mainly due to increasing NAD+ levels. Therefore, NAM could have a therapeutic role against trauma, ischemia and neurodegeneration, in addition to neuropsychological disorders including depression and schizophrenia. Likewise, NAM could be beneficial against diabetes, HIV infection and glaucoma. Regarding cancer, NAM has already demonstrated clinical efficacy against non-melanoma skin cancer and resistance to radiotherapy due to tumor hypoxia. NAM has demonstrated the ability to counteract UV-induced immunosuppression. Topical administration of NAM reduced immunosuppression and suppressed tumor formation in UV-irradiated animal models. There is also evidence for the chemopreventive role of NAM in other types of cancer. A previous study demonstrated that intraperitoneal NAM suppressed breast cancer volume in animal models. Accumulating evidence suggests that NAM plays a role in cancer chemoprevention and therapy. Phase III clinical trials have demonstrated the effectiveness of NAM in chemoprevention in the treatment of head and neck, larynx and urinary bladder cancers, incorporating their results into clinical practice. More references in the link
Mitochondrial dysfunction is caused by poor nutrition. highly processed and pesticide-contaminated diet, load of sugars and additives, vaccines, fluoridated and contaminated water, stress, etc., NAD+ increases mitochondrial energy and its deficiency is an essential factor in chronic diseases and aging.
Individual metabolic processes to produce NAD may be different depending on age, diseases and genetics. The "raw materials" or "building blocks" (metabolic precursors) that the body needs to produce (synthesis) NAD+:
Additional support for mitochondrial function includes acetyl-L-carnitine, nicotinamide, Q10, pyrroloquinoline quinone, vitamin C, choline, NADH, α-lipoic acid, α-ketoglutaric acid, resveratrol, N-acetylcysteine, magnesium, and a multivitamin and quality mineral. In the following link more references:
I take higher doses Niacin and notice my skin and vision improves and there is less hair in my brush. Eating enough protein helps with my hair as well.
I have taken suggested dosage of niacinimide but I don’t see the same benefits. Maybe didn’t use long enough. Thankful for the article! 🙏
The potential impact of the link between gut microbiota and NAD+ metabolites on overall health is noteworthy. Although the microorganisms that inhabit the intestine play a role in the metabolism of NAD+ and its metabolites, NMN and NR also affect the composition of the intestinal microbiota, reversing dysbiosis and promoting beneficial effects both at the intestinal and extraintestinal levels.
Furthermore, it is worth mentioning the role of the microbiota in the synthesis of NAD+. Unlike mammals, bacteria present in the intestine have enzymes that convert NMN into nicotinic acid mononucleotide (NAMN) through a deamidation process. After that, NAMN follows the Preiss-Handler pathway to the synthesis of NAD+.
Clinical trials have reported that a single oral dose of NMN (100 to 500 mg) was metabolized safely and effectively in healthy subjects. . Although NAM has been shown to be effective in increasing NAD+ in tissues, it also exerts an inhibitory effect on the activity of sirtuin and PARP. This could lead to a reduction in DNA and protein methylation and, as a consequence, alter gene expression patterns and protein activity, since DNA methylation in gene promoter regions is generally associated with transcriptional repression.
Proposed as a nutraceutical to prevent age-related physiological decline, NMN has been shown to improve diabetes and Alzheimer's disease, improve aerobic capacity, and exhibit cardio- and vasoprotective actions. It inhibits inflammation and reduces oxidative stress, preventing arterial and endothelial dysfunction and protecting against heart failure, ischemia and reperfusion.
https://link.springer.com/article/10.1007/s13668-023-00475-y
What about for people like me with MTHFR? I don’t think my body processes niacinimide well….
As Guillermou stated NAM is a neuroprotective. My son has MTHFR. Evidence says I have it too. We take L-Merhylfolate every day. MTHFR people need it every day. Kudos for Gary Brecka, the first person I heard Finally Say Everyone on this planet needs to take L-Methyfolate and stop taking folic acid.
I’m saying that, be sure to take the above supplement so all your other supplements such as NAM can work effectively. God bless
Several studies have shown that nicotinamide (NAM) could offer benefit in various diseases and pathological conditions. NAM is a neuroprotective mainly due to increasing NAD+ levels. Therefore, NAM could have a therapeutic role against trauma, ischemia and neurodegeneration, in addition to neuropsychological disorders including depression and schizophrenia. Likewise, NAM could be beneficial against diabetes, HIV infection and glaucoma. Regarding cancer, NAM has already demonstrated clinical efficacy against non-melanoma skin cancer and resistance to radiotherapy due to tumor hypoxia. NAM has demonstrated the ability to counteract UV-induced immunosuppression. Topical administration of NAM reduced immunosuppression and suppressed tumor formation in UV-irradiated animal models. There is also evidence for the chemopreventive role of NAM in other types of cancer. A previous study demonstrated that intraperitoneal NAM suppressed breast cancer volume in animal models. Accumulating evidence suggests that NAM plays a role in cancer chemoprevention and therapy. Phase III clinical trials have demonstrated the effectiveness of NAM in chemoprevention in the treatment of head and neck, larynx and urinary bladder cancers, incorporating their results into clinical practice. More references in the link
.
https://www.mdpi.com/2218-273X/10/3/477 (2020)
https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23673 (2024).---
Mitochondrial dysfunction is caused by poor nutrition. highly processed and pesticide-contaminated diet, load of sugars and additives, vaccines, fluoridated and contaminated water, stress, etc., NAD+ increases mitochondrial energy and its deficiency is an essential factor in chronic diseases and aging.
https://www.liebertpub.com/doi/abs/10.1089/ars.2017.7445 (2018).---
Individual metabolic processes to produce NAD may be different depending on age, diseases and genetics. The "raw materials" or "building blocks" (metabolic precursors) that the body needs to produce (synthesis) NAD+:
1.- Nicotinamide riboside (NR)
2.- Nicotinic acid
3.- Nicotinamide
4.- Nicotinamide mononucleotide (NMN)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112140/ (2014)
https://pubmed.ncbi.nlm.nih.gov/19286518/ (2009)
Additional support for mitochondrial function includes acetyl-L-carnitine, nicotinamide, Q10, pyrroloquinoline quinone, vitamin C, choline, NADH, α-lipoic acid, α-ketoglutaric acid, resveratrol, N-acetylcysteine, magnesium, and a multivitamin and quality mineral. In the following link more references:
33 NATURAL WAYS TO IMPROVE MITOCHONDRIAL FUNCTION
https://selfhacked.com/blog/natural-ways-to-improve-mitochondrial-function/ (2022). .---
http://onlinelibrary.wiley.com/doi/10.1111/cns.12655/full (2017).---
https://www.annualreviews.org/doi/abs/10.1146/annurev-pharmtox-010716-104908 (2018).--
https://link.springer.com/book/10.1007%2F978-3-319-73344-9#page=493 (2018).---
I already take a B Complex with 100mg of Niacin, should/can I take additional Niacinamide, say another 50mg at night?